Cerebellar mutism: A review

Journal of Neurosurgery: Pediatrics

Volumn 12, Issue 6, 2013, Pages 604-614

  Pitsika, Marina ^a   Tsitouras, Vassilios ^a  

^a Mitera Children's Hospital   (Greece)

Author keywords

Cerebellum; Children; Cognitive; Mutism; Posterior fossa surgery; Tumor

Indexed keywords

CEREBELLAR MUTISM; CEREBELLUM; HIGH RISK PATIENT; HUMAN; MEDULLOBLASTOMA; MUTISM; NEUROIMAGING; NEUROSURGERY; PATHOPHYSIOLOGY; PREOPERATIVE EVALUATION; PRIORITY JOURNAL; PROSPECTIVE STUDY; REVIEW; SPEECH; CEREBELLUM DISEASE; CEREBELLUM TUMOR; GUNSHOT INJURY; HISTORY; INJURY; PATHOLOGY; RISK FACTOR; COMPLICATION; INFRATENTORIAL NEOPLASMS;

CEREBELLAR DISEASES; CEREBELLUM; HISTORY, 20TH CENTURY; HUMANS; INFRATENTORIAL NEOPLASMS; MEDULLOBLASTOMA; MUTISM; NEUROSURGICAL PROCEDURES; RISK FACTORS; SPEECH; WOUNDS, GUNSHOT;

EID: 84889244160     PISSN: 19330707     EISSN: 19330715     Source Type: Journal    
DOI: 10.3171/2013.8.PEDS13168     Document Type: Review

References (110)

