Mechanistic evaluation of echocardiographic dyssynchrony indices patient data combined with multiscale computer simulations

Circulation: Cardiovascular Imaging

Volumn 5, Issue 4, 2012, Pages 491-499

  Lumens, Joost ^a   Leenders, Geert E ^b   Cramer, Maarten J ^b   De Boeck, Bart W L ^c   Doevendans, Pieter A ^b   Prinzen, Frits W ^a   Delhaas, Tammo ^a  

^a MAASTRICHT UNIVERSITY   (Netherlands)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^c LUZERNER KANTONSSPITAL   (Switzerland)

Author keywords

Asynchrony; Computer model; Echocardiography; Heart failure; Strain

Indexed keywords

AGED; ARTICLE; CARDIAC IMAGING; CARDIAC RESYNCHRONIZATION THERAPY; COMPUTER SIMULATION; ECHOCARDIOGRAPHIC DYSSYNCHRONY INDEX; FEMALE; HEART LEFT VENTRICLE EJECTION FRACTION; HEART LEFT VENTRICLE ENDSYSTOLIC VOLUME; HEART MOVEMENT; HEART MUSCLE CONTRACTILITY; HEMODYNAMICS; HUMAN; MAJOR CLINICAL STUDY; MALE; NOISE; PREDICTIVE VALUE; PRIORITY JOURNAL; PROSPECTIVE STUDY; QUANTITATIVE ANALYSIS; RADIOLOGICAL PARAMETERS; SYSTOLE; TREATMENT RESPONSE; ULTRASOUND;

AGED; BIOMECHANICS; CARDIAC RESYNCHRONIZATION THERAPY; COMPUTER SIMULATION; ECHOCARDIOGRAPHY; FEMALE; HEART FAILURE; HEMODYNAMICS; HUMANS; LINEAR MODELS; MALE; MODELS, CARDIOVASCULAR; MYOCARDIAL CONTRACTION; PREDICTIVE VALUE OF TESTS; PROSPECTIVE STUDIES; THORACIC SURGERY, VIDEO-ASSISTED; TREATMENT OUTCOME;

EID: 84867162204     PISSN: 19419651     EISSN: 19420080     Source Type: Journal    
DOI: 10.1161/CIRCIMAGING.112.973446     Document Type: Article

References (35)

