메뉴 건너뛰기




Volumn , Issue , 2008, Pages 259-272

Heart Simulation, Arrhythmia, and the Actions of Drugs

Author keywords

Arrhythmia; Biosimulation; Drug metabolism; Heart simulation; Linking levels; Multiple cellular mechanisms; Problem

Indexed keywords


EID: 84889419086     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9783527622672.ch9     Document Type: Chapter
Times cited : (1)

References (44)
  • 1
    • 76949111722 scopus 로고
    • Effect of current flow on the membrane potential of cardiac muscle
    • Weidmann, S.: Effect of current flow on the membrane potential of cardiac muscle. Journal of Physiology 1951, 115:227-236.
    • (1951) Journal of Physiology , vol.115 , pp. 227-236
    • Weidmann, S.1
  • 2
    • 84992156134 scopus 로고
    • Electric impedance of the squid giant axon during activity
    • Cole, K. S. and Curtis, H. J.: Electric impedance of the squid giant axon during activity. Journal of General Physiology 1939, 22:649-670.
    • (1939) Journal of General Physiology , vol.22 , pp. 649-670
    • Cole, K.S.1    Curtis, H.J.2
  • 3
    • 35649001607 scopus 로고
    • A quantitative description of membrane current and its application to conduction and excitation in nerve
    • Hodgkin, A. L. and Huxley, A. F.: A quantitative description of membrane current and its application to conduction and excitation in nerve. Journal of Physiology 1952, 117:500-544.
    • (1952) Journal of Physiology , vol.117 , pp. 500-544
    • Hodgkin, A.L.1    Huxley, A.F.2
  • 4
    • 33947494924 scopus 로고    scopus 로고
    • The music of life
    • OUP, Oxford
    • Noble, D.: The music of life. OUP, Oxford, 2006.
    • (2006)
    • Noble, D.1
  • 5
    • 36949074283 scopus 로고
    • Rectifying properties of heart muscle
    • Hutter, O. F. and Noble, D.: Rectifying properties of heart muscle. Nature 1960, 188:495.
    • (1960) Nature , vol.188 , pp. 495
    • Hutter, O.F.1    Noble, D.2
  • 6
    • 73849164199 scopus 로고
    • A modification of the Hodgkin-Huxley equations applicable to Purkinje fibre action and pacemaker potentials
    • Noble, D.: A modification of the Hodgkin-Huxley equations applicable to Purkinje fibre action and pacemaker potentials. Journal of Physiology 1962, 160:317-352.
    • (1962) Journal of Physiology , vol.160 , pp. 317-352
    • Noble, D.1
  • 7
    • 0036499997 scopus 로고    scopus 로고
    • Modelling the heart: from genes to cells to the whole organ
    • Noble, D.: Modelling the heart: from genes to cells to the whole organ. Science 2002a, 295:1678-1682.
    • (2002) Science , vol.295 , pp. 1678-1682
    • Noble, D.1
  • 8
    • 0036901631 scopus 로고    scopus 로고
    • Modelling the heart: insights, failures and progress
    • Noble, D.: Modelling the heart: insights, failures and progress. BioEssays 2002b, 24:1155-1163.
    • (2002) BioEssays , vol.24 , pp. 1155-1163
    • Noble, D.1
  • 10
    • 0002814313 scopus 로고    scopus 로고
    • A return to rational drug discovery: computer-based models of cells, organs and systems in drug target identification
    • Noble, D. and Colatsky, T. J.: A return to rational drug discovery: computer-based models of cells, organs and systems in drug target identification. Emerging Therapeutic Targets 2000, 4:39-49.
    • (2000) Emerging Therapeutic Targets , vol.4 , pp. 39-49
    • Noble, D.1    Colatsky, T.J.2
  • 12
    • 0033527032 scopus 로고    scopus 로고
    • Linking a genetic defect to its cellular phenotype in a cardiac arrhythmia
    • Clancy, C. E. and Rudy, Y.: Linking a genetic defect to its cellular phenotype in a cardiac arrhythmia. Nature 1999, 400:566-569.
    • (1999) Nature , vol.400 , pp. 566-569
