Cardiac resynchronization therapy: State-of-the-art of current applications, guidelines, ongoing trials, and areas of controversy

Circulation

Volumn 128, Issue 22, 2013, Pages 2407-2418

  Prinzen, Frits W ^a   Vernooy, Kevin ^a   Auricchio, Angelo ^b  

^a MAASTRICHT UNIVERSITY   (Netherlands)

^b DIVISION OF CARDIOLOGY   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CARDIAC RESYNCHRONIZATION THERAPY; CARDIOVASCULAR MORTALITY; CARDIOVASCULAR RISK; CLINICAL TRIAL (TOPIC); ELECTROCARDIOGRAM; EXERCISE; HEART ATRIUM FIBRILLATION; HEART FAILURE; HEART HEMODYNAMICS; HEART LEFT VENTRICLE EJECTION FRACTION; HEART LEFT VENTRICLE ENDSYSTOLIC VOLUME; HEART RIGHT BUNDLE BRANCH BLOCK; HEART VENTRICLE CONDUCTION; HEART VENTRICLE EXTRASYSTOLE; HUMAN; IMPLANTABLE CARDIOVERTER DEFIBRILLATOR; IMPLANTABLE CLIP; LIFE EXPECTANCY; M MODE ECHOCARDIOGRAPHY; MITRAL VALVE REGURGITATION; MULTICENTER STUDY (TOPIC); NEW YORK HEART ASSOCIATION CLASS; OXYGEN CONSUMPTION; PATIENT SELECTION; PRACTICE GUIDELINE; PRIORITY JOURNAL; QRS COMPLEX; QUALITY OF LIFE; SINUS RHYTHM; SYSTOLIC HEART FAILURE; TISSUE DOPPLER IMAGING; TRANSCATHETER AORTIC VALVE IMPLANTATION; CARDIOLOGY; HEART FAILURE, SYSTOLIC; PROCEDURES; STANDARDS;

CARDIAC RESYNCHRONIZATION THERAPY; CARDIOLOGY; CLINICAL TRIALS AS TOPIC; HEART FAILURE, SYSTOLIC; HUMANS; PRACTICE GUIDELINES AS TOPIC;

EID: 84888590740     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.112.000112     Document Type: Article

References (86)

1. Daubert JC, Saxon L, Adamson PB, Auricchio A, Berger RD, Beshai JF, Breithard O, Brignole M, et al. 2012 EHRA/HRS expert consensus statement on cardiac resynchronization therapy in heart failure: Implant and follow-up recommendations and management. Europace. 2012;14:1236-1286
2. Linde C, Abraham WT, Gold MR, St John Sutton M, Ghio S, Daubert C; REVERSE (REsynchronization reVErses Remodeling in Systolic left vEntricular dysfunction) Study Group. Randomized trial of cardiac resynchronization in mildly symptomatic heart failure patients and in asymptomatic patients with left ventricular dysfunction and previous heart failure symptoms. J Am Coll Cardiol. 2008;52:1834-1843
3. Moss AJ, Hall WJ, Cannom DS, Klein H, Brown MW, Daubert JP, Estes NA 3rd, Foster E, Greenberg H, Higgins SL, Pfeffer MA, Solomon SD, Wilber D, Zareba W; MADIT-CRT Trial Investigators. Cardiacresynchronization therapy for the prevention of heart-failure events. N Engl J Med. 2009;361:1329-1338
4. Tang ASL, Wells GA, Taljic M, Arnold MA, Sheldon R, Conolly S, et al. Cardiac resynchronization therapy for mild-To-moderate heart failure. N Engl J Med. 2010;363:2385-2395
5. Auricchio A, Prinzen FW. Non-responders to cardiac resynchronization therapy: The magnitude of the problem and the issues. Circ J. 2011;75:521-527
6. Van Geldorp IE, Vernooy K, Delhaas T, Prins M, Crijns HJ, Prinzen FW, Dijkman B. Beneficial effects of biventricular pacing in chronically right ventricular paced patients without severe heart failure. Europace 2010;12:223-229
7. Vernooy K, Cornelussen RN, Verbeek XA, Vanagt WY, van Hunnik A, Kuiper M, Arts T, Crijns HJ, Prinzen FW. Cardiac resynchronization therapy cures dyssynchronopathy in canine left bundle-branch block hearts. Eur Heart J. 2007;28:2148-2155
