Suspension thermal spraying of hydroxyapatite: Microstructure and in vitro behaviour

Materials Science and Engineering C

Volumn 34, Issue 1, 2014, Pages 287-303

  Bolelli, Giovanni ^a   Bellucci, Devis ^a   Cannillo, Valeria ^a   Lusvarghi, Luca ^a   Sola, Antonella ^a   Stiegler, Nico ^b   Müller, Philipp ^b   Killinger, Andreas ^b   Gadow, Rainer ^b   Altomare, Lina ^c   De Nardo, Luigi ^c  

^a UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^b UNIVERSITY OF STUTTGART   (Germany)

^c POLITECNICO DI MILANO   (Italy)

Author keywords

Bioactive coating; Cytocompatibility; Cytotoxicity; High Velocity Suspension Flame Spraying (HVSFS); Hydroxyapatite; Simulated body fluid (SBF)

Indexed keywords

BIOACTIVE COATINGS; CYTOCOMPATIBILITY; DEPOSITION PARAMETERS; HIGH VELOCITY SUSPENSION FLAME SPRAYING (HVSFS); HYDROXYAPATITE COATING; HYDROXYAPATITE LAYERS; PRECIPITATION BEHAVIOUR; SIMULATED BODY FLUIDS;

CELL PROLIFERATION; COATINGS; CYTOTOXICITY; FLAME SPRAYING; HARDNESS; HYDROXYAPATITE; PROSTHETICS; SINTERING; WEIBULL DISTRIBUTION;

PLASMA SPRAYING;

BIOMATERIAL; HYDROXYAPATITE;

ARTICLE; BIOACTIVE COATING; BODY FLUID; CELL COMMUNICATION; CELL DEATH; CELL LINE; CELL SURVIVAL; CHEMISTRY; CRYSTALLIZATION; CYTOCOMPATIBILITY; CYTOTOXICITY; DIFFERENTIAL SCANNING CALORIMETRY; DRUG EFFECT; HARDNESS; HIGH VELOCITY SUSPENSION FLAME SPRAYING (HVSFS); HUMAN; MATERIALS TESTING; METHODOLOGY; PLASMA GAS; POWDER; RAMAN SPECTROMETRY; SCANNING ELECTRON MICROSCOPY; SIMULATED BODY FLUID (SBF); STATIC ELECTRICITY; SUSPENSION; TEMPERATURE; TENSILE STRENGTH; THERMOGRAVIMETRY; X RAY DIFFRACTION; YOUNG MODULUS;

BIOACTIVE COATING; CYTOCOMPATIBILITY; CYTOTOXICITY; HIGH VELOCITY SUSPENSION FLAME SPRAYING (HVSFS); HYDROXYAPATITE; SIMULATED BODY FLUID (SBF);

BODY FLUIDS; CELL COMMUNICATION; CELL DEATH; CELL LINE; CELL SURVIVAL; COATED MATERIALS, BIOCOMPATIBLE; CRYSTALLIZATION; DIFFERENTIAL THERMAL ANALYSIS; DURAPATITE; ELASTIC MODULUS; HARDNESS; HUMANS; MATERIALS TESTING; MICROSCOPY, ELECTRON, SCANNING; PLASMA GASES; POWDERS; SPECTRUM ANALYSIS, RAMAN; STATIC ELECTRICITY; SUSPENSIONS; TEMPERATURE; TENSILE STRENGTH; THERMOGRAVIMETRY; X-RAY DIFFRACTION;

EID: 84889090781     PISSN: 09284931     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.msec.2013.09.017     Document Type: Article

References (112)

