The loss of estrogen efficacy against cerebral ischemia in aged postmenopausal female mice

Neuroscience Letters

Volumn 558, Issue , 2014, Pages 115-119

  Cai, Min ^a   Ma, Yu Long ^a   Qin, Pei ^a   Li, Yan ^a   Zhang, Li Xia ^a   Nie, Huang ^a   Peng, Zhengwu ^a   Dong, Hui ^a   Dong, Hai Long ^a   Hou, Wu Gang ^a   Xiong, Li Ze ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Aged; Estrogen; Ischemia; Neuroprotection; Postmenopausal

Indexed keywords

ESTRADIOL; ESTROGEN; ESTROGEN RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN INFARCTION; BRAIN ISCHEMIA; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFICACY; ESTROGEN BLOOD LEVEL; ESTROGEN THERAPY; FEMALE; MIDDLE CEREBRAL ARTERY OCCLUSION; MOUSE; NEUROPROTECTION; NONHUMAN; POSTMENOPAUSE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REPERFUSION; REPERFUSION INJURY;

17Β-ESTRADIOL; 2,3,5-TRIPHENYLTETRAZOLIUM CHLORIDE; AGED; C TERMINUS OF HEAT SHOCK COGNATE PROTEIN 70 (HSC70)-INTERACTING PROTEIN; CENTRAL NERVOUS SYSTEM; CHIP; CNS; E2; ER; ESTROGEN; ESTROGEN RECEPTOR; GCI; GLOBAL CEREBRAL ISCHEMIA; HORMONE REPLACEMENT THERAPY; HRT; ISCHEMIA; LONG-TERM 17Β-ESTRADIOL DEPRIVATION; LTED; MCAO; NEUROPROTECTION; OVARIECTOMIZED; OVX; POSTMENOPAUSAL; RCBF; REGIONAL CEREBRAL BLOOD FLOW; TRANSIENT MIDDLE CEREBRAL ARTERY OCCLUSION; TTC;

AGE FACTORS; ANIMALS; BRAIN ISCHEMIA; CEREBRAL CORTEX; CEREBRAL INFARCTION; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; ESTROGEN REPLACEMENT THERAPY; ESTROGENS; FEMALE; INFARCTION, MIDDLE CEREBRAL ARTERY; MICE, INBRED C57BL; NEUROPROTECTIVE AGENTS; OVARIECTOMY; POSTMENOPAUSE;

EID: 84889588214     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2013.11.007     Document Type: Article

References (18)

