메뉴 건너뛰기




Volumn 19, Issue 39, 2013, Pages 6873-6879

Supplementation of creatine and ribose prevents apoptosis and right ventricle hypertrophy in hypoxic hearts

Author keywords

Akt; AMPK; Apoptosis; Creatine; Hypoxia; Pulmonary endothelium; Ribose; Right vs left ventricle

Indexed keywords

ADENYLATE KINASE; CREATININE; ENDOTHELIN 1; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE B; RIBOSE; STRESS ACTIVATED PROTEIN KINASE;

EID: 84889013549     PISSN: 13816128     EISSN: 18734286     Source Type: Journal    
DOI: 10.2174/138161281939131127114218     Document Type: Article
Times cited : (8)

References (48)
  • 1
    • 0023888231 scopus 로고
    • Prediction of the oxygenation of human organs at varying blood oxygen carrying properties
    • Samaja M. Prediction of the oxygenation of human organs at varying blood oxygen carrying properties. Respir Physiol 1988; 72: 211-8.
    • (1988) Respir Physiol , vol.72 , pp. 211-218
    • Samaja, M.1
  • 2
    • 0023625931 scopus 로고
    • Protection of ischemic myiocardium by exogenus phosphocreatine
    • Sharov V, Saks V, Kupriyanov V, et al. Protection of ischemic myiocardium by exogenus phosphocreatine. J Thorac Cardiovasc Surg 1987; 94: 749-61.
    • (1987) J Thorac Cardiovasc Surg , vol.94 , pp. 749-761
    • Sharov, V.1    Saks, V.2    Kupriyanov, V.3
  • 3
    • 0029595277 scopus 로고
    • Attenuation by creatine of myocardial metabolic stress in Brattleboro rats caused by chronic inhibition of nitric oxide synthase
    • Constantin-Teodosiu D, Greenhaff PL, Gardiner SM, Randall MD, March JE, Bennett T. Attenuation by creatine of myocardial metabolic stress in Brattleboro rats caused by chronic inhibition of nitric oxide synthase. Br J Pharmacol 1995; 116(8): 3288-92.
    • (1995) Br J Pharmacol , vol.116 , Issue.8 , pp. 3288-3292
    • Constantin-Teodosiu, D.1    Greenhaff, P.L.2    Gardiner, S.M.3    Randall, M.D.4    March, J.E.5    Bennett, T.6
  • 4
    • 0029098914 scopus 로고
    • Inhibition of the creatine kinase reaction decreases the contractile reserve of isolated rat hearts
    • Hamman B, Bittl J, Jacobus W, et al. Inhibition of the creatine kinase reaction decreases the contractile reserve of isolated rat hearts. Am J Physiol 1995; 269: H1030-H6.
    • (1995) Am J Physiol , vol.269 , pp. 1030-1036
    • Hamman, B.1    Bittl, J.2    Jacobus, W.3
  • 5
    • 0346730899 scopus 로고    scopus 로고
    • D-Ribose improves diastolic function and quality of life in congestive heart failure patients: A prospective feasibility study
    • Omran H, Illien S, MacCarter D, St Cyr J, Luderitz B. D-Ribose improves diastolic function and quality of life in congestive heart failure patients: a prospective feasibility study. Eur J Heart Fail 2003; 5(5): 615-9.
    • (2003) Eur J Heart Fail , vol.5 , Issue.5 , pp. 615-619
    • Omran, H.1    Illien, S.2    McCarter, D.3    St Cyr, J.4    Luderitz, B.5
  • 6
    • 0026801526 scopus 로고
    • Effects of ribose on exercise-induced ischaemia in stable coronary artery disease
    • Pliml W, von Arnim T, Stablein A, Hofmann H, Zimmer HG, Erdmann E. Effects of ribose on exercise-induced ischaemia in stable coronary artery disease. Lancet 1992; 340(8818): 507-10.
    • (1992) Lancet , vol.340 , Issue.8818 , pp. 507-510
    • Pliml, W.1    von Arnim, T.2    Stablein, A.3    Hofmann, H.4    Zimmer, H.G.5    Erdmann, E.6
  • 7
    • 0037246892 scopus 로고    scopus 로고
    • Preischemic administration of ribose to delay the onset of irreversible ischemic injury and improve function: Studies in normal and hypertrophied hearts
    • Wallen WJ, Belanger MP, Wittnich C. Preischemic administration of ribose to delay the onset of irreversible ischemic injury and improve function: studies in normal and hypertrophied hearts. Can J Physiol Pharmacol 2003; 81(1): 40-7.