1. M.T. Manley, J.H. Dumbleton, and K. Sutton Fixation choices for primary hip and knee applications Semin. Arthroplast. 17 2006 56 60 (Pubitemid 44201750)
2. H.F. Morris, and S. Ochi Hydroxyapatite-coated implants: a case for their use J. Oral Maxillofac. Surg. 56 1998 1303 1311 (Pubitemid 28515920)
3. O. Reikerås, and R.B. Gunderson Long-term results of HA coated threaded versus HA coated hemispheric press fit cups: 287 hips followed for 11 to 16 years Arch. Orthop. Trauma Surg. 126 2006 503 508 (Pubitemid 44473273)
4. T. Albrektsson, and C. Johansson Osteoinduction, osteoconduction and osseointegration Eur. Spine J. 10 2001 S96 S101
5. R. Petit The use of hydroxyapatite in orthopaedic surgery: a ten-year review Eur. J. Orthop. Surg. Traumatol. 9 1999 71 74
6. L. Sun, C.C. Berndt, K.A. Gross, and A. Kucuk Material fundamentals and clinical performance of plasma-sprayed hydroxyapatite coatings: a review J. Biomed. Mater. Res. 58 5 2001 570 592 (Pubitemid 32899914)
7. L. Visai, L. De Nardo, C. Punta, L. Melone, A. Cigada, M. Imbriani, and C.R. Arciola Titanium oxide antibacterial surfaces in biomedical devices Int. J. Artif. Organs 34 9 2011 929 946
8. L. De Nardo, L. Altomare, B. Del Curto, A. Cigada, and L. Draghi Electrochemical surface modifications of titanium and titanium alloys for biomedical applications M. Driver, Coatings for Biomedical Applications 2012 Woodhead Publishing Ltd. Cambridge. UK 106 142
9. Y.-K. Lee, Y.-C. Ha, B.-K. Chang, K.-C. Kim, T.-y. Kim, and K.-H. Koo Cementless bipolar hemiarthroplasty using a hydroxyapatite-coated long stem for osteoporotic unstable intertrochanteric fractures J. Arthroplast. 26 4 2011 626 632
10. G.Y. Lee, A. Srivastava, D.D. D'Lima, P.A. Pulido, and C.W. Colwell Hydroxyapatite-coated femoral stem survivorship at 10 years J. Arthroplast. 20 7 2005 57 62 (Pubitemid 41425787)
11. O. Reikerås, and R.B. Gunderson Excellent results with femoral revision surgery using an extensively hydroxyapatite-coated stem Acta Orthop. 77 1 2006 98 103 (Pubitemid 43879160)
12. I. Landor, P. Vavrik, A. Sosna, D. Jahoda, H. Hahn, and M. Daniel Hydroxyapatite porous coating and the osteointegration of the total hip replacement Arch. Orthop. Trauma Surg. 127 2007 81 89 (Pubitemid 46165348)
13. W.N. Capello, J.A. D'Antonio, W.L. Jaffe, R.G. Geesink, M.T. Manley, and J.R. Feinberg Hydroxyapatite-coated femoral components. 15-year minimum followup Clin. Orthop. Relat. Res. 453 2006 75 80 (Pubitemid 44900962)
14. C.S. Ranawat, V.J. Rasquinha, M. Meftah, and A.S. Ranawat The hydroxyapatite-tapered stem: any added value? Semin. Arthroplast. 22 2011 75 78
15. P. Chandran, M. Azzabi, M. Andrews, and J.G. Bradley Periprosthetic bone remodeling after 12 years differs in cemented and uncemented hip arthroplasties Clin. Orthop. Relat. Res. 470 2012 1431 1435
16. C. Courtney, B. Hooks, and M.I. Froimson Hydroxyapatite-coated, tapered titanium hip arthroplasty Semin. Arthroplast. 20 2009 50 54
17. M. Degidi, A. Piattelli, P. Gehrke, P. Felice, and F. Carinci Five-year outcome of 111 immediate nonfunctional single restorations J. Implantol. 32 6 2006 277 285