8. Yu CM, Chan JY, Zhang Q, Omar R, Yip GW, Hussin A, Fang F, Lam KH, Chan HC, Fung JW. Biventricular pacing in patients with bradycardia and normal ejection fraction. N Engl J Med. 2009;361:2123-2134
9. Curtis AB, Worley SJ, Adamson PB, Chung ES, Niazi I, Sherfesee L, Shinn T, Sutton MS; Biventricular versus Right Ventricular Pacing in Heart Failure Patients with Atrioventricular Block (BLOCK HF) Trial Investigators. Biventricular pacing for atrioventricular block and systolic dysfunction. N Engl J Med. 2013;368:1585-1593
10. Funck RC, Blanc JJ, Mueller HH, Schade-Brittinger C, Bailleul C, Maisch B; BioPace Study Group. Biventricular stimulation to prevent cardiac desynchronization: Rationale, design, and endpoints of the 'Biventricular Pacing for Atrioventricular Block to Prevent Cardiac Desynchronization (BioPace)' study. Europace. 2006;8:629-635
11. Wilkoff BL, Cook JR, Epstein AE, Greene HL, Hallstrom AP, Hsia H, Kutalek SP, Sharma A. Dual-chamber pacing or ventricular back-up pacing in patients with an implantable defibrillator. JAMA. 2002;288:3115-3123
12. Sweeney MO, Hellkamp AS, Ellenbogen KA, Greenspon AJ, Freedman RA, Lee KL, Lamas GA; MOde Selection Trial Investigators. Adverse effect of ventricular pacing on heart failure and atrial fibrillation among patients with normal baseline QRS duration in a clinical trial of pacemaker therapy for sinus node dysfunction. Circulation. 2003;107:2932-2937
13. Healey JS, Hohnloser SH, Exner DV, Birnie DH, Parkash R, Connolly SJ, Krahn AD, Simpson CS, Thibault B, Basta M, Philippon F, Dorian P, Nair GM, Sivakumaran S, Yetisir E, Wells GA, Tang AS; RAFT Investigators. Cardiac resynchronization therapy in patients with permanent atrial fibrillation: Results from the Resynchronization for Ambulatory Heart Failure Trial (RAFT). Circ Heart Fail. 2012;5:566-570
14. Wilton SB, Leung AA, Ghali WA, Faris P, Exner DV. Outcomes of cardiac resynchronization therapy in patients with versus those without atrial fibrillation: A systematic review and meta-Analysis. Heart Rhythm. 2011;8:1088-1094
15. Achilli A, Sassara M, Ficili S, Pontillo D, Achilli P, Alessi C, De Spirito S, Guerra R, Patruno N, Serra F. Long-Term effectiveness of cardiac resynchronization therapy in patients with refractory heart failure and narrow QRS. J Am Coll Cardiol. 2003;42:2117-2124
16. Bleeker GB, Holman ER, Steendijk P, Boersma E, Van Der Wall EE, Schalij MJ, Bax JJ. Cardiac resynchronization therapy in patients with a narrow QRS complex. J Am Coll Cardiol. 2006;48:2243-2250
17. Yu CM, Chan YS, Zhang Q, Yip GW, Chan CK, Kum LC, Wu L, Lee AP, Lam YY, Fung JW. Benefits of cardiac resynchronization therapy for heart failure patients with narrow QRS complexes and coexisting systolic asynchrony by echocardiography. J Am Coll Cardiol. 2006;48:2251-2257
18. Foley PW, Patel K, Irwin N, Sanderson JE, Frenneaux MP, Smith RE, Stegemann B, Leyva F. Cardiac resynchronisation therapy in patients with heart failure and a normal QRS duration: The RESPOND study. Heart. 2011;97:1041-1047
19. Beshai JF, Grimm RA, Nagueh SF, Baker JH 2nd, Beau SL, Greenberg SM, Pires LA, Tchou PJ; RethinQ Study Investigators. Cardiacresynchronization therapy in heart failure with narrow QRS complexes. N Engl J Med. 2007;357:2461-2471