    • (2003) Can J Physiol Pharmacol , vol.81 , Issue.1 , pp. 40-47
    • Wallen, W.J.1    Belanger, M.P.2    Wittnich, C.3
  • 8
    • 78651225353 scopus 로고    scopus 로고
    • Supplementation of creatine and ribose prevents apoptosis in ischemic cardiomyocytes
    • Epub 2011/01/12
    • Caretti A, Bianciardi P, Sala G, Terruzzi C, Lucchina F, Samaja M. Supplementation of creatine and ribose prevents apoptosis in ischemic cardiomyocytes. Cell Physiol Biochem 2010; 26(6): 831-8. Epub 2011/01/12.
    • (2010) Cell Physiol Biochem , vol.26 , Issue.6 , pp. 831-838
    • Caretti, A.1    Bianciardi, P.2    Sala, G.3    Terruzzi, C.4    Lucchina, F.5    Samaja, M.6
  • 9
    • 77949486397 scopus 로고    scopus 로고
    • Daily reoxygenation decreases myocardial injury and improves post-ischaemic recovery after chronic hypoxia
    • Milano G, Corno AF, Samaja M, Morel S, Vassalli G, von Segesser LK. Daily reoxygenation decreases myocardial injury and improves post-ischaemic recovery after chronic hypoxia. Eur J Cardiothorac Surg 2010; 37(4): 942-9.
    • (2010) Eur J Cardiothorac Surg , vol.37 , Issue.4 , pp. 942-949
    • Milano, G.1    Corno, A.F.2    Samaja, M.3    Morel, S.4    Vassalli, G.5    von Segesser, L.K.6
  • 10
    • 10044244814 scopus 로고    scopus 로고
    • Myocardial impairment in chronic hypoxia is abolished by short aeration episodes: Involvement of K+ATP channels
    • Milano G, Bianciardi P, Corno AF, et al. Myocardial impairment in chronic hypoxia is abolished by short aeration episodes: involvement of K+ATP channels. Exp Biol Med (Maywood) 2004; 229(11): 1196-205.
    • (2004) Exp Biol Med (Maywood) , vol.229 , Issue.11 , pp. 1196-1205
    • Milano, G.1    Bianciardi, P.2    Corno, A.F.3
  • 11
    • 82155188820 scopus 로고    scopus 로고
    • Phosphodiesterase-5 inhibition mimics intermittent reoxygenation and improves cardioprotection in the hypoxic myocardium
    • Milano G, Bianciardi P, Rochemont V, et al. Phosphodiesterase-5 inhibition mimics intermittent reoxygenation and improves cardioprotection in the hypoxic myocardium. PLoS One 2011; 6(11): e27910.
    • (2011) PLoS One , vol.6 , Issue.11
    • Milano, G.1    Bianciardi, P.2    Rochemont, V.3
  • 12
    • 33745285018 scopus 로고    scopus 로고
    • Brief reoxygenation episodes during chronic hypoxia enhance posthypoxic recovery of LV function: Role of mitogen-activated protein kinase signaling pathways
    • Morel S, Milano G, Ludunge KM, et al. Brief reoxygenation episodes during chronic hypoxia enhance posthypoxic recovery of LV function: Role of mitogen-activated protein kinase signaling pathways. Basic Res Cardiol 2006; 101(4): 336-45.
    • (2006) Basic Res Cardiol , vol.101 , Issue.4 , pp. 336-345
    • Morel, S.1    Milano, G.2    Ludunge, K.M.3
  • 13
    • 34347371574 scopus 로고    scopus 로고
    • Heart HIF-1alpha and MAP kinases during hypoxia: Are they associated in vivo?
    • Caretti A, Morel S, Milano G, et al. Heart HIF-1alpha and MAP kinases during hypoxia: are they associated in vivo? Exp Biol Med (Maywood) 2007; 232(7): 887-94.
    • (2007) Exp Biol Med (Maywood) , vol.232 , Issue.7 , pp. 887-894
    • Caretti, A.1    Morel, S.2    Milano, G.3
  • 14
    • 77950210575 scopus 로고    scopus 로고
    • Phosphorylation of phosphatidylinositol-3-kinase-protein kinase B and extracellular signal-regulated kinases 1/2 mediate reoxygenation-induced cardioprotection during hypoxia
    • Milano G, von Segesser LK, Morel S, et al. Phosphorylation of phosphatidylinositol-3-kinase-protein kinase B and extracellular signal-regulated kinases 1/2 mediate reoxygenation-induced cardioprotection during hypoxia. Exp Biol Med (Maywood) 2010; 235(3): 401-10.