18. I. Landor, P. Vavrik, A. Sosna, D. Jahoda, H. Hahn, and M. Daniel Hydroxyapatite porous coating and the osteointegration of the total hip replacement Arch. Orthop. Trauma Surg. 127 2007 81 89 (Pubitemid 46165348)
19. A. Paulsen, A.B. Pedersen, S.P. Johnsen, A. Riis, U. Lucht, and S. Overgaard Effect of hydroxyapatite coating on risk of revision after primary total hip arthroplasty in younger patients. Findings from the Danish Hip Arthroplasty Registry Acta Orthop. 78 5 2007 622 628 (Pubitemid 350034938)
20. T. Uehara, K. Takaoka, and K. Ito Histological evidence of osseointegration in human retrieved fractured hydroxyapatite-coated screw- type implants: a case report Clin. Oral Impl. Res. 15 2004 540 545 (Pubitemid 40104948)
21. K. Rungcharassaeng, J.L. Lozada, J.Y.K. Kan, J.S. Kim, W.V. Campagni, and C.A. Munoz Peri-implant tissue response of immediately loaded, threaded, HA-coated implants: 1-year results J. Prosthet. Dent. 87 2002 173 181 (Pubitemid 40434013)
22. S.-Y. Kim, D.-H. Kim, Y.-G. Kim, C.-W. Oh, and J.-C. Ihn Early failure of hemispheric hydroxyapatite-coated acetabular cups Clin. Orthop. Relat. Res. 446 2006 233 238 (Pubitemid 44318287)
23. J.D. Voigt, and M. Mosier Hydroxyapatite (HA) coating appears to be of benefit for implant durability of tibial components in primary total knee arthroplasty. A systematic review of the literature and meta-analysis of 14 trials and 926 evaluable total knee arthroplasties Acta Orthop. 82 4 2011 448 459
24. J.-K. Chang, C.-H. Chen, K.-Y. Huang, and G.-J. Wang Eight-year results of hydroxyapatite-coated hip arthroplasty J. Arthroplast. 21 4 2006 541 546 (Pubitemid 43866406)
25. K.-w. Cheung, S.-h. Yung, K.-ch. Wong, and K.-h. Chiu Early failure of smooth hydroxyapatite-coated press-fit acetabular cup - 7 years of follow-up J. Arthroplast. 20 5 2005 627 631
26. A. Tindall, K.D. James, and R. Slack Long-term follow-up of a hydroxyapatite ceramic-coated threaded cup. An analysis of survival and fixation at up to 15 years J. Arthroplast. 22 8 2007 1079 1082 (Pubitemid 350216987)
27. J.-P. Vidalain Twenty-year results of the cementless Corail stem Int. Orthop. 35 2011 189 194
28. B.G. Bøe, S.M. Röhrl, T. Heier, F. Snorrason, and L. Nordsletten A prospective randomized study comparing electrochemically deposited hydroxyapatite and plasma-sprayed hydroxyapatite on titanium stems. 55 hips followed for 2 years with RSA and DXA Acta Orthop. 82 1 2011 13 19
29. M. Stilling, O. Rahbek, and K. Søballe Inferior survival of hydroxyapatite versus titanium-coated cups at 15 years Clin. Orthop. Relat. Res. 467 2009 2872 2879
30. O. Reigstad, C. Johansson, V. Stenport, A. Wennerberg, A. Reigstad, and M. Røkkum Different patterns of bone fixation with hydroxyapatite and resorbable CaP coatings in the rabbit tibia at 6, 12, and 52 weeks J. Biomed. Mater. Res. B Appl. Biomater. 99 2011 14 20
31. K. de Groot, J.G.C. Wolke, and J.A. Jansen Calcium phosphate coatings for medical implants Proc. Inst. Mech. Eng. H J. Eng. Med. 212 1998 137 147 (Pubitemid 128769991)
