Effect of hemoglobin target on progression of kidney disease: A secondary analysis of the CHOIR (Correction of Hemoglobin and Outcomes in Renal Insufficiency) trial

American Journal of Kidney Diseases

Volumn 60, Issue 3, 2012, Pages 390-401

  Inrig, Jula K ^a,b   Barnhart, Huiman X ^c,d   Reddan, Donal ^b,e   Patel, Uptal D ^b,c   Sapp, Shelly ^c   Califf, Robert M ^d   Singh, Ajay K ^f   Szczech, Lynda A ^b,c  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

^c DUKE CLINICAL RESEARCH INSTITUTE   (United States)

^d DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e NATIONAL UNIVERSITY OF IRELAND   (Ireland)

^f BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Anemia; chronic kidney disease; erythropoiesis stimulating agents; hemoglobin

Indexed keywords

HEMOGLOBIN; RECOMBINANT ERYTHROPOIETIN;

AGED; ANEMIA; ARTICLE; CHRONIC KIDNEY DISEASE; CLINICAL TRIAL; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DIABETES MELLITUS; DISEASE COURSE; FEMALE; GLOMERULUS FILTRATION RATE; HEART FAILURE; HEMOGLOBIN BLOOD LEVEL; HUMAN; MAJOR CLINICAL STUDY; MALE; POST HOC ANALYSIS; PROPORTIONAL HAZARDS MODEL; PROTEINURIA; RANDOMIZED CONTROLLED TRIAL; RENAL REPLACEMENT THERAPY; SECONDARY ANALYSIS; SMOKING; TREATMENT OUTCOME;

AGED; AGED, 80 AND OVER; ANALYSIS OF VARIANCE; ANEMIA; CONFIDENCE INTERVALS; DISEASE PROGRESSION; DRUG DELIVERY SYSTEMS; ERYTHROPOIETIN; FEMALE; FOLLOW-UP STUDIES; GLOMERULAR FILTRATION RATE; HEMATINICS; HEMOGLOBINOMETRY; HEMOGLOBINS; HUMANS; KAPLAN-MEIER ESTIMATE; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; PROPORTIONAL HAZARDS MODELS; PROSPECTIVE STUDIES; RECOMBINANT PROTEINS; REGRESSION ANALYSIS; RENAL INSUFFICIENCY, CHRONIC; RISK ASSESSMENT; SEVERITY OF ILLNESS INDEX; SURVIVAL RATE; TREATMENT OUTCOME;

EID: 84865700331     PISSN: 02726386     EISSN: 15236838     Source Type: Journal    
DOI: 10.1053/j.ajkd.2012.03.009     Document Type: Article

References (28)