    • (2010) Exp Biol Med (Maywood) , vol.235 , Issue.3 , pp. 401-410
    • Milano, G.1    von Segesser, L.K.2    Morel, S.3
  • 15
    • 33644626916 scopus 로고    scopus 로고
    • Chronic in vivo hypoxia in various organs: Hypoxia-inducible factor-1alpha and apoptosis
    • Bianciardi P, Fantacci M, Caretti A, et al. Chronic in vivo hypoxia in various organs: hypoxia-inducible factor-1alpha and apoptosis. Biochem Biophys Res Commun 2006; 342(3): 875-80.
    • (2006) Biochem Biophys Res Commun , vol.342 , Issue.3 , pp. 875-880
    • Bianciardi, P.1    Fantacci, M.2    Caretti, A.3
  • 19
    • 84860701457 scopus 로고    scopus 로고
    • In vivo upregulation of the unfolded protein response after hypoxia
    • Tagliavacca L, Caretti A, Bianciardi P, Samaja M. In vivo upregulation of the unfolded protein response after hypoxia. Biochim Biophys Acta 2012; 1820(7): 900-6.
    • (2012) Biochim Biophys Acta , vol.1820 , Issue.7 , pp. 900-906
    • Tagliavacca, L.1    Caretti, A.2    Bianciardi, P.3    Samaja, M.4
  • 20
    • 77951289481 scopus 로고    scopus 로고
    • Oxidative stress in the denervated muscle
    • Abruzzo PM, Di Tullio S, Marchionni C, et al. Oxidative stress in the denervated muscle. Free Radic Res 2010; 44(5): 563-76.
    • (2010) Free Radic Res , vol.44 , Issue.5 , pp. 563-576
    • Abruzzo, P.M.1    Di Tullio, S.2    Marchionni, C.3
  • 21
    • 17344392308 scopus 로고    scopus 로고
    • A new mathematical model for relative quantification in real-time RT-PCR
    • Pfaffl MW. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 2001; 29(9): e45.
    • (2001) Nucleic Acids Res , vol.29 , Issue.9
    • Pfaffl, M.W.1
  • 22
  • 23
    • 26444480274 scopus 로고    scopus 로고
    • Acclimatization to chronic hypobaric hypoxia is associated with a differential transcriptional profile between the right and left ventricle
    • Adrogue JV, Sharma S, Ngumbela K, Essop MF, Taegtmeyer H. Acclimatization to chronic hypobaric hypoxia is associated with a differential transcriptional profile between the right and left ventricle. Mol Cell Biochem 2005; 278(1-2): 71-8.
    • (2005) Mol Cell Biochem , vol.278 , Issue.1-2 , pp. 71-78
    • Adrogue, J.V.1    Sharma, S.2    Ngumbela, K.3    Essop, M.F.4    Taegtmeyer, H.5
  • 24
    • 77951093077 scopus 로고    scopus 로고
    • Development of left ventricular diastolic dysfunction with preservation of ejection fraction during progression of infant right ventricular hypertrophy
    • Kitahori K, He H, Kawata M, et al. Development of left ventricular diastolic dysfunction with preservation of ejection fraction during progression of infant right ventricular hypertrophy. Circ Heart Fail 2009; 2(6): 599-607.
    • (2009) Circ Heart Fail , vol.2 , Issue.6 , pp. 599-607
    • Kitahori, K.1    He, H.2    Kawata, M.3
  • 25
    • 67650221201 scopus 로고    scopus 로고
    • Autophagy, redox signaling, and ventricular remodeling
    • Gurusamy N, Das DK. Autophagy, redox signaling, and ventricular remodeling. Antioxid Redox Signal 2009; 11(8): 1975-88.
    • (2009) Antioxid Redox Signal , vol.11 , Issue.8 , pp. 1975-1988
    • Gurusamy, N.1    Das, D.K.2
  • 26
    • 84856603825 scopus 로고    scopus 로고
    • Protein modulation in mouse heart under acute and chronic hypoxia
    • Vigano A, Vasso M, Caretti A, et al. Protein modulation in mouse heart under acute and chronic hypoxia. Proteomics 2011; 11(21): 4202-17.