32. K.A. Gross, and C.C. Berndt Biomedical application of apatites M.J. Kohn, J. Rakovan, J.M. Hughes, Phosphates: Geochemical, Geobiological, and Materials Importance - Reviews in Mineralogy and Geochemistry 48 2008 631 672
33. M. Philippe, and M. Ameil Survival analysis at 10 years of a cohort of 297 atlas total hip prostheses Eur. J. Orthop. Surg. Traumatol. 17 2007 573 578 (Pubitemid 350045123)
34. Y.-Y. Chung, J. Kim, C.H. Lim, K.-S. Kim, and Y.S. Lee Measurement of extent of bone ongrowth and hydroxyapatite absorption in retrieved acetabular cups J. Orthop. Sci. 13 2008 198 201 (Pubitemid 351799211)
35. V. Borsari, M. Fini, G. Giavaresi, L. Rimondini, U. Consolo, L. Chiusoli, A. Salito, A. Volpert, R. Chiesa, and R. Giardino Osteointegration of titanium and hydroxyapatite rough surfaces in healthy and compromised cortical and trabecular bone: in vivo comparative study on young, aged, and estrogen-deficient sheep J. Orthop. Res. 25 2007 1250 1260 (Pubitemid 47365299)
36. R.B. Heimann Thermal spraying of biomaterials Surf. Coat. Technol. 201 2006 2012 2019 (Pubitemid 44348557)
37. D. Alves Cardoso, J.A. Jansen, and S.C.G. Leeuwenburgh Synthesis and application of nanostructured calcium phosphate ceramics for bone regeneration J. Biomed. Mater. Res. B Appl. Biomater. 100 2012 2316 2326
38. P. Choudhury, and D.C. Agrawal Sol-gel derived hydroxyapatite coatings on titanium substrates Surf. Coat. Technol. 206 2-3 2011 360 365
39. A. Abrishamchian, T. Hooshmand, M. Mohammadi, and F. Najafi Preparation and characterization of multi-walled carbon nanotube/hydroxyapatite nanocomposite film dip coated on Ti-6Al-4V by sol-gel method for biomedical applications: An in vitro study Mater. Sci. Eng. C 33 4 2013 2002 2010
40. P. Yin, F.F. Feng, T. Lei, X.H. Zhong, and X.C. Jian Osteoblastic cell response on biphasic fluorhydroxyapatite/strontium-substituted hydroxyapatite coatings J. Biomed. Mater. Res. A 2013 10.1002/jbm.a.34723 (in press)
41. C.J. Tredwin, G. Georgiou, H.-W. Kimc, and J.C. Knowles Hydroxyapatite, fluor-hydroxyapatite and fluorapatite produced via the sol-gel method: bonding to titanium and scanning electron microscopy Dent. Mater. 29 5 2013 521 529
42. S. Samani, S.M. Hossainalipour, M. Tamizifar, and H.R. Rezaie In vitro antibacterial evaluation of sol-gel-derived Zn-, Ag-, and(Zn + Ag)-doped hydroxyapatite coatings against methicillin-resistant Staphylococcus aureus J. Biomed. Mater. Res. A 101 2013 222 230
43. S. Zhang, Z. Xianting, W. Yongsheng, C. Kui, and W. Wenjian Adhesion strength of sol-gel derived fluoridated hydroxyapatite coatings Surf. Coat. Technol. 200 22-23 2006 6350 6354
44. A. Abdi Bastami, H. Farnoush, A. Sadeghi, and J. Aghazadeh Mohandesi Sol-gel derived nanohydroxyapatite film on friction stir processed Ti-6Al-4V substrate Surf. Eng. 29 3 2013 205 210
45. J. Breme, Y. Zhou, and L. Groh Development of a titanium alloy suitable for an optimized coating with hydroxyapatite Biomaterials 16 1995 239 244
46. A. Killinger, M. Kuhn, and R. Gadow High-Velocity Suspension Flame Spraying (HVSFS), a new approach for spraying nanoparticles with hypersonic speed Surf. Coat. Technol. 201 2006 1922 1929 (Pubitemid 44341050)
47. 2 coatings Surf. Coat. Technol. 203 12 2009 1722 1732
