PDE2 inhibition: Potential for the treatment of cognitive disorders

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 24, 2013, Pages 6522-6527

  Gomez, Laurent ^a   Breitenbucher, J Guy ^a  

^a DART NEUROSCIENCE LLC   (United States)

Author keywords

Cognition; Drug discovery; Memory; Phosphodiesterase

Indexed keywords

CYCLIC NUCLEOTIDE; PF 999; PHOSPHODIESTERASE 2 INHIBITOR; PHOSPHODIESTERASE INHIBITOR; SILDENAFIL; SPLEEN EXONUCLEASE; UNCLASSIFIED DRUG; VARDENAFIL;

ARTICLE; BRAIN FUNCTION; COGNITION; COGNITIVE DEFECT; DRUG CLEARANCE; DRUG HALF LIFE; ENZYME INHIBITION; HUMAN; IC 50; INTERPERSONAL COMMUNICATION; NONHUMAN; PATENT; PHYSICAL CHEMISTRY; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION;

COGNITION; DRUG DISCOVERY; MEMORY; PHOSPHODIESTERASE;

ANIMALS; COGNITION DISORDERS; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 2; HUMANS; LIGANDS; PERMEABILITY; PHOSPHODIESTERASE INHIBITORS; PROTEIN BINDING; QUINOLONES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84888876598     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.10.014     Document Type: Review

References (49)

