The effect of high level natural ionizing radiation on expression of PSA, CA19-9 and CEA tumor markers in blood serum of inhabitants of Ramsar, Iran

Journal of Environmental Radioactivity

Volumn 128, Issue , 2014, Pages 64-67

  Heidari, Mohammad Hassan ^a   Porghasem, Mohsen ^b   Mirzaei, Nazanin ^c   Mohseni, Jafar Hesam ^d   Heidari, Matine ^e   Azargashb, Eznollah ^a   Movafagh, Abolfazl ^a   Heidari, Reihane ^f   Molouki, Aidin ^g   Larijani, Leila ^a  

^a SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b BABOL UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c Emam Sajjad Hospital of Ramsar   (Iran)

^d Mohseni Clinical Diagnostic Laboratory   (Iran)

^e TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^f TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^g UNIVERSITY PUTRA MALAYSIA   (Malaysia)

Author keywords

ELISA; High level natural radiation area; HLNRA; Ramsar; Tumor marker

Indexed keywords

ANTIGENS; BIOMARKERS; BLOOD; IONIZING RADIATION;

ELISA; HLNRA; NATURAL RADIATION; RAMSAR; TUMOR MARKERS;

TUMORS;

CA 19-9 ANTIGEN; CARCINOEMBRYONIC ANTIGEN; PROSTATE SPECIFIC ANTIGEN;

ANTIGEN; BIOMARKER; GENE EXPRESSION; HEALTH IMPACT; HEALTH STATUS; RADIATION EXPOSURE; SERUM; STATISTICAL ANALYSIS; TUMOR;

ADULT; ANTIGEN EXPRESSION; ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; IONIZING RADIATION; IRAN; MALE; MEDICAL EXAMINATION; NORMAL HUMAN; VOLUNTEER;

IRAN; MAZANDARAN; SAKHT SAR;

AEOI; ATOMIC ENERGY ORGANIZATION OF IRAN; CA19-9; CARCINO ANTIGEN 19-9; CARCINOEMBRYONIC ANTIGEN; CEA; ELISA; HIGH LEVEL NATURAL RADIATION AREA; HLNRA; LINEAR NO-THRESHOLD; LNT; PROSTATE-SPECIFIC ANTIGEN; PSA; RAMSAR; REACTIVE OXYGEN SPECIES; ROS; TUMOR MARKER;

ADULT; AGED; AGED, 80 AND OVER; ANTIGENS, TUMOR-ASSOCIATED, CARBOHYDRATE; BACKGROUND RADIATION; CARCINOEMBRYONIC ANTIGEN; ENVIRONMENTAL EXPOSURE; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; IRAN; MALE; MIDDLE AGED; PROSTATE-SPECIFIC ANTIGEN; RADIATION MONITORING;

EID: 84888809599     PISSN: 0265931X     EISSN: 18791700     Source Type: Journal    
DOI: 10.1016/j.jenvrad.2013.11.001     Document Type: Article

References (43)