    • (2011) Proteomics , vol.11 , Issue.21 , pp. 4202-4217
    • Vigano, A.1    Vasso, M.2    Caretti, A.3
  • 27
    • 0023154642 scopus 로고
    • Why do cells need phosphocreatine and a phosphocreatine shuttle
    • Kammermeier H. Why do cells need phosphocreatine and a phosphocreatine shuttle. J Mol Cell Cardiol 1987; 19: 115-8.
    • (1987) J Mol Cell Cardiol , vol.19 , pp. 115-118
    • Kammermeier, H.1
  • 28
    • 0032032455 scopus 로고    scopus 로고
    • Adenine/ribose supply increases adenosine production and protects ATP pool in adenosine kinase-inhibited cardiac cells
    • Smolenski RT, Kalsi KK, Zych M, Kochan Z, Yacoub MH. Adenine/ribose supply increases adenosine production and protects ATP pool in adenosine kinase-inhibited cardiac cells. J Mol Cell Cardiol 1998; 30(3): 673-83.
    • (1998) J Mol Cell Cardiol , vol.30 , Issue.3 , pp. 673-683
    • Smolenski, R.T.1    Kalsi, K.K.2    Zych, M.3    Kochan, Z.4    Yacoub, M.H.5
  • 29
    • 1542328927 scopus 로고    scopus 로고
    • Structure, regulation and function of PKB/AKT-a major therapeutic target
    • Hanada M, Feng J, Hemmings BA. Structure, regulation and function of PKB/AKT-a major therapeutic target. Biochim Biophys Acta 2004; 1697(1-2): 3-16.
    • (2004) Biochim Biophys Acta , vol.1697 , Issue.1-2 , pp. 3-16
    • Hanada, M.1    Feng, J.2    Hemmings, B.A.3
  • 30
    • 33744937886 scopus 로고    scopus 로고
    • Activation of cardiac AMPactivated protein kinase by LKB1 expression or chemical hypoxia is blunted by increased Akt activity
    • Soltys CL, Kovacic S, Dyck JR. Activation of cardiac AMPactivated protein kinase by LKB1 expression or chemical hypoxia is blunted by increased Akt activity. Am J Physiol Heart Circ Physiol 2006; 290(6): H2472-9.
    • (2006) Am J Physiol Heart Circ Physiol , vol.290 , Issue.6 , pp. 2472-2479
    • Soltys, C.L.1    Kovacic, S.2    Dyck, J.R.3
  • 31
    • 34547124878 scopus 로고    scopus 로고
    • Agonist-modulated regulation of AMP-activated protein kinase (AMPK) in endothelial cells. Evidence for an AMPK-> Rac1-> Akt-> endothelial nitric-oxide synthase pathway
    • Levine YC, Li GK, Michel T. Agonist-modulated regulation of AMP-activated protein kinase (AMPK) in endothelial cells. Evidence for an AMPK-> Rac1-> Akt-> endothelial nitric-oxide synthase pathway. J Biol Chem 2007; 282(28): 20351-64.
    • (2007) J Biol Chem , vol.282 , Issue.28 , pp. 20351-20364
    • Levine, Y.C.1    Li, G.K.2    Michel, T.3
  • 32
    • 0042733154 scopus 로고    scopus 로고
    • AMP-activated protein kinase (AMPK) signaling in endothelial cells is essential for angiogenesis in response to hypoxic stress
    • Nagata D, Mogi M, Walsh K. AMP-activated protein kinase (AMPK) signaling in endothelial cells is essential for angiogenesis in response to hypoxic stress. J Biol Chem 2003; 278(33): 31000-6.
    • (2003) J Biol Chem , vol.278 , Issue.33 , pp. 31000-31006
    • Nagata, D.1    Mogi, M.2    Walsh, K.3
  • 33
    • 0346463030 scopus 로고    scopus 로고
    • Adiponectin stimulates angiogenesis by promoting cross-talk between AMP-activated protein kinase and Akt signaling in endothelial cells
    • Ouchi N, Kobayashi H, Kihara S, et al. Adiponectin stimulates angiogenesis by promoting cross-talk between AMP-activated protein kinase and Akt signaling in endothelial cells. J Biol Chem 2004; 279(2): 1304-9.