1. Ackermann H, Mathiak K, Riecker A: The contribution of the cerebellum to speech production and speech perception: clinical and functional imaging data. Cerebellum 6:202-213, 2007
2. Aguiar PH, Plese JP, Ciquini O, Marino R: Transient mutism following a posterior fossa approach to cerebellar tumors in children: a critical review of the literature. Childs Nerv Syst 11:306-310, 1995
3. Akhaddar A, Salami M, El Asri AC, Boucetta M: Treatment of postoperative cerebellar mutism with fluoxetine. Childs Nerv Syst 28:507-508, 2012
4. Al-Afif S, Staden M, Krauss JK, Schwabe K, Hermann EJ: Splitting of the cerebellar vermis in juvenile rats - effects on social behavior, vocalization and motor activity. Behav Brain Res 250:293-298, 2013
5. Ammirati M, Mirzai S, Samii M: Transient mutism following removal of a cerebellar tumor. A case report and review of the literature. Childs Nerv Syst 5:12-14, 1989
6. Asamoto M, Ito H, Suzuki N, Oiwa Y, Saito K, Haraoka J: Transient mutism after posterior fossa surgery. Childs Nerv Syst 10:275-278, 1994
7. Buckner RL, Krienen FM, Castellanos A, Diaz JC, Yeo BT: The organization of the human cerebellum estimated by intrinsic functional connectivity. J Neurophysiol 106:2322-2345, 2011
8. Catsman-Berrevoets CE, Aarsen FK: The spectrum of neurobehavioural deficits in the Posterior Fossa Syndrome in children after cerebellar tumour surgery. Cortex 46:933-946, 2010
9. Catsman-Berrevoets CE, Van Dongen HR, Mulder PG, Paz y Geuze D, Paquier PF, Lequin MH: Tumour type and size are high risk factors for the syndrome of "cerebellar" mutism and subsequent dysarthria. J Neurol Neurosurg Psychiatry 67:755-757, 1999
10. Catsman-Berrevoets CE, van Dongen HR, Zwetsloot CP: Transient loss of speech followed by dysarthria after removal of posterior fossa tumour. Dev Med Child Neurol 34:1102-1109, 1992
11. Clerico A, Sordi A, Ragni G, Festa A, Cappelli C, Maini CL: Brief report: transient mutism following posterior fossa surgery studied by single photon emission computed tomography (SPECT). Med Pediatr Oncol 38:445-448, 2002
12. Coplin WM, Kim DK, Kliot M, Bird TD: Mutism in an adult following hypertensive cerebellar hemorrhage: nosological discussion and illustrative case. Brain Lang 59:473-493, 1997
13. D'Avanzo R, Scuotto A, Natale M, Scotto P, Cioffi FA: Transient "cerebellar" mutism in lesions of the mesencephalic-cerebellar region. Acta Neurol (Napoli) 15:289-296, 1993
14. Dailey AT, McKhann GM II, Berger MS: The pathophysiology of oral pharyngeal apraxia and mutism following posterior fossa tumor resection in children. J Neurosurg 83:467-475, 1995
15. De Smet HJ, Baillieux H, Catsman-Berrevoets C, De Deyn PP, Mariën P, Paquier PF: Postoperative motor speech production in children with the syndrome of 'cerebellar' mutism and subsequent dysarthria: a critical review of the literature. Eur J Paediatr Neurol 11:193-207, 2007
16. De Smet HJ, Mariën P: Posterior fossa syndrome in an adult patient following surgical evacuation of an intracerebellar haematoma. Cerebellum 11:587-592, 2012
17. Di Rocco C, Chieffo D, Frassanito P, Caldarelli M, Massimi L, Tamburrini G: Heralding cerebellar mutism: evidence for pre-surgical language impairment as primary risk factor in posterior fossa surgery. Cerebellum 10:551-562, 2011
18. Dietze DD Jr, Mickle JP: Cerebellar mutism after posterior fossa surgery. Pediatr Neurosurg 16:25-31, 1990-1991
19. Dimova PS, Bojinova VS, Milanov IG: Transient mutism and pathologic laughter in the course of cerebellitis. Pediatr Neurol 41:49-52, 2009
20. Echiverri HC, Tatum WO, Merens TA, Coker SB: Akinetic mutism: pharmacologic probe of the dopaminergic mesencephalofrontal activating system. Pediatr Neurol 4:228-230, 1988
21. El-Bahy K: Telovelar approach to the fourth ventricle: operative findings and results in 16 cases. Acta Neurochir (Wien) 147:137-142, 2005
