In vitro drug release behavior, mechanism and antimicrobial activity of rifampicin loaded low molecular weight PLGA-PEG-PLGA triblock copolymeric nanospheres

Current Drug Delivery

Volumn 10, Issue 6, 2013, Pages 722-731

  Gajendiran, M ^a   Divakar, S ^a   Raaman, N ^a   Balasubramanian, S ^a  

^a UNIVERSITY OF MADRAS   (India)

Author keywords

Antibacterial activity; In vitro drug release; Korsmeyer Peppas and higuchi models; PLGA PEG PLGA triblock copolymers; Polymeric nanospheres; Rifampicin

Indexed keywords

COPOLYMER; MACROGOL; NANOSPHERE; POLYGLACTIN; RIFAMPICIN; TETRACYCLINE; WATER OIL CREAM;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACILLUS SUBTILIS; CONTROLLED STUDY; DIFFUSION; DRUG DOSAGE FORM COMPARISON; DRUG FORMULATION; DRUG MECHANISM; ESCHERICHIA COLI; FIELD EMISSION SCANNING ELECTRON MICROSCOPY; GEL PERMEATION CHROMATOGRAPHY; IN VITRO STUDY; INFRARED SPECTROSCOPY; KLEBSIELLA PNEUMONIAE; LIGHT SCATTERING; MELTING POINT; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR WEIGHT; NONHUMAN; PARTICLE SIZE; POLYMERIZATION; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS; SUSTAINED DRUG RELEASE; TRANSMISSION ELECTRON MICROSCOPY; ULTRASOUND; ULTRAVIOLET SPECTROSCOPY; VISCOSITY; X RAY POWDER DIFFRACTION;

ANTI-BACTERIAL AGENTS; CHROMATOGRAPHY, GEL; DELAYED-ACTION PREPARATIONS; DIFFUSION; DRUG CARRIERS; LACTIC ACID; MAGNETIC RESONANCE SPECTROSCOPY; MICROSPHERES; MOLECULAR WEIGHT; NANOSPHERES; POLYETHYLENE GLYCOLS; POLYGLACTIN 910; POLYGLYCOLIC ACID; POLYMERS; RIFAMPIN; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; TETRACYCLINE; VISCOSITY; X-RAY DIFFRACTION;

EID: 84888991780     PISSN: 15672018     EISSN: 18755704     Source Type: Journal    
DOI: 10.2174/15672018113109990002     Document Type: Article

References (35)

