Predictors of suppurative complications for acute sore throat in primary care: Prospective clinical cohort study

BMJ (Online)

Volumn 347, Issue , 2013, Pages

  Little, Paul ^a   Stuart, Beth ^a   Richard Hobbs, F D ^b   Butler, Chris C ^c   Hay, Alastair D ^d   Campbell, John ^e   Delaney, Brendan ^f   Broomfield, Sue ^a   Barratt, Paula ^a   Hood, Kerenza ^c   Everitt, Hazel ^a   Mullee, Mark ^a   Williamson, Ian ^a   Mant, David ^b   Moore, Michael ^a  

^a UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c CARDIFF UNIVERSITY   (United Kingdom)

^d UNIVERSITY OF BRISTOL   (United Kingdom)

^e UNIVERSITY OF EXETER MEDICAL SCHOOL   (United Kingdom)

^f KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT;

ADULT; ARTICLE; BACTERIAL INFECTION; BODY TEMPERATURE; CELLULITIS; CLINICAL EXAMINATION; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE DURATION; DISEASE SEVERITY; FEMALE; GENDER; HUMAN; IMPETIGO; MAJOR CLINICAL STUDY; MALE; MEDICAL HISTORY; MYALGIA; OTALGIA; OTITIS MEDIA; PERITONSILLAR ABSCESS; PREDICTION; PRIMARY MEDICAL CARE; PRIORITY JOURNAL; PROGNOSIS; PROSPECTIVE STUDY; QUINSY; SCORING SYSTEM; SINUSITIS; SORE THROAT; SUPPURATION;

ABSCESS; ACUTE DISEASE; ADOLESCENT; ADULT; ANTI-BACTERIAL AGENTS; AREA UNDER CURVE; CELLULITIS; EARACHE; FEMALE; HUMANS; IMPETIGO; MALE; MIDDLE AGED; OFFICE VISITS; OTITIS MEDIA, SUPPURATIVE; PALATINE TONSIL; PHARYNGITIS; PRIMARY HEALTH CARE; PROSPECTIVE STUDIES; ROC CURVE; SINUSITIS; TONSILLITIS; YOUNG ADULT;

EID: 84888997181     PISSN: None     EISSN: 17561833     Source Type: Journal    
DOI: 10.1136/bmj.f6867     Document Type: Article

References (30)