1. Abraham WT, Fisher WG, Smith AL, Delurgio DB, Leon AR, Loh E, Kocovic DZ, Packer M, Clavell AL, Hayes DL, Ellestad M, Trupp RJ, Underwood J, Pickering F, Truex C, McAtee P, Messenger J. Cardiac resynchronization in chronic heart failure. N Engl J Med. 2002;346:1845-1853.
2. Moss AJ, Hall WJ, Cannom DS, Klein H, Brown MW, Daubert JP, Estes NA III, Foster E, Greenberg H, Higgins SL, Pfeffer MA, Solomon SD, Wilber D, Zareba W. Cardiac-resynchronization therapy for the prevention of heart-failure events. N Engl J Med. 2009;361:1329-1338.
3. Chung ES, Leon AR, Tavazzi L, Sun JP, Nihoyannopoulos P, Merlino J, Abraham WT, Ghio S, Leclercq C, Bax JJ, Yu CM, Gorcsan J III, St John Sutton M, De Sutter J, Murillo J. Results of the Predictors of Response to CRT (PROSPECT) trial. Circulation. 2008;117:2608-2616.
4. Miyazaki C, Redfield MM, Powell BD, Lin GM, Herges RM, Hodge DO, Olson LJ, Hayes DL, Espinosa RE, Rea RF, Bruce CJ, Nelson SM, Miller FA, Oh JK. Dyssynchrony indices to predict response to cardiac resynchronization therapy: a comprehensive prospective single-center study. Circ Heart Fail. 2010;3:565-573.
5. Bax JJ, Marwick TH, Molhoek SG, Bleeker GB, van Erven L, Boersma E, Steendijk P, van der Wall EE, Schalij MJ. Left ventricular dyssynchrony predicts benefit of cardiac resynchronization therapy in patients with end-stage heart failure before pacemaker implantation. Am J Cardiol. 2003;92:1238-1240.
6. Gorcsan J, III. Role of echocardiography to determine candidacy for cardiac resynchronization therapy. Curr Opin Cardiol. 2008;23:16-22.
7. Yu CM, Fung WH, Lin H, Zhang Q, Sanderson JE, Lau CP. Predictors of left ventricular reverse remodeling after cardiac resynchronization therapy for heart failure secondary to idiopathic dilated or ischemic cardiomyopathy. Am J Cardiol. 2003;91:684-688.
8. Leenders GE, Cramer MJ, Bogaard MD, Meine M, Doevendans PA, De Boeck BW. Echocardiographic prediction of outcome after cardiac resynchronization therapy: conventional methods and recent developments. Heart Fail Rev. 2011;16:235-250.
9. Hawkins NM, Petrie MC, Burgess MI, McMurray JJ. Selecting patients for cardiac resynchronization therapy: the fallacy of echocardiographic dyssynchrony. J Am Coll Cardiol. 2009;53:1944-1959.
10. De Boeck BW, Teske AJ, Meine M, Leenders GE, Cramer MJ, Prinzen FW, Doevendans PA. Septal rebound stretch reflects the functional substrate to cardiac resynchronization therapy and predicts volumetric and neurohormonal response. Eur J Heart Fail. 2009;11:863-871.
11. Schiller NB, Shah PM, Crawford M, DeMaria A, Devereux R, Feigenbaum H, Gutgesell H, Reichek N, Sahn D, Schnittger I. Recommendations for quantitation of the left ventricle by two-dimensional echocardiography: American Society of Echocardiography Committee on Standards, Subcommittee on Quantitation of Two-Dimensional Echocardiograms. J Am Soc Echocardiogr. 1989;2:358-367.
12. De Boeck BW, Meine M, Leenders GE, Teske AJ, van Wessel H, Kirkels JH, Prinzen FW, Doevendans PA, Cramer MJ. Practical and conceptual limitations of tissue Doppler imaging to predict reverse remodelling in cardiac resynchronisation therapy. Eur J Heart Fail. 2008;10:281-290.
13. Leenders GE, Lumens J, Cramer MJ, De Boeck BW, Doevendans PA, Delhaas T, Prinzen FW. Septal deformation patterns delineate mechanical dyssynchrony and regional differences in contractility: analysis of patient data using a computer model. Circ Heart Fail. 2012;5:87-96.
14. Rouleau F, Merheb M, Geffroy S, Berthelot J, Chaleil D, Dupuis JM, Victor J, Geslin P. Echocardiographic assessment of the interventricular delay of activation and correlation to the QRS width in dilated cardiomyopathy. Pacing Clin Electrophysiol. 2001;24:1500-1506.
15. Suffoletto MS, Dohi K, Cannesson M, Saba S, Gorcsan J III. Novel speckle-tracking radial strain from routine black-and-white echocardiographic images to quantify dyssynchrony and predict response to cardiac resynchronization therapy. Circulation. 2006;113:960-968.
16. Pitzalis MV, Iacoviello M, Romito R, Massari F, Rizzon B, Luzzi G, Guida P, Andriani A, Mastropasqua F, Rizzon P. Cardiac resynchronization therapy tailored by echocardiographic evaluation of ventricular asynchrony. J Am Coll Cardiol. 2002;40:1615-1622.
17. Arts T, Delhaas T, Bovendeerd P, Verbeek X, Prinzen FW. Adaptation to mechanical load determines shape and properties of heart and circulation: the Circadapt model. Am J Physiol Heart Circ Physiol. 2005;288:H1943-H1954.
