GABA-induced uncoupling of GABA/benzodiazepine site interactions is mediated by increased GABAA receptor internalization and associated with a change in subunit composition

Neuroscience

Volumn 257, Issue , 2014, Pages 119-129

  Gutierrez M L ^a   Ferreri, M C ^a   Gravielle, M C ^a  

^a Instituto de Investigaciones Farmacologicas   (Argentina)

Author keywords

Benzodiazepine; Endocytosis; GABA; Uncoupling

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR ALPHA3; BENZODIAZEPINE; CALCIUM CHANNEL L TYPE; MESSENGER RNA; PICROTOXIN; SUCROSE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CALCIUM TRANSPORT; CONTROLLED STUDY; DRUG BINDING SITE; EMBRYO; ENDOCYTOSIS; GABAERGIC TRANSMISSION; IMMUNOCYTOCHEMISTRY; INTERNALIZATION; INTRACELLULAR SIGNALING; MOLECULAR INTERACTION; NERVE CELL CULTURE; NEUROMODULATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; RAT; RECEPTOR DOWN REGULATION; RECEPTOR INTERNALIZATION;

BENZODIAZEPINE; BOVINE SERUM ALBUMIN; BSA; EDTA; ENDOCYTOSIS; ETHYLENEDIAMINETETRAACETIC; FLUNITRAZEPAM; FNZ; GABA; GABA(A) RECEPTORS; HORSERADISH PEROXIDASE; HRP; PBS; PHENYLMETHYLSULFONYL FLUORIDE; PHOSPHATE-BUFFERED SALINE; PMSF; RADIOIMMUNOPRECIPITATION ASSAY; RIPA; UNCOUPLING; VGCC; VOLTAGE-GATED CALCIUM CHANNEL;

ANIMALS; BENZODIAZEPINES; BINDING SITES; CELLS, CULTURED; CEREBRAL CORTEX; EMBRYO, MAMMALIAN; FLUNITRAZEPAM; GABA ANTAGONISTS; GABA MODULATORS; GAMMA-AMINOBUTYRIC ACID; GENE EXPRESSION REGULATION; NEURONS; PICROTOXIN; PROTEIN BINDING; PROTEIN TRANSPORT; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GABA-A; TIME FACTORS; TRITIUM;

EID: 84889599281     PISSN: 03064522     EISSN: 18737544     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2013.10.077     Document Type: Article

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