Syntheses of diacyltanshinol derivatives and their suppressive effects on macrophage foam cell formation by reducing oxidized LDL uptake

Bioorganic Chemistry

Volumn 52, Issue , 2014, Pages 24-30

  Cheng, Xi ^a   Zhang, Da Li ^a   Li, Xiao Bing ^a   Ye, Jian Tao ^a   Shi, Lei ^b   Huang, Zhi Shu ^a   Gu, Lian Quan ^a   An, Lin Kun ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b GUANGZHOU GENERAL HOSPITAL OF GUANGZHOU MILITARY COMMAND   (China)

Author keywords

Atherosclerosis; Diacyltanshinol derivative; Foam cell formation; Lipid uptake; Tanshinone

Indexed keywords

1,6 DIMETHYLPHENANTHRO[1,2 B]FURAN 10,11 DIYL DINICOTINATE; 1,6,6 TRIMETHYL 1,2,6,7,8,9 HEXAHYDROPHENANTHRO[1,2 B] FURAN 10,11 DIYL BIS(2 FLUORONICOTINATE); 1,6,6 TRIMETHYL 1,2,6,7,8,9 HEXAHYDROPHENANTHRO[1,2 B] FURAN 10,11 DIYL BIS(5 FLUORONICOTINATE); 1,6,6 TRIMETHYL 1,2,6,7,8,9 HEXAHYDROPHENANTHRO[1,2 B] FURAN 10,11 DIYL DIISONICOTINATE; 1,6,6 TRIMETHYL 1,2,6,7,8,9 HEXAHYDROPHENANTHRO[1,2 B] FURAN 10,11 DIYL DINICOTINATE; 1,6,6 TRIMETHYL 6,7,8,9 TETRAHYDROPHENANTHRO[1,2 B]FURAN 10,11 DIYL BIS(2 FLUORONICOTINATE); 1,6,6 TRIMETHYL 6,7,8,9 TETRAHYDROPHENANTHRO[1,2 B]FURAN 10,11 DIYL BIS(5 FLUORONICOTINATE); 1,6,6 TRIMETHYL 6,7,8,9 TETRAHYDROPHENANTHRO[1,2 B]FURAN 10,11 DIYL DIISONICOTINATE; 1,6,6 TRIMETHYL 6,7,8,9 TETRAHYDROPHENANTHRO[1,2 B]FURAN 10,11 DIYL DINICOTINATE; CRYPTOTANSHINONE; DIACYLTANSHINOL DERIVATIVE; NICOTINIC ACID DERIVATIVE; OXIDIZED LOW DENSITY LIPOPROTEIN; OXIDIZED LOW DENSITY LIPOPROTEIN RECEPTOR 1; PROTECTIVE AGENT; TANSHINONE; TANSHINONE I; TANSHINONE IIA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CELL PROTECTION; CELL VIABILITY; CONTROLLED STUDY; DRUG ACTIVITY; DRUG CYTOTOXICITY; DRUG SYNTHESIS; FOAM CELL; IC 50; LIPID STORAGE; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TRANSPORT; PROTON NUCLEAR MAGNETIC RESONANCE; UPREGULATION; WESTERN BLOTTING;

ATHEROSCLEROSIS; DIACYLTANSHINOL DERIVATIVE; FOAM CELL FORMATION; LIPID UPTAKE; TANSHINONE;

ANIMALS; CAFFEIC ACIDS; CELL LINE; CHEMISTRY TECHNIQUES, SYNTHETIC; DITERPENES, ABIETANE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; FOAM CELLS; LIPOPROTEINS, LDL; MACROPHAGES; MICE; PROTECTIVE AGENTS; SCAVENGER RECEPTORS, CLASS E;

EID: 84888598599     PISSN: 00452068     EISSN: 10902120     Source Type: Journal    
DOI: 10.1016/j.bioorg.2013.11.001     Document Type: Article

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