18. Lumens J, Delhaas T, Kirn B, Arts T. Three-wall segment (Triseg) model describing mechanics and hemodynamics of ventricular interaction. Ann Biomed Eng. 2009;37:2234-2255.
19. Kerckhoffs RC, Lumens J, Vernooy K, Omens JH, Mulligan LJ, Delhaas T, Arts T, McCulloch AD, Prinzen FW. Cardiac resynchronization: insight from experimental and computational models. Prog Biophys Mol Biol. 2008;97:543-561.
20. Lumens J, Arts T, Broers B, Boomars KA, van Paassen P, Prinzen FW, Delhaas T. Right ventricular free wall pacing improves cardiac pump function in severe pulmonary arterial hypertension: a computer simulation analysis. Am J Physiol Heart Circ Physiol. 2009;297:H2196-H2205.
21. Prinzen FW, Vernooy K, De Boeck BW, Delhaas T. Mechano-energetics of the asynchronous and resynchronized heart. Heart Fail Rev. 2011;16:215-224.
22. Anderson LJ, Miyazaki C, Sutherland GR, Oh JK. Patient selection and echocardiographic assessment of dyssynchrony in cardiac resynchronization therapy. Circulation. 2008;117:2009-2023.
23. Russell K, Opdahl A, Remme EW, Gjesdal O, Skulstad H, Kongsgaard E, Edvardsen T, Smiseth OA. Evaluation of left ventricular dyssynchrony by onset of active myocardial force generation: a novel method that differentiates between electrical and mechanical etiologies. Circ Cardiovasc Imaging. 2010;3:405-414.
24. Kass DA. An epidemic of dyssynchrony: but what does it mean? J Am Coll Cardiol. 2008;51:12-17.
25. Faris OP, Evans FJ, Ennis DB, Helm PA, Taylor JL, Chesnick AS, Guttman MA, Ozturk C, McVeigh ER. Novel technique for cardiac electromechanical mapping with magnetic resonance imaging tagging and an epicardial electrode sock. Ann Biomed Eng. 2003;31:430-440.
26. Wyman BT, Hunter WC, Prinzen FW, McVeigh ER. Mapping propagation of mechanical activation in the paced heart with MRI tagging. Am J Physiol Heart Circ Physiol. 1999;276:H881-H891.
27. Diaz-Infante E, Sitges M, Vidal B, Mont L, Delgado V, Marigliano A, Macias A, Tolosana JM, Tamborero D, Azqueta M, Roig E, Pare C, Brugada J. Usefulness of ventricular dyssynchrony measured using m-mode echocardiography to predict response to resynchronization therapy. Am J Cardiol. 2007;100:84-89.
28. Tanaka H, Nesser HJ, Buck T, Oyenuga O, Janosi RA, Winter S, Saba S, Gorcsan J III. Dyssynchrony by speckle-tracking echocardiography and response to cardiac resynchronization therapy: results of the Speckle Tracking And Resynchronization (STAR) study. Eur Heart J. 2010;31:1690-1700.
29. Delgado V, van Bommel RJ, Bertini M, Borleffs CJ, Marsan NA, Arnold CT, Nucifora G, van de Veire NR, Ypenburg C, Boersma E, Holman ER, Schalij MJ, Bax JJ. Relative merits of left ventricular dyssynchrony, left ventricular lead position, and myocardial scar to predict long-term survival of ischemic heart failure patients undergoing cardiac resynchronization therapy. Circulation. 2011;123:70-78.
30. White JA, Yee R, Yuan X, Krahn A, Skanes A, Parker M, Klein G, Drangova M. Delayed enhancement magnetic resonance imaging predicts response to cardiac resynchronization therapy in patients with intraventricular dyssynchrony. J Am Coll Cardiol. 2006;48:1953-1960.
31. Cleland J, Freemantle N, Ghio S, Fruhwald F, Shankar A, Marijanowski M, Verboven Y, Tavazzi L. Predicting the long-term effects of cardiac resynchronization therapy on mortality from baseline variables and the early response a report from the CARE-HF (Cardiac Resynchronization in Heart Failure) trial. J Am Coll Cardiol. 2008;52:438-445.
32. Wang CL, Powell BD, Redfield MM, Miyazaki C, Fine NM, Olson LJ, Cha YM, Espinosa RE, Hayes DL, Hodge DO, Lin G, Friedman PA, Oh JK. Left ventricular discoordination index measured by speckle tracking strain rate imaging predicts reverse remodelling and survival after cardiac resynchronization therapy. Eur J Heart Fail. 2012;14:517-525.
33. Spragg DD, Akar FG, Helm RH, Tunin RS, Tomaselli GF, Kass DA. Abnormal conduction and repolarization in late-activated myocardium of dyssynchronously contracting hearts. Cardiovasc Res. 2005;67: 77-86.
34. Vernooy K, Verbeek XA, Peschar M, Crijns HJ, Arts T, Cornelussen RN, Prinzen FW. Left bundle branch block induces ventricular remodelling and functional septal hypoperfusion. Eur Heart J. 2005;26:91-98.
35. Soliman OI, Geleijnse ML, Theuns DA, Nemes A, Vletter WB, van Dalen BM, Motawea AK, Jordaens LJ, ten Cate FJ. Reverse of left ventricular volumetric and structural remodeling in heart failure patients treated with cardiac resynchronization therapy. Am J Cardiol. 2008;101:651-657.