1. E.J. Sharples, N. Patel, P. Brown Erythropoietin protects the kidney against the injury and dysfunction caused by ischemia-reperfusion J Am Soc Nephrol 15 8 2004 2115 2124
2. W.F. Keane, Z. Zhang, P.A. Lyle Risk scores for predicting outcomes in patients with type 2 diabetes and nephropathy: the RENAAL Study Clin J Am Soc Nephrol 1 4 2006 761 767
3. C. Gouva, P. Nikolopoulos, J.P. Ioannidis, K.C. Siamopoulos Treating anemia early in renal failure patients slows the decline of renal function: a randomized controlled trial Kidney Int 66 2 2004 753 760
4. J. Rossert, A. Levin, S.D. Roger Effect of early correction of anemia on the progression of CKD Am J Kidney Dis 47 5 2006 738 750
5. A.K. Singh, L. Szczech, K.L. Tang Correction of anemia with epoetin alfa in chronic kidney disease N Engl J Med 355 20 2006 2085 2098
6. T.B. Drueke, F. Locatelli, N. Clyne Normalization of hemoglobin level in patients with chronic kidney disease and anemia N Engl J Med 355 20 2006 2071 2084
7. M.A. Pfeffer, E.A. Burdmann, C.Y. Chen A trial of darbepoetin alfa in type 2 diabetes and chronic kidney disease N Engl J Med 361 21 2009 2019 2032
8. L.A. Szczech, H.X. Barnhart, S. Sapp A secondary analysis of the CHOIR trial shows that comorbid conditions differentially affect outcomes during anemia treatment Kidney Int 77 3 2010 239 246
9. M.K. Haroun, B.G. Jaar, S.C. Hoffman, G.W. Comstock, M.J. Klag, J. Coresh Risk factors for chronic kidney disease: a prospective study of 23,534 men and women in Washington County, Maryland J Am Soc Nephrol 14 11 2003 2934 2941
10. B. Baggio, A. Budakovic, E. Perissinotto Atherosclerotic risk factors and renal function in the elderly: the role of hyperfibrinogenaemia and smoking Results from the Italian Longitudinal Study on Ageing (ILSA) Nephrol Dial Transplant 20 1 2005 114 123
11. G. Gambaro, F. Verlato, A. Budakovic Renal impairment in chronic cigarette smokers J Am Soc Nephrol 9 4 1998 562 567
12. A.S. Levey, J.P. Bosch, J.B. Lewis, T. Greene, N. Rogers, D. Roth A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation Modification of Diet in Renal Disease Study Group Ann Intern Med 130 6 1999 461 470
13. X. Zhang, M.J. Zhang SAS macros for estimation of direct adjusted cumulative incidence curves under proportional subdistribution hazards models Comput Methods Programs Biomed 101 1 2010 87 93
14. J.P. Fine, R.J. Gray A proportional hazards model for the subdistribution of a competing risk J Am Stat Assoc 94 1999 496 509
15. S.C. Palmer, S.D. Navaneethan, J.C. Craig Meta-analysis: erythropoiesis-stimulating agents in patients with chronic kidney disease Ann Intern Med 153 1 2010 23 33
16. E. Ritz, U. Benck, E. Franek, C. Keller, M. Seyfarth, J. Clorius Effects of smoking on renal hemodynamics in healthy volunteers and in patients with glomerular disease J Am Soc Nephrol 9 10 1998 1798 1804
17. D.W. Johnson, B. Pat, D.A. Vesey, Z. Guan, Z. Endre, G.C. Gobe Delayed administration of darbepoetin or erythropoietin protects against ischemic acute renal injury and failure Kidney Int 69 10 2006 1806 1813
18. M. Abdelrahman, E.J. Sharples, M.C. McDonald Erythropoietin attenuates the tissue injury associated with hemorrhagic shock and myocardial ischemia Shock 22 1 2004 63 69
19. H. Sartelet, M. Fabre, M. Castaing Expression of erythropoietin and its receptor in neuroblastomas Cancer 110 5 2007 1096 1106
20. L.V. d'Uscio, L.A. Smith, A.V. Santhanam, D. Richardson, K.A. Nath, Z.S. Katusic Essential role of endothelial nitric oxide synthase in vascular effects of erythropoietin Hypertension 49 5 2007 1142 1148
21. R.S. Barua, J.A. Ambrose, L.J. Eales-Reynolds, M.C. DeVoe, J.G. Zervas, D.C. Saha Dysfunctional endothelial nitric oxide biosynthesis in healthy smokers with impaired endothelium-dependent vasodilatation Circulation 104 16 2001 1905 1910
22. L.A. Szczech, H.X. Barnhart, J.K. Inrig Secondary analysis of the CHOIR trial epoetin-alpha dose and achieved hemoglobin outcomes Kidney Int 74 6 2008 791 798
23. D.B. Petitti, J. Wingerd, F. Pellegrin, S. Ramcharan Oral contraceptives, smoking, and other factors in relation to risk of venous thromboembolic disease Am J Epidemiol 108 6 1978 480 485
24. D.B. Petitti, J. Wingerd Use of oral contraceptives, cigarette smoking, and risk of subarachnoid haemorrhage Lancet 2 8083 1978 234 235
25. Bayer Pharmaceuticals Yaz prescribing information http://www.yaz-us.com/ Accessed August 4, 2010
26. S.F. Assmann, S.J. Pocock, L.E. Enos, L.E. Kasten Subgroup analysis and other (mis)uses of baseline data in clinical trials Lancet 355 9209 2000 1064 1069
27. S.J. Pocock, M.D. Hughes, R.J. Lee Statistical problems in the reporting of clinical trials A survey of three medical journals N Engl J Med 317 7 1987 426 432
28. S. Yusuf, J. Wittes, J. Probstfield, H.A. Tyroler Analysis and interpretation of treatment effects in subgroups of patients in randomized clinical trials JAMA 266 1 1991 93 98