1. Hachinski V., Donnan G.A., Gorelick P.B., Hacke W., Cramer S.C., Kaste M., Fisher M., Brainin M., Buchan A.M., Lo E.H., Skolnick B.E., Furie K.L., Hankey G.J., Kivipelto M., Morris J., Rothwell P.M., Sacco R.L., Smith S.C., Wang Y., Bryer A., Ford G.A., Iadecola C., Martins S.C.O., Saver J., Skvortsova V., Bayley M., Bednar M.M., Duncan P., Enney L., Finklestein S., Jones T.A., Kalra L., Kleim J., Nitkin R., Teasell R., Weiller C., Desai B., Goldberg M.P., Heiss W.-D., Saarelma O., Schwamm L.H., Shinohara Y., Trivedi B., Wahlgren N., Wong L.K., Hakim A., Norrving B., Prudhomme S., Bornstein N.M., Davis S.M., Edin F.R.C.P., Goldstein L.B., Leys D., Tuomilehto J. Stroke: working toward a prioritized world agenda. Stroke 2011, 41:1084-1099.
2. Towfighi A., Saver J.L., Engelhardt R., Ovbiagele B. A midlife stroke surge among women in the United States. Neurology 2007, 69:1898-1904.
3. Bushnell C.D. Stroke in women: risk and prevention throughout the lifespan. Neurologic Clinics 2008, 26:1161-1176.
4. Glendenning M.L., Lovekamp-swan T., Schreihofer D.A. Protective effect of estrogen in endothelin-induced middle cerebral artery occlusion in female rats. Neuroscience Letters 2008, 445:188-192.
5. Rapp S.R., Espeland M.A., Shumaker S.A., Henderson V.W., Brunner R.L., Manson J.E., Gass M.L., Stefanick M.L., Lane D.S., Hays J., Johnson K.C., Coker L.H., Dailey M., Bowen D. Effect of estrogen plus progestin on global cognitive function in postmenopausal women: the Women's Health Initiative Memory Study: a randomized controlled trial. Journal of American Medical Association 2003, 289:2663-2672.
6. Wassertheil-Smoller S., Hendrix S.L., Limacher M., Heiss G., Kooperberg C., Baird A., Kotchen T., Curb J.D., Black H., Rossouw J.E., Aragaki A., Safford M., Stein E., Laowattana S., Mysiw W.J. Effect of estrogen plus progestin on stroke in postmenopausal women: the Women's Health Initiative: a randomized trial. Journal of American Medical Association 2003, 289:2673-2684.
7. Renoux C., Suissa S. Hormone therapy administration in postmenopausal women and risk of stroke. Womens Health (London, England) 2011, 7:355-361.
8. Bushnell C. Stroke Hormones and Outcomes in Women (SHOW) study: is the 'healthy-user effect' valid for women after stroke?. Womens Health (London, England) 2009, 5:485-496.
9. Leon R.L., Li X., Huber J.D., Rosen C.L. Worsened outcome from middle cerebral artery occlusion in aged rats receiving 17β-estradiol. Endocrinology 2012, 153:3386-3393.
10. Wappler E.A., Felszeghy K., Szilágyi G., Gál A., Skopál J., Mehra R.D., Nyakas C., Nagy Z. Neuroprotective effects of estrogen treatment on ischemia-induced behavioural deficits in ovariectomized gerbils at different ages. Behavioural Brain Research 2010, 209:42-48.
11. Mohamed M.K., Abdel-Rahman A.A. Effect of long-term ovariectomy and estrogen replacement on the expression of estrogen receptor gene in female rats. European Journal of Endocrinology 2000, 142:307-314.
12. Yang Q., Yan W., Li X., Hou L., Dong H., Wang Q., Dong H., Wang S., Zhang X., Xiong L. Activation of canonical notch signaling pathway is involved in the ischemic tolerance induced by sevoflurane preconditioning in mice. Anesthesiology 2012, 117:996-1005.
13. Longa E.Z., Weinstein P.R., Carlson S., Cummins R. Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke 1989, 20:84-91.
14. Swanson R.A., Sharp F.R. Infarct measurement methodology. Journal of Cerebral Blood Flow and Metabolism 1994, 14:697-698.
15. Zhang Q.G., Han D., Wang R.M., Dong Y., Yang F., Vadlamudi R.K., Brann D.W. C terminus of Hsc70-interacting protein (CHIP)-mediated degradation of hippocampal estrogen receptor-alpha and the critical period hypothesis of estrogen neuroprotection. Proceedings of the National Academy of Sciences of the United States of America 2011, 108:E617-E624.
16. Kuppers E., Beyer C. Expression of estrogen receptor-alpha and beta mRNA in the developing and adult mouse striatum. Neuroscience Letters 1999, 276:95-98.
17. Gingerich S., Kim G.L., Chalmers J.A., Koletar M.M., Wang X., Wang Y., Belsham D.D. Estrogen receptor alpha and G-protein coupled receptor 30 mediate the neuroprotective effects of 17beta-estradiol in novel murine hippocampal cell models. Neuroscience 2010, 170:54-66.
18. De Marinis E., Acaz-Fonseca E., Arevalo M.A., Ascenzi P., Fiocchetti M., Marino M., Garcia-Segura L.M. 17β-Oestradiol anti-inflammatory effects in primary astrocytes require oestrogen receptor β-mediated neuroglobin up-regulation. Journal of Neuroendocrinology 2013, 25:260-270.