20. Donahue T, Niazi I, Leon A, Stucky M, Herrmann K; ESTEEM-CRT Investigators. Acute and chronic response to CRT in narrow QRS patients. J Cardiovasc Transl Res. 2012;5:232-241
21. Ruschitzka M, Abraham WT, Singh JP, Bax JJ, Borer JS, Brugada J, Dickstein K, Ford I, Gorcsan III J, Gras D, Krum H, Sogaard P, Holzmeister J, Group ES. Cardiac-resynchronization therapy in heart failure with a narrow QRS complex. N Engl J Med. 2013;DOI: 10.1056/NEJMoa1306687
22. Thibault B, Harel F, Ducharme A, White M, Ellenbogen KA, Frasure-Smith N, Roy D, Philippon F, Dorian P, Talajic M, Dubuc M, Guerra PG, Macle L, Rivard L, Andrade J, Khairy P; LESSER-EARTH Investigators. Cardiac resynchronization therapy in patients with heart failure and a QRS complex 120 milliseconds: The Evaluation of Resynchronization Therapy for Heart Failure (LESSER-EARTH) trial. Circulation. 2013;127:873-881
23. Brignole M, Auricchio A, Baron-Esquivias G, Bordachar P, Boriani G, Breithardt OA, Cleland J, Deharo JC, Delgado V, Elliott PM, Gorenek B, Israel CW, Leclercq C, Linde C, Mont L, Padeletti L, Sutton R, Vardas PE. 2013 ESC guidelines on cardiac pacing and cardiac resynchronization therapy: The task force on cardiac pacing and resynchronization therapy of the European Society of Cardiology (ESC). Developed in collaboration with the european heart rhythm association (EHRA). Europace. 2013;15:1070-1118
24. Zareba W, Klein H, Cygankiewicz I, Hall WJ, McNitt S, Brown M, Cannom D, Daubert JP, Eldar M, Gold MR, Goldberger JJ, Goldenberg I, Lichstein E, Pitschner H, Rashtian M, Solomon S, Viskin S, Wang P, Moss AJ; MADIT-CRT Investigators. Effectiveness of Cardiac Resynchronization Therapy by QRS Morphology in the Multicenter Automatic Defibrillator Implantation Trial-Cardiac Resynchronization Therapy (MADIT-CRT). Circulation. 2011;123:1061-1072
25. Strik M, Ploux S, Vernooy K, Prinzen FW. Cardiac resynchronization therapy: Refocus on the electrical substrate. Circ J. 2011;75:1297-1304
26. Dupont M, Rickard J, Baranowski B, Varma N, Dresing T, Gabi A, Finucan M, Mullens W, Wilkoff BL, Tang WH. Differential response to cardiac resynchronization therapy and clinical outcomes according to QRS morphology and QRS duration. J Am Coll Cardiol. 2012;60:592-598
27. Zareba W, Klein H, Cygankiewicz I, Hall WJ, Goldberger JJ, Daubert JP, Gold MR, Rashtian M, Viskin S, Kargul W, Pitschner H, MiNitt S, Moss AJ. CRT-D effectiveness by QRS duration and morphology in the maditcrt patients. Heart Rhythm. 2010;5S:S24
28. Sweeney MO, van Bommel RJ, Schalij MJ, Borleffs CJ, Hellkamp AS, Bax JJ. Analysis of ventricular activation using surface electrocardiography to predict left ventricular reverse volumetric remodeling during cardiac resynchronization therapy. Circulation. 2010;121:626-634
29. Hsu JC, Solomon SD, Bourgoun M, McNitt S, Goldenberg I, Klein H, Moss AJ, Foster E; MADIT-CRT Executive Committee. Predictors of super-response to cardiac resynchronization therapy and associated improvement in clinical outcome: The MADIT-CRT (multicenter automatic defibrillator implantation trial with cardiac resynchronization therapy) study. J Am Coll Cardiol. 2012;59:2366-2373
30. Auricchio A, Fantoni C, Regoli F, Carbucicchio C, Goette A, Geller C, Kloss M, Klein H. Characterization of left ventricular activation in patients with heart failure and left bundle-branch block. Circulation. 2004;109:1133-1139
