Actively phosphorylating mitochondria are more resistant to lactic acidosis than inactive mitochondria

American Journal of Physiology - Cell Physiology

Volumn 277, Issue 2 46-2, 1999, Pages

  Tonkonogi, M ^b   Sahlin, K ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b NONE

Author keywords

Adenosine 5' diphosphate sensitivity; Hydrogen ions; Lactate; Oxygen consumption; Skeletal muscle

Indexed keywords

ADENOSINE DIPHOSPHATE; MALIC ACID; OLIGOMYCIN; PYRUVIC ACID;

ARTICLE; CONTROLLED STUDY; LACTIC ACIDOSIS; MALE; MEMBRANE POTENTIAL; MITOCHONDRIAL RESPIRATION; MUSCLE METABOLISM; NONHUMAN; OXIDATIVE PHOSPHORYLATION; OXYGEN CONSUMPTION; PHOSPHORYLATION; PRIORITY JOURNAL; RAT; SKELETAL MUSCLE;

EID: 0032871677     PISSN: 03636143     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpcell.1999.277.2.c288     Document Type: Article

References (12)

1. - concentration do not decrease force in cat skeletal muscle. Am. J. Physiol. 260 (Cell Physiol. 29): C805-C812, 1991.
2. Brand, M. D., L. F. Chien, E. K. Ainscow, D. F. Rolfe, and R. K. Porter. The causes and functions of mitochondrial proton leak. Biochim. Biophys. Acta 1187: 132-139, 1994.
3. 2+. Biochemistry 35: 8483-8488, 1996.
4. + transport by free fatty acids, which is further stimulated by mersalyl. J. Biol. Chem. 269: 27329-27336, 1994.
5. Chance, B., and G. R. Williams. Respiratory enzymes in oxidative phosphorylation. I. Kinetics of oxygen utilisation. J. Biol. Chem. 217: 383-393, 1955.
6. Duerr, J. M., and S. S. Hillman. An analysis of pH tolerance and substrate preference of isolated skeletal muscle mitochondria from Bufo marinus and Rana catesbeiana. Comp. Biochem. Physiol. B Biochem. Mol. Biol. 106: 889-893, 1993.
7. Emaus, R. K., R. Grunwald, and J. J. Lemasters. Rhodamine 123 as a probe of transmembrane potential in isolated rat liver mitochondria: spectral and metabolic properties. Biochim. Biophys. Acta 850: 436-448, 1986.
8. Febbraio, M. A., M. J. McKenna, R. J. Snow, D. Jenkins, and M. Hargreaves. Muscle energy metabolism during recovery from intermittent, maximal exercise (Abstract). Proc. Aust. Physiol. Pharmacol. Soc. 26: 136P, 1995.
9. Fitts, R. H. Cellular, molecular, and metabolic basis of muscle fatigue. In: Handbook of Physiology. Exercise: Regulation and Integration of Multiple Systems. Bethesda, MD: Am. Physiol. Soc., 1996, sect. 12, chapt. 26, p. 1151-1183.
10. Fry, D. E., D. J. Ratcliffe, and J. R. Yates. The effects of acidosis on canine hepatic and renal oxidative phosphorylation. Surgery 88: 269-273, 1980.
11. Hafner, R. P., G. C. Brown, and M. D. Brand. Analysis of the control of respiration rate, phosphorylation rate, proton leak rate and protonmotive force in isolated mitochondria using the "top-down" approach of metabolic control theory. Eur. J. Biochem. 188: 313-319, 1990.
12. Harkema, S. J., and R. A. Meyer. Effect of acidosis on control of respiration in skeletal muscle. Am. J. Physiol. 272 (Cell Physiol. 41): C491-C500, 1997.