1. Attar M., Molaie Kondolousy Y., Khansari N. Effect of high dose natural ionizing radiation on the immune system of the exposed residents of Ramsar Town, Iran. Iran J. Allergy Asthma Immunol. 2007, 6:73-78.
2. Bahrami A., Mortazavizadeh M.R., Yazdi M.F., Chamani M. Serial tumour markers serum carcinoembryonic antigen and cancer antigen 15-3 assays in detecting symptomatic metastasis in breast cancer patients. East Mediterr. Health J. 2012, 18:1055-1059.
3. Catalona W.J., Richie J.P., Ahmann F.R., Hudson M.A., Scardino P.T., Flanigan R.C., deKernion J.B., Ratliff T.L., Kavoussi L.R., Dalkin B.L., et al. Comparison of digital rectal examination and serum prostate specific antigen in the early detection of prostate cancer: results of a multicenter clinical trial of 6,630 men. J.Urol. 1994, 151:1283-1290.
4. Feinendegen L.E. Evidence for beneficial low level radiation effects and radiation hormesis. Br. J. Radiol. 2005, 78:3-7.
5. Gendler S.J., Spicer A.P. Epithelial mucin genes. Annu. Rev. Physiol. 1995, 57:607-634.
6. Ghiassi-nejad M., Mortazavi S.M., Cameron J.R., Niroomand-rad A., Karam P.A. Very high background radiation areas of Ramsar, Iran: preliminary biological studies. Health Phys. 2002, 82:87-93.
7. Ghiassi-Nejad M., Zakeri F., Assaei R.G., Kariminia A. Long-term immune and cytogenetic effects of high level natural radiation on Ramsar inhabitants in Iran. J.Environ. Radioact. 2004, 74:107-116.
8. Gold P., Freedman S.O. Demonstration of tumor-specific antigens in human Colonic Carcinomata by immunological tolerance and absorption techniques. J.Exp. Med. 1965, 121:439-462.
9. Hammarstrom S. The carcinoembryonic antigen (CEA) family: structures, suggested functions and expression in normal and malignant tissues. Semin. Cancer Biol. 1999, 9:67-81.
10. Hayes D.F., Bast R.C., Desch C.E., Fritsche H., Kemeny N.E., Jessup J.M., Locker G.Y., Macdonald J.S., Mennel R.G., Norton L., Ravdin P., Taube S., Winn R.J. Tumor marker utility grading system: a framework to evaluate clinical utility of tumor markers. J.Natl. Cancer Inst. 1996, 88:1456-1466.
11. Hendry J.H., Simon S.L., Wojcik A., Sohrabi M., Burkart W., Cardis E., Laurier D., Tirmarche M., Hayata I. Human exposure to high natural background radiation: what can it teach us about radiation risks?. J.Radiol. Prot. 2009, 29:A29-A42.
12. Hlatky L., Sachs R.K., Vazquez M., Cornforth M.N. Radiation-induced chromosome aberrations: insights gained from biophysical modeling. Bioessays 2002, 24:714-723.
13. Jagger J. Natural background radiation and cancer death in Rocky Mountain states and Gulf Coast states. Health Phys. 1998, 75:428-430.
14. Kim Y.S., Gum J.R., Crawley S.C., Deng G., Ho J.J. Mucin gene and antigen expression in biliopancreatic carcinogenesis. Ann. Oncol. 1999, 10(Suppl 4):51-55.
15. Koprowski H., Herlyn M., Steplewski Z., Sears H.F. Specific antigen in serum of patients with colon carcinoma. Science 1981, 212:53-55.
16. Kulms D., Zeise E., Poppelmann B., Schwarz T. DNA damage, death receptor activation and reactive oxygen species contribute to ultraviolet radiation-induced apoptosis in an essential and independent way. Oncogene 2002, 21:5844-5851.
17. Makarov D.V., Carter H.B. The discovery of prostate specific antigen as a biomarker for the early detection of adenocarcinoma of the prostate. J.Urol. 2006, 176:2383-2385.
18. Matsui T., Kojima H., Suzuki H., Hamajima H., Nakazato H., Ito K., Nakao A., Sakamoto J. Sialyl Lewisa expression as a predictor of the prognosis of colon carcinoma patients in a prospective randomized clinical trial. Jpn. J. Clin. Oncol. 2004, 34:588-593.
19. Mifune M., Sobue T., Arimoto H., Komoto Y., Kondo S., Tanooka H. Cancer mortality survey in a spa area (Misasa, Japan) with a high radon background. Jpn. J. Cancer Res. 1992, 83:1-5.
20. Mitchel R.E. The dose window for radiation-induced protective adaptive responses. Dose Response 2010, 8:192-208.
21. Mitchel R.E., Burchart P., Wyatt H. Alower dose threshold for the invivo protective adaptive response to radiation. Tumorigenesis in chronically exposed normal and Trp53 heterozygous C57BL/6 mice. Rad. res. 2008, 170:765-775.
