Mitochondrial Adaptation to Exercise and Training: A Physiological Approach

Molecular System Bioenergetics: Energy for Life

Volumn , Issue , 2007, Pages 457-478

  Sahlin, Kent ^a,b  

^a SWEDISH SCHOOL OF SPORT AND HEALTH SCIENCES   (Sweden)

^b UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

Author keywords

Applied molecular system bioenergetics; Control of oxidative phosphorylation; Exercise; Mitochondrial adaptation; Mitochondrial efficiency; Mitochondrial uncoupling; Training

Indexed keywords

EID: 84889404393     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9783527621095.ch14     Document Type: Chapter

References (57)

1. Andersen, P., Saltin, B. (1985) Maximal perfusion of skeletal muscle in man. J Physiol. 366, 233-249.
2. Brand, M.D., Chien, L.F., Ainscow, E.K., Rolfe, D.F., Porter, R.K. (1994) The causes and functions of mitochondrial proton leak. Biochim Biophys Acta. 1187, 132-139.
3. Chance, B., Williams, G.R. (1955) Respiratory enzymes in oxidative phosphorylation. I. Kinetics of oygen utilisation. J Biol Chem. 217, 383-393.
4. Connett, R.J., Sahlin, K. (1996) Control of glycolysis and glycogen metabolism. In Handbook of Physiology. Section 12. Exercise: regulation and integration of multiple systems. ed. Rowell, L.B.S., J.T., pp. 870-911. Oxford University Press, New York.
5. Dudley, G.A., Tullson, P.C., Terjung, R.L. (1987) Influence of mitochondrial content on the sensitivity of respiratory control. J Biol Chem. 262, 9109-9114.
6. Echtay, K.S., Roussel, D., St-Pierre, J., Jekabsons, M.B., Cadenas, S., Stuart, J.A., Harper, J.A., Roebuck, S.J., et al. (2002) Superoxide activates mitochondrial uncoupling proteins. Nature. 415, 96-99.
7. Edwards, H.T. (1936) Lactic acid in rest and work at high altitude. Am. J. Physiol. 116, 367.
8. Erecinska, M., Wilson, D.F., Nishiki, K. (1978) Homeostatic regulation of cellular energy metabolism: experimental characterization in vivo and fit to a model. Am J Physiol. 234, C82-89.
9. Fernstrom, M., Bakkman, L., Tonkonogi, M., Shabalina, I.G., Rozhdestvenskaya, Z., Mattsson, M., Enqvist, J., Ekblom, B., et al. (2007) Reduced efficiency but increased fat oxidation in mitochondria from human skeletal muscle after 24 hours ultra-endurance exercise. J. Appl. Physiol. 102, 1844-1849.
10. Fernstrom, M., Tonkonogi, M., Sahlin, K. (2004) Effects of acute and chronic endurance exercise on mitochondrial uncoupling in human skeletal muscle. J Physiol. 554, 755-763.
11. Gayeski, T.E., Connett, R.J., Honig, C.R. (1987) Minimum intracellular PO2 for maximum cytochrome turnover in red muscle in situ. Am J Physiol. 252, H906-915.
12. Gollnick, P.D., Bertocci, L.A., Kelso, T.B., Witt, E.H., Hodgson, D.R. (1990) The effect of high-intensity exercise on the respiratory capacity of skeletal muscle. Pflugers Arch. 415, 407-413.
13. Haseler, L.J., Richardson, R.S., Videen, J.S., Hogan, M.C. (1998) Phosphocreatine hydrolysis during submaximal exercise: the effect of FIO2. J Appl Physiol. 85, 1457-1463.
14. Henriksson, J., Reitman, J.S. (1977) Time course of changes in human skeletal muscle succinate dehydrogenase and cytochrome oxidase activities and maximal oxygen uptake with physical activity and inactivity. Acta Physiol Scand. 99, 91-97.
15. Holloszy, J.O. (1967) Biochemical adaptations in muscle. Effects of exercise on mitochondrial oxygen uptake and respiratory enzyme activity in skeletal muscle. J Biol Chem. 242, 2278-2282.
16. Hoppeler, H., Fluck, M. (2003) Plasticity of skeletal muscle mitochondria: structure and function. Med Sci Sports Exerc. 35, 95-104.
17. Katz, A., Sahlin, K. (1987) Effect of decreased oxygen availability on NADH and lactate contents in human skeletal muscle during exercise. Acta Physiol Scand. 131, 119-127.
18. Katz, A., Sahlin, K. (1988) Regulation of lactic acid production during exercise. J Appl Physiol. 65, 509-518.