    • Clancy, C.E.1    Rudy, Y.2
  • 13
    • 67049171081 scopus 로고    scopus 로고
    • Influence of transmural gradients on the electrophysiology and pharmacology of ventricular myocardium. Cellular basis for the Brugada and long-QT syndromes
    • Antzelevitch, C., Nesterenko, V. V., Muzikant, A. L., Rice, J. J., Chien, G. and Colatsky, T.: Influence of transmural gradients on the electrophysiology and pharmacology of ventricular myocardium. Cellular basis for the Brugada and long-QT syndromes. Philosophical Transactions of the Royal Society, Series A 2001, 359:1201-1216.
    • (2001) Philosophical Transactions of the Royal Society, Series A , vol.359 , pp. 1201-1216
    • Antzelevitch, C.1    Nesterenko, V.V.2    Muzikant, A.L.3    Rice, J.J.4    Chien, G.5    Colatsky, T.6
  • 14
    • 0031917543 scopus 로고    scopus 로고
    • Improved guinea-pig ventricular cell model incorporating a diadic space, iKr and iKs, and length-and tensiondependent processes
    • Noble, D., Varghese, A., Kohl, P. and Noble, P. J.: Improved guinea-pig ventricular cell model incorporating a diadic space, iKr and iKs, and length-and tensiondependent processes. Canadian Journal of Cardiology 1998, 14:123-134.
    • (1998) Canadian Journal of Cardiology , vol.14 , pp. 123-134
    • Noble, D.1    Varghese, A.2    Kohl, P.3    Noble, P.J.4
  • 15
    • 0029067417 scopus 로고
    • Electrophysiological effect of BRL-32872, a novel antiarrhythmic agent with potassium and calcium channel blocking properties, in guinea pig cardiac isolated preparations
    • Bril, A., Faivre, J. F., Forest, M. C., Cheval, B., Gout, B., Linee, P., Ruffolo, R. R. J. and Poyser, R. H.: Electrophysiological effect of BRL-32872, a novel antiarrhythmic agent with potassium and calcium channel blocking properties, in guinea pig cardiac isolated preparations. Journal of Pharmacology and Experimental Therapeutics 1995, 273:1264-1272.
    • (1995) Journal of Pharmacology and Experimental Therapeutics , vol.273 , pp. 1264-1272
    • Bril, A.1    Faivre, J.F.2    Forest, M.C.3    Cheval, B.4    Gout, B.5    Linee, P.6    Ruffolo, R.R.J.7    Poyser, R.H.8
  • 16
    • 0033816569 scopus 로고    scopus 로고
    • Inhibitory effect of amiodarone on Na+/Ca2+ exchange current in guinea-pig cardiac myocytes
    • Watanabe, Y. and Kimura, J.: Inhibitory effect of amiodarone on Na+/Ca2+ exchange current in guinea-pig cardiac myocytes. British Journal of Pharmacology 2000, 131:80-84.
    • (2000) British Journal of Pharmacology , vol.131 , pp. 80-84
    • Watanabe, Y.1    Kimura, J.2
  • 17
    • 0024503561 scopus 로고
    • Late sodium current and its contribution to action potential configuration in guinea pig ventricular myocytes
    • Kiyosue, T. and Arita, M.: Late sodium current and its contribution to action potential configuration in guinea pig ventricular myocytes. Circulation Research 1989, 64:389-397.
    • (1989) Circulation Research , vol.64 , pp. 389-397
    • Kiyosue, T.1    Arita, M.2
  • 19
    • 29244484461 scopus 로고    scopus 로고
    • A multi-modal composition of the late Na+ current in human ventricular cardiomyocytes
    • Maltsev, V. A. and Undrovinas, A. I.: A multi-modal composition of the late Na+ current in human ventricular cardiomyocytes. Cardiovascular Research 2006, 69:116-127.
    • (2006) Cardiovascular Research , vol.69 , pp. 116-127
    • Maltsev, V.A.1    Undrovinas, A.I.2
  • 20
    • 0034634299 scopus 로고    scopus 로고
    • Distribution of a persistent sodium current across the ventricular wall in guinea pigs
    • Sakmann, B. F. A. S., Spindler, A. J., Bryant, S. M., Linz, K. W. and Noble, D.: Distribution of a persistent sodium current across the ventricular wall in guinea pigs. Circulation Research 2000, 87:910-914.
