Ethical review of projects involving non-human primates funded under the European Union's 7th Research Framework Programme

Alternatives to Laboratory Animals

Volumn 41, Issue 4, 2013, Pages 271-306

  Sauer, Ursula G ^a   Phillips, Barry ^b   Reid, Kirsty ^c   Schmit, Véronique ^c   Jennings, Maggy ^b  

^a Scientific Consultancy Animal Welfare   (Germany)

^b Research Animals Department   (United Kingdom)

^c Eurogroup for Animal Welfare   (Belgium)

Author keywords

7th Research Framework Programme; Directive 2010 63 EU; Ethical review; Evolutionary biology; Infectious disease research; Neuroscience; Non human primates; Severity classification

Indexed keywords

ACCESS TO INFORMATION; BABOON; CEBUS; CHIKUNGUNYA; ETHICS; EUROPEAN UNION; EXPERIMENTAL ANIMAL; EXPERIMENTAL ANIMAL WELFARE; FARM ANIMAL; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INFECTION; INFLUENZA A; MACACA; MALARIA; NERVE DEGENERATION; NONHUMAN; PARKINSON DISEASE; PRIMATE; PRIORITY JOURNAL; RESEARCH ETHICS; REVIEW; ROBOTICS; TRYPANOSOMIASIS; TUBERCULOSIS; WEST NILE FLAVIVIRUS;

ANIMALIA; PRIMATES;

EID: 84888633092     PISSN: 02611929     EISSN: None     Source Type: Journal    
DOI: 10.1177/026119291304100405     Document Type: Review

References (54)