1. Petersen I, Johnson A, Islam A, Duckworth G, Livermore D, Hayward A. Protective effect of antibiotics against serious complications of common respiratory tract infections: retrospective cohort study with the UK General Practice Research Database. BMJ 2007;335:982. doi:10.1136/bmj.39345.405243.BE. (Pubitemid 350144672)
2. House of Lords. House of Lords Select Committee on Science and Technology: 7th report. Occasional Report 1998.
3. Standing Medical Advisory Committee (SMAC) Sub-Group on Antimicrobial resistance. The path of least resistance. Occasional Report. Department of Health, 1998.
4. Spinks A, Glasziou PP, Del Mar CB. Antibiotics for sore throat. Cochrane Database Syst Rev 2013;(11):CD000023.
5. Zwart S, Sachs A, Ruijs G, Hoes A, DeMelker R. Penicillin for acute sore throat: randomised double blind trial of seven days versus three days treatment or placebo in adults. BMJ 2000;320: 150-4. (Pubitemid 30179365)
6. Dagnelie CF, Van der Graf Y, De Melker R, Touw-Otten FWMM. Do patients with sore throat benefit from penecillin? A randomised double blind placebo controlled clinical trial with penicillin V in general practice. Br J Gen Pract 1996;46: 589-93. (Pubitemid 26364754)
7. Kumar S, Little P, Britten N. Why do GPs prescribe antibiotics for sore throat? A grounded theory interview study of general practitioners. BMJ 2003;326:138.
8. Del Mar C. Managing sore throat: a literature review I: making the diagnosis. Med J Austr 1992;156: 572-5.
9. Dagnelie C, Bartelink M, Van Der Graaf Y, Goessens W, De Melker R. Towards better diagnosis of throat infections with GABHS in general practice. Br J Gen Pract 1998;48: 959-62.
10. Dobbs F. A scoring system for predicting Group A streptococcal throat infection. Br J Gen Pract 1996;46: 461-4. (Pubitemid 26280152)
11. NICE guideline development group. Prescribing of antibiotics for self-limiting respiratory tract infections in adults and children in primary care. (Clinical guideline 69.) 2008. http://guidance.nice.org.uk/CG69.
12. McIsaac W, Kellner J, Aufricht P, Vanjaka A, Low D. Empirical validation of guidelines for the management of pharyngitis in children and adults. JAMA 2004;291: 1587-95. (Pubitemid 38552431)
13. Cooper R, Hoffman J, Bartlett J, Besser R, Gonzales R, Hickner JM. Principles of appropriate antibiotic use for acute pharyngitis in adults. Ann Intern Med 2001;134: 509-17. (Pubitemid 32225955)
14. Principles of appropriate antibiotic use for acute pharyngitis in adults. 2001. www.acponline. org/clinical-information/guidelines.
15. Vincent M, Celestin N, Hussain A. Pharyngitis. Am Fam Phys 2004;69: 1465-70. (Pubitemid 38380767)
16. Lindbaek M, Hoiby E, Steinsholt I, Hjortdahl P. Clinical symptoms and signs in sore throat patients with large colony variant β-haemolytic streptococci groups C or G versus group A. Br J Gen Pract 2005;55: 615-9. (Pubitemid 41149830)
17. Little P, Hobbs R, Mant D, McNulty C, Mullee M. Incidence and clinical variables associated with streptococcal throat infections:a prospective diagnostic cohort study. Br J Gen Pract 2012;62:e787-94. doi:10.3399/ bjgp12X658322.
18. Dunn N, Lane D, Everitt H, Little P. Use of antibiotics for sore throat and incidence of quinsy. Br J Gen Pract 2007;57: 45-9. (Pubitemid 46070810)
19. Little PS, Gould C, Williamson I, Warner G, Gantley M, Kinmonth AL. Reattendance and complications in a randomised trial of prescribing strategies for sore throat: the medicalising effect of prescribing antibiotics. BMJ 1997;315: 350-2. (Pubitemid 27332007)
20. Centor RM, Witherspoon JM, Dalton HP. The diagnosis of strep throat in the emergency room. Med Decis Making 1981;1: 239-46. (Pubitemid 12129428)
21. Breese B. A simple scorecard for the tentative diagnosis of streptococcal pharyngitis. Am J Dis Child 1977;131: 514-7. (Pubitemid 8107897)
22. Hay A, Fahey T, Peters T, Wilson A. Predicting complications from acute cough in pre-school children in primary care: a prospective cohort study. Br J Gen Pract 2004;54: 9-14. (Pubitemid 38071835)
23. Little P, Stuart B, Moore M, Coenen S, Butler C, Godycki-Cwirko M, et al. Amoxicillin for acute lower respiratory tract infection in primary care when pneumonia is not suspected: a 12 country, randomised, placebo controlled trial in primary care. Lancet Infect Dis 2012;13: 123-9. http://dx.doi.org/10.1016/ S1473-3099(12)70300-6.
24. Little PS, Williamson I, Warner G, Gould C, Gantley M, Kinmonth AL. An open randomised trial of prescribing strategies for sore throat. BMJ 1997;314: 722-7. (Pubitemid 27113078)
25. Harrel FE. Regression modeling strategies. With applications to linear models, logistic regression, and survival analysis. Springer Verlag, 2001.
26. Francis N, Gillespie D, Nuttall J, Hood K, Little P, Verheij T, et al. Antibiotics for acute cough: an international observational study of patient adherence in primary care. Br J Gen Pract 2012;62:e429-37.
27. Little P, Rumsby K, Kelly J, Watson L, Moore M, Warner G, et al. Information leaflet and antibiotic prescribing strategies for acute lower respiratory tract infection: a randomised controlled trial. JAMA 2005;293: 3029-35. (Pubitemid 40965073)
28. Fine A, Nizet V, Mandl K. Large-scale validation of the Centor and McIsaac scores to predict group A streptococcal pharyngitis. Arch Intern Med 2012;172: 847-52. doi:10.1001/ archinternmed.2012.95.
29. Little P, Hobbs FD, Moore M, Mant D, Williamson I, McNulty C, et al. Clinical score and rapid antigen detection test to guide antibiotic use for sore throats: randomised controlled trial of PRISM (primary care streptococcal management). BMJ 2013;347:f5806.
30. Almond S, Mant D, Thompson M. Diagnostic safety-netting. Br J Gen Pract 2009;59: 872-4.