-
1
-
-
84862528335
-
Targeting mTOR pathways in human malignancies
-
Fasolo A, Sessa C. Targeting mTOR pathways in human malignancies. Curr Pharm Des. 2012;18(27):66-77.
-
(2012)
Curr Pharm Des.
, vol.18
, Issue.27
, pp. 66-77
-
-
Fasolo, A.1
Sessa, C.2
-
2
-
-
84861515834
-
Targeting PI3 kinase/AKT/mTOR signaling in cancer
-
22471665 10.1615/CritRevOncog.v17.i1.60
-
Sheppard K, Kinross KM, Solomon B, Pearson RB, Phillips WA. Targeting PI3 kinase/AKT/mTOR signaling in cancer. Crit Rev Oncog. 2012;17:69-95.
-
(2012)
Crit Rev Oncog.
, vol.17
, pp. 69-95
-
-
Sheppard, K.1
Kinross, K.M.2
Solomon, B.3
Pearson, R.B.4
Phillips, W.A.5
-
3
-
-
80052207596
-
Therapeutic rationale for mTOR inhibition in advanced renal cell carcinoma
-
1:CAS:528:DC%2BC3MXhtlKitr7F 21827395 10.2174/157488411797189433
-
Husseinzadeh HD, Garcia JA. Therapeutic rationale for mTOR inhibition in advanced renal cell carcinoma. Curr Clin Pharmacol. 2011;6:214-21.
-
(2011)
Curr Clin Pharmacol.
, vol.6
, pp. 214-221
-
-
Husseinzadeh, H.D.1
Garcia, J.A.2
-
4
-
-
48649107474
-
Efficacy of everolimus in advanced renal cell carcinoma: A double-blind, randomised, placebo-controlled phase III trial
-
1:CAS:528:DC%2BD1cXps1GmsLY%3D 18653228 10.1016/S0140-6736(08)61039-9
-
Motzer RJ, Escudier B, Oudard S, et al. Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled phase III trial. Lancet. 2008;372:449-56.
-
(2008)
Lancet.
, vol.372
, pp. 449-456
-
-
Motzer, R.J.1
Escudier, B.2
Oudard, S.3
-
5
-
-
34249779568
-
Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma
-
DOI 10.1056/NEJMoa066838
-
Hudes G, Carducci M, Tomczak P, et al. Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma. N Engl J Med. 2007;356:2271-81. (Pubitemid 46849157)
-
(2007)
New England Journal of Medicine
, vol.356
, Issue.22
, pp. 2271-2281
-
-
Hudes, G.1
Carducci, M.2
Tomczak, P.3
Dutcher, J.4
Figlin, R.5
Kapoor, A.6
Staroslawska, E.7
Sosman, J.8
McDermott, D.9
Bodrogi, I.10
Kovacevic, Z.11
Lesovoy, V.12
Schmidt-Wolf, I.G.H.13
Barbarash, O.14
Gokmen, E.15
O'Toole, T.16
Lustgarten, S.17
Moore, L.18
Motzer, R.J.19
-
6
-
-
0028929682
-
Results of treatment of 255 patients with metastatic renal cell carcinoma who received high-dose recombinant interleukin-2 therapy
-
1:STN:280:DyaK2M7ptVGiuw%3D%3D 7884429
-
Fyfe G, Fisher RI, Rosenberg SA, Sznol M, Parkinson DR, Louie AC. Results of treatment of 255 patients with metastatic renal cell carcinoma who received high-dose recombinant interleukin-2 therapy. J Clin Oncol. 1995;13:688-96.
-
(1995)
J Clin Oncol.