1. M.P. Mattson, S.L. Chan, and W. Duan Physiol. Rev. 82 2002 637
2. M.J. Millan, Y. Agid, M. Brüne, E.T. Bullmore, C.S. Carter, N.S. Clayton, N. Connor, S. Davis, B. Deakin, R.J. DeRubeis, B. Dubois, M.A. Geyer, G.M. Goodwin, P. Gorwood, T.M. Jay, M. Joëls, I.M. Mansuy, A. Meyer-Lindenberg, D. Murphy, E. Rolls, B. Saletu, M. Spedding, J. Sweeney, M. Whittington, and L.J. Young Nat. Rev. Drug Disc. 11 2012 141
3. K. Esposito, G.W. Reierson, H.R. Luo, G.S. Wu, J. Licinio, and M.L. Wong Ann. Med. 41 2009 177
4. M. Conti, and J. Beavo Annu. Rev. Biochem. 76 2007 481
5. C. Lugnier Pharmacol. Ther. 109 2006 366
6. C.J. Schmidt Curr. Top. Med. Chem. 10 2010 222
7. S.R. Bitner Biochem. Pharmacol. 83 2011 705
8. Y.F. Lu, E.R. Kandel, and R.D. Hawkins J. Neurosci. 19 1999 10250
9. T.V. Bliss, and G.L. Collingridge Nature 361 1993 31
10. U. Frey, Y.Y. Huang, and E.R. Kandel Science 260 1993 1661
11. Y. Xu, H.-T. Zhang, and J.M. O'Donnell Handbook Exp. Pharm. 2011 204
12. O.A.H. Reneerkens, K. Rutten, H.W.M. Steinbusch, A. Blokland, and J. Prickaerts Psychopharmacology 202 2009 419
13. Ahn, J.; Jin, Y.; Liu, J.; Kumar, V. Presented at 113th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics (ASCPT) 2012, National Harbor, MD, March 12-17, 2012 Abstract #: LBI-7.
14. D.T. Stephenson, T.M. Coskran, M.B. Wilhelms, W.O. Adamowicz, M.M. O'Donnell, K.B. Muravnick, F.S. Menniti, R.J. Kleiman, and D. Morton J. Histochem. Cytochem. 57 2009 933
15. A. Stangherlin, F. Gesellchen, A. Zoccarato, A. Terrin, L.A. Fields, M. Berrera, N.C. Surdo, M.A. Craig, G. Smith, G. Hamilton, and M. Zaccolo Circ. Res. 108 2011 8
16. J.A. Beavo, J.G. Hardman, and E.W. Sutherland J. Biol. Chem. 245 1970 5649
17. C. Erneux, D. Couchie, and J.E. Dumont Eur. J. Biochem. 104 1980 1
18. T.J. Martins, M.C. Mumby, and J.A. Beavo J. Biol. Chem. 257 1982 4
19. J. Pandit, M.D. Forman, K.F. Fennell, K.S. Dillman, and F.S. Menniti Proc. Natl. Acad. Sci. 106 2009 18225
20. M. Bessodes, G. Bastian, E. Abushanab, R.P. Panzica, S.F. Berman, and E.J. Marcaccio Biochem. Pharmacol. 31 1982 879
21. Boess, F.-J.; Grosser, R.; Hendrix, M.; Koenig, G.; Niewoehner, U.; Schauss, D.; Schlemmer, K.-H.; Schreiber, R.; Van Der Staay F.-J. WO 2,002,050,078.
22. F.G. Boess, M. Hendrix, J.-F. van der Staay, C. Erb, R. Schreiber, W. van Staveren, J. deVente, J. Prickaerts, A. Blokland, and G. Koenig Neuropharmacology 47 2004 1081
23. K. Domek-Lopacinska, and J.B. Strosznajder Brain Res. 2008 68
24. K. Rutten, J. Prickaerts, M. Hendrix, F.J. van der Staay, A. Sik, and A. Blokland Eur. J. Pharmacol. 558 2007 107
25. K. Rutten, E.L. VanDonkelaar, L. Ferrington, A. Blokland, E. Bollen, H.W. Steinbusch, P.A. Kelly, and J. Prickaerts Neuropsychopharmacology 2009 1
26. A. Masood, Y. Huang, H. Hajjhussein, L. Xiao, H. Li, W. Wang, A. Hamza, C.-G. Zhan, and J.M. O'Donnell JPET 331 2009 690
27. Y. Xu, J. Pan, L. Chen, C. Zhang, J. Sun, J. Li, L. Nguyen, N. Nair, H. Zhang, and J.M. O'Donnell Int. J. Neuropsychopharmacol. 2012 1
28. J. Zhu, Q. Yang, D. Dai, and Q. Huang J. Am. Chem. Soc. 135 2013 11708
29. Abarghaz, M.; Biondi, S.; Duranton, J.; Limanton, E.; Mondadori, C.; Wagner, P. WO 2,005,063,723.
30. A. Hamza, and C.G. Zhan J. Phys. Chem. B 113 2009 2896
31. 2nd Rodman & Renshaw Techvest Global Healthcare Conf (Paris), 2005.
32. Egerland, U.; Erdei, J. J.; Hoefgen, N.; Langen, B.; Malamas, M. S.; Ni, Y.; Priebs, M.; Stange, H. US 20,100,120,762.
33. Stange, H.; Langen, B.; Egerland, U.; Hoefgen, N.; Priebs, M.; Malamas, M. S.; Erdei, J. J.; Ni, Y. WO 2,010,054,260.
34. M.S. Malamas, Y. Ni, J. Erdei, H. Stange, R. Schindler, H.J. Lankau, C. Grunwald, K.Y. Fan, K. Parris, B. Langen, U. Egerland, T. Hage, K.L. Marquis, S. Grauer, J. Brennan, R. Navarra, R. Graf, B.L. Harrison, A. Robichaud, T. Kronbach, M.N. Pangalos, N. Hoefgen, and N.J. Brandon J. Med. Chem. 54 2011 7621
35. Dost, R.; Egerland, U.; Grunwald, C.; Hoefgen, N.; Langen, B.; Lankau, H. J.; Stange, H. WO 2,012,104,293.
36. Biocrea Press Release February 29, 2012.
37. J.I. Andrés, P. Buijnsters, M. de Angelis, X. Langlois, F. Rombouts, A.A. Trabanco, and G. Vanhoof Bioorg. Med. Chem. Lett. 23 2013 785
38. Andres-Gil, J. I.; Rombouts, F. J. R.; Trabanco-Suarez, A. A.; Vanhoof, G. C. P.; Buijnsters, A.; Guillemont, J. E. G.; Bormans, G. M. R.; Celen, S. J. L.; Vliegen, M. WO 2,013,000,924.
39. Jorgensen, M.; Bruun, A. T.; Rasmussen, L. K. WO 2,013,034,758, WO 2,013,034,761 and WO 2,013,034,755.
40. Helal, C. J.; Chappie, T. A.; Humphrey, J. M. WO 2,012,168,817.
41. H. Haning, U. Niewöhner, T. Schenke, T. Lampe, A. Hillisch, and E. Bischoff Bioorg. Med. Chem. Lett. 15 2005 3900
42. Helal, C. J.; Chappie, T. A.; Humphrey, J. M.; Verhoest, P. R.; Yang, E. US 20,120,214,791.
43. Helal, C. J. Identification of a brain penetrant, highly selective phosphodiesterase 2A inhibitor for the treatment of cognitive impairment associated with schizophrenia (CIAS) Abstracts of Papers, 244th ACS National Meeting & Exposition, Philadelphia, PA, United States, August 19-23, 2012.
44. M.S. Plummer, J. Cornicelli, H. Roark, D.J. Skalitzky, C.J. Stankovic, S. Bove, J. Pandit, A. Goodman, J. Hicks, A. Shahripour, D. Beidler, X.K. Lu, B. Sanchez, C. Whitehead, R. Sarver, T. Braden, R. Gowan, X.Q. Shen, K. Welch, A. Ogden, N. Sadagopan, H. Baum, H. Miller, C. Banotai, C. Spessard, and S. Lightle Bioorg. Med. Chem. Lett. 23 2013 3438
45. L. Zhang, A. Villalobos, E.M. Beck, T. Bocan, T.A. Chappie, L. Chen, S. Grimwood, S.D. Heck, C.J. Helal, X. Hou, J.M. Humphrey, J. Lu, M.B. Skaddan, T.J. McCarthy, P.R. Verhoest, T.T. Wager, and K. Zasadny J. Med. Chem. 56 2013 4568
46. de Leon, P.; Egbertson, P.; Hills, I. D.; Johnson, A. W.; Machacek, M. US 20,120,115,885.
47. Flockerzi, D.; Kley, H. P.; Kuelzer, R.; Schmidt, B.; Tenor, H.; Weinbrenner, S. WO 2,006,072,615, WO 2,006,072,612 and WO 2,006,024,640.
48. Chambers, R. J.; Lam, K. T. WO 2,005,041,957.
49. R.J. Chambers, K. Abrams, N.Y. Garceau, A.V. Kamath, C.M. Manley, S.C. Lilley, D.A. Otte, D.O. Scott, A.L. Sheils, D.A. Tess, A.S. Vellekoop, Y. Zhang, and K.T. Lam Bioorg. Med. Chem. Lett. 16 2006 307