1. Sauer, U. G. (2004). The moral standing of nonhuman primates: Why they merit special consideration. ATLA 32, 309-313.
2. Flury, A. (1999). Sind operative Eingriffe in Gehirne lebender Primaten in der Grundlagen - forschung moralisch vertretbar? [Are surgical interventions into the brains of live primates for fundamental research morally defensible?] ALTEX 16, 267-270.
3. Prescott, M. J. (2010). Ethics of primate use. Advances in Science & Research 5, 11-22.
4. Anon. (2007). Written Declaration of the European Parliament (No 40/2007) pursuant to Rule 116 of the rules of procedure, by Jens Holm, Rebecca Harms, John Bowis, Martine Roure, and Mojca Drcar Murko on primates in scientific experiments, 2pp. Brussels, Belgium: European Parliament. Available at: http://www.europarl.europa.eu/sides/getDoc.do?pubRef=-//EP//NONSGML+WDECL+P6- DCL-2007-0040+0+DOC+PDF+V0//EN&language=EN (Accessed 31.07.13).
5. Anon. (2010). Directive 2010/63/EU of the European Parliament and of the Council of 22 September 2010 on the protection of animals used for scientific purposes. Official Journal of the European Union L276, 20.10.2010, 33-79.
6. Anon. (2006). Decision No 1982/2006/EC of the European Parliament and of the Council of 18 December 2006 concerning the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007-2013). Official Journal of the European Union L412, 30.12.2006, 1-41.
7. Anon. (2006). Regulation (EC) No 1906/2006 of the European Parliament and of the Council of 18 December 2006 laying down the rules for the participation of undertakings, research centres and universities in actions under the Seventh Frame - work Programme and for the dissemination of research results (2007-2013). Official Journal of the European Union L391, 30.12.2006, 1-18.
8. European Commission (2011). Commission decision of 28 February 2011 amending Decision C (2008) 4617 related to the rules for proposals submission, evaluation, selection and award procedures for indirect actions under the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007-2013) and under the Seventh Frame - work Programme of the European Atomic Energy Community (Euratom) for nuclear research and training activities (2007-2011). Official Journal of the European Union L75, 22.03.2011, 1-44.
9. Commission of the European Communities (2006). Green Paper: European Transparency Initiative, 17pp. Brussels, Belgium: Commission of the European Communities. Available at: http://ec.europa.eu/transparency/eti/docs/gp-en.pdf (Accessed 31.07. 13).
10. Russell, W. M. S. & Burch, R. L. (1959). The Principles of Humane Experimental Technique, xiv+238pp. London, UK: Methuen.
11. Anon. (2011). Proposal for a Regulation of the European Parliament and of the Council Establishing Horizon 2020 - The Framework Programme for Research and Innovation (2014-2020), 119pp. Brussels, Belgium: European Commission. Available at: available at: http://eur-lex.europa.eu/LexUriServ/LexUriServ. do?uri=COM:2011:0809:FIN:en:PDF (Accessed 31.07.13).
12. Anon. (2012). Consolidated version of the Treaty on the Functioning of the European Union. Official Journal of the European Union C326, 26.10.2012, 47-199.
13. European Commission (1986). Council Directive 86/609/EEC of 24 November 1986 on the approximation of laws, regulations and administrative provisions of the Member States regarding the protection of animals used for experimental and other scientific purposes. Official Journal of the European Union L358, 18.12.1986, 1-28.
14. Animal Procedures Committee (2002). The Use of Primates Under the Animals (Scientific Procedures) act (1986), Analysis of Current Trends with Particular Reference to Regulatory Toxicology, 39pp. London, UK: Animal Procedures Committee. Available at: http://content.www.rspca.org.uk/cmsprd/Satellite? blobcol=urldata&blobheader=application%2Fpdf&blobkey=id&blobnocache= false&blobtable=MungoBlobs&blobwhere=1232992606213&ssbinary=true (Accessed 31.07.13).
15. Weatherall, D. (2006). The Use of Non-human Primates in Research. A Working Group Report Chaired by Sir David Weatherall FRS FMedSci. 153pp. London, UK: Academy of Medical Sciences, Medical Research Council, The Royal Society and Wellcome Trust. Available at: http://www.acmedsci.ac.uk/images/project/ nhpdownl.pdf (Accessed 31.07.13).
16. Anon. (2008). Declaration of the European Parliament on Non-human Primates in Scientific Experiments, 3pp. Available at: http://ec.europa.eu/ environment/chemicals/lab-animals/pdf/fische-suite-en.pdf (Accessed 31.07.13).