1. Khushwant, S.Y.; Krutika, K.S. Formulation Optimization of Etoposide Loaded PLGA Nanoparticles by Double Factorial Design and their Evaluation. Current Drug Deliv., 2010, 7, 51-64.
2. Gajendiran, M.; Gopi, V.; Elangovan, V.; Venkatakrishna M.R.; Balasubramanian, S. Isoniazid loaded core shell nanoparticles derived from PLGA-PEG-PLGA tri-block copolymers: In vitro and in vivo drug release. Colloids Surf. B, 2013, 104, 107-115.
3. Vassiliou, A.A.; Papadimitriou, S.A.; Bikiaris, D.N.; Mattheolabakis, G.; Avgoustakis, K. Facile synthesis of polyester- PEG triblock copolymers and preparation of amphiphilic nanoparticles as drug carriers. J. Control. Release, 2010, 148, 388-395.
4. Li, Y.P.; Pei, Y.Y.; Zhang, X.Y.; Gu, Z.H.; Zhou, Z.H.; Yuan, W.F.; Zhou, J.J.; Zhu, J.H.; Gao, X.J. PEGylated PLGA nanoparticles as protein carriers: Synthesis, preparation and biodistribution in rats. J. Control. Release, 2001, 71, 203-211.
5. Choi, S.W.; Kim, J.H. Design of surface-modified poly (D,Llactide- co-glycolide) nanoparticles for targeted drug delivery to bone. J. Control. Release, 2007, 122, 24-30.
6. Liu, Y.; Li, K.; Liu, B.; Feng, S.S. A strategy for precision engineering of nanoparticles of biodegradable copolymers for quantitative control of targeted drug delivery. Biomaterials, 2010, 31, 9145-9155.
7. Onoshita, T.; Shimizu, Y.; Yamaya, N. The behavior of PLGA microspheres containing rifampicin in alveolar macrophages. Colloids. Surf. B, 2010, 76, 151-157.
8. Ohashi K.; Kabasawa T.; Ozeki T.; Okada, H. One-step preparation of rifampicin/poly(lactic-co-glycolic acid) nanoparticle-containing manitol microspheres using a four-fluid nozzle spray drier for inhalation therapy of tuberculosis. J. Control. Release, 2009, 135, 19-24.
9. Yoshida, A.; Matumoto, M.; Hshizume, H.; Oba, Y.; Tomishige, T.; Inagawa, H.; Kohchi, C.; Hino, M.; Ito, F.; Tomoda, K.; Nakajima, T.; Makino, K.; Terada, H.; Hori, H.; Soma, G.I. Selective delivery of rifampicin incorporated into poly (DL-lactic-co-glycolic) acid microspheres after phagocytotic uptake by alveolar macrophages, and the killing effect against intracellular Mycobacterium bovis Calmettee- Guérin. Microb. Infect., 2006, 8, 2484-2491.
10. Doan, T.V.P.; Olivier, J.C. Preparation of rifampicin-loaded PLGA microspheres for lung delivery as aerosol by premix membrane homogenization. Int. J. Pharm., 2009, 382, 61-66.
11. Ito, F.; Fujimori, H.; Honnami, H.; Kawakami, H; Kanamura, K; Makino, K. Effect of polyethylene glycol on preparation of rifampicin- loaded PLGA microspheres with membrane emulsification technique. Colloids. Surf. B, 2008, 66, 65-70.
12. Duran, N.; Alvarenga, M.A.; Da Silva, E.C.; Melo, P.S.; Marcato, P.D. Microencapsulation of Antibiotic Rifampicin in Poly(3- hydroxybutyrate-co-3- hydroxyvalerate). Arch. Pharm. Res., 2008, 31, 1509-1516.
13. Singh, G.; Raghuvanshi, H.K.; Anand, A.; Pundir, R.; Dwivedi, H. Targeted Delivery of Rifampicin by Niosomal Drug Delivery System. J. Pharmacy Res., 2010, 3, 1152-1154.
14. Mehta, S.K.; Kaur, G.; Verma, A. Fabrication of plant protein microspheres for encapsulation, stabilization and in-vitro release of multiple anti-tuberculosis drugs. Colloids. Surf. A, 2011, 375, 219-230.
15. Poole, G.; Stradling, P.; Worlledge, S. Potentially Serious Side Effects of High- dose Twice-weekly Rifampicin. Postgrad. Med. J., 1971, 47, 742-747.
16. Blajchman, M.A.; Lowry, R.C.; Pettit, J.E.; Stradling, P. Rifampicininduced immune thrombocytopenia. Br. Med. J., 1970, 3, 24-26.
17. Lee, C.H.; Lee, C.J. Thrombocytopenia - a rare but potentially serious side effect of initial daily and interrupted use of rifampicin. Chest, 1989, 96, 202-203.