22. El Beltagy MA, Atteya MM: The benefits of navigated intraoperative ultrasonography during resection of fourth ventricular tumors in children. Childs Nerv Syst 29:1079-1088, 2013
23. Ellis DL, Kanter J, Walsh JW, Drury SS: Posterior fossa syndrome after surgical removal of a pineal gland tumor. Pediatr Neurol 45:417-419, 2011
24. Erol I, Ozkale Y, Saygi S, Alehan F: Cerebellar mutism caused by primary varicella infection in an immunocompetent child. J Child Neurol [epub ahead of print], 2013
25. Erşahin Y, Mutluer S, Saydam S, Barçin E: Cerebellar mutism: report of two unusual cases and review of the literature. Clin Neurol Neurosurg 99:130-134, 1997
26. Erşahin Y, Yararbas U, Duman Y, Mutluer S: Single photon emission tomography following posterior fossa surgery in patients with and without mutism. Childs Nerv Syst 18:318- 325, 2002
27. Ferrante L, Mastronardi L, Acqui M, Fortuna A: Mutism after posterior fossa surgery in children. Report of three cases. J Neurosurg 72:959-963, 1990
28. Fiez JA, Petersen SE, Cheney MK, Raichle ME: Impaired non-motor learning and error detection associated with cerebellar damage. A single case study. Brain 115:155-178, 1992
29. Fraioli B, Guidetti B: Effects of stereotactic lesions of the dentate nucleus of the cerebellum in man. Appl Neurophysiol 38:81-90, 1975
30. Frassanito P, Massimi L: Cerebellar mutism: review of the literature. Childs Nerv Syst 27:867-868, 2011 (Letter)
31. Frassanito P, Massimi L, Caldarelli M, Di Rocco C: Cerebellar mutism after spontaneous intratumoral bleeding involving the upper cerebellar vermis: a contribution to the physiopathogenic interpretation. Childs Nerv Syst 25:7-11, 2009
32. Frim DM, Ogilvy CS: Mutism and cerebellar dysarthria after brain stem surgery: case report. Neurosurgery 36:854-857, 1995
33. Gelabert-González M, Fernández-Villa J: Mutism after posterior fossa surgery. Review of the literature. Clin Neurol Neurosurg 103:111-114, 2001
34. Germanò A, Baldari S, Caruso G, Caffo M, Montemagno G, Cardia E, et al: Reversible cerebral perfusion alterations in children with transient mutism after posterior fossa surgery. Childs Nerv Syst 14:114-119, 1998
35. Gordon N: Mutism: elective or selective, and acquired. Brain Dev 23:83-87, 2001
36. Grill J, Viguier D, Kieffer V, Bulteau C, Sainte-Rose C, Hartmann O, et al: Critical risk factors for intellectual impairment in children with posterior fossa tumors: the role of cerebellar damage. J Neurosurg 101 (2 Suppl):152-158, 2004
37. Grodd W, Hülsmann E, Lotze M, Wildgruber D, Erb M: Sensorimotor mapping of the human cerebellum: fMRI evidence of somatotopic organization. Hum Brain Mapp 13:55-73, 2001
38. Gudrunardottir T, Sehested A, Juhler M, Grill J, Schmiegelow K: Cerebellar mutism: definitions, classification and grading of symptoms. Childs Nerv Syst 27:1361-1363, 2011 (Letter)
39. Gudrunardottir T, Sehested A, Juhler M, Schmiegelow K: Cerebellar mutism: incidence, risk factors and prognosis. Childs Nerv Syst 27:513-515, 2011 (Letter)
40. Gudrunardottir T, Sehested A, Juhler M, Schmiegelow K: Cerebellar mutism: review of the literature. Childs Nerv Syst 27:355-363, 2011
41. Habas C: Functional imaging and the cerebellum: recent developments and challenges. Editorial. Cerebellum 11:311-313, 2012
42. Habas C, Kamdar N, Nguyen D, Prater K, Beckmann CF, Menon V, et al: Distinct cerebellar contributions to intrinsic connectivity networks. J Neurosci 29:8586-8594, 2009
43. Hermann EJ, Rittierodt M, Krauss JK: Combined transventricular and supracerebellar infratentorial approach preserving the vermis in giant pediatric posterior fossa midline tumors. Neurosurgery 63 (1 Suppl 1):ONS30-ONS37, 2008
44. Hirsch JF, Renier D, Czernichow P, Benveniste L, Pierre-Kahn A: Medulloblastoma in childhood. Survival and functional results. Acta Neurochir (Wien) 48:1-15, 1979