31. Lambiase PD, Rinaldi A, Hauck J, Mobb M, Elliott D, Mohammad S, Gill JS, Bucknall CA. Non-contact left ventricular endocardial mapping in cardiac resynchronisation therapy. Heart. 2004;90:44-51
32. Fung JW, Yu CM, Yip G, Zhang Y, Chan H, Kum CC, Sanderson JE. Variable left ventricular activation pattern in patients with heart failure and left bundle branch block. Heart. 2004;90:17-19
33. Ghosh S, Silva JN, Canham RM, Bowman TM, Zhang J, Rhee EK, Woodard PK, Rudy Y. Electrophysiologic substrate and intraventricular left ventricular dyssynchrony in nonischemic heart failure patients undergoing cardiac resynchronization therapy. Heart Rhythm. 2011;8:692-699
34. Ploux S, Lumens J, Whinnett Z, Montaudon M, Strom M, Ramanathan C, Derval N, Zemmoura A, Denis A, De Guillebon M, Shah A, Hocini M, Jaïs P, Ritter P, Haïssaguerre M, Wilkoff BL, Bordachar P. Noninvasive electrocardiographic mapping to improve patient selection for cardiac resynchronization therapy: Beyond QRS duration and left bundle branch block morphology. J Am Coll Cardiol. 2013;61:2435-2443
35. De Boeck BW, Meine M, Leenders GE, Teske AJ, van Wessel H, Kirkels JH, Prinzen FW, Doevendans PA, Cramer MJ. Practical and conceptual limitations of tissue Doppler imaging to predict reverse remodelling in cardiac resynchronisation therapy. Eur J Heart Fail. 2008;10:281-290
36. Gorcsan J 3rd, Oyenuga O, Habib PJ, Tanaka H, Adelstein EC, Hara H, McNamara DM, Saba S. Relationship of echocardiographic dyssynchrony to long-Term survival after cardiac resynchronization therapy. Circulation. 2010;122:1910-1918
37. Kirn B, Jansen A, Bracke F, van Gelder B, Arts T, Prinzen FW. Mechanical discoordination rather than dyssynchrony predicts reverse remodeling upon cardiac resynchronization. Am J Physiol Heart Circ Physiol. 2008;295:H640-H646
38. Lumens J, Leenders GE, Cramer MJ, De Boeck BW, Doevendans PA, Prinzen FW, Delhaas T. Mechanistic evaluation of echocardiographic dyssynchrony indices: Patient data combined with multiscale computer simulations. Circ Cardiovasc Imaging. 2012;5:491-499
39. Bilchick KC, Dimaano V, Wu KC, Helm RH, Weiss RG, Lima JA, Berger RD, Tomaselli GF, Bluemke DA, Halperin HR, Abraham T, Kass DA, Lardo AC. Cardiac magnetic resonance assessment of dyssynchrony and myocardial scar predicts function class improvement following cardiac resynchronization therapy. JACC Cardiovasc Imaging. 2008;1:561-568
40. Rutz AK, Manka R, Kozerke S, Roas S, Boesiger P, Schwitter J. Left ventricular dyssynchrony in patients with left bundle branch block and patients after myocardial infarction: Integration of mechanics and viability by cardiac magnetic resonance. Eur Heart J. 2009;30:2117-2127
41. De Boeck BW, Teske AJ, Meine M, Leenders GE, Cramer MJ, Prinzen FW, Doevendans PA. Septal rebound stretch reflects the functional substrate to cardiac resynchronization therapy and predicts volumetric and neurohormonal response. Eur J Heart Fail. 2009;11:863-871
42. Leenders GE, De Boeck BW, Teske AJ, Meine M, Bogaard MD, Prinzen FW, Doevendans PA, Cramer MJ. Septal rebound stretch is a strong predictor of outcome after cardiac resynchronization therapy. J Card Fail. 2012;18:404-412