, vol.13
, pp. 688-696
-
-
Fyfe, G.1
Fisher, R.I.2
Rosenberg, S.A.3
Sznol, M.4
Parkinson, D.R.5
Louie, A.C.6
-
7
-
-
0036138580
-
Interferon-alfa as a comparative treatment for clinical trials of new therapies against advanced renal cell carcinoma
-
DOI 10.1200/JCO.20.1.289
-
Motzer RJ, Bacik J, Murphy BA, Russo P, Mazumdar M. Interferon-alfa as a comparative treatment for clinical trials of new therapies against advanced renal cell carcinoma. J Clin Oncol. 2002;20:289-96. (Pubitemid 34032623)
-
(2002)
Journal of Clinical Oncology
, vol.20
, Issue.1
, pp. 289-296
-
-
Motzer, R.J.1
Bacik, J.2
Murphy, B.A.3
Russo, P.4
Mazumdar, M.5
-
8
-
-
33845992568
-
Expression of Major Heat Shock Proteins in Prostate Cancer: Correlation With Clinicopathological Outcomes in Patients Undergoing Radical Prostatectomy
-
DOI 10.1016/j.juro.2006.09.073, PII S0022534706024682
-
Kurahashi T, Miyake H, Hara I, Fujisawa M. Expression of major heat shock proteins in prostate cancer: correlation with clinicopathological outcomes in patients undergoing radical prostatectomy. J Urol. 2007;177:757-61. (Pubitemid 46054000)
-
(2007)
Journal of Urology
, vol.177
, Issue.2
, pp. 757-761
-
-
Kurahashi, T.1
Miyake, H.2
Hara, I.3
Fujisawa, M.4
-
9
-
-
78650990540
-
The mammalian target of rapamycin pathway is widely activated without PTEN deletion in renal cell carcinoma metastases
-
1:CAS:528:DC%2BC3MXhs1yrsbc%3D 20830770 10.1002/cncr.25402
-
Abou Youssif T, Fahmy MA, Koumakpayi IH, et al. The mammalian target of rapamycin pathway is widely activated without PTEN deletion in renal cell carcinoma metastases. Cancer. 2011;117:290-300.
-
(2011)
Cancer.
, vol.117
, pp. 290-300
-
-
Abou Youssif, T.1
Fahmy, M.A.2
Koumakpayi, I.H.3
-
10
-
-
6044223545
-
Activation of the Akt/mammalian target of rapamycin/4E-BP1 pathway by ErbB2 overexpression predicts tumor progression in breast cancers
-
DOI 10.1158/1078-0432.CCR-04-0112
-
Zhou X, Tan M, Stone Hawthorne V, et al. Activation of the Akt/mammalian target of rapamycin/4E-BP1 pathway by ErbB2 overexpression predicts tumor progression in breast cancers. Clin Cancer Res. 2004;10:6779-88. (Pubitemid 39383026)
-
(2004)
Clinical Cancer Research
, vol.10
, Issue.20
, pp. 6779-6788
-
-
Zhou, X.1
Tan, M.2
Hawthorne, V.S.3
Klos, K.S.4
Lan, K.-H.5
Yang, Y.6
Yang, W.7
Smith, T.L.8
Shi, D.9
Yu, D.10
-
11
-
-
70049113978
-
Activation of the mammalian target of rapamycin signalling pathway in prostate cancer and its association with patient clinicopathological characteristics
-
10.1111/j.1464-410X.2009.08538.x
-
Dai B, Kong YY, Ye DW, Ma CG, Zhou X, Yao XD. Activation of the mammalian target of rapamycin signalling pathway in prostate cancer and its association with patient clinicopathological characteristics. BJU Int. 2012;104:1009-16.
-
(2012)
BJU Int.
, vol.104
, pp. 1009-1016
-
-
Dai, B.1
Kong, Y.Y.2
Ye, D.W.3
Ma, C.G.4
Zhou, X.5
Yao, X.D.6
-
13
-
-
84863116501
-
MTOR-independent 4E-BP1 phosphorylation is associated with cancer resistance to mTOR kinase inhibitors
-
1:CAS:528:DC%2BC38Xjs1KrtLs%3D 22262166 10.4161/cc.11.3.19096
-
Zhang Y, Zheng XF. mTOR-independent 4E-BP1 phosphorylation is associated with cancer resistance to mTOR kinase inhibitors. Cell Cycle. 2012;11:594-603.
-
(2012)
Cell Cycle.
, vol.11
, pp. 594-603
-
-
Zhang, Y.1
Zheng, X.F.2
-
14
-
-
84897033468
-
Incomplete inhibition of phosphorylation of 4E-BP1 as a mechanism of primary resistance to ATP-competitive mTOR inhibitors
-
doi: 10.1038/onc.2013.92
-
Ducker GS, Atreya CE, Simko JP, et al. Incomplete inhibition of phosphorylation of 4E-BP1 as a mechanism of primary resistance to ATP-competitive mTOR inhibitors. Oncogene. 2013. doi: 10.1038/onc.2013.92.
