Animal Models: Allelic Determinants for BMD

Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism: Seventh Edition

Volumn , Issue , 2009, Pages 51-56

  Beamer, Wesley G ^a   Rosen, Clifford J ^b  

^a The Juckson Laboratory   (United States)

^b Maine Medical Center Research Institute   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84889366871     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9780470623992.ch9     Document Type: Chapter

References (36)

1. Lee Y, Rho Y, Choi S, Ji J, Song G 2006 Meta-analysis of genome-wide linkage studies for bone mineral density. J Hum Genet 51:480-486.
2. Ioannidis JPA, Ng MY, Sham PC, Zintzaras E, Lewis CM, Deng H-W, Econs MJ, Karasik D, Devoto M, Kammerer CM, Spector T, Andrew T, Cupples LA, Duncan EL, Foroud T, Kiel DP. Koller DP, Langdahl B, Mitchell AG, Peacock M, Recker R, Shcn H, Sol-Church K, Spotila LD, Uitterlinden AG, Wilson SG, Kung AWC, Ralston SH 2007 Meta-analysis of genome wide scans provides evidence for sex- and site specific regulation of bone mass. J Bone Miner Res 22:173-183.
3. Beamer WG, Donahue LR, Rosen CJ, Baylink DJ 1996 Genetic variability in adult bone density among inbred strains of mice. Bone 18:397-403.
4. Beamer WG, Shultz KL, Churchill GA, Frankel WN, Baylink DJ, Rosen CJ, Donahue LR 1999 Quantitative trait loci for bone density in C57BL/6J and CAST/EiJ inbred mice. Mamm Genome 10:1043-1049.
5. Lander ES, Botstein D 1989 Mapping Mendelian factors underlying quantittive traits using RFLP linkage maps. Genetics 121:185-199.
6. Bailey DW 1981 Recombinant inbred strains and bilineal congenic strains. In: Foster HL, Fox JG (eds.) The Mouse in Biomedical Research. Academic Press, New York, NY, USA, pp. 223-240.
7. Eppig JT, Bult CJ, Kadin JA, Richardson JE, Blake JA, Group MGD 2005 The Mouse Genome Database (MGD): From genes to mice-a community resource for mouse biology. Nucleic Acids Res 33:D471-D475.
8. Turner CH, Hsieh Y-F, Mueller R, Bouxsein ML, Rosen CJ, Mc-Crann ME, Donahue LR, Beamer WG 2001 Variation in bone biomechanical properties, microstructure, and density in BXH recombinant inbred mice. J Bone Miner Res 16:206-213.
9. Klein R, Carlos A, Vartanian K, Chambers V, Turner R, Phillips T, Belknap J, Orwoll E 2001 Confirmation and fine mapping of chromosomal regions influencing peak bone mass in mice. J Bone Miner Res 16:1953-1961.
10. Bower AL, Lang DH, Vogler GP, Vandenbergh DJ, Blizzard DA, Stout JT, McClearn GE, Sharkey NA 2006 QTL Analysis of trabecular bone in BXD F2 and RI mice. J Bone Miner Res 21:1267-1275.
11. Park Y, Clifford R, Buetow K, Hunter K 2003 Multiple cross and inbred strain haplotype mapping of complex-trait candidate genes. Genome Res 13:118-121.
12. DiPetrillo K, Wang X, Stylianou IM, Paigen B 2005 Bioinformatics toolbox for narrowing rodent quantitative trait loci. Trends Genet 21:683-692.
13. Shimizu M, Higuchi K, Kasai S, Tsuboyama T, Matsushita M, Matsumura T, Okudaira S, Mori M, Koizumi A, Nakamura T, Hosokawa M 2002 A congenic mouse and candidate gene at the Chr 13 locus regulating bone density. Mamm Genome 13:335-340.