43. Mele D, Agricola E, Galderisi M, Rigo F, Citro R, Dal Monte A, Della Valentina P, Calabrese A, Ferrari R; Study Group of Echocardiography, Italian Society of Cardiology. Echocardiographic myocardial scar burden predicts response to cardiac resynchronization therapy in ischemic heart failure. J Am Soc Echocardiogr. 2009;22:702-708
44. White JA, Yee R, Yuan X, Krahn A, Skanes A, Parker M, Klein G, Drangova M. Delayed enhancement magnetic resonance imaging predicts response to cardiac resynchronization therapy in patients with intraventricular dyssynchrony. J Am Coll Cardiol. 2006;48:1953-1960
45. Ypenburg C, Roes SD, Bleeker GB, Kaandorp TA, de Roos A, Schalij MJ, Van Der Wall EE, Bax JJ. Effect of total scar burden on contrast-enhanced magnetic resonance imaging on response to cardiac resynchronization therapy. Am J Cardiol. 2007;99:657-660
46. Ypenburg C, Schalij MJ, Bleeker GB, Steendijk P, Boersma E, Dibbets-Schneider P, Stokkel MP, Van Der Wall EE, Bax JJ. Impact of viability and scar tissue on response to cardiac resynchronization therapy in ischaemic heart failure patients. Eur Heart J. 2007;28:33-41
47. Khan FZ, Virdee MS, Palmer CR, Pugh PJ, O'Halloran D, Elsik M, Read PA, Begley D, Fynn SP, Dutka DP. Targeted left ventricular lead placement to guide cardiac resynchronization therapy: The TARGET study: A randomized, controlled trial. J Am Coll Cardiol. 2012;59:1509-1518
48. Leyva F, Foley PW, Chalil S, Ratib K, Smith RE, Prinzen F, Auricchio A. Cardiac resynchronization therapy guided by late gadolinium-enhancement cardiovascular magnetic resonance. J Cardiovasc Magn Reson. 2011;13:29
49. Leyva F, Taylor RJ, Foley PW, Umar F, Mulligan LJ, Patel K, Stegemann B, Haddad T, Smith RE, Prasad SK. Left ventricular midwall fibrosis as a predictor of mortality and morbidity after cardiac resynchronization therapy in patients with nonischemic cardiomyopathy. J Am Coll Cardiol. 2012;60:1659-1667
50. Rademakers L, van Kerckhoven R, Van Deursen CJM, Strik M, van Hunnik A, Kuiper M, Lampert A, Klersy C, Leyva F, Auricchio A, Maessen JG, Prinzen FW. Myocardial infarction does not preclude electrical and hemodynamic benefits of crt in dyssynchronous canine hearts. Circulation: Arrhythmia & Electrophysiol. 2010;3:361-368
51. Helm RH, Byrne M, Helm PA, Daya SK, Osman NF, Tunin R, Halperin HR, Berger RD, Kass DA, Lardo AC. Three-dimensional mapping of optimal left ventricular pacing site for cardiac resynchronization. Circulation. 2007;115:953-961
52. Singh JP, Klein HU, Huang DT, Reek S, Kuniss M, Quesada A, Barsheshet A, Cannom D, Goldenberg I, McNitt S, Daubert JP, Zareba W, Moss AJ. Left ventricular lead position and clinical outcome in the multicenter automatic defibrillator implantation trial-cardiac resynchronization therapy (MADIT-CRT) trial. Circulation. 2011;123:1159-1166
53. Derval N, Steendijk P, Gula LJ, Deplagne A, Laborderie J, Sacher F, Knecht S, Wright M, Nault I, Ploux S, Ritter P, Bordachar P, Lafitte S, Réant P, Klein GJ, Narayan SM, Garrigue S, Hocini M, Haissaguerre M, Clementy J, Jaïs P. Optimizing hemodynamics in heart failure patients by systematic screening of left ventricular pacing sites: The lateral left ventricular wall and the coronary sinus are rarely the best sites. J Am Coll Cardiol. 2010;55:566-575
