A new alternative method for testing skin irritation using a human skin model: A pilot study

Toxicology in Vitro

Volumn 28, Issue 2, 2014, Pages 240-247

  Miles, A ^a   Berthet, A ^b   Hopf, N B ^b   Gilliet, M ^a   Raffoul, W ^a   Vernez, D ^b   Spring, P ^a  

^a LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^b UNIVERSITY OF LAUSANNE   (Switzerland)

Author keywords

1 Bromohexane; Bentazon; Butylmethacrylate; DEHP; Draize test; Epiderm ; Episkin ; Folpet; Heptylbutyrate; Hexylsalicylate; Irritation scale; Isoproturon; Methylchloroisothiazolinone (MCI MI); Methylisothiazolinone (MI); NaCl; Sodiumlaurylsulfate

Indexed keywords

2 METHYL 4 ISOTHIAZOLIN 3 ONE; 5 CHLORO 2 METHYL 4 ISOTHIAZOLIN 3 ONE; BENTAZON; BUTYLMETHACRYLIC ACID; DODECYL SULFATE SODIUM; FOLPET; HEPTYLBUTYRIC ACID; IRRITANT AGENT; ISOPROTURON; SALICYLIC ACID HEXYL ESTER; SODIUM CHLORIDE; UNCLASSIFIED DRUG;

ARTICLE; BIOLOGICAL MODEL; CELL VACUOLE; CHEMICAL ANALYSIS; COMPARATIVE STUDY; CONTROLLED STUDY; DERMATOME; DIAGNOSTIC ACCURACY; EXPERIMENTAL ANIMAL; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; PATCH TEST; PILOT STUDY; PROCESS DEVELOPMENT; RECONSTRUCTED HUMAN EPIDERMIS MODEL; REPRODUCIBILITY; SKIN IRRITATION; SKIN MANIFESTATION; SKIN NECROSIS; SKIN TEST; SPONGIOSIS; VALIDATION PROCESS;

1-BROMOHEXANE; BENTAZON; BUTYLMETHACRYLATE; DEHP; DRAIZE TEST; EPIDERM®; EPISKIN®; FOLPET; HEPTYLBUTYRATE; HEXYLSALICYLATE; IRRITATION SCALE; ISOPROTURON; METHYLCHLOROISOTHIAZOLINONE (MCI/MI); METHYLISOTHIAZOLINONE (MI); NACL; SODIUMLAURYLSULFATE;

ADULT; FALSE NEGATIVE REACTIONS; FALSE POSITIVE REACTIONS; FEMALE; HUMANS; IRRITANTS; MIDDLE AGED; MODELS, BIOLOGICAL; NECROSIS; PILOT PROJECTS; SKIN; SKIN DISEASES; SKIN IRRITANCY TESTS; VACUOLES;

EID: 84889569007     PISSN: 08872333     EISSN: 18793177     Source Type: Journal    
DOI: 10.1016/j.tiv.2013.10.022     Document Type: Article

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