18. Esmaeili, F.; Nasr, M.H. Rad-Malekshahi, M. et al. Preparation and antibacterial activity evaluation of rifampicin-loaded poly lactideco- glycolide nanoparticles. Nanomedicine, 2007, 3, 161-167.
19. Diez, F.V.; Sastre, H.; Coca, J. Effect of the operating conditions on the preparation of stannous octanoate from stannous oxide. Ind. Eng. Chem. Res., 1988, 27, 845-847.
20. Wang, Z.Y.; Zhao, Y.M.; Wang, F.; Wang, J. Syntheses of Poly(lactic acid-co-glycolic acid) serial biodegradable polymer materials via direct melt polycondensation and their characterization. J. Appl. Polym. Sci., 2006, 99, 244-252.
21. Jeong, J.H.; Lim, D.W.; Han, D.K.; Park, T.G. Synthesis, characterization and protein adsorption behaviors of PLGA: PEG diblock co-polymer blend films. Colloids. Surf. B, 2000, 18, 371-379.
22. Ronnie, H.F.; Santosh, A.; Che-Ming, J.H.; Liangfang, Z. Quick Synthesis of Lipid-Polymer Hybrid Nanoparticles with Low Polydispersity Using a Single-Step Sonication Method. Langmuir, 2010, 26, 16958-16962.
23. Santos, R.H.T.; Santos, N.G.; Alves, J.P.H.; Garcia, C.A.B.; Romao, L.C.P.; Arguelho, M.L.P.M. Evaluation of physico-chemical properties of chitosan as a potential carrier for Rifampicin using voltammetric and spectrophotometric techniques. Bioelectrochemistry, 2008, 72, 122-126.
24. Perez, C.; Paul, M.; Bazerque, P. Antibiotic assay by agar-well diffusion method. Acta. Biol. Med. Exp., 1990, 15, 113-115.
25. Wang, L.; Zhang, Z.; Chen, H. Preparation and characterization of biodegradable thermoplastic Elastomers (PLCA/PLGA blends). J. Polym. Res., 2010, 17, 77-82.
26. Cho, H.; Chung, D.; Jeongho, A. Poly (dl-lactide-ran ξ -caprolactone)- poly(ethylene glycol)- poly(dl- lactide-ran-e-caprolactone) as parenteral drug-delivery systems. Biomaterials, 2004, 25, 3733-3742.
27. Jeong, Y.I.; Shim, Y.H.; Song, K.C.; Park, Y.G.; Ryu, H.W.; Nah, J.W. Testosterone encapsulated Surfactant-free Nanoparticles of Poly (DL-lactide-co- glycolide): Preparation and Release Behavior. Bull. Korean Chem. Soc., 2002, 23, 1579-1584.
28. Prajapati, R.K.; Mahajan, H.S.; Surana, S.J. PLGA Based Mucoadhesive Microspheres for Nasal Delivery: in-vitro/ex vivo Studies. Indian J. Novel Drug Del., 2011, 3, 9-16.
29. Vaishali, G.; Mangesh, B.; Makarand, G. Development of rifampicin nanoparticles by 32 factorial designs. Int. J. Pharm. Sci. Nanotech., 2010, 3, 1085-1091.
30. Makino, K.; Nakajima, T.; Shikamura, M.; Ito, F.; Ando, S.; Kochi, C. Ingawa, H.; Soma, G.I.; Terada, H. Efficient intracellular delivery of Rifampicin to alveolar macrophages using rifampicin-loaded PLGA microspheres: effects of molecular weight and composition of PLGA on release of Rifampicin. Colloids. Surf. B, 2004, 36, 35-42.
31. Pang, J.; Luan, Y.; Li, F.; Cai, X.; Du, J.; Li, Z. Ibuprofen-loaded poly(lactic-co- glycolic acid) films for controlled drug release. Int. J. Nanomed., 2011, 6, 659-665.
32. Korsmeyer, R.W.; Gurny, R.; Doelker, E.M.; Buri, P.; Peppas, N.A. Mechanism of solute release from porous hydrophilic polymers. Int. J. Pharm., 1983, 15, 25-35.
33. Raval, A.; Parikh, J.; Engineer, C. Mechanism and in-vitro Release Kinetic Study of Sirolimus from a Biodegradable Polymeric Matrix Coated Cardiovascular Stent. Ind. Eng. Chem. Res., 2011, 50, 9539-9549.
34. Jeong, Y.I.; Na, H.S.; Seo, D.H.; Kim, D.G.; Lee, H.C.; Jang, M.K.; Na, S.K.; Roh, S.H.; Kim, S.I.; Nah, J.W. Ciprofloxacinencapsulated poly(dl-lactide-co-glycolide) nanoparticles and its antibacterial activity. Int. J. Pharm., 2008, 352, 317-323.
35. Thornsberry, C.; Hill, B.C.; Swenson, J.M.; McDougal, L.K. Rifampin: Spectrum of Antibacterial Activity. Rev. Infect. Dis., 1983, 5, S412-S417.