45. Holmes G: The symptoms of acute cerebellar injuries due to gunshot injuries. Brain 40:461-535, 1917
46. Huber JF, Bradley K, Spiegler BJ, Dennis M: Long-term effects of transient cerebellar mutism after cerebellar astrocytoma or medulloblastoma tumor resection in childhood. Childs Nerv Syst 22:132-138, 2006
47. Ildan F, Tuna M, Erman T, Göçer AI, Zeren M, Cetinalp E: The evaluation and comparison of cerebellar mutism in children and adults after posterior fossa surgery: report of two adult cases and review of the literature. Acta Neurochir (Wien) 144:463-473, 2002
48. Kellogg JX, Piatt JH Jr: Resection of fourth ventricle tumors without splitting the vermis: the cerebellomedullary fissure approach. Pediatr Neurosurg 27:28-33, 1997
49. Kelly RM, Strick PL: Cerebellar loops with motor cortex and prefrontal cortex of a nonhuman primate. J Neurosci 23:8432-8444, 2003
50. Kim SG, Uǧurbil K, Strick PL: Activation of a cerebellar output nucleus during cognitive processing. Science 265:949-951, 1994
51. Koh S, Turkel SB, Baram TZ: Cerebellar mutism in children: report of six cases and potential mechanisms. Pediatr Neurol 16:218-219, 1997
52. Korah MP, Esiashvili N, Mazewski CM, Hudgins RJ, Tighiouart M, Janss AJ, et al: Incidence, risks, and sequelae of posterior fossa syndrome in pediatric medulloblastoma. Int J Radiat Oncol Biol Phys 77:106-112, 2010
53. Kotil K, Eras M, Akçetin M, Bilge T: Cerebellar mutism following posterior fossa tumor resection in children. Turk Neurosurg 18:89-94, 2008
54. Krienen FM, Buckner RL: Segregated fronto-cerebellar circuits revealed by intrinsic functional connectivity. Cereb Cortex 19:2485-2497, 2009
55. Küpeli S, Yalçin B, Bilginer B, Akalan N, Haksal P, Büyükpamukçu M: Posterior fossa syndrome after posterior fossa surgery in children with brain tumors. Pediatr Blood Cancer 56:206-210, 2011
56. Küper M, Timmann D: Cerebellar mutism. Brain Lang [epub ahead of print], 2013
57. Kusano Y, Tanaka Y, Takasuna H, Wada N, Tada T, Kakizawa Y, et al: Transient cerebellar mutism caused by bilateral damage to the dentate nuclei after the second posterior fossa surgery. Case report. J Neurosurg 104:329-331, 2006
58. Law N, Greenberg M, Bouffet E, Taylor MD, Laughlin S, Strother D, et al: Clinical and neuroanatomical predictors of cerebellar mutism syndrome. Neuro Oncol 14:1294-1303, 2012
59. Lotze M, Montoya P, Erb M, Hülsmann E, Flor H, Klose U, et al: Activation of cortical and cerebellar motor areas during executed and imagined hand movements: an fMRI study. J Cogn Neurosci 11:491-501, 1999
60. Mariën P, De Smet HJ, Wijgerde E, Verhoeven J, Crols R, De Deyn PP: Posterior fossa syndrome in adults: a new case and comprehensive survey of the literature. Cortex 49:284-300, 2013
61. McMillan HJ, Keene DL, Matzinger MA, Vassilyadi M, Nzau M, Ventureyra EC: Brainstem compression: a predictor of postoperative cerebellar mutism. Childs Nerv Syst 25:677-681, 2009
62. Mei C, Morgan AT: Incidence of mutism, dysarthria and dysphagia associated with childhood posterior fossa tumour. Childs Nerv Syst 27:1129-1136, 2011
63. Miller NG, Reddick WE, Kocak M, Glass JO, Löbel U, Morris B, et al: Cerebellocerebral diaschisis is the likely mechanism of postsurgical posterior fossa syndrome in pediatric patients with midline cerebellar tumors. AJNR Am J Neuroradiol 31:288-294, 2010
64. Morgan AT, Liégeois F, Liederkerke C, Vogel AP, Hayward R, Harkness W, et al: Role of cerebellum in fine speech control in childhood: persistent dysarthria after surgical treatment for posterior fossa tumour. Brain Lang 117:69-76, 2011
65. Morris EB, Phillips NS, Laningham FH, Patay Z, Gajjar A, Wallace D, et al: Proximal dentatothalamocortical tract involvement in posterior fossa syndrome. Brain 132:3087-3095, 2009