14. Shimizu M, Higuchi K, Bennett B, Xia C, Tsuboyama T, Kasai S, Chiba T, Fujisawa H, Kogishi K, Kitado H, Kimoto M, Takeda N, Matsuchita M, Okumura H, Serikawa T, Nakamura T, Johnson TE, Hosokawa M 1999 Identification of peak bone mass QTL in a spontaneously osteoporotic mouse strain. Mamm Genome 10:81-87.
15. Nakanishi R, Shimizu M, Mori M, Akiyama H, Okudaira S, Otsuki B, Hashimoto B, Higuchi K, Hosokawa M, Tsuboyama T, Nakamura T 2006 Secreted frizzle-related protein 4 is a negative regulator of peak BMD in SAMP6 mice. J Bone Miner Res 21:1713-1721.
16. Rosen CJ. Churchill GA, Donahue LR, Shultz KL, Burgess JK, Powell DR, Beamer WG 2000 Mapping quantitative trait loci for serum insulin-like growth factor-I levels in mice. Bone 27:521-528.
17. Delahunty KM, Koczon-Jaremko B, Adamo ML, Horton LG, Lorenzo J, Donahue LR, Ackert-Bicknell CL, Kream BE, Beamer WG, Rosen CJ 2006 Congenic mice provide in vivo evidence for a genetic locus that modulates serum insulin-like growth factor-I and bone acquisition. Endocrinology 147:3915-3923.
18. Beamer WG, Shultz KL, Donahue LR, Churchill GA, Sen S, Wergedal JE, Baylink DJ, Rosen CJ 2001 Quantitative trait loci for femoral and vertebral bone mineral density in C57BL/6J and C3H/HeJ inbred strains of mice. J Bone Miner Res 16:1195-1206.
19. Shultz KL, Donahue LR, Bouxsein ML, Baylink DJ, Rosen CJ, Beamer WG 2003 Congenic strains of mice for verification and genetic decomposition of quantitative trait loci for femoral bone mineral density. J Bone Miner Res 18:175-185.
20. Edderkaoui B, Baylink DJ, Beamer WG, Wergedal JE, Dunn N, Shultz KL, Mohan S 2006 Multiple genetic loci from CAST/EiJ Chromosome 1 affect vBMD either positively or negatively in a C57BL/6J background. J Bone Miner Res 21:97-104.
21. Edderkaoui B, Baylink DJ, Beamer WG, Shultz KL, Wergedal JE, Mohan S 2007 Genetic regulation of femoral bone mineral density: Complexity of sex effect in Chromosome 1 revealed by congenic cublines of mice. Bone 41:340-345.
22. Edderkaoui B, Baylink DJ, Beamer WG, Wergedal JE, Porte R, Chaudhuri A, Mohan S 2007 Identification of mouse duffy antigen receptor for chemokines (Dare) as a BMD QTL gene. Genome Res 17:577-585.
23. Chakera A, Seeber RM, John AE, Eidne KA, Greaves DR 2008 The Duffy Antigen/Receptor for Chemokines (DARC) exists in an oligomeric form in living cells and functionally antagonises CCR5 signalling through hetero-oligomerization. Mol Pharmacol (in press).
24. Beamer WG, Shultz KL, Ackert-Bicknell CL, Horton LG, Dela-hunty KM, Coombs HF III, Donahue LR, Canalis E, Rosen CJ 2007 Genetic dissection of mouse distal Chromosome 1 reveals three linked BMD QTLs with sex-dependent regulation of bone phenotypes. J Bone Miner Res 22:1187-1196.
25. Koller DL, Econs MJ, Morin PA, Christian JC, Hui SL, Parry P, Curran M, Rodriguez LA, Conneally PM, Joslyn G, Peacock M, Johnston CC, Foroud T 2000 Genome screen for QTLs contributing to normal variation in bone mineral density and osteoporosis. J Clin Endocrinol Metab 85:3116-3120.
26. Peacock M, Koller D, Lai D, Hui S, Foroud T, Econs MJ 2005 Sex-specific quantitative trait loci contribute to normal variation in bone structure at the proximal femur in men. Bone 37:467-73.
