Ex vivo expansion of cord blood-CD34+ cells using IGFBP2 and Angptl-5 impairs short-term lymphoid repopulation in vivo

Journal of Tissue Engineering and Regenerative Medicine

Volumn 7, Issue 12, 2013, Pages 944-954

  Ventura Ferreira, Mónica S ^a   Labude, Norina ^a   Walenda, Gudrun ^a   Adamzyk, Carina ^a   Wagner, Wolfgang ^a   Piroth, Daniela ^a   Müller, Albrecht M ^b   Knüchel, Ruth ^a   Hieronymus, Thomas ^a   Zenke, Martin ^a   Jahnen Dechent, Willi ^a   Neuss, Sabine ^a  

^a RWTH AACHEN UNIVERSITY   (Germany)

^b UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

Cytokines; Expansion; Haematopoietic stem cells; Transplantation

Indexed keywords

BLOOD; CELL PROLIFERATION; PATIENT TREATMENT; STEM CELLS;

CD34+ CELLS; CELL-BE; CELL/B.E; CELL/BE; CORD BLOOD; CYTOKINES; EX VIVO EXPANSION; HAEMATOPOIETIC STEM CELLS; REPOPULATION; TRANSPLANTATION;

EXPANSION;

ANGIOPOIETIN; ANGIOPOIETIN LIKE PROTEIN 5; CD34 ANTIGEN; FIBROBLAST GROWTH FACTOR 1; INTERLEUKIN 3; INTERLEUKIN 6; SOMATOMEDIN BINDING PROTEIN 2; STEM CELL FACTOR; THROMBOPOIETIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD CELL; CELL ACTIVITY; CELL COUNT; CELL LINEAGE; CELL MIGRATION; CELL POPULATION; CELL PROLIFERATION; COLONY FORMING UNIT; CONTROLLED STUDY; CULTURE MEDIUM; ENGRAFTMENT; EX VIVO STUDY; HEMATOPOIETIC STEM CELL; IN VIVO STUDY; LYMPHOID CELL; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; STEM CELL CULTURE; STEM CELL EXPANSION; UMBILICAL CORD BLOOD;

CYTOKINES; EXPANSION; HAEMATOPOIETIC STEM CELLS; TRANSPLANTATION;

ANGIOPOIETINS; ANIMALS; ANTIGENS, CD34; ANTIGENS, CD45; BONE MARROW CELLS; CELL DIFFERENTIATION; CELL MOVEMENT; CELL POLARITY; CELL PROLIFERATION; CELLS, CULTURED; CLONE CELLS; COLONY-FORMING UNITS ASSAY; CYTOKINES; FETAL BLOOD; HUMANS; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 2; LYMPHOCYTES; MICE; MICE, INBRED NOD; MICE, SCID; SPLEEN; STEM CELL FACTOR; THROMBOPOIETIN;

EID: 84888428082     PISSN: 19326254     EISSN: 19327005     Source Type: Journal    
DOI: 10.1002/term.1486     Document Type: Article

References (44)