66. Mortimer DS: Clinical case study: a 4-year-old boy with posterior fossa syndrome after resection of a medulloblastoma. J Neurosci Nurs 43:225-229, 2011
67. Murdoch BE: The cerebellum and language: historical perspective and review. Cortex 46:858-868, 2010
68. Nagatani K, Waga S, Nakagawa Y: Mutism after removal of a vermian medulloblastoma: cerebellar mutism. Surg Neurol 36:307-309, 1991
69. Ozgur BM, Berberian J, Aryan HE, Meltzer HS, Levy ML: The pathophysiologic mechanism of cerebellar mutism. Surg Neurol 66:18-25, 2006
70. Ozimek A, Richter S, Hein-Kropp C, Schoch B, Gorissen B, Kaiser O, et al: Cerebellar mutism - report of four cases. J Neurol 251:963-972, 2004
71. Palmer SL, Hassall T, Evankovich K, Mabbott DJ, Bonner M, Deluca C, et al: Neurocognitive outcome 12 months following cerebellar mutism syndrome in pediatric patients with medulloblastoma. Neuro Oncol 12:1311-1317, 2010
72. Papavasiliou AS, Kotsalis C, Trakadas S: Transient cerebellar mutism in the course of acute cerebellitis. Pediatr Neurol 30:71-74, 2004
73. Petersen SE, Fox PT, Posner MI, Mintun M, Raichle ME: Positron emission tomographic studies of the cortical anatomy of single-word processing. Nature 331:585-589, 1988
74. Petersen SE, Fox PT, Posner MI, Mintum M, Raichle ME: Positron emission tomographic studies of the processing of single words. J Cogn Neurosci 1:153-170, 1989
75. Piatt JH, Kellogg JX: A hazard of combining the infratentorial supracerebellar and the cerebellomedullary fissure approaches: cerebellar venous insufficiency. Pediatr Neurosurg 33:243-248, 2000
76. Pollack IF: Neurobehavioral abnormalities after posterior fossa surgery in children. Int Rev Psychiatry 13:302-312, 2001
77. Pollack IF, Polinko P, Albright AL, Towbin R, Fitz C: Mutism and pseudobulbar symptoms after resection of posterior fossa tumors in children: incidence and pathophysiology. Neurosurgery 37:885-893, 1995
78. Puget S, Boddaert N, Viguier D, Kieffer V, Bulteau C, Garnett M, et al: Injuries to inferior vermis and dentate nuclei predict poor neurological and neuropsychological outcome in children with malignant posterior fossa tumors. Cancer 115:1338-1347, 2009
79. Rajesh BJ, Rao BR, Menon G, Abraham M, Easwer HV, Nair S: Telovelar approach: technical issues for large fourth ventricle tumors. Childs Nerv Syst 23:555-558, 2007
80. Rekate HL, Grubb RL, Aram DM, Hahn JF, Ratcheson RA: Muteness of cerebellar origin. Arch Neurol 42:697-698, 1985
81. Riva D, Giorgi C: The cerebellum contributes to higher functions during development: evidence from a series of children surgically treated for posterior fossa tumours. Brain 123:1051-1061, 2000
82. Robertson PL, Muraszko KM, Holmes EJ, Sposto R, Packer RJ, Gajjar A, et al: Incidence and severity of postoperative cerebellar mutism syndrome in children with medulloblastoma: a prospective study by the Children's Oncology Group. J Neurosurg 105 (6 Suppl):444-451, 2006
83. Sagiuchi T, Ishii K, Aoki Y, Kan S, Utsuki S, Tanaka R, et al: Bilateral crossed cerebello-cerebral diaschisis and mutism after surgery for cerebellar medulloblastoma. Ann Nucl Med 15:157-160, 2001
84. Schmahmann JD, Sherman JC: The cerebellar cognitive affective syndrome. Brain 121:561-579, 1998
85. Sherman JH, Sheehan JP, Elias WJ, Jane JA Sr: Cerebellar mutism in adults after posterior fossa surgery: a report of 2 cases. Surg Neurol 63:476-479, 2005
86. Shyu C, Burke K, Souweidane MM, Dunkel IJ, Gilheeney SW, Gershon T, et al: Novel use of zolpidem in cerebellar mutism syndrome. J Pediatr Hematol Oncol 33:148-149, 2011
87. Siffert J, Poussaint TY, Goumnerova LC, Scott RM, LaValley B, Tarbell NJ, et al: Neurological dysfunction associated with postoperative cerebellar mutism. J Neurooncol 48:75-81, 2000
88. Silveri MC, Leggio MG, Molinari M: The cerebellum contributes to linguistic production: a case of agrammatic speech following a right cerebellar lesion. Neurology 44:2047-2050, 1994