54. Gold MR, Birgersdotter-Green U, Singh JP, Ellenbogen KA, Yu Y, Meyer TE, Seth M, Tchou PJ. The relationship between ventricular electrical delay and left ventricular remodelling with cardiac resynchronization therapy. Eur Heart J. 2011;32:2516-2524
55. Kandala J, Upadhyay GA, Altman RK, Parks KA, Orencole M, Mela T, Kevin Heist E, Singh JP. QRS morphology, left ventricular lead location, and clinical outcome in patients receiving cardiac resynchronization therapy. Eur Heart J. 2013;34:2252-2262
56. Leclercq C, Gadler F, Kranig W, Ellery S, Gras D, Lazarus A, Clémenty J, Boulogne E, Daubert JC; TRIP-HF (Triple Resynchronization In Paced Heart Failure Patients) Study Group. A randomized comparison of triplesite versus dual-site ventricular stimulation in patients with congestive heart failure. J Am Coll Cardiol. 2008;51:1455-1462
57. Van Deursen C, van Geldorp IE, Rademakers LM, van Hunnik A, Kuiper M, Klersy C, Auricchio A, Prinzen FW. Left ventricular endocardial pacing improves resynchronization therapy in canine left bundle-branch hearts. Circ Arrhythm Electrophysiol. 2009;2:580-587
58. Strik M, Rademakers LM, Van Deursen CJ, van Hunnik A, Kuiper M, Klersy C, Auricchio A, Prinzen FW. Endocardial left ventricular pacing improves cardiac resynchronization therapy in chronic asynchronous infarction and heart failure models. Circ Arrhythm Electrophysiol. 2012;5:191-200
59. Padeletti L, Pieragnoli P, Ricciardi G, Perrotta L, Grifoni G, Porciani MC, Lionetti V, Valsecchi S. Acute hemodynamic effect of left ventricular endocardial pacing in cardiac resynchronization therapy: Assessment by pressure-volume loops. Circ Arrhythm Electrophysiol. 2012;5:460-467
60. Spragg DD, Dong J, Fetics BJ, Helm R, Marine JE, Cheng A, Henrikson CA, Kass DA, Berger RD. Optimal left ventricular endocardial pacing sites for cardiac resynchronization therapy in patients with ischemic cardiomyopathy. J Am Coll Cardiol. 2010;56:774-781
61. Jaïs P, Douard H, Shah DC, Barold S, Barat JL, Clémenty J. Endocardial biventricular pacing. Pacing Clin Electrophysiol. 1998;21(11 Pt 1):2128-2131
62. van Gelder BM, Scheffer MG, Meijer A, Bracke FA. Transseptal endocardial left ventricular pacing: An alternative technique for coronary sinus lead placement in cardiac resynchronization therapy. Heart Rhythm. 2007;4:454-460
63. Houthuizen P, Bracke FA, van Gelder BM. Atrioventricular and interventricular delay optimization in cardiac resynchronization therapy: Physiological principles and overview of available methods. Heart Fail Rev. 2011;16:263-276
64. Ellenbogen KA, Gold MR, Meyer TE, Fernndez Lozano I, Mittal S, Waggoner AD, Lemke B, Singh JP, Spinale FG, Van Eyk JE, Whitehill J, Weiner S, Bedi M, Rapkin J, Stein KM. Primary results from the SmartDelay determined AV optimization: A comparison to other AV delay methods used in cardiac resynchronization therapy (SMART-AV) trial: A randomized trial comparing empirical, echocardiography-guided, and algorithmic atrioventricular delay programming in cardiac resynchronization therapy. Circulation. 2010;122:2660-2668
65. Abraham WT, Gras D, Yu CM, Guzzo L, Gupta MS; FREEDOM Steering Committee. Rationale and design of a randomized clinical trial to assess the safety and efficacy of frequent optimization of cardiac resynchronization therapy: The Frequent Optimization Study Using the QuickOpt Method (FREEDOM) trial. Am Heart J. 2010;159:944-948