1. + hematopoietic stem cells during ex vivo expansion. Exp Hematol 37(4): 504-513.
2. Araki H, Mahmud N, Milhem M, et al. 2006; Expansion of human umbilical cord blood SCID-repopulating cells using chromatin-modifying agents. Exp Hematol 34(2): 140-149.
3. + hematopoietic stem and progenitor cells. Int J Mol Med 25(1): 89-96.
4. Broxmeyer HE. 2010; Cord blood hematopoietic stem cell transplantation. In StemBook. Harvard Stem Cell Institute: Cambridge.
5. Brunstein C, Wagner J. 2006; Umbilical cord blood transplantation and banking. Annu Rev Med 57: 403-417.
6. Cabrita GJ, Ferreira BS, da Silva CL, et al. 2003; Hematopoietic stem cells: from the bone to the bioreactor. Trends Biotechnol 21(5): 233-240.
7. Calvi LM, Adams GB, Weibrecht KW, et al. 2003; Osteoblastic cells regulate the haematopoietic stem cell niche. Nature 425(6960): 841-846.
8. Chao NJ, Emerson SG, Weinberg KI. 2004; Stem cell transplantation (cord blood transplants). Hematol Am Soc Hematol Educ Program 354-371.
9. Chua KN, Chai C, Lee PC, et al. 2007; Functional nanofiber scaffolds with different spacers modulate adhesion and expansion of cryopreserved umbilical cord blood hematopoietic stem/progenitor cells. Exp Hematol 35(5): 771-781.
10. Czechowicz A, Weissman I. 2010; Purified hematopoietic stem cell transplantation: the next generation of blood and immune replacement. Immunol Allergy Clin North Am 30(2): 159-171.
11. + cells. J Tissue Eng Regen Med 4(2): 149-158.
12. de Lima M, McMannis J, Gee A, et al. 2008; Transplantation of ex vivo expanded cord blood cells using the copper chelator tetraethylenepentamine: a phase I/II clinical trial. Bone Marrow Transpl 41(9): 771-778.
13. Delaney C, Ratajczak M, Laughlin M. 2010a; Strategies to enhance umbilical cord blood stem cell engraftment in adult patients. Expert Rev Hematol 3(3): 273-283.
14. Delaney C, Heimfeld S, Brashem-Stein C, et al. 2010b; Notch-mediated expansion of human cord blood progenitor cells capable of rapid myeloid reconstitution. Nat Med 16(2): 232-236.
15. Devine S, Lazarus H, Emerson S. 2003; Clinical application of hematopoietic progenitor cell expansion: current status and future prospects. Bone Marrow Transpl 31(4): 241-252.
16. -/- (NSG) mice. PLoS One 6(4): e18382.
17. Ehring B, Biber K, Upton TM, et al. 2003; Expansion of HPCs from cord blood in a novel 3D matrix. Cytotherapy 5(6): 490-499.
18. Fischer M, Goldschmitt J, Peschel C, et al. 1997; A bioactive designer cytokine for human hematopoietic progenitor cell expansion. Nat Biotechnol 15(2): 142-145.
19. Foguenne J, Di Stefano I, Giet O, et al. 2009; Ex vivo expansion of hematopoietic progenitor cells is associated with downregulation of α4 integrin- and CXCR4-mediated engraftment in NOD/SCID β2-microglobulin-null mice. Haematologica 94(2): 185-194.
20. Giebel B, Corbeil D, Beckmann J, et al. 2004; Segregation of lipid raft markers including CD133 in polarized human hematopoietic stem and progenitor cells. Blood 104(8): 2332-2338.
21. Gluckman E, Rocha V. 2009; Cord blood transplantation: state of the art. Haematologica 94(4): 451-454.
22. + human universal stromal feeder layer to expand/maintain human bone marrow hematopoietic stem/progenitor cells in a serum-free culture system. Exp Hematol 34(10): 1353-1359.
23. Heining C, Spyridonidis A, Bernhardt E, et al. 2007; Lymphocyte reconstitution following allogeneic hematopoietic stem cell transplantation: a retrospective study including 148 patients. Bone Marrow Transpl 39(10): 613-622.
24. Ju XS, Hacker C, Madruga J, et al. 2003; Towards determining the differentiation program of antigen-presenting dendritic cells by transcriptional profiling. Eur J Cell Biol 82(2): 75-86.