27. Wilson S, Reed P, Bansal A, Chiano M, Lindersson M, Langdown M, Prince R, Thompson E, Bailey M, Kleyn P, Sambrook P, Shi M, Spector T 2003 Comparison of genome screens for two independent cohorts provides replication of suggestive linkage of bone mineral density to 3p21 and lp36. Am J Hum Genet 72:144-155.
28. Klein R, Carlos A, Kansagor J, Olson D, Wagoner W, Larson E. Dinulescu D, Munsey T, Vanek C, Madison D, Lundblad J, Belknap J, Orwoll E 2005 Identification of Akp2 as a gene that regulates peak bone density in mice. J Bone Miner Res 20:S1-S9.
29. Koller DL, Alam I, Liu L, Fishburn T, Carr LG, Econs MJ, Foroud T, Turner CH 2005 Genome screen for bone mineral density phenotypes in Fisher 344 and Lewis rat strains. Mamm Genome 16:578-586.
30. Rubin CJ, Brandstrom H, Wright D, Kerje S, Gunnarsson U, Schutz K, Fredriksson R, Jensen P, Andersson L, Ohlsson C, Malllmin H, Larsson S, Kindmark A 2007 Quantitative trait loci for BMD and bone strength in an intercross between domestic and wildtype chickens. J Bone Miner Res 22:375-384.
31. Abiola O, Angel JM, Avner P, Bachmanov AA, Belknap JK, Bennett B, Blankenborn EP, Blizard DA, Bolivar V, Brockmann GA, Buck KJ, Bureau JF, Casley WL, Chesler EJ, Cheverud JM. Churchill GA. Cook M, Crabbe JC, Crusio WE. Darvasi A, de Haan G, Dermant P, Doerge RW, Elliot RW, Farber CR, Flaherty L, Flint J. Gershenfeld H, Gibson JP, Gu J, Gu W, Himmelbauer H, Hitzemann R, Hsu HC, Hunter K, Iraqi FF, Jansen RC, Johnson TE, Jones BC, Kempermann G, Lammert F, Lu L, Manly KF, Matthews DB. Medrano JF, Mehrabian M, Mittlemann G, Mock BA, MogilJS, Montagutelli X, Morahan G, Mountz JD, Nagase H, Nowakowski RS, O'Hara BF, Osadchuk AV, Paigen B, Palmer AA, Peirce JL, Pomp D, Rosemann M, Rosen GD, Schalkwyk LC, Seltzer Z, Settle S, Shimomura K, Shou S, Sikela JM, Siracusa LD, Spearow JL, Teuscher C, Threadgill DW, Toth LA, Toye AA, Vadasz C, Van Zant G, Wakeland E, Williams RW, Zhang HG, Zou F, Complex Trait Consortium 2003 The nature and identification of quantitative trait loci: A community's view. Nat Rev Genet 4:911-916.
32. Ishimori N, Li R, Walsh KA, Korstanje R, Rollins J, Petkov P, Pletcher MT, Wiltshire T, Donahue LR, Rosen CJ, Beamer WG, Churchill GA, Paigen BJ 2006 Quantitative trait loci that determine BMD in C57BL/6J and 129Sl/SvImJ inbred mice. J Bone Miner Res 21:105-112.
33. Li XM, Masinde GL, Gu W, Wergedal JE, Mohan S, Baylink DJ 2002 Genetic dissection of femur breaking strength in a large population (MRL/MpJ x SJL/J) of F2 mice: Single QTL effects, epistasis, and pleiotropy. Genomics 79:734-740.
34. Masinde GL, Li XM, Gu W, Wergedal JE, Mohan S, Baylink DJ 2002 Quantitative trait loci for bone density in mice: The genes determining total skeletal density and femur density show little overlap in F2 mice. Calcif Tissue Int 71:421-128.
35. Benes H, Weinstein RS, Zheng W, Thaden JJ, Jilka RL, Mano-lagos SC, Smookler Reis RJ 2000 Chromosomal mapping of osteopenia-associated quantitative trait loci using closely related mouse strains. J Bone Miner Res 15:626-633.
36. Wergedal JE, Ackert-Bicknell CL, Tsaih S-W, Sheng MH-C, Li R, Mohan S. Beamer WG, Churchill GA, Baylink DJ 2006 Femur mechanical properties in the F2 progeny of an NZB/B1NJ x RF/J cross are regulated predominantly by genetic loci that regulate bone geometry. J Bone Miner Res 22:1256-1266.