-
(2013)
Oncogene
-
-
Ducker, G.S.1
Atreya, C.E.2
Simko, J.P.3
-
15
-
-
81855224569
-
High-dose rapamycin induces apoptosis in human cancer cells by dissociating mTOR complex 1 and suppressing phosphorylation of 4E-BP1
-
1:CAS:528:DC%2BC38XmsFartg%3D%3D 22071574 10.4161/cc.10.22.18124
-
Yellen P, Saqcena M, Salloum D, et al. High-dose rapamycin induces apoptosis in human cancer cells by dissociating mTOR complex 1 and suppressing phosphorylation of 4E-BP1. Cell Cycle. 2011;10:3948-56.
-
(2011)
Cell Cycle.
, vol.10
, pp. 3948-3956
-
-
Yellen, P.1
Saqcena, M.2
Salloum, D.3
-
16
-
-
84861768887
-
Increase in cholesterol predicts survival advantage in renal cell carcinoma patients treated with temsirolimus
-
1:CAS:528:DC%2BC38XnvVOnsrs%3D 22472176 10.1158/1078-0432.CCR-11-3137
-
Lee CK, Marschner IC, Simes RJ, et al. Increase in cholesterol predicts survival advantage in renal cell carcinoma patients treated with temsirolimus. Clin Cancer Res. 2012;18:3188-96.
-
(2012)
Clin Cancer Res.
, vol.18
, pp. 3188-3196
-
-
Lee, C.K.1
Marschner, I.C.2
Simes, R.J.3
-
17
-
-
68549092780
-
Analysis of PTEN and HIF-1alpha and correlation with efficacy in patients with advanced renal cell carcinoma treated with temsirolimus versus interferon-alpha
-
1:CAS:528:DC%2BD1MXhtVOnurnJ 19526589 10.1002/cncr.24438
-
Figlin RA, de Souza P, McDermott D, et al. Analysis of PTEN and HIF-1alpha and correlation with efficacy in patients with advanced renal cell carcinoma treated with temsirolimus versus interferon-alpha. Cancer. 2009;115:3651-60.
-
(2009)
Cancer.
, vol.115
, pp. 3651-3660
-
-
Figlin, R.A.1
De Souza, P.2
McDermott, D.3
-
18
-
-
79957444423
-
Future directions of mammalian target of rapamycin (mTOR) inhibitor therapy in renal cell carcinoma
-
3253822 21484496 10.1007/s11523-011-0172-y
-
Pal SK, Figlin RA. Future directions of mammalian target of rapamycin (mTOR) inhibitor therapy in renal cell carcinoma. Target Oncol. 2011;6:5-16.
-
(2011)
Target Oncol.
, vol.6
, pp. 5-16
-
-
Pal, S.K.1
Figlin, R.A.2
-
19
-
-
34548028705
-
4E-binding protein 1: A key molecular "funnel factor" in human cancer with clinical implications
-
DOI 10.1158/0008-5472.CAN-07-0881
-
Armengol G, Rojo F, CastellvI J, et al. 4E-binding protein 1: a key molecular ''funnel factor'' in human cancer with clinical implications. Cancer Res. 2007;67:7551-5. (Pubitemid 47281345)
-
(2007)
Cancer Research
, vol.67
, Issue.16
, pp. 7551-7555
-
-
Armengol, G.1
Rojo, F.2
Castellvi, J.3
Iglesias, C.4
Cuatrecasas, M.5
Pons, B.6
Baselga, J.7
Ramon Y Cajal, S.8
-
20
-
-
77954296394
-
4E-BP1 is a key effector of the oncogenic activation of the AKT and ERK signaling pathways that integrates their function in tumors
-
1:CAS:528:DC%2BC3cXpslSjt7k%3D 3286650 20609351 10.1016/j.ccr.2010.05.023
-
She QB, Halilovic E, Ye Q, et al. 4E-BP1 is a key effector of the oncogenic activation of the AKT and ERK signaling pathways that integrates their function in tumors. Cancer Cell. 2010;18:39-51.
-
(2010)
Cancer Cell.
, vol.18
, pp. 39-51
-
-
She, Q.B.1
Halilovic, E.2
Ye, Q.3
-
21
-
-
84873045417
-
Expression of drug targets in primary and matched metastatic renal cell carcinoma tumors
-
10.1186/1472-6890-13-3
-
Aziz SA, Sznol JA, Adeniran A, et al. Expression of drug targets in primary and matched metastatic renal cell carcinoma tumors. BMC Clin Pathol. 2013;1(13):3.
-
(2013)
BMC Clin Pathol.
, vol.1
, Issue.13
, pp. 3
-
-
Aziz, S.A.1
Sznol, J.A.2
Adeniran, A.3
|