    • (2000) Circulation Research , vol.87 , pp. 910-914
    • Sakmann, B.F.A.S.1    Spindler, A.J.2    Bryant, S.M.3    Linz, K.W.4    Noble, D.5
  • 21
    • 84889287674 scopus 로고    scopus 로고
    • Inhibition of the late sodium current as a potential cardioprotective principle: effects of the selective late sodium current inhibitor, ranolazine
    • Heart, in press
    • Belardinelli, L., Shryock, J. and Fraser, H.: Inhibition of the late sodium current as a potential cardioprotective principle: effects of the selective late sodium current inhibitor, ranolazine. Heart 2005, in press.
    • (2005)
    • Belardinelli, L.1    Shryock, J.2    Fraser, H.3
  • 22
    • 84889347044 scopus 로고    scopus 로고
    • Preclinical cardiac safety assessment of pharmaceutical compounds using an integrated systems-based computer model of the heart
    • Progress in Biophysics and Molecular Biology, in press
    • Bottino, D., Penland, R. C., Stamps, A., Traebert, M., Dumotier, B., Georgieva, A., Helmlinger, G. and Lett, G. S.: Preclinical cardiac safety assessment of pharmaceutical compounds using an integrated systems-based computer model of the heart. Progress in Biophysics and Molecular Biology 2005, in press.
    • (2005)
    • Bottino, D.1    Penland, R.C.2    Stamps, A.3    Traebert, M.4    Dumotier, B.5    Georgieva, A.6    Helmlinger, G.7    Lett, G.S.8
  • 23
    • 33646007982 scopus 로고    scopus 로고
    • Ranolazine improves abnormal repolarization and contraction in left ventricular myocytes of dogs with heart failure by inhibiting late sodium current
    • Undrovinas, A. I., Belardinelli, L., Nidas, A., Undrovinas, R. N. and Sabbah, H. N.: Ranolazine improves abnormal repolarization and contraction in left ventricular myocytes of dogs with heart failure by inhibiting late sodium current. Journal of Cardiovascular Electrophysiology 2006, 17:S169-S177.
    • (2006) Journal of Cardiovascular Electrophysiology , vol.17
    • Undrovinas, A.I.1    Belardinelli, L.2    Nidas, A.3    Undrovinas, R.N.4    Sabbah, H.N.5
  • 24
    • 33745392178 scopus 로고    scopus 로고
    • Late sodium current in the pathophysiology of cardiovascular disease: consequences of sodiumcalcium overload
    • Noble, D. and Noble, P. J.: Late sodium current in the pathophysiology of cardiovascular disease: consequences of sodiumcalcium overload. Heart 2006, 92:iv1-iv5.
    • (2006) Heart , vol.92
    • Noble, D.1    Noble, P.J.2
  • 25
    • 0031918452 scopus 로고    scopus 로고
    • Modeling of sodium-calcium overload arrhythmias and their suppression
    • Noble, D. and Varghese, A.: Modeling of sodium-calcium overload arrhythmias and their suppression. Canadian Journal of Cardiology 1998, 14:97-100.
    • (1998) Canadian Journal of Cardiology , vol.14 , pp. 97-100
    • Noble, D.1    Varghese, A.2
  • 26
    • 0025351530 scopus 로고
    • A model of the single atrial cell: relation between calcium current and calcium release
    • Earm, Y. E. and Noble, D.: A model of the single atrial cell: relation between calcium current and calcium release. Proceedings of the Royal Society Series B 1990, 240:83-96.
    • (1990) Proceedings of the Royal Society Series B , vol.240 , pp. 83-96
    • Earm, Y.E.1    Noble, D.2
  • 27
    • 0026733599 scopus 로고
    • Theory of excitationcontraction coupling in cardiac muscle
    • Stern, M. D.: Theory of excitationcontraction coupling in cardiac muscle. Biophysical Journal 1992, 63:497-517.
    • (1992) Biophysical Journal , vol.63 , pp. 497-517
    • Stern, M.D.1
  • 28
    • 0023162347 scopus 로고