48. 3 Coatings J. Therm. Spray Technol. 18 1 2009 35 49
49. N. Stiegler, D. Bellucci, G. Bolelli, V. Cannillo, R. Gadow, A. Killinger, L. Lusvarghi, and A. Sola High-Velocity Suspension Flame Sprayed (HVSFS) hydroxyapatite coatings for biomedical applications J. Therm. Spray Technol. 21 2 2012 275 287
50. G. Bolelli, V. Cannillo, R. Gadow, A. Killinger, L. Lusvarghi, and J. Rauch Microstructural and in vitro characterisation of high-velocity suspension flame sprayed (HVSFS) bioactive glass coatings J. Eur. Ceram. Soc. 29 2009 2249 2257
51. 2 bond coat Surf. Coat. Technol. 206 2012 3857 3868
52. L. Altomare, D. Bellucci, G. Bolelli, B. Bonferroni, V. Cannillo, L. De Nardo, R. Gadow, A. Killinger, L. Lusvarghi, A. Sola, and N. Stiegler Microstructure and in vitro behaviour of 45S5 bioglass coatings deposited by high velocity suspension flame spraying (HVSFS) J. Mater. Sci. Mater. Med. 22 2011 1303 1319
53. G. Bolelli, N. Stiegler, D. Bellucci, V. Cannillo, R. Gadow, A. Killinger, L. Lusvarghi, and A. Sola Deposition mechanisms in high velocity suspension spraying: case study for two bioactive materials Surf. Coat. Technol. 210 2012 28 45
54. E. Dongmo, R. Gadow, A. Killinger, and M. Wenzelburger Modeling of combustion as well as heat, mass, and momentum transfer during thermal spraying by HVOF and HVSFS J. Therm. Spray Technol. 18 5-6 2009 896 908
55. J.H.M. Goosen, A.J. Swieringa, J.G.M. Keet, and C.C.P.M. Verheyen Excellent results from proximally HA-coated femoral stems with a minimum of 6 years follow-up. A prospective evaluation of 100 patients Acta Orthop. 76 2 2005 190 197 (Pubitemid 40769663)
56. L. Palm, S.-A. Jacobsson, and I. Ivarsson Hydroxyapatite coating improves 8- to 10-year performance of the link RS cementless femoral stem J. Arthroplast. 17 2 2002 172 175 (Pubitemid 34160568)
57. T. Thierer, J.P. Davliakos, J. Daulton Keith Jr., J.J. Sanders, D.P. Tarnow, and J.A. Rivers Five-year prospective clinical evaluation of highly crystalline HA MP-1-coated dental implants J. Oral Implantol. 34 1 2008 39 46
58. W. Xue, X. Liu, X. Zheng, and C. Ding Effect of hydroxyapatite coating crystallinity on dissolution and osseointegration in vivo J. Biomed. Mater. Res. A 74 2005 553 561 (Pubitemid 41216257)
59. R.S. Lima, K.A. Khor, H. Li, P. Cheang, and B.R. Marple HVOF spraying of nanostructured hydroxyapatite for biomedical applications Mater. Sci. Eng. A 396 1-2 2005 181 187 (Pubitemid 40447313)
60. R.B. Heimann, H.V. Tran, and P. Hartmann Laser-Raman and Nuclear Magnetic Resonance (NMR) studies on plasma-sprayed hydroxyapatite coatings: Influence of bioinert bond coats on phase composition and resorption kinetics in simulated body fluid Materialwiss. Werkst. 34 12 2003 1163 1169 (Pubitemid 38136483)
61. I. Demnati, M. Parco, D. Grossin, I. Fagoaga, C. Drouet, G. Barykin, C. Combes, I. Braceras, S. Goncalves, and C. Rey Hydroxyapatite coating on titanium by a low energy plasma spraying mini-gun Surf. Coat. Technol. 206 2012 2346 2353
62. 3 coatings using Vickers indentation technique J. Phys. D. Appl. Phys. 40 2007 7090 7096 (Pubitemid 350163956)
