Anemia is a predictor of graft loss but not cardiovascular events and all-cause mortality in renal transplant recipients: Follow-up data from the ALERT study

Clinical Transplantation

Volumn 27, Issue 6, 2013, Pages

  Schjelderup, Patrick ^a   Dahle, Dag Olav ^b   Holdaas, Hallvard ^b   Mjøen, Geir ^b   Nordby, Gudrun ^b   Abedini, Sadollah ^c   Jardine, Alan ^d   Fellström, Bengt ^e   Svensson, My ^f  

^a AALBORG UNIVERSITY HOSPITAL   (Denmark)

^b OSLO UNIVERSITY HOSPITAL   (Norway)

^c VESTFOLD HOSPITAL TRUST   (Norway)

^d UNIVERSITY OF GLASGOW   (United Kingdom)

^e UPPSALA UNIVERSITY   (Sweden)

^f AARHUS UNIVERSITY HOSPITAL   (Denmark)

Author keywords

Anemia; Chronic kidney disease; Graft survival; Kidney transplantation; Mortality

Indexed keywords

ACETYLSALICYLIC ACID; COUMARIN; CYCLOSPORIN; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; FLUINDOSTATIN; HEMOGLOBIN; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PREDNISOLONE;

ADULT; ANEMIA; ARTICLE; CARDIOVASCULAR DISEASE; COHORT ANALYSIS; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; FOLLOW UP; GRAFT FAILURE; GRAFT RECIPIENT; GRAFT SURVIVAL; HAZARD RATIO; HEMOGLOBIN BLOOD LEVEL; HUMAN; KIDNEY TRANSPLANTATION; MAJOR CLINICAL STUDY; MALE; MORTALITY; MULTIVARIATE ANALYSIS; PRIORITY JOURNAL; PROPORTIONAL HAZARDS MODEL; PROSPECTIVE STUDY; SURVIVAL;

ANEMIA; CHRONIC KIDNEY DISEASE; GRAFT SURVIVAL; KIDNEY TRANSPLANTATION; MORTALITY;

ADULT; ANEMIA; CARDIOVASCULAR DISEASES; CAUSE OF DEATH; DOUBLE-BLIND METHOD; FEMALE; FOLLOW-UP STUDIES; GLOMERULAR FILTRATION RATE; HUMANS; KIDNEY FAILURE, CHRONIC; KIDNEY FUNCTION TESTS; KIDNEY TRANSPLANTATION; MALE; MIDDLE AGED; POSTOPERATIVE COMPLICATIONS; PROGNOSIS; PROSPECTIVE STUDIES; RISK FACTORS; SURVIVAL RATE;

EID: 84889080926     PISSN: 09020063     EISSN: 13990012     Source Type: Journal    
DOI: 10.1111/ctr.12220     Document Type: Article

References (30)

