SCOPUS 정보 검색 플랫폼

Volumn 21, Issue 24, 2013, Pages 7988-7998

Design, synthesis and biological evaluation of novel 4-anilinoquinazolines with C-6 urea-linked side chains as inhibitors of the epidermal growth factor receptor

(13) Zhang, Xu a,b Peng, Ting a Ji, Xun a,c Li, Jian a Tong, Linjiang a Li, Zeng a Yang, Wei a Xu, Yungen b Li, Mengyuan a Ding, Jian a Jiang, Hualiang a,c Xie, Hua a Liu, Hong a

a SHANGHAI INSTITUTE OF MATERIA MEDICA (China)

b CHINA PHARMACEUTICAL UNIVERSITY (China)

c SHENYANG PHARMACEUTICAL UNIVERSITY (China)

Author keywords

Binding mode; EGFR inhibitor; EGFR T790M L858R; Irreversible EGFR inhibitor

Indexed keywords

1 [4 (3 CHLORO 4 FLUOROPHENYLAMINO) 7 (TETRAHYDROFURAN3 YLOXY)QUINAZOLIN 6 YL] 1 [2 (DIETHYLAMINO)ETHYL] 1 METHYLUREA; 1 [4 (3 CHLORO 4 FLUOROPHENYLAMINO) 7 (TETRAHYDROFURAN3 YLOXY)QUINAZOLIN 6 YL] 1 [2 (DIMETHYLAMINO)ETHYL] 1 METHYLUREA; 1 [4 (3 CHLORO 4 FLUOROPHENYLAMINO) 7 (TETRAHYDROFURAN3 YLOXY)QUINAZOLIN 6 YL] 1 [3 (DIMETHYLAMINO)PROPYL] 1 METHYLUREA; 1 [4 (3 CHLORO 4 FLUOROPHENYLAMINO) 7 (TETRAHYDROFURAN3 YLOXY)QUINAZOLIN 6 YL] 3 (2 HYDROXYETHYL)UREA; 1 [4 (3 CHLORO 4 FLUOROPHENYLAMINO) 7 (TETRAHYDROFURAN3 YLOXY)QUINAZOLIN 6 YL] 3 (2 METHOXYETHYL)UREA; 1 [4 (3 CHLORO 4 FLUOROPHENYLAMINO) 7 (TETRAHYDROFURAN3 YLOXY)QUINAZOLIN 6 YL] 3 (3 METHOXYPROPYL)UREA; 1 [4 (3 CHLORO 4 FLUOROPHENYLAMINO) 7 (TETRAHYDROFURAN3 YLOXY)QUINAZOLIN 6 YL] 3 (3 METHOXYROYL)UREA; 1 [4 (3 CHLORO 4 FLUOROPHENYLAMINO) 7 (TETRAHYDROFURAN3 YLOXY)QUINAZOLIN 6 YL] 3 (3,3 DIMETHOXYPROPYL)UREA; 1 [4 (3 CHLORO 4 FLUOROPHENYLAMINO) 7 (TETRAHYDROFURAN3 YLOXY)QUINAZOLIN 6 YL] 3 [2 (DIETHYLAMINO)ETHYL]UREA; 1 [4 (3 CHLORO 4 FLUOROPHENYLAMINO) 7 (TETRAHYDROFURAN3 YLOXY)QUINAZOLIN 6 YL] 3 [2 (DIMETHYLAMINO)ETHYL]UREA; 1 [4 (3 CHLORO 4 FLUOROPHENYLAMINO) 7 (TETRAHYDROFURAN3 YLOXY)QUINAZOLIN 6 YL] 3 [2 (METHYLSULFONYL)ETHYL]UREA; 1 [4 (3 CHLORO 4 FLUOROPHENYLAMINO) 7 (TETRAHYDROFURAN3 YLOXY)QUINAZOLIN 6 YL] 3 [2 (MORPHOLINOETHYL)ETHYL]UREA; 1 [4 (3 CHLORO 4 FLUOROPHENYLAMINO) 7 (TETRAHYDROFURAN3 YLOXY)QUINAZOLIN 6 YL] 3 [2 (PIPERIDIN 1 YL)ETHYL]UREA; 1 [4 (3 CHLORO 4 FLUOROPHENYLAMINO) 7 (TETRAHYDROFURAN3 YLOXY)QUINAZOLIN 6 YL] 3 [2 (PYRROLIDIN 1 YL)ETHYL]UREA; 1 [4 (3 CHLORO 4 FLUOROPHENYLAMINO) 7 (TETRAHYDROFURAN3 YLOXY)QUINAZOLIN 6 YL] 3 [3,3 (DIMETHYLAMINO)PROPYL]UREA; 4 ANILINOQUINAZOLINE; ADENOSINE TRIPHOSPHATE; AFATINIB; CANERTINIB; EPIDERMAL GROWTH FACTOR RECEPTOR; ERLOTINIB; GEFITINIB; LAPATINIB; N [4 (3 CHLORO 4 FLUOROPHENYLAMINO) 7 (TETRAHYDROFURAN 3 YLOXY)QUINAZOLIN 6 YL] 3 HYDROXYAZETIDINE 1 CARBOXAMIDE; N [4 (3 CHLORO 4 FLUOROPHENYLAMINO) 7 (TETRAHYDROFURAN 3 YLOXY)QUINAZOLIN 6 YL] 3,3 DIFLUOROPYRROLIDINE 1 CARBOXAMIDE; N [4 (3 CHLORO 4 FLUOROPHENYLAMINO) 7 (TETRAHYDROFURAN 3 YLOXY)QUINAZOLIN 6 YL] 4 FLUOROPIPERIDINE 1 CARBOXAMIDE; N [4 (3 CHLORO 4 FLUOROPHENYLAMINO) 7 (TETRAHYDROFURAN 3 YLOXY)QUINAZOLIN 6 YL] 4 METHYLPIPERAZINE 1 CARBOXAMIDE; NERATINIB; QUINAZOLINE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; AUTOPHOSPHORYLATION; CARBOXY TERMINAL SEQUENCE; CELL PROLIFERATION; DILUTION; DRUG BINDING; DRUG DESIGN; DRUG MECHANISM; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HYDROGEN BOND; IC 50; MICHAEL ADDITION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN PHOSPHORYLATION; STRUCTURE ACTIVITY RELATION; WILD TYPE;

BINDING MODE; EGFR INHIBITOR; EGFR T790M/L858R; IRREVERSIBLE EGFR INHIBITOR;

ANILINE COMPOUNDS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MOLECULAR STRUCTURE; PROTEIN KINASE INHIBITORS; QUINAZOLINES; RECEPTOR, EPIDERMAL GROWTH FACTOR; STRUCTURE-ACTIVITY RELATIONSHIP; UREA;

EID: 84888440538 PISSN: 09680896 EISSN: 14643391 Source Type: Journal
DOI: 10.1016/j.bmc.2013.09.049 Document Type: Article

Times cited : (28)

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