63. R. Gadow, A. Killinger, and N. Stiegler Hydroxyapatite coatings for biomedical applications deposited by different thermal spray techniques Surf. Coat. Technol. 205 4 2010 1157 1164
64. T. Kokubo, and H. Takadama How useful is SBF in predicting in vivo bone bioactivity? Biomaterials 27 15 2006 2907 2915 (Pubitemid 43208916)
65. A.L. Patterson The Scherrer formula for X-ray particle size determination Phys. Rev. 56 15 1939 978 982
66. 3 coatings Surf. Coat. Technol. 204 8 2010 1163 1179
67. J. Fazilleau, C. Delbos, V. Rat, J.F. Coudert, P. Fauchais, and B. Pateyron Phenomena involved in suspension plasma spraying. Part 1: suspension injection and behavior Plasma Chem. Plasma Process. 26 2006 371 391 (Pubitemid 44121443)
68. C. Delbos, J. Fazilleau, V. Rat, J.F. Coudert, P. Fauchais, and B. Pateyron Phenomena involved in suspension plasma spraying. Part 2: Zirconia particle treatment and coating formation Plasma Chem. Plasma Process. 26 2006 393 414 (Pubitemid 44117352)
69. S. Basu, and B.M. Cetegen Modeling of liquid ceramic precursor droplets in a high velocity oxy-fuel flame jet Acta Mater. 56 12 2008 2750 2759
70. P. Kulkarni, P.A. Baron, and K. Willeke P. Kulkarni, P.A. Baron, K. Willeke, Aerosol Measurement. Principles, Techniques, and applications Third edition 2011 J. Wiley & Sons Ltd. Chichester, UK 15 30
71. C. Qiu, and Y. Chen Manufacturing process of nanostructured alumina coatings by suspension plasma spraying J. Therm. Spray Technol. 18 2 2009 272 283
72. S. Dyshlovenko, B. Pateyron, L. Pawlowski, and D. Murano Numerical simulation of hydroxyapatite powder behaviour in plasma jet Surf. Coat. Technol. 179 1 2004 110 117 (Pubitemid 38237609)
73. F.J. Krieger Calculation of the viscosity of gas mixtures U.S. Air Force Project RAND Research Memorandum 1951 The RAND Corporation Santa Monica, CA, USA (Available on-line at http://www.rand.org/pubs/research-memoranda/2008/RM649. pdf (retrieved 29/08/2012))
74. E. Dongmo, A. Killinger, M. Wenzelburger, and R. Gadow Numerical approach and optimization of the combustion and gas dynamics in High Velocity Suspension Flame Spraying (HVSFS) Surf. Coat. Technol. 203 15 2009 2139 2145
75. K. VanEvery, M.J.M. Krane, R.W. Trice, H. Wang, W. Porter, M. Besser, D. Sordelet, J. Ilavsky, and J. Almer Column formation in suspension plasma-sprayed coatings and resultant thermal properties J. Therm. Spray Technol. 20 4 2011 817 828
76. H. Podlesak, L. Pawlowski, R. d'Haese, J. Laureyns, T. Lampke, and S. Bellayer Advanced microstructural study of suspension plasma sprayed hydroxyapatite coatings J. Therm. Spray Technol. 19 3 2010 657 664
77. A. Antonakosa, E. Liarokapisa, and T. Leventouri Micro-Raman and FTIR studies of synthetic and natural apatites Biomaterials 28 2007 3043 3054 (Pubitemid 46560866)
78. R. Cuscó, F. Guitián, S. de Aza, and L. Artús Differentiation between hydroxyapatite and β-tricalcium phosphate by means of μ-Raman spectroscopy J. Eur. Ceram. Soc. 18 1998 1301 1305 (Pubitemid 128370009)
79. M.B. Volf Mathematical Approach to Glass 1988 Elsevier The Netherlands