17. Bosco, A., Breveglieri, R., Chinellato, E., Galletti, C. & Fattori, P. (2010). Reaching activity in the medial posterior parietal cortex of monkeys is modulated by visual feedback. Journal of Neuroscience 30, 14773-14785.
18. Bonini, L., Serventi, F. U., Simone, L., Rozzi, S., Ferrari, P. F. & Fogassi, L. (2011). Grasping neurons of monkey parietal and premotor cortices encode action goals at distinct levels of abstraction during complex action sequences. Journal of Neuroscience 31, 5876-5886.
19. Chahboun, S., Hust, M., Liu, Y., Pelat, T., Miethe, S., Helmsing, S., Jones, R. G., Sesardic, D. & Thullier, P. (2011). Isolation of a nanomolar scFv inhibiting the endopeptidase activity of botulinum toxin A, by single-round panning of an immune phage-displayed library of macaque origin. BioMed Central Biotechnology 11, 113.
20. Truppa, V., Piano Mortari, E., Garofoli, D., Privitera, S. & Visalberghi, E. (2011). Same/different concept learning by capuchin monkeys in matching-tosample tasks. PLoS One 6, e23809.
21. Porras, G., Berthet, A., Dehay, B., Li, Q., Ladepeche, L., Normand, E., Dovero, S., Martinez, A., Doudnikoff, E., Martin-Négrier, M-L., Chuan, Q., Bloch, B., Choquet, D., Boué-Grabot, E., Groc, L. & Bezard, E. (2012). PSD-95 expression controls l-DOPA dyskinesia through dopamine D1 receptor trafficking. Journal of Clinical Investigation 122, 3977-3989.
22. Klavir, O., Genud-Gabai, R. & Paz, R. (2012). Lowfrequency stimulation depresses the primate anteriorcingulate-cortex and prevents spontaneous recovery of aversive memories. Journal of Neuro - science 32, 8589-8597.
23. Livneh, U. & Paz, R. (2012). Aversive-bias and stage-selectivity in neurons of the primate amygdala during acquisition, extinction, and overnight retention. Journal of Neuroscience 32, 8598-8610.
24. Antonow-Schlorke, I., Schwab, M., Cox, L. A., Li, C., Stuchlik, K., Witte, O. W., Nathanielsz, P. W. & McDonald, T. J. (2011). Vulnerability of the fetal primate brain to moderate reduction in maternal global nutrient availability. Proceedings of the National Academy of Sciences of the USA 108, 3011-3016.
25. Herrmann, E., Hare, B., Call, J. & Tomasello, M. (2010). Differences in the cognitive skills of bonobos and chimpanzees. PLoS One 5, e12438.
26. European Commission (2006). Commission recommendation of 18 June 2007 on guidelines for the accommodation and care of animals used for experimental and other scientific purposes. Official Journal of the European Union L197, 30.07.2007, 1-89.
27. Kilkenny, C., Browne, W. J., Cuthill, I. C., Merson, M. & Altman D. G. (2010). Improving bioscience research reporting: The ARRIVE guidelines for reporting animal research. PLoS Biology 8, e1000412.
28. Beignon, A. S., Mollier, K., Liard, C., Coutant, F., Munier, S., Riviere, J., Souque, P. & Charneau, P. (2009). Lentiviral vector-based prime/boost vaccination against AIDS: Pilot study shows protection against Simian immunodeficiency virus SIVmac251 challenge in macaques. Journal of Virology 83, 10, 963-10, 974.
29. Prüfer, K., Munch, K., Hellmann, I., Akagi, K., Miller, J. R., Walenz, B., Koren, S., Sutton, G., Kodira, C., Winer, R., Knight, J. R., Mullikin, J. C., Meader, S. J., Ponting, C. P., Lunter, G., Higashino, S., Hobolth, A., Dutheil, J., Karakoç, E., Alkan, C., Sajjadian, S., Catacchio, C. R., Ventura, M., Marques-Bonet, T., Eichler, E. E., André, C., Atencia, R., Mugisha, L., Junhold, J., Patterson, N., Siebauer, M., Good, J. M., Fischer, A., Ptak, S. E., Lachmann, M., Symer, D. E., Mailund, T., Schierup, M. H., Andrés, A. M., Kelso, J. & Pääbo, S. (2012). The bonobo genome compared with the chimpanzee and human genomes. Nature, London 486, 527-531.
30. Porras, G., Li, Q. & Bezard, E. (2012). Modeling Parkinson's disease in primates: The MPTP model. Cold Spring Harbour Perspectives in Medicine 2, a009308.
31. Berthet, A., Bezard, E., Porras, G., Fasano, S., Barroso-Chinea, P., Dehay, B., Martinez, A., Thiolat, M-L., Nosten-Bertrand, M., Giros, B., Baufreton, J., Li, Q., Bloch, B. & Martin-Negrier, M-L. (2012). LDOPA impairs proteasome activity in Parkin - sonism through D1 dopamine receptor. Journal of Neuroscience 32, 681-691.
32. Borra, E., Gerbella, M., Rozzi, S. & Luppino, G. (2011). Anatomical evidence for the involvement of the macaque prefrontal area 12r in controlling goaldirected actions. Journal of Neuroscience 31, 12, 351-12, 363.
33. Savaki, H. E., Gregoriou, G. G., Bakola, S., Raos, V. & Moschovakis, A. K. (2010). The place code of saccade metrics in the lateral bank of the intraparietal sulcus. Journal of Neuroscience 30, 1118-1127.