66. Martin DO, Lemke B, Birnie D, Krum H, Lee KL, Aonuma K, Gasparini M, Starling RC, Milasinovic G, Rogers T, Sambelashvili A, Gorcsan J 3rd, Houmsse M; Adaptive CRT Study Investigators. Investigation of a novel algorithm for synchronized left-ventricular pacing and ambulatory optimization of cardiac resynchronization therapy: Results of the adaptive CRT trial. Heart Rhythm. 2012;9:1807-1814
67. Ritter P, Delnoy PP, Padeletti L, Lunati M, Naegele H, Borri-Brunetto A, Silvestre J. A randomized pilot study of optimization of cardiac resynchronization therapy in sinus rhythm patients using a peak endocardial acceleration sensor vs. standard methods. Europace. 2012;14:1324-1333
68. Pabari PA, Willson K, Stegemann B, van Geldorp IE, Kyriacou A, Moraldo M, Mayet J, Hughes AD, Francis DP. When is an optimization not an optimization? Evaluation of clinical implications of information content (signal-To-noise ratio) in optimization of cardiac resynchronization therapy, and how to measure and maximize it. Heart Fail Rev. 2011;16:277-290
69. Bogaard MD, Houthuizen P, Bracke FA, Doevendans PA, Prinzen FW, Meine M, van Gelder BM. Baseline left ventricular dP/dtmax rather than the acute improvement in dP/dtmax predicts clinical outcome in patients with cardiac resynchronization therapy. Eur J Heart Fail. 2011;13:1126-1132
70. Mullens W, Grimm RA, Verga T, Dresing T, Starling RC, Wilkoff BL, Tang WH. Insights from a cardiac resynchronization optimization clinic as part of a heart failure disease management program. J Am Coll Cardiol. 2009;53:765-773
71. Mullens W, Kepa J, De Vusser P, Vercammen J, Rivero-Ayerza M, Wagner P, Dens J, Vrolix M, Vandervoort P, Tang WH. Importance of adjunctive heart failure optimization immediately after implantation to improve longterm outcomes with cardiac resynchronization therapy. Am J Cardiol. 2011;108:409-415
72. Altman RK, Parks KA, Schlett CL, Orencole M, Park MY, Truong QA, Deeprasertkul P, Moore SA, Barrett CD, Lewis GD, Das S, Upadhyay GA, Heist EK, Picard MH, Singh JP. Multidisciplinary care of patients receiving cardiac resynchronization therapy is associated with improved clinical outcomes. Eur Heart J. 2012;33:2181-2188
73. Kamath GS, Cotiga D, Koneru JN, Arshad A, Pierce W, Aziz EF, Mandava A, Mittal S, Steinberg JS. The utility of 12-lead Holter monitoring in patients with permanent atrial fibrillation for the identification of nonresponders after cardiac resynchronization therapy. J Am Coll Cardiol. 2009;53:1050-1055
74. Lakkireddy D, Di Biase L, Ryschon K, Biria M, Swarup V, Reddy YM, Verma A, Bommana S, Burkhardt D, Dendi R, Dello Russo A, Casella M, Carbucicchio C, Tondo C, Dawn B, Natale A. Radiofrequency ablation of premature ventricular ectopy improves the efficacy of cardiac resynchronization therapy in nonresponders. J Am Coll Cardiol. 2012;60:1531-1539
75. Patwala AY, Woods PR, Sharp L, Goldspink DF, Tan LB, Wright DJ. Maximizing patient benefit from cardiac resynchronization therapy with the addition of structured exercise training: A randomized controlled study. J Am Coll Cardiol. 2009;53:2332-2339