1. Jones H, Talwar M, Nogueira JM et al. Anemia after kidney transplantation; its prevalence, risk factors, and independent association with graft and patient survival: a time-varying analysis. Transplantation 2012: 93: 923.
2. Vanrenterghem Y, Ponticelli C, Morales JM et al. Prevalence and management of anemia in renal transplant recipients: a European survey. Am J Transplant 2003: 3: 835.
3. Molnar MZ, Mucsi I, Macdougall IC et al. Prevalence and management of anaemia in renal transplant recipients: data from ten European centres. Nephron Clin Pract 2011: 117: c127.
4. Mix TC, Kazmi W, Khan S et al. Anemia: a continuing problem following kidney transplantation. Am J Transplant 2003: 3: 1426.
5. Yorgin PD, Scandling JD, Belson A, Sanchez J, Alexander SR, Andreoni KA. Late post-transplant anemia in adult renal transplant recipients. An under-recognized problem? Am J Transplant 2002: 2: 429.
6. Winkelmayer WC, Kewalramani R, Rutstein M, Gabardi S, Vonvisger T, Chandraker A. Pharmacoepidemiology of anemia in kidney transplant recipients. J Am Soc Nephrol 2004: 15: 1347.
7. Chadban SJ, Baines L, Polkinghorne K et al. Anemia after kidney transplantation is not completely explained by reduced kidney function. Am J Kidney Dis 2007: 49: 301.
8. Winkelmayer WC, Chandraker A. Pottransplantation anemia: management and rationale. Clin J Am Soc Nephrol 2008: 3(Suppl 2): S49.
9. Locatelli F, Pozzoni P, Del Vecchio L. Anemia and heart failure in chronic kidney disease. Semin Nephrol 2005: 25: 392.
10. Locatelli F, Pisoni RL, Combe C et al. Anaemia in haemodialysis patients of five European countries: association with morbidity and mortality in the Dialysis Outcomes and Practice Patterns Study (DOPPS). Nephrol Dial Transplant 2004: 19: 121.
11. Rigatto C, Parfrey P, Foley R, Negrijn C, Tribula C, Jeffery J. Congestive heart failure in renal transplant recipients: risk factors, outcomes, and relationship with ischemic heart disease. J Am Soc Nephrol 2002: 13: 1084.
12. Chhabra D, Grafals M, Skaro AI, Parker M, Gallon L. Impact of anemia after renal transplantation on patient and graft survival and on rate of acute rejection. Clin J Am Soc Nephrol 2008: 3: 1168.
13. Molnar MZ, Czira M, Ambrus C et al. Anemia is associated with mortality in kidney-transplanted patients-a prospective cohort study. Am J Transplant 2007: 7: 818.
14. Kamar N, Rostaing L. Negative impact of one-year anemia on long-term patient and graft survival in kidney transplant patients receiving calcineurin inhibitors and mycophenolate mofetil. Transplantation 2008: 85: 1120.
15. Winkelmayer WC, Chandraker A, Alan Brookhart M, Kramar R, Sunder-Plassmann G. A prospective study of anaemia and long-term outcomes in kidney transplant recipients. Nephrol Dial Transplant 2006: 21: 3559.
16. Vanrenterghem YF, Claes K, Montagnino G et al. Risk factors for cardiovascular events after successful renal transplantation. Transplantation 2008: 85: 209.
17. Imoagene-Oyedeji AE, Rosas SE, Doyle AM, Goral S, Bloom RD. Posttransplantation anemia at 12 months in kidney recipients treated with mycophenolate mofetil: risk factors and implications for mortality. J Am Soc Nephrol 2006: 17: 3240.
18. Gheith O, Wafa E, Hassan N et al. Does posttransplant anemia at 6 months affect long-term outcome of live-donor kidney transplantation? A single-center experience Clin Exp Nephrol 2009: 13: 361.
19. Moore J, He X, Cockwell P, Little MA, Johnston A, Borrows R. The impact of hemoglobin levels on patient and graft survival in renal transplant recipients. Transplantation 2008: 86: 564.
20. Kolonko A, Pinocy-Mandok J, Kocierz M et al. Anemia and erythrocytosis after kidney transplantation: a 5-year graft function and survival analysis. Transplant Proc 2009: 41: 3046.
21. Holdaas H, Fellstrom B, Jardine AG et al. Effect of fluvastatin on cardiac outcomes in renal transplant recipients: a multicentre, randomised, placebo-controlled trial. Lancet 2003: 361: 2024.
22. Yabu JM, Winkelmayer WC. Posttransplantation anemia: mechanisms and management. Clin J Am Soc Nephrol 2011: 6: 1794.
23. Drueke TB, Locatelli F, Clyne N et al. Normalization of hemoglobin level in patients with chronic kidney disease and anemia. N Engl J Med 2006: 355: 2071.
24. Pfeffer MA, Burdmann EA, Chen CY et al. A trial of darbepoetin alfa in type 2 diabetes and chronic kidney disease. N Engl J Med 2009: 361: 2019.
25. Inrig JK, Barnhart HX, Reddan D et al. Effect of hemoglobin target on progression of kidney disease: a secondary analysis of the Correction of Hemoglobin and Outcomes in Renal Insufficiency (CHOIR) trial. Am J Kidney Dis 2012: 60: 390.
26. Heinze G, Kainz A, Horl WH, Oberbauer R. Mortality in renal transplant recipients given erythropoietins to increase haemoglobin concentration: cohort study. BMJ 2009: 339: b4018.
27. Singh AK, Szczech L, Tang KL et al. Correction of anemia with epoetin alfa in chronic kidney disease. N Engl J Med 2006: 355: 2085.
28. Choukroun G, Kamar N, Dussol B, et al. Correction of postkidney transplant anemia reduces progression of allograft nephropathy. J Am Soc Nephrol 2012: 23: 360.
29. Zeisberg M, Neilson EG. Mechanisms of tubulointerstitial fibrosis. J Am Soc Nephrol 2010: 21: 1819.
30. Cassis P, Gallon L, Benigni A et al. Erythropoietin, but not the correction of anemia alone, protects from chronic kidney allograft injury. Kidney Int 2012: 81: 903.