Substituted phenyl as a steroid A-ring mimetic: Providing agonist activity to a class of arylsulfonamide nonsteroidal glucocorticoid ligands

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 24, 2013, Pages 6645-6649

  Disalvo, Darren ^a   Kuzmich, Daniel ^a   Bentzien, Jörg ^a   Regan, John ^a   Kukulka, Alison ^a   Fadra Khan, Tazmeen ^a   Nelson, Richard ^a   Harcken, Christian ^a   Thomson, David ^a   Nabozny, Gerald ^a  

^a BOEHRINGER INGELHEIM PHARMACEUTICALS INC   (United States)

Author keywords

Arylsulfonamide; Glucocorticoid receptor; Glucocorticoid receptor agonist; Glucocorticoids; Mineralocorticoid receptor; Nuclear hormone receptor; Progesterone receptor

Indexed keywords

ARYLSULFONAMIDE NONSTEROIDAL GLUCOCORTICOID LIGAND; DEXAMETHASONE; GLUCOCORTICOID; GLUCOCORTICOID ANTAGONIST; GLUCOCORTICOID RECEPTOR; HORMONE RECEPTOR; PHENYL GROUP; PREDNISOLONE; PROGESTERONE RECEPTOR; STEROID; SULFONAMIDE; UNCLASSIFIED DRUG;

ARTICLE; HYDROGEN BOND;

ARYLSULFONAMIDE; GLUCOCORTICOID RECEPTOR; GLUCOCORTICOID RECEPTOR AGONIST; GLUCOCORTICOIDS; MINERALOCORTICOID RECEPTOR; NUCLEAR HORMONE RECEPTOR; PROGESTERONE RECEPTOR;

BINDING SITES; GLUCOCORTICOIDS; HYDROGEN BONDING; LIGANDS; MOLECULAR DOCKING SIMULATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, GLUCOCORTICOID; STEROIDS; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 84888862507     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.10.047     Document Type: Article

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