19. Kushmerick, M.J. (1983) Energetics of muscle contraction, Handbook of physiology, Peachey, L.D., Adrian, R.H., Geiger, S.R. (eds.) Vol. 10. Am Physiol Soc, Bethesda.
20. Kuznetsov, A.V., Tiivel, T., Sikk, P., Kaambre, T., Kay, L., Daneshrad, Z., Rossi, A., Kadaja, L., et al. (1996) Striking differences between the kinetics of regulation of respiration by ADP in slowtwitch and fast-twitch muscles in vivo. Eur J Biochem. 241, 909-915.
21. Linnarsson, D., Karlsson, J., Fagraeus, L., Saltin, B. (1974) Muscle metabolites and oxygen deficit with exercise in hypoxia and hyperoxia. J Appl Physiol. 36, 399-402.
22. Lopez, P., Ledoux, M., Garrel, D.R. (2000) Increased thermogenic response to food and fat oxidation in female athletes: relationship with VO(2 max). Am J Physiol Endocrinol Metab. 279, E601-607.
23. Madsen, K., Ertbjerg, P., Djurhuus, M.S., Pedersen, P.K. (1996) Calcium content and respiratory control index of skeletal muscle mitochondria during exercise and recovery. Am J Physiol. 271, E1044-1050.
24. Madsen, K., Ertbjerg, P., Pedersen, P.K. (1996) Calcium content and respiratory control index of isolated skeletal muscle mitochondria: effects of different isolation media. Anal Biochem. 237, 37-41.
25. Marcinek, D.J. (2004) Mitochondrial dysfunction measured in vivo. Acta Physiol Scand. 182, 343-352.
26. Marcinek, D.J., Schenkman, K.A., Ciesielski, W.A., Conley, K.E. (2004) Mitochondrial coupling in vivo in mouse skeletal muscle. Am J Physiol Cell Physiol. 286, C457-463.
27. Marcinek, D.J., Schenkman, K.A., Ciesielski, W.A., Lee, D., Conley, K.E. (2005) Reduced mitochondrial coupling in vivo alters cellular energetics in aged mouse skeletal muscle. J Physiol. 569, 467-473.
28. Mogensen, M., Bagger, M., Pedersen, P.K., Fernstrom, M., Sahlin, K. (2006) Cycling efficiency in humans is related to low UCP3 content and to type I fibres but not to mitochondrial efficiency. J Physiol. 571, 669-681.
29. Mogensen, M., Sahlin, K. (2005) Mitochondrial efficiency in rat skeletal muscle: influence of respiration rate, substrate and muscle type. Acta Physiol Scand. 185, 229-236.
30. Nemirovskaia, T.L., Shenkman, B.S., Nekrasov, A.N., Kuznetsov, A.V., Saks, V.A. (1993) [Effect of training on the structural-metabolic indicators in athletes' skeletal muscles]. Biokhimiia. 58, 471-479.
31. Newsholme, E., Start, C. (1974). Regulation in metabolism (eds.). Wiley, London.
32. Ponsot, E., Dufour, S.P., Zoll, J., Doutrelau, S., N'Guessan, B., Geny, B., Hoppeler, H., Lampert, E., et al. (2006) Exercise training in normobaric hypoxia in endurance runners. II. Improvement of mitochondrial properties in skeletal muscle. J Appl Physiol. 100, 1249-1257.
33. Rasmussen, U.F., Krustrup, P., Bangsbo, J., Rasmussen, H.N. (2001) The effect of high-intensity exhaustive exercise studied in isolated mitochondria from human skeletal muscle. Pflugers Arch. 443, 180-187.
34. Ray, J., Noll, F., Daut, J., Hanley, P.J. (2002) Long-chain fatty acids increase basal metabolism and depolarize mitochondria in cardiac muscle cells. Am J Physiol Heart Circ Physiol. 282, H1495-1501.
35. Richardson, R.S., Noyszewski, E.A., Leigh, J.S., Wagner, P.D. (1998) Lactate efflux from exercising human skeletal muscle: role of intracellular PO2. J Appl Physiol. 85, 627-634.
36. Sahlin, K. (1991) Control of energetic processes in contracting human skeletal muscle. Biochem Soc Trans. 19, 353-358.
37. Sahlin, K., Katz, A., Henriksson, J. (1987) Redox state and lactate accumulation in human skeletal muscle during dynamic exercise. Biochem J. 245, 551-556.
38. Sahlin, K., Nielsen, J.S., Mogensen, M., Tonkonogi, M. (2006) Repeated static contractions increase mitochondrial vulnerability toward oxidative stress in human skeletal muscle. J Appl Physiol. 101, 833-839.
