Fundamental differences in promoter CpG island DNA hypermethylation between human cancer and genetically engineered mouse models of cancer

Epigenetics

Volumn 8, Issue 12, 2013, Pages 1254-1260

  Diede, Scott J ^a,b   Yao, Zizhen ^a   Chip Keyes, C ^a   Tyler, Ashlee E ^a   Dey, Joyoti ^a   Hackett, Christopher S ^c,d   Elsaesser, Katrina ^a   Kemp, Christopher J ^a   Neiman, Paul E ^a,b   Weiss, William A ^c,d   Olson, James M ^a,b   Tapscott, Stephen J ^a,b  

^a Fred Hutchinson Cancer Research Center   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Cancer; DNA methylation; Epigenomics; Genetically engineered mouse models; Medulloblastoma

Indexed keywords

TRANSCRIPTION FACTOR HOXA10;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOINFORMATICS; BREAST CANCER; BURKITT LYMPHOMA; CELL CULTURE; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; CPG ISLAND; DNA ISOLATION; DNA METHYLATION; FIBROBLAST; GENE FREQUENCY; HUMAN; HUMAN CELL; MEDULLOBLASTOMA; MOUSE; NEOPLASM; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PROMOTER REGION; SEQUENCE ANALYSIS;

CANCER; DNA METHYLATION; EPIGENOMICS; GENETICALLY ENGINEERED MOUSE MODELS; MEDULLOBLASTOMA;

ANIMALS; BREAST NEOPLASMS; BURKITT LYMPHOMA; CEREBELLAR NEOPLASMS; CPG ISLANDS; DNA METHYLATION; FEMALE; HUMANS; MEDULLOBLASTOMA; MICE; MICE, TRANSGENIC; NEOPLASMS; NEOPLASMS, EXPERIMENTAL; PROMOTER REGIONS, GENETIC;

EID: 84888772211     PISSN: 15592294     EISSN: 15592308     Source Type: Journal    
DOI: 10.4161/epi.26486     Document Type: Article

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