80. K.A. Gross, V. Gross, and C.C. Berndt Thermal analysis of amorphous phases in hydroxyapatite coatings J. Am. Ceram. Soc. 81 1 1998 106 112 (Pubitemid 128575191)
81. C.F. Feng, K.A. Khor, E.J. Liu, and P. Cheang Phase transformations in plasma sprayed hydroxyapatite coatings Scripta Mater. 42 2000 103 109
82. H. Füredi-Milhofer, V. Hlady, F.S. Baker, R.A. Beebe, N. Wolejko Wikholm, and J.S. Kittelberger Temperature-programmed dehydration of hydroxyapatite J. Colloid Interface Sci. 70 1 1979 1 9
83. H. Owada, K. Ymashita, and T. Kanazawa High-temperature stability of hydroxyl ions in yttrium-substituted oxyhydroxyapatites J. Mater. Sci. Lett. 10 1 1991 26 28
84. Y.S. Touloukian, and C.Y. Ho Thermophysical Properties of Matter: The TPRC Data Series 1970 Plenum Publishing Company Limited New York, NY, USA
85. R. McPherson A model for the thermal conductivity of plasma-sprayed ceramic coatings Thin Solid Films 112 1984 89 95 (Pubitemid 14549447)
86. O. Babushkin, T. Lindback, A. Holmgren, J. Li, and L. Hermansson Thermal expansion of hot isostatically pressed hydroxyapatite J. Mater. Chem. 4 3 1994 413 415
87. C. Chu, J. Zhu, Z. Yin, and P. Lin Optimal design and fabrication of hydroxyapatite-Ti asymmetrical functionally graded biomaterial Mater. Sci. Eng. A 348 1-2 2003 244 250 (Pubitemid 36333596)
88. K.P. Sanosh, M.-C. Chu, A. Balakrishnan, T.N. Kim, and S.-J. Cho Pressureless sintering of nanocrystalline hydroxyapatite at different temperatures Met. Mater. Int. 16 4 2010 605 611
89. S. Ramesh, K.L. Aw, R. Tolouei, M. Amiriyan, C.Y. Tan, M. Hamdi, J. Purbolaksono, M.A. Hassan, and W.D. Teng Sintering properties of hydroxyapatite powders prepared using different methods Ceram. Int. 39 1 2013 111 119
90. S. Saber-Samandari, and K.A. Gross Amorphous calcium phosphate offers improved crack resistance: a design feature from nature? Acta Biomater. 7 2011 4235 4241
91. X. Fan, E.D. Case, F. Ren, Y. Shu, and M.J. Baumann Part II: Fracture strength and elastic modulus as a function of porosity for hydroxyapatite and other brittle materials J. Mech. Behav. Biomed. Mater. 8 2012 99 110
92. S.W.K. Kweh, K.A. Khor, and P. Cheang Plasma-sprayed hydroxyapatite (HA) coatings with flame-spheroidized feedstock: microstructure and mechanical properties Biomaterials 21 2000 1223 1234 (Pubitemid 30195720)
93. K.A. Khor, H. Li, and P. Cheang Significance of melt-fraction in HVOF-sprayed hydroxyapatite particles, splats and coatings Biomaterials 25 2004 1177 1186 (Pubitemid 37476195)
94. C.-W. Yang, T.-M. Lee, T.-S. Lui, and E. Chang Effect of post vacuum heating on the microstructural feature and bonding strength of plasma-sprayed hydroxyapatite coatings Mater. Sci. Eng. C 26 2006 1395 1400 (Pubitemid 44163183)
95. S. Yang, H.C. Man, W. Xing, and X. Zheng Adhesion strength of plasma-sprayed hydroxyapatite coatings on laser gas-nitrided pure titanium Surf. Coat. Technol. 203 2009 3116 3122
96. C. Renghini, E. Girardin, A.S. Fomin, A. Manescu, A. Sabbioni, S.M. Barinov, V.S. Komlev, G. Albertini, and F. Fiori Plasma sprayed hydroxyapatite coatings from nanostructured granules Mater. Sci. Eng. B 152 2008 86 90
