Efficacy of Alvimopan Following Bowel Resection: A Comparison of Two Dosing Strategies

Annals of Pharmacotherapy

Volumn 47, Issue 11, 2013, Pages 1406-1413

  Winegar, Bradley ^a   Cox, Mark ^a   Truelove, Daniel ^a   Brock, Guy ^b   Scherrer, Noah ^a   Pass, Leigh Ann ^a  

^a University of Louisville Health Care   (United States)

^b UNIVERSITY OF LOUISVILLE   (United States)

Author keywords

alvimopan; anastomosis; bowel resection; ileus; preoperative dose

Indexed keywords

ALVIMOPAN;

ADULT; ANASTOMOSIS; ARTICLE; CLINICAL ARTICLE; COLORECTAL CANCER; CONTROLLED STUDY; CROHN DISEASE; DIET; DIVERTICULITIS; DRUG EFFICACY; ELECTIVE SURGERY; FEMALE; GASTROINTESTINAL TRACT FUNCTION; HOSPITAL COST; HUMAN; INTESTINE; INTESTINE RESECTION; LAPAROSCOPIC SURGERY; LARGE BOWEL RESECTION; LENGTH OF STAY; MALE; POSTOPERATIVE ILEUS; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SMALL INTESTINE RESECTION; STOMA;

ALVIMOPAN; ANASTOMOSIS; BOWEL RESECTION; ILEUS; PREOPERATIVE DOSE;

ANASTOMOSIS, SURGICAL; DRUG ADMINISTRATION SCHEDULE; FEMALE; GASTROINTESTINAL AGENTS; HUMANS; ILEUS; INTESTINE, LARGE; INTESTINE, SMALL; KAPLAN-MEIER ESTIMATE; LENGTH OF STAY; MALE; MIDDLE AGED; PIPERIDINES; PREOPERATIVE CARE; PROPORTIONAL HAZARDS MODELS; RETROSPECTIVE STUDIES; TREATMENT OUTCOME;

EID: 84888990426     PISSN: 10600280     EISSN: 15426270     Source Type: Journal    
DOI: 10.1177/1060028013504289     Document Type: Article

References (16)

1. Holte K,Kehlet H.Postoperative ileus: a preventable event.Br J Surg. 2000;87:1480-1493.
2. Bauer AJ,Boeckxstaens GE.Mechanisms of postoperative ileus.Neurogastroenterol Motil. 2004;16:54-60.
3. Wolff BG,Michelassi F,Gerkin TM,et al.Alvimopan, a novel, peripherally acting mu opioid antagonist: results of a multicenter, randomized, double-blind, placebo-controlled, phase III trial of major abdominal surgery and postoperative ileus.Ann Surg. 2004;240:728-734.
4. Story SK,Chamberlain RS.A comprehensive review of evidence-based strategies to prevent and treat postoperative ileus.Dig Surg. 2009;26:265-275.
5. Person B,Wexner SD.The management of postoperative ileus.Curr Probl Surg. 2006;43:6-65.
6. Senagore AJ.Pathogenesis and clinical and economic consequences of postoperative ileus.Am J Health Syst Pharm. 2007;64:S3-S7.
7. Luckey A,Livingston E,Tache Y.Mechanisms and treatment of postoperative ileus.Arch Surg. 2003;138:206-214.
8. Kehlet H,Holte K.Review of postoperative ileus.Am J Surg. 2001;182:3S-10S.
9. Kraft M,Maclaren R,Du W,Owens G.Alvimopan (entereg) for the management of postoperative ileus in patients undergoing bowel resection.P T. 2010;35:44-49.
10. Schmidt WK.Alvimopan* (ADL 8-2698) is a novel peripheral opioid antagonist.Am J Surg. 2001;182:27-38.
11. Delaney CP,Weese JL,Hyman NH,et al.Phase III trial of alvimopan, a novel, peripherally acting, mu opioid antagonist, for postoperative ileus after major abdominal surgery.Dis Colon Rectum. 2005;48:1114-1125.
12. Büchler MW,Seiler CM,Monson JR,et al.Clinical trial: alvimopan for the management of post-operative ileus after abdominal surgery: results of an international randomized, double-blind, multicentre, placebo-controlled clinical study.Aliment Pharmacol Ther. 2008;28:312-325.
13. Viscusi ER,Goldstein S,Witkowski T,et al.Alvimopan, a peripherally acting mu-opioid receptor antagonist, compared with placebo in postoperative ileus after major abdominal surgery: results of a randomized, double-blind, controlled study.Surg Endosc. 2006;20:64-70.
14. Ludwig K,Enker WE,Delaney CP,et al.Gastrointestinal tract recovery in patients undergoing bowel resection: results of a randomized trial of alvimopan and placebo with a standardized accelerated postoperative care pathway.Arch Surg. 2008;143:1098-1105.
15. Absher RK,Gerkin TM,Banares LW.Alvimopan use in laparoscopic and open bowel resections: clinical results in a large community hospital system.Ann Pharmacother. 2010;44:1701-1708.
16. ENTEREG (alvimopan) capsules [package insert]. Exton, PA: Adolor Corporation; Jan2012. http://www.entereg.com. Accessed November 3, 2012.