89. Sinha AK, Rajender Y, Dinakar I: Transient cerebellar mutism after evacuation of a spontaneous vermian haematoma. Childs Nerv Syst 14:460-462, 1998
90. Snell RS: Clinical Neuroanatomy for Medical Students, ed 5. Baltimore: Lippincott Williams & Wilkins, 2001, pp 237-238
91. Soelva V, Hernáiz Driever P, Abbushi A, Rueckriegel S, Bruhn H, Eisner W, et al: Fronto-cerebellar fiber tractography in pediatric patients following posterior fossa tumor surgery. Childs Nerv Syst 29:597-607, 2013
92. Steinbok P, Cochrane DD, Perrin R, Price A: Mutism after posterior fossa tumour resection in children: incomplete recovery on long-term follow-up. Pediatr Neurosurg 39:179-183, 2003
93. Steinlin M, Imfeld S, Zulauf P, Boltshauser E, Lövblad KO, Ridolfi Lüthy A, et al: Neuropsychological long-term sequelae after posterior fossa tumour resection during childhood. Brain 126:1998-2008, 2003
94. Stoodley CJ, Schmahmann JD: Evidence for topographic organization in the cerebellum of motor control versus cognitive and affective processing. Cortex 46:831-844, 2010
95. Strick PL, Dum RP, Fiez JA: Cerebellum and nonmotor function. Annu Rev Neurosci 32:413-434, 2009
96. Tasdemiroǧlu E, Kaya M, Yildirim CH, Firat L: Postoperative cerebellar mutism and autistic spectrum disorder. Childs Nerv Syst 27:869-878, 2011
97. Thomale UW, Driever PH: Inconsistent terminology for cerebellar mutism. Childs Nerv Syst 29:717-718, 2013 (Letter)
98. Tohgi H, Takahashi S, Chiba K, Hirata Y: Cerebellar infarction. Clinical and neuroimaging analysis in 293 patients. Stroke 24:1697-1701, 1993
99. Turgut M: Transient "cerebellar" mutism. Childs Nerv Syst 14:161-166, 1998
100. Turkstra LS, Bayles KA: Acquired mutism: physiopathy and assessment. Arch Phys Med Rehabil 73:138-144, 1992
101. van Baarsen K, Kleinnijenhuis M, Konert T, van Cappellen van Walsum AM, Grotenhuis A: Tractography demonstrates dentate-rubro-thalamic tract disruption in an adult with cerebellar mutism. Cerebellum [epub ahead of print], 2013
102. Van Dijk KR, Hedden T, Venkataraman A, Evans KC, Lazar SW, Buckner RL: Intrinsic functional connectivity as a tool for human connectomics: theory, properties, and optimization. J Neurophysiol 103:297-321, 2010
103. van Dongen HR, Catsman-Berrevoets CE, van Mourik M: The syndrome of 'cerebellar' mutism and subsequent dysarthria. Neurology 44:2040-2046, 1994
104. van Mourik M, Catsman-Berrevoets CE, van Dongen HR, Neville BG: Complex orofacial movements and the disappearance of cerebellar mutism: report of five cases. Dev Med Child Neurol 39:686-690, 1997
105. Vandeinse D, Hornyak JE: Linguistic and cognitive deficits associated with cerebellar mutism. Pediatr Rehabil 1:41-44, 1997
106. von Hoff K, Kieffer V, Habrand JL, Kalifa C, Dellatolas G, Grill J: Impairment of intellectual functions after surgery and posterior fossa irradiation in children with ependymoma is related to age and neurologic complications. BMC Cancer 8:15, 2008
107. Watanabe Y, Yamasaki F, Nakamura K, Kajiwara Y, Takayasu T, Nosaka R, et al: Evaluation of cerebellar mutism by arterial spin-labeling perfusion magnetic resonance imaging in a patient with atypical teratoid/rhabdoid tumor (AT/RT): a case report. Childs Nerv Syst 28:1257-1260, 2012
108. Wells EM, Khademian ZP, Walsh KS, Vezina G, Sposto R, Keating RF, et al: Postoperative cerebellar mutism syndrome following treatment of medulloblastoma: neuroradiographic features and origin. Clinical article. J Neurosurg Pediatr 5:329-334, 2010
109. Wells EM, Walsh KS, Khademian ZP, Keating RF, Packer RJ: The cerebellar mutism syndrome and its relation to cerebellar cognitive function and the cerebellar cognitive affective disorder. Dev Disabil Res Rev 14:221-228, 2008
110. Wisoff JH, Epstein FJ: Pseudobulbar palsy after posterior fossa operation in children. Neurosurgery 15:707-709, 1984