    • (2004) J Biol Chem , vol.279 , Issue.2 , pp. 1304-1309
    • Ouchi, N.1    Kobayashi, H.2    Kihara, S.3
  • 34
    • 79960091427 scopus 로고    scopus 로고
    • Myocardial AKT: The omnipresent nexus
    • Sussman MA, Volkers M, Fischer K, et al. Myocardial AKT: the omnipresent nexus. Physiol Rev 2011; 91(3): 1023-70.
    • (2011) Physiol Rev , vol.91 , Issue.3 , pp. 1023-1070
    • Sussman, M.A.1    Volkers, M.2    Fischer, K.3
  • 35
    • 35349023691 scopus 로고    scopus 로고
    • Heme-oxygenase-1-induced protection against hypoxia/reoxygenation is dependent on biliverdin reductase and its interaction with PI3K/Akt pathway
    • Pachori AS, Smith A, McDonald P, Zhang L, Dzau VJ, Melo LG. Heme-oxygenase-1-induced protection against hypoxia/reoxygenation is dependent on biliverdin reductase and its interaction with PI3K/Akt pathway. J Mol Cell Cardiol 2007; 43(5): 580-92.
    • (2007) J Mol Cell Cardiol , vol.43 , Issue.5 , pp. 580-592
    • Pachori, A.S.1    Smith, A.2    McDonald, P.3    Zhang, L.4    Dzau, V.J.5    Melo, L.G.6
  • 36
    • 49349100948 scopus 로고    scopus 로고
    • Cardioprotection with alpha-tocopheryl phosphate: Amelioration of myocardial ischemia reperfusion injury is linked with its ability to generate a survival signal through Akt activation
    • Mukherjee S, Lekli I, Das M, Azzi A, Das DK. Cardioprotection with alpha-tocopheryl phosphate: Amelioration of myocardial ischemia reperfusion injury is linked with its ability to generate a survival signal through Akt activation. Biochim Biophys Acta 2008; 1782: 498-503.
    • (2008) Biochim Biophys Acta , vol.1782 , pp. 498-503
    • Mukherjee, S.1    Lekli, I.2    Das, M.3    Azzi, A.4    Das, D.K.5
  • 37
    • 33748323383 scopus 로고    scopus 로고
    • Regulation of cardiac hypertrophy by intracellular signalling pathways
    • Heineke J, Molkentin JD. Regulation of cardiac hypertrophy by intracellular signalling pathways. Nat Rev Mol Cell Biol 2006; 7(8): 589-600.
    • (2006) Nat Rev Mol Cell Biol , vol.7 , Issue.8 , pp. 589-600
    • Heineke, J.1    Molkentin, J.D.2
  • 38
    • 64049092884 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase Akt signaling pathway interacts with protein kinase Cbeta2 in the regulation of physiologic developmental hypertrophy and heart function
    • Rigor DL, Bodyak N, Bae S, et al. Phosphoinositide 3-kinase Akt signaling pathway interacts with protein kinase Cbeta2 in the regulation of physiologic developmental hypertrophy and heart function. Am J Physiol Heart Circ Physiol 2009; 296(3): H566-72.
    • (2009) Am J Physiol Heart Circ Physiol , vol.296 , Issue.3 , pp. 566-572
    • Rigor, D.L.1    Bodyak, N.2    Bae, S.3
  • 39
    • 63349095616 scopus 로고    scopus 로고
    • The role of Akt/GSK-3beta signaling in familial hypertrophic cardiomyopathy
    • Luckey SW, Walker LA, Smyth T, et al. The role of Akt/GSK-3beta signaling in familial hypertrophic cardiomyopathy. J Mol Cell Cardiol 2009; 46(5): 739-47.
    • (2009) J Mol Cell Cardiol , vol.46 , Issue.5 , pp. 739-747
    • Luckey, S.W.1    Walker, L.A.2    Smyth, T.3
  • 40
    • 1242316958 scopus 로고    scopus 로고
    • JNK suppresses apoptosis via phosphorylation of the proapoptotic Bcl-2 family protein BAD
    • Yu C, Minemoto Y, Zhang J, et al. JNK suppresses apoptosis via phosphorylation of the proapoptotic Bcl-2 family protein BAD. Mol Cell 2004; 13(3): 329-40.
