Structure-based approach for the discovery of pyrrolo[3,2- d ]pyrimidine-based EGFR T790M/L858R mutant inhibitors

ACS Medicinal Chemistry Letters

Volumn 4, Issue 2, 2013, Pages 201-205

  Sogabe, Satoshi ^a   Kawakita, Youichi ^a   Igaki, Shigeru ^a   Iwata, Hidehisa ^a   Miki, Hiroshi ^a   Cary, Douglas R ^a   Takagi, Terufumi ^a   Takagi, Shinji ^a   Ohta, Yoshikazu ^a   Ishikawa, Tomoyasu ^a  

^a TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

Author keywords

crystal structure; drug sensitivity and resistance; EGFR T790 L858 mutant inhibitors; NSCLC; pyrrolo 3,2 d pyrimidine derivatives; TAK 285

Indexed keywords

ANTINEOPLASTIC AGENT; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; ERLOTINIB; GEFITINIB; LAPATINIB; NERATINIB; PYRIMIDINE DERIVATIVE; TAK 285; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG SENSITIVITY; DRUG STRUCTURE; IC 50; LUNG NON SMALL CELL CANCER; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

EID: 84873973328     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml300327z     Document Type: Article

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