97. J. Nohava, B. Bonferroni, G. Bolelli, and L. Lusvarghi Interesting aspects of indentation and scratch methods for characterization of thermally-sprayed coatings Surf. Coat. Technol. 205 4 2010 1127 1131
98. S.W.K. Kweh, K.A. Khor, and P. Cheang An in vitro investigation of plasma sprayed hydroxyapatite (HA) coatings produced with flame-spheroidized feedstock Biomaterials 23 2002 775 785 (Pubitemid 33108953)
99. K.A. Gross, S. Saber-Samandari, and K.S. Heemann Evaluation of commercial implants with Na91noindentation defines future development needs for hydroxyapatite coatings J. Biomed. Mater. Res. B Appl. Biomater. 93 2010 1 8
100. R. Ahmed, N.H. Faisal, A.M. Paradowska, M.E. Fitzpatrick, and K.A. Khor Neutron diffraction residual strain measurements in nanostructured hydroxyapatite coatings for orthopaedic implants J. Mech. Behav. Biomed. Mater. 2011 2043 2054
101. P. Ostojic, and C.C. Berndt The variability in strength of thermally sprayed coatings Surf. Coat. Technol. 34 1988 43 50
102. C.-W. Yang, and T.-S. Lui Effect of crystallization on the bonding strength and failures of plasma-sprayed hydroxyapatite Mater. Trans. 48 2 2007 211 218 (Pubitemid 46515665)
103. C.-W. Yang, and T.-S. Lui Microstructural self-healing effect of hydrothermal crystallization on bonding strength and failure mechanism of hydroxyapatite coatings J. Eur. Ceram. Soc. 28 2008 2151 2159
104. R.S. Lima, and B.R. Marple High Weibull modulus HVOF titania coatings J. Therm. Spray Technol. 12 2 2003 240 249
105. H.-M. Kim, T. Himeno, T. Kokubo, and T. Nakamura Process and kinetics of bonelike apatite formation on sintered hydroxyapatite in a simulated body fluid Biomaterials 26 2005 4366 4373 (Pubitemid 40208597)
106. S.-W. Ha, R. Reber, K.-L. Eckert, M. Petitmermet, J. Mayer, and E. Wintermantel Chemical and morphological changes of vacuum-plasma-sprayed hydroxyapatite coatings during immersion in simulated physiological solutions J. Am. Ceram. Soc. 81 1 1998 81 88 (Pubitemid 128575188)
107. L. Sun, C.C. Berndt, K.A. Khor, H.N. Cheang, and K.A. Gross Surface characteristics and dissolution behavior of plasma-sprayed hydroxyapatite coating J. Biomed. Mater. Res. 62 2002 228 236 (Pubitemid 34988500)
108. R.B. Heimann Characterization of as-plasma-sprayed and incubated hydroxyapatite coatings with high resolution techniques Mater.-wiss. Werkstofftech. 40 1-2 2009 23 30
109. Y.C. Tsui, C. Doyle, and T.W. Clyne Plasma sprayed hydroxyapatite coatings on titanium substrates. Part 2: optimisation of coating properties Biomaterials 19 1998 2031 2043 (Pubitemid 28539848)
110. C.M. Botelho, M.A. Lopes, I.R. Gibson, S.M. Best, and J.D. Santos Structural analysis of Si-substituted hydroxyapatite: zeta potential and X-ray photoelectron spectroscopy J. Mater. Sci. Mater. Med. 13 2002 1123 1127 (Pubitemid 36172471)
111. W. Janusz, and E. Skwarek The study of the properties of the hydroxyapatite/electrolyte interface Ann. Univ. Mariae Curie-Skłodowska 64 1 2010 11 20
112. N. Puvvada, P. Kumar Panigrahi, and A. Pathak Room temperature synthesis of highly hemocompatible hydroxyapatite, study of their physical properties and spectroscopic correlation of particle size Nanoscale 2 2010 2631 2638