Modelling of sodium-overload arrhythmias and their suppression

Canadian Journal of Cardiology

Volumn 14, Issue 1, 1998, Pages 97-100

  Noble, Denis ^a   Varghese, Anthony ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Cardiac arrhythmias; Ectopic beats; Lidocaine; Pump inhibition; Sodium potassium

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); LIDOCAINE;

ANTIARRHYTHMIC ACTIVITY; ARTICLE; EXTRASYSTOLE; HEART ARRHYTHMIA; HEART ELECTROPHYSIOLOGY; MODEL;

ANIMALS; CARDIAC COMPLEXES, PREMATURE; HUMANS; HYPERNATREMIA; MATHEMATICS; MODELS, CARDIOVASCULAR; POTASSIUM CHANNELS; SODIUM CHANNELS;

EID: 0031918452     PISSN: 0828282X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (8)

1. Hilgemann D, Noble D. Excitation-contraction coupling and extracellular calcium transients in rabbit atrium: reconstruction of basic cellular mechanisms. Proc R Soc Lend B 1987;230:163-205.
2. Earm Y, Noble D. A model of the single atrial cell: relation between calcium current and calcium release. Proc R Soc Lond B 1990;240:83-96.
3. Fedida DD, Noble A, Rankin C, Spindler AJ. The transient inward current, ij|, and related contraction in guinea-pig ventricular myocytes. J Physiol 1987;392:523-42.
4. Winslow RL, Varghese A, Noble D, Adlakha D, Hoythya A. Generation and propagation of ectopic beats induced by spatially localized Na-K pump inhibition in atrial network models. Proc R Soc Lond B 1993;254:55-61.
5. Members of the Sicilian Gambit, Breithardt G, et al. Antiarrhythmic Therapy: A Pathophysiologic Approach. Armonk: Futura, 1994:158.
6. Hondeghem L, Katzung B. Time- and voltage-dependent interactions of antiarrhythmic drugs with cardiac sodium channels. Biochim Biophys Acta 1977:472:373-98.
7. Hille B, Courtney K, Dum R. Rate and site of action of local anesthetics in myelinated nerve fibres. In: Fink BR, ed. Molecular Mechanisms of Anesthesia. Progress in Anesthesiology, vol 1. New York: Raven Press, 1975:13-20.
8. Varghese A, Spindler A, Paterson D, Noble D. Mechanism of antiarrhythmic action of lidocaine in heart cells. Symposium on Cardiac Electrophysiology. Banff, November 15,1996.