39. Sahlin, K., Soderlund, K., Tonkonogi, M., Hirakoba, K. (1997) Phosphocreatine content in single fibers of human muscle after sustained submaximal exercise. Am J Physiol. 273, C172-178.
40. Sahlin, K., Tonkonogi, M., Soderlund, K. (1998) Energy supply and muscle fatigue in humans. Acta Physiol Scand. 162, 261-266.
41. Saks, V.A., Kuznetsov, A.V., Khuchua, Z.A., Vasilyeva, E.V., Belikova, J.O., Kesvatera, T., Tiivel, T. (1995) Control of cellular respiration in vivo by mitochondrial outer membrane and by creatine kinase. A new speculative hypothesis: possible involvement of mitochondrial-cytoskeleton interactions. J Mol Cell Cardiol. 27, 625-645.
42. Sugano, T., Oshino, N., Chance, B. (1974) Mitochondrial functions under hypoxic conditions. The steady states of cytochrome c reduction and of energy metabolism. Biochim Biophys Acta. 347, 340-358.
43. Terjung, R.L., Baldwin, K.M., Mole, P.A., Klinkerfuss, G.H., Holloszy, J.O. (1972) Effect of running to exhaustion on skeletal muscle mitochondria: a biochemical study. Am J Physiol. 223, 549-554.
44. Tonkonogi, M., Harris, B., Sahlin, K. (1998) Mitochondrial oxidative function in human saponin-skinned muscle fibres: effects of prolonged exercise. J Physiol. 510, 279-286.
45. Tonkonogi, M., Krook, A., Walsh, B., Sahlin, K. (2000) Endurance training increases stimulation of uncoupling of skeletal muscle mitochondria in humans by non-esterified fatty acids: an uncoupling-protein-mediated effect? Biochem J. 351 Pt 3, 805-810.
46. Tonkonogi, M., Sahlin, K. (1997) Rate of oxidative phosphorylation in isolated mitochondria from human skeletal muscle: effect of training status. Acta Physiol Scand. 161, 345-353.
47. Tonkonogi, M., Sahlin, K. (1999) Actively phosphorylating mitochondria are more resistant to lactic acidosis than inactive mitochondria. Am J Physiol. 277, C288-293.
48. Tonkonogi, M., Walsh, B., Svensson, M., Sahlin, K. (2000) Mitochondrial function and antioxidative defence in human muscle: effects of endurance training and oxidative stress. J Physiol. 528 Pt 2, 379-388.
49. Tonkonogi, M., Walsh, B., Tiivel, T., Saks, V., Sahlin, K. (1999) Mitochondrial function in human skeletal muscle is not impaired by high intensity exercise. Pflugers Arch. 437, 562-568.
50. Walsh, B., Hooks, R.B., Hornyak, J.E., Koch, L.G., Britton, S.L., Hogan, M.C. (2006) Enhanced mitochondrial sensitivity to creatine in rats bred for high aerobic capacity. J Appl Physiol. 100, 1765-1769.
51. Walsh, B., Tonkonogi, M., Sahlin, K. (2001) Effect of endurance training on oxidative and antioxidative function in human permeabilized muscle fibres. Pflugers Arch. 442, 420-425.
52. Walsh, B., Tonkonogi, M., Soderlund, K., Hultman, E., Saks, V., Sahlin, K. (2001) The role of phosphorylcreatine and creatine in the regulation of mitochondrial respiration in human skeletal muscle. J Physiol. 537, 971-978.
53. Wilson, D.F. (1994) Factors affecting the rate and energetics of mitochondrial oxidative phosphorylation. Med Sci Sports Exerc. 26, 37-43.
54. Wilson, D.F., Rumsey, W.L., Green, T.J., Vanderkooi, J.M. (1988) The oxygen dependence of mitochondrial oxidative phosphorylation measured by a new optical method for measuring oxygen concentration. J Biol Chem. 263, 2712-2718.
55. Wojtczak, L., Schonfeld, P. (1993) Effect of fatty acids on energy coupling processes in mitochondria. Biochim Biophys Acta. 1183, 41-57.
56. Zoll, J., Koulmann, N., Bahi, L., Ventura-Clapier, R., Bigard, A.X. (2003) Quantitative and qualitative adaptation of skeletal muscle mitochondria to increased physical activity. J Cell Physiol. 194, 186-193.
57. Zoll, J., Sanchez, H., N'Guessan, B., Ribera, F., Lampert, E., Bigard, X., Serrurier, B., Fortin, D., et al. (2002) Physical activity changes the regulation of mitochondrial respiration in human skeletal muscle. J Physiol. 543, 191-200.