    • (2004) Mol Cell , vol.13 , Issue.3 , pp. 329-340
    • Yu, C.1    Minemoto, Y.2    Zhang, J.3
  • 41
    • 0033499801 scopus 로고    scopus 로고
    • BCL-2 is phosphorylated and inactivated by an ASK1/Jun N-terminal protein kinase pathway normally activated at G(2)/M
    • Yamamoto K, Ichijo H, Korsmeyer SJ. BCL-2 is phosphorylated and inactivated by an ASK1/Jun N-terminal protein kinase pathway normally activated at G(2)/M. Mol Cell Biol 1999; 19(12): 8469-78.
    • (1999) Mol Cell Biol , vol.19 , Issue.12 , pp. 8469-8478
    • Yamamoto, K.1    Ichijo, H.2    Korsmeyer, S.J.3
  • 42
    • 0034607702 scopus 로고    scopus 로고
    • Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway
    • Tournier C, Hess P, Yang DD, et al. Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway. Science 2000; 288(5467): 870-4.
    • (2000) Science , vol.288 , Issue.5467 , pp. 870-874
    • Tournier, C.1    Hess, P.2    Yang, D.D.3
  • 43
    • 0141953270 scopus 로고    scopus 로고
    • A JNK-dependent pathway is required for TNFalpha-induced apoptosis
    • Deng Y, Ren X, Yang L, Lin Y, Wu X. A JNK-dependent pathway is required for TNFalpha-induced apoptosis. Cell 2003; 115(1): 61-70.
    • (2003) Cell , vol.115 , Issue.1 , pp. 61-70
    • Deng, Y.1    Ren, X.2    Yang, L.3    Lin, Y.4    Wu, X.5
  • 44
    • 4644333142 scopus 로고    scopus 로고
    • Cross-talk between phosphatidylinositol 3-kinase/AKT and c-jun NH2-terminal kinase mediates survival of isolated human islets
    • Aikin R, Maysinger D, Rosenberg L. Cross-talk between phosphatidylinositol 3-kinase/AKT and c-jun NH2-terminal kinase mediates survival of isolated human islets. Endocrinology 2004; 145(10): 4522-31.
    • (2004) Endocrinology , vol.145 , Issue.10 , pp. 4522-4531
    • Aikin, R.1    Maysinger, D.2    Rosenberg, L.3
  • 45
    • 0038363852 scopus 로고    scopus 로고
    • AMP-activated protein kinase can induce apoptosis of insulin-producing MIN6 cells through stimulation of c-Jun-N-terminal kinase
    • Kefas BA, Cai Y, Ling Z, et al. AMP-activated protein kinase can induce apoptosis of insulin-producing MIN6 cells through stimulation of c-Jun-N-terminal kinase. J Mol Endocrinol 2003; 30(2): 151-61.
    • (2003) J Mol Endocrinol , vol.30 , Issue.2 , pp. 151-161
    • Kefas, B.A.1    Cai, Y.2    Ling, Z.3
  • 46
    • 79954606507 scopus 로고    scopus 로고
    • c-Jun N-terminal kinase (JNK-1) confers protection against brief but not extended ischemia during acute myocardial infarction
    • Wei J, Wang W, Chopra I, et al. c-Jun N-terminal kinase (JNK-1) confers protection against brief but not extended ischemia during acute myocardial infarction. J Biol Chem 2011; 286(16): 13995-4006.
    • (2011) J Biol Chem , vol.286 , Issue.16 , pp. 13995-14006
    • Wei, J.1    Wang, W.2    Chopra, I.3
  • 47
    • 77956364637 scopus 로고    scopus 로고
    • Angiotensin II and the ERK pathway mediate the induction of myocardin by hypoxia in cultured rat neonatal cardiomyocytes
    • Chiu CZ, Wang BW, Chung TH, Shyu KG. Angiotensin II and the ERK pathway mediate the induction of myocardin by hypoxia in cultured rat neonatal cardiomyocytes. Clin Sci (Lond) 2010; 119(7): 273-82.
    • (2010) Clin Sci (Lond) , vol.119 , Issue.7 , pp. 273-282
    • Chiu, C.Z.1    Wang, B.W.2    Chung, T.H.3    Shyu, K.G.4
  • 48
    • 1842562380 scopus 로고    scopus 로고
    • Hypoxia-induced ischemic tolerance in neonatal rat brain involves enhanced ERK1/2 signaling
    • Jones NM, Bergeron M. Hypoxia-induced ischemic tolerance in neonatal rat brain involves enhanced ERK1/2 signaling. J Neurochem 2004; 89(1): 157-67.
    • (2004) J Neurochem , vol.89 , Issue.1 , pp. 157-167
    • Jones, N.M.1    Bergeron, M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.