25. Khoury M, Drake A, Chen Q, et al. 2011; Mesenchymal stem cells secreting angiopoietin-like-5 support efficient expansion of human hematopoietic stem cells without compromising their repopulating potential. Stem Cells Dev 20(8): 1371-1381.
26. Kimura T, Wang J, Minamiguchi H, et al. 2000; Signal through gp130 activated by soluble interleukin (IL)-6 receptor (R) and IL-6 or IL-6R/IL-6 fusion protein enhances ex vivo expansion of human peripheral blood-derived hematopoietic progenitors. Stem Cells 18(6): 444-452.
27. Koh KR, Janz M, Mapara MY, et al. 2005; Immunomodulatory derivative of thalidomide (IMiD CC-4047) induces a shift in lineage commitment by suppressing erythropoiesis and promoting myelopoiesis. Blood 105(10): 3833-3840.
28. Madlambayan GJ, Rogers I, Purpura KA, et al. 2006; Clinically relevant expansion of hematopoietic stem cells with conserved function in a single-use, closed-system bioprocess. Biol Blood Marrow Transpl 12(10): 1020-1030.
29. McNiece I. 2004; Ex vivo expansion of hematopoietic cells. Exp Hematol 32(5): 409-410.
30. Mendez-Ferrer S, Michurina TV, Ferraro F, et al. 2010; Mesenchymal and haematopoietic stem cells form a unique bone marrow niche. Nature 466: 829-836.
31. Milsom MD, Schiedlmeier B, Bailey J, et al. 2009; Ectopic HOXB4 overcomes the inhibitory effect of tumor necrosis factor-α on Fanconi anemia hematopoietic stem and progenitor cells. Blood 113(21): 5111-5120.
32. Oh I-H, Kwon K-R. 2010; Concise review: multiple niches for hematopoietic stem cell regulations. Stem Cells 28: 1243-1249.
33. Panoskaltsis N, Mantalaris A, Wu JH. 2005; Engineering a mimicry of bone marrow tissue ex vivo. J Biosci Bioeng 100(1): 28-35.
34. Schiedlmeier B, Santos A, Ribeiro A, et al. 2007; HOXB4's road map to stem cell expansion. Proc Natl Acad Sci USA 104(43): 16952-16957.
35. Schlenk R, Pasquini M, Pérez W, et al. 2008; HLA-identical sibling allogeneic transplants versus chemotherapy in acute myelogenous leukemia with t(8;21) in first complete remission: collaborative study between the German AML Intergroup and CIBMTR. Biol Blood Marrow Transpl 14(2): 187-196.
36. Seet LF, Teng E, Lai YS, et al. 2009; Valproic acid enhances the engraftability of human umbilical cord blood hematopoietic stem cells expanded under serum-free conditions. Eur J Haematol 82(2): 124-132.
37. Suzuki T, Yokoyama Y, Kumano K, et al. 2006; Highly efficient ex vivo expansion of human hematopoietic stem cells using Δ1-Fc chimeric protein. Stem Cells 24(11): 2456-2465.
38. Takagi M. 2005; Cell processing engineering for ex vivo expansion of hematopoietic cells. J Biosci Bioeng 99(3): 189-196.
39. Wagner J, Barker J, DeFor T, et al. 2002; Transplantation of unrelated donor umbilical cord blood in 102 patients with malignant and nonmalignant diseases: influence of CD34 cell dose and HLA disparity on treatment-related mortality and survival. Blood 100(5): 1611-1618.
40. Walenda T, Bork S, Horn P, et al. 2010; Co-culture with mesenchymal stromal cells increases proliferation and maintenance of hematopoietic progenitor cells. J Cell Mol Med 14(1-2): 337-350.
41. Walenda T, Bokermann G, Ferreira MSV, et al. 2011; Synergistic effects of growth factors and mesenchymal stromal cells for expansion of hematopoietic stem and progenitor cells. Exp Hematol 39(6): 617-628.
42. Xu C, Zhang Y, Jiang H. 2009; Ex vivo expansion of hematopoietic stem cell by fusion protein TAT-Zfx. Biochem Biophys Res Commun 379(3): 771-774.
43. + stem/progenitor cells, proliferation of bone marrow stromal cells, and antiapoptosis. Stem Cells 25(7): 1800-1806.
44. Zhang CC, Kaba M, Iizuka S, et al. 2008; Angiopoietin-like 5 and IGFBP2 stimulate ex vivo expansion of human cord blood hematopoietic stem cells as assayed by NOD/SCID transplantation. Blood 111(7): 3415-3423.