76. Auricchio A, Schillinger W, Meyer S, Maisano F, Hoffmann R, Ussia GP, Pedrazzini GB, Van Der Heyden J, Fratini S, Klersy C, Komtebedde J, Franzen O; PERMIT-CARE Investigators. Correction of mitral regurgitation in nonresponders to cardiac resynchronization therapy by MitraClip improves symptoms and promotes reverse remodeling. J Am Coll Cardiol. 2011;58:2183-2189
77. Abraham J, Abraham TP. Is echocardiographic assessment of dyssynchrony useful to select candidates for cardiac resynchronization therapy? Echocardiography is useful before cardiac resynchronization therapy if QRS duration is available. Circ Cardiovasc Imaging. 2008;1:79-84; discussion 84
78. Prinzen FW, Auricchio A. Is echocardiographic assessment of dyssynchrony useful to select candidates for cardiac resynchronization therapy? Echocardiography is not useful before cardiac resynchronization therapy if QRS duration is available. Circ Cardiovasc Imaging. 2008;1:70-7; discussion 78
79. Chung ES, Leon AR, Tavazzi L, Sun JP, Nihoyannopoulos P, Merlino J, Abraham WT, Ghio S, Leclercq C, Bax JJ, Yu CM, Gorcsan J 3rd, St John Sutton M, De Sutter J, Murillo J. Results of the Predictors of Response to CRT (PROSPECT) trial. Circulation. 2008;117:2608-2616
80. Seo Y, Ito H, Nakatani S, Takami N, Naito S, Shiga T, Ando K, Wakayama Y, Aonuma K, investigators. J-C. The role of echocardiography in predicting responders to cardiac resynchronization therapy: Results from the japan cardiac resynchronization therapy registry trial (J-CRT). Circ. J. 75:1156-1163. 2011
81. Marwick TH. Hype and hope in the use of echocardiography for selection for cardiac resynchronization therapy: The Tower of Babel revisited. Circulation. 2008;117:2573-2576
82. van Bommel RJ, Bax JJ, Abraham WT, Chung ES, Pires LA, Tavazzi L, Zimetbaum PJ, Gerritse B, Kristiansen N, Ghio S. Characteristics of heart failure patients associated with good and poor response to cardiac resynchronization therapy: A PROSPECT (Predictors of Response to CRT) subanalysis. Eur Heart J. 2009;30:2470-2477
83. Hara H, Oyenuga OA, Tanaka H, Adelstein EC, Onishi T, McNamara DM, Schwartzman D, Saba S, Gorcsan III J. The relationship of QRS morphology and mechanical dyssynchrony to long-Term outcome following cardiac resynchronization therapy. Eur Heart J. 2012;33:2680-2691
84. Tzikas A, Van Dalen BM, Van Mieghem NM, Gutierrez-Chico JL, Nuis RJ, Kauer F, Schultz C, Serruys PW, de Jaegere PP, Geleijnse ML. Frequency of conduction abnormalities after transcatheter aortic valve implantation with the Medtronic-CoreValve and the effect on left ventricular ejection fraction. Am J Cardiol. 2011;107:285-289
85. Urena M, Mok M, Serra V, Dumont E, Nombela-Franco L, DeLarochelliè re R, Doyle D, Igual A, Larose E, Amat-Santos I, Côté M, Cuéllar H, Pibarot P, de Jaegere P, Philippon F, Garcia del Blanco B, Rodés-Cabau J. Predictive factors and long-Term clinical consequences of persistent left bundle branch block following transcatheter aortic valve implantation with a balloon-expandable valve. J Am Coll Cardiol. 2012;60:1743-1752
86. Houthuizen P, Van Garsse LA, Poels TT, de Jaegere P, Van Der Boon RM, Swinkels BM, Ten Berg JM, Van Der Kley F, Schalij MJ, Baan J Jr, Cocchieri R, Brueren GR, van Straten AH, den Heijer P, Bentala M, van Ommen V, Kluin J, Stella PR, Prins MH, Maessen JG, Prinzen FW. Left bundle-branch block induced by transcatheter aortic valve implantation increases risk of death. Circulation. 2012;126:720-728