    • Effects of repetitive activity on developed force and intracellular sodium in isolated sheep and dog Purkinje fibres
    • Boyett, M. R., Hart, G., Levi, A. J. and Roberts, A.: Effects of repetitive activity on developed force and intracellular sodium in isolated sheep and dog Purkinje fibres. Journal of Physiology 1987, 388:295-322.
    • (1987) Journal of Physiology , vol.388 , pp. 295-322
    • Boyett, M.R.1    Hart, G.2    Levi, A.J.3    Roberts, A.4
  • 29
    • 0027922457 scopus 로고
    • Generation and propagation of triggered activity induced by spatially localised Na-K pump inhibition in atrial network models
    • Winslow, R., Varghese, A., Noble, D., Adlakha, C. and Hoythya, A.: Generation and propagation of triggered activity induced by spatially localised Na-K pump inhibition in atrial network models. Proceedings of the Royal Society B 1993, 254:55-61.
    • (1993) Proceedings of the Royal Society B , vol.254 , pp. 55-61
    • Winslow, R.1    Varghese, A.2    Noble, D.3    Adlakha, C.4    Hoythya, A.5
  • 30
    • 0242574069 scopus 로고
    • Propagation of pacemaker activity: interaction between pacemaker cells and atrial tissue
    • Huizinga JD, ed., CRC Press, New York
    • Noble, D., Brown, H. F. andWinslow, R.: Propagation of pacemaker activity: interaction between pacemaker cells and atrial tissue. In: Huizinga JD, ed., Pacemaker activity and intercellular communication. CRC Press, New York, 1995, pp 73-92.
    • (1995) Pacemaker activity and intercellular communication , pp. 73-92
    • Noble, D.1    Brown, H.F.2    Winslow, R.3
  • 34
    • 0036302210 scopus 로고    scopus 로고
    • An anatomically based model of transient coronary blood flow in the heart
    • Smith, N. P., Pullan, A. J. and Hunter, P. J.: An anatomically based model of transient coronary blood flow in the heart. SIAM Journal of Applied Mathematics 2001, 62:990-1018.
    • (2001) SIAM Journal of Applied Mathematics , vol.62 , pp. 990-1018
    • Smith, N.P.1    Pullan, A.J.2    Hunter, P.J.3
  • 35
    • 84889278262 scopus 로고    scopus 로고
    • 1D and 2D models of the origin and propagation of cardiac excitation from the sino-atrial node into the right atrium
    • Philosophical Transactions of the Royal Society of London B
    • Garny, A., Kohl, P., Noble, D. and Hunter, P. J.: 1D and 2D models of the origin and propagation of cardiac excitation from the sino-atrial node into the right atrium. Philosophical Transactions of the Royal Society of London B 2000.
    • (2000)
    • Garny, A.1    Kohl, P.2    Noble, D.3    Hunter, P.J.4
  • 36
  • 40
    • 84889289734 scopus 로고    scopus 로고
    • Modeling cardiac ischemia
    • Annals of the New York Academy of Sciences, in press
    • Rodriguez, B., Trayanova, N. and Noble, D.: Modeling cardiac ischemia. Annals of the New York Academy of Sciences 2007, in press.
    • (2007)
    • Rodriguez, B.1    Trayanova, N.2    Noble, D.3
  • 41
    • 0346887205 scopus 로고    scopus 로고
    • Quantifying ventricular fibrillation: in silico research and clinical implications
    • Panfilov, A. and Kerkhof, P.: Quantifying ventricular fibrillation: in silico research and clinical implications. IEEE Trans. Biomed. Eng. 2004, 51:195-196.
    • (2004) IEEE Trans. Biomed. Eng. , vol.51 , pp. 195-196
    • Panfilov, A.1    Kerkhof, P.2
  • 43
    • 84889331466 scopus 로고    scopus 로고
    • Computational electromechanics of the mammalian ventricles
    • PhD thesis, University of Leeds, Leeds
    • Benson, A. P.: Computational electromechanics of the mammalian ventricles. PhD thesis, University of Leeds, Leeds, 2006.
    • (2006)
    • Benson, A.P.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.