22. Mohammadi S., Taghavi-Dehaghani M., Gharaati M.R., Masoomi R., Ghiassi-Nejad M. Adaptive response of blood lymphocytes of inhabitants residing in high background radiation areas of ramsar-micronuclei, apoptosis and comet assays. J.Radiat. Res. 2006, 47:279-285.
23. Mohanty A.K., Sengupta D., Das S.K., Saha S.K., Van K.V. Natural radioactivity and radiation exposure in the high background area at Chhatrapur beach placer deposit of Orissa, India. J.Environ. Radioact. 2004, 75:15-33.
24. Molouki A., Hsu Y.T., Jahanshiri F., Abdullah S., Rosli R., Yusoff K. The matrix (M) protein of newcastle disease virus binds to human bax through its BH3 domain. Virol. J. 2011, 8:385.
25. Molouki A., Hsu Y.T., Jahanshiri F., Rosli R., Yusoff K. Newcastle disease virus infection promotes Bax redistribution to mitochondria and cell death in HeLa cells. Intervirology 2010, 53:87-94.
26. Mortazavi S.M.J., Karam P.A. High levels of natural radiation in Ramsar, Iran: Should regulatory authorities protect the inhabitants?. Iranian J. Sci. 2002, 2:1-9.
27. Mosavi-Jarrahi A., Mohagheghi M., Akiba S., Yazdizadeh B., Motamedi N., Shabestani Monfared A. Mortality and morbidity from cancer in the population exposed to high level of natural radiation area in Ramsar, Iran. Int. Congr. Ser. 2005, 1276:106-109.
28. Nair R.R., Rajan B., Akiba S., Jayalekshmi P., Nair M.K., Gangadharan P., Koga T., Morishima H., Nakamura S., Sugahara T. Background radiation and cancer incidence in Kerala, India-Karanagappally cohort study. Health Phys. 2009, 96:55-66.
29. Nambi K.S., Soman S.D. Environmental radiation and cancer in India. Health Phys. 1987, 52:653-657.
30. Nelson W.G., Kastan M.B. DNA strand breaks: the DNA template alterations that trigger p53-dependent DNA damage response pathways. Mol. Cell Biol. 1994, 14:1815-1823.
31. Olivieri G., Bodycote J., Wolff S. Adaptive response of human lymphocytes to low concentrations of radioactive thymidine. Science 1984, 223:594-597.
32. Orntoft T.F., Vestergaard E.M., Holmes E., Jakobsen J.S., Grunnet N., Mortensen M., Johnson P., Bross P., Gregersen N., Skorstengaard K., Jensen U.B., Bolund L., Wolf H. Influence of Lewis alpha1-3/4-L-fucosyltransferase (FUT3) gene mutations on enzyme activity, erythrocyte phenotyping, and circulating tumor marker sialyl-Lewis a levels. J.Biol. Chem. 1996, 271:32260-32268.
33. Riley P.A. Free radicals in biology: oxidative stress and the effects of ionizing radiation. Int. J. Radiat. Biol. 1994, 65:27-33.
34. Saghirzadeh M., Gharaati M.R., Mohammadi S., Ghiassi-Nejad M. Evaluation of DNA damage in the root cells of Allium cepa seeds growing in soil of high background radiation areas of Ramsar-Iran. J.Environ. Radioact. 2008, 99:1698-1702.
35. Schrohl A.S., Holten-Andersen M., Sweep F., Schmitt M., Harbeck N., Foekens J., Brunner N. Tumor markers: from laboratory to clinical utility. Mol. Cell Proteomics 2003, 2:378-387.
36. Sohrabi M. Recent radiological studies of high level natural radiation areas of Ramsar. Proceeding of International Conference on High Levels of Natural Radiation (ICHLNR), Ramsar, Iran 1990, 3-7.
37. Takada A., Ohmori K., Yoneda T., Tsuyuoka K., Hasegawa A., Kiso M., Kannagi R. Contribution of carbohydrate antigens sialyl Lewis A and sialyl Lewis X to adhesion of human cancer cells to vascular endothelium. Cancer Res. 1993, 53:354-361.
38. Tao Z., Zha Y., Akiba S., Sun Q., Zou J., Li J., Liu Y., Kato H., Sugahara T., Wei L. Cancer mortality in the high background radiation areas of Yangjiang, China during the period between 1979 and 1995. J.Radiat. Res. 2000, 41(Suppl):31-41.
39. Tapio S., Jacob V. Radioadaptive response revisited. Radiat. Environ. Biophys. 2007, 46:1-12.
40. UNSCEAR Report on Sources and Effects of Ionizing Radiation to the General Assembly 2000, United Nations, Vienna.
41. Vaiserman A.M. Radiation hormesis: historical perspective and implications for low-dose cancer risk assessment. Dose Response 2010, 8:172-191.
42. Wei L., Sugahara T. An introductory overview of the epidemiological study on the population at the high background radiation areas in Yangjiang, China. J.Radiat. Res. 2000, 41(Suppl):1-7.
43. Wei L.X., Zha Y.R., Tao Z.F., He W.H., Chen D.Q., Yuan Y.L. Epidemiological investigation of radiological effects in high background radiation areas of Yangjiang, China. J.Radiat. Res. 1990, 31:119-136.