34. Antonow-Schlorke, I., Schlabritz-Loutsevitch, N., Brodhun, M., Stuchlik, K., Witte, O. W., Schwab, M. & Nathanielsz, P. W. (2005). Moderate maternal nutrient restriction (MNR) alters fetal brain development in baboons at 0.5 gestation. Journal of the Society of Gynecological Investigation 12, Suppl. 2, 112A.
35. Buonaguro, L., Tagliamonte, M., Visciano, M. L., Andersen, H., Lewis, M., Pal, R., Tornesello, M. L., Schroeder, U., Hinkula, J., Wahren, B. & Buonaguro, F. M. (2012). Immunogenicity of HIV viruslike particles in rhesus macaques by intranasal administration. Clinical & Vaccine Immunology 19, 970-973.
36. Sesardic, D., Rasetti-Escargueil, C., Liu, Y., Chahboun, S., Hust, M., Pelat, T., Helmsing, S., Merens, A., Jones, R. G. A. & Thullier, P. (2011). Preliminary results of AntiBotABE project: Identification of neutralizing scFvs antibodies against Botulinum A and B toxins. [Poster.] Toxins International Conference, Santa Fe, NM, USA 2-5 October.
37. Baldassare, G. (2011). Overview of IM-CLeVeR Work 05/2010-04/2011, 43pp. Lugano, Switzerland: IMCLeVeR Review Meeting. Available at: http://www.im- clever.eu/project/project-description/description-1/110711Baldassarre- OverviewIMCLeVeRWork2010-2011.pdf (Accessed 31.07.13).
38. Anon. (2010). IM-CLeVeR Project Summary Report 2010. Available at: http://www.im-clever.eu/ (Accessed 31.07.13).
39. Kolar, R. (2004). Ethical evaluation of research proposals by ethics panels advising the European Commission. ATLA 32, 429-439.
40. Pauwels, E. (2007). Ethics for Researchers, Facilitating Research Excellence in FP7, 36pp. Brussels, Belgium: European Commission. Available at: ftp://ftp.cordis.europa.eu/pub/fp7/docs/ethics-forresearchers.pdf (Accessed 31.07.13)
41. Kilkenny, C., Parsons, N., Kadyszewski, E., Festing, M. F. W, Cuthill, I. C., Fry, D., Hutton, J. & Altman, D. G. (2009). Survey of the quality of experimental design, statistical analysis and reporting of research using animals. PloS One 4, e7824.
42. Jennings, M. (2010). Special protection for primates - the need for faster progress. ALTEX 27, Special Issue, 185-189.
43. Janssen, P., Srivastava, S., Ombelet, S. & Orban, G. A. (2008). Coding of shape and position in macaque lateral intraparietal area. Journal of Neuroscience 28, 6679-6690.
44. Davare, M., Kraskov, A., Rothwell, J. C. & Lemon, R. N. (2011). Interactions between areas of the cortical grasping network. Current Opinion in Neurobiology 21, 565-570.
45. Detemple, P. (2011). Neuroprosthetic interface systems for restoring motor functions. Concertation & Consultation Workshop on Micro-Nano-Bio Convergence Systems (MNBS); Arrasate-Mondrago.n, Spain April 5-6, 2011. Available at: http://cordis.europa.eu/fp7/ict/micro-nanosystems/docs/mnbs2011- workshop-mondragon/neuwalkpresentation-en.pdf (Accessed 20.08.13).
46. Khamassi, M., Lallée, S., Enel, P., Procyk, E. & Dominey, P. F. (2011). Robot cognitive control with a neurophysiologically inspired reinforcement learning model. Frontiers in Neurorobotics 5, 1.
47. Gregoriou, G. G., Gotts, S. J., Zhou, H. & Desimone, R. (2009). High-frequency, long-range coupling between prefrontal and visual cortex during attention. Science, New York 324, 1207-1210.
48. Cecchinato, V. & Franchini, G. (2012). Th17 cells in pathogenic simian immunodeficiency virus infection of macaques. Current Opinion in HIV & AIDS 5, 141-145.
49. De-Filette, M., Ulbert, S., Diamond, M. S. & Sanders, N. N. (2012). Recent progress in West Nile virus diagnosis and vaccination. Veterinary Research 43, 1-16.
50. Harvati, K., Frost, S. R. & McNulty, K. P. (2004). Neanderthal taxonomy reconsidered: Implications of 3D primate models of intra- and interspecific differences. Proceedings of the National Academy of Sciences of the USA 101, 1147-1152.
51. Singh, N., Harvati, K., Hublin, J-J. & Klingenberg, C. (2012). Morphological evolution through integration: A quantitative study of cranial integration in Homo, Pan, Gorilla and Pongo. Journal of Human Evolution 62, 155-164.
52. Farré, M., Bosch, M., López-Giréldez, F., Ponsà, M. & Ruiz-Herrera, A. (2011). Assessing the role of tandem repeats in shaping the genomic architecture of great apes. PLoS One 6, e27239.
53. Wobber, V. & Hare, B. (2011). Psychological health of orphan bonobos and chimpanzees in African sanctuaries. PLoS One 6, e17147.
54. Labbette, P. (2011). Periodic Report Summary 2 - CHAARM (Combined Highly Active Anti-retroviral Microbicides). Available at: http://cordis.europa.eu/ search/index.cfm?fuseaction=result.document&RS-LANG=EN&RS-RCN= 13435123&q=2101D40954491D7A77EA296A666E7A7D&pid=0&type=sim (Accessed 20.08.13).