Effect of stereochemistry, chain length and sequence pattern on antimicrobial properties of short synthetic β-sheet forming peptide amphiphiles

Biomaterials

Volumn 35, Issue 4, 2014, Pages 1315-1325

  Ong, Zhan Yuin ^a   Cheng, Junchi ^b   Huang, Yuan ^b   Xu, Kaijin ^c   Ji, Zhongkang ^c   Fan, Weimin ^b   Yang, Yi Yan ^a  

^a INSTITUTE OF BIOENGINEERING AND NANOTECHNOLOGY   (Singapore)

^b ZHEJIANG UNIVERSITY   (China)

^c ZHEJIANG UNIVERSITY   (China)

Author keywords

Sheet; Antibiotics resistance; Antimicrobial peptide (AMP); Broad spectrum; Protease stability; Stereochemistry

Indexed keywords

ANTI-MICROBIAL PROPERTIES; ANTIBIOTICS RESISTANCE; ANTIMICROBIAL PEPTIDE; BACTERICIDAL PROPERTIES; BROAD SPECTRUM; HYDROPHOBIC AMINO ACIDS; MYCOBACTERIUM TUBERCULOSIS; PROTEASE STABILITIES;

AMINO ACIDS; ANTIBIOTICS; BACTERIA; CELL CULTURE; CHAIN LENGTH; ENZYME ACTIVITY; PEPTIDES; STEREOCHEMISTRY; STEREOSELECTIVITY;

POLYPEPTIDES;

AMPHOPHILE; PEPTIDE IK12 ALL D; PEPTIDE IK12 ALL L; PEPTIDE IK8 ALL D; PEPTIDE IK8 ALL L; POLYPEPTIDE ANTIBIOTIC AGENT; PROTEINASE K; SYNTHETIC PEPTIDE; TRYPSIN; UNCLASSIFIED DRUG;

ACINETOBACTER BAUMANNII; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMAL CELL; ANTIBIOTIC RESISTANCE; ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIAL COUNT; BACTERIAL GROWTH; BACTERIUM ISOLATION; BETA SHEET; CIRCULAR DICHROISM; CONTROLLED STUDY; CRYPTOCOCCUS NEOFORMANS; ENANTIOMER; HEMOLYSIS; HYDROPHOBICITY; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MOUSE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN FOLDING; PSEUDOMONAS AERUGINOSA; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; VANCOMYCIN RESISTANT ENTEROCOCCUS;

ACINETOBACTER BAUMANNII; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MYCOBACTERIUM TUBERCULOSIS; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS;

ANTIBIOTICS RESISTANCE; ANTIMICROBIAL PEPTIDE (AMP); BROAD SPECTRUM; PROTEASE STABILITY; STEREOCHEMISTRY; Β-SHEET;

AMINO ACID SEQUENCE; ANIMALS; ANTI-INFECTIVE AGENTS; ANTIMICROBIAL CATIONIC PEPTIDES; BACTERIA; BACTERIAL INFECTIONS; CELL LINE; MICE; MICROBIAL SENSITIVITY TESTS; PEPTIDE HYDROLASES; PROTEIN STRUCTURE, SECONDARY; RABBITS; STEREOISOMERISM;

EID: 84888439590     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2013.10.053     Document Type: Article

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