Midlife iron status is inversely associated with subsequent cognitive performance, particularly in perimenopausal women

Journal of Nutrition

Volumn 143, Issue 12, 2013, Pages 1974-1981

  Andreeva, Valentina A ^a   Galan, Pilar ^a   Arnaud, Josiane ^b   Julia, Chantal ^a   Hercberg, Serge ^a,c   Kesse Guyot, Emmanuelle ^a  

^a UMR University of Paris XIII INSERM U557/INRA U1125/CNAM ^*  (France)

^b GRENOBLE UNIVERSITY HOSPITAL   (France)

^c AVICENNE HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

FERRITIN; HEMOGLOBIN; IRON; MINERAL; VITAMIN; PLACEBO;

ADULT; ARTICLE; COGNITION; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; FEMALE; FERRITIN BLOOD LEVEL; HEALTH STATUS; HUMAN; IRON STORAGE; LINEAR REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; POSTMENOPAUSE; PRIMARY PREVENTION; PSYCHOLOGIC TEST; RANDOMIZED CONTROLLED TRIAL; TASK PERFORMANCE; VITAMIN SUPPLEMENTATION; BLOOD; CLIMACTERIUM; MIDDLE AGED;

COGNITION; DOUBLE-BLIND METHOD; FEMALE; FERRITINS; HEMOGLOBINS; HUMANS; IRON; MIDDLE AGED; PERIMENOPAUSE; PLACEBOS;

EID: 84888395725     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.3945/jn.113.177089     Document Type: Article

References (53)

1. Beard J, Han O. Systemic iron status. Biochim Biophys Acta. 2009; 1790:584-8.
2. World Health Organization. Serum ferritin concentrations for the assessment of iron status and iron deficiency in populations. Geneva: WHO; 2011.
3. Galan P, Yoon HC, Preziosi P, Viteri F, Valeix P, Fieux B, Briançon S, Malvy D, Roussel AM, Favier A, et al. Determining factors in the iron status of adult women in the SU.VI.MAX study. Supplementation en Vltamines et Mineraux AntioXydants. Eur J Clin Nutr. 1998; 52:383-8.
4. Beard JL, Connor JR. Iron status and neural functioning. Annu Rev Nutr. 2003; 23:41-58.
5. Murray-Kolb LE. Iron status and neuropsychological consequences in women of reproductive age: what do we know and where are we headed? J Nutr. 2011;141:747S-55S.
6. Tucker DM, Sandstead HH, Penland JG, Dawson SL, Milne DB. Iron status and brain function: serum ferritin levels associated with asymmetries of cortical electrophysiology and cognitive performance. Am J Clin Nutr. 1984; 39:105-13.
7. Marsh JT, Brown WS, Wolcott D, Carr CR, Harper R, Schweitzer SV, Nissenson AR. rHuEPO treatment improves brain and cognitive function of anemic dialysis patients. Kidney Int. 1991; 39:155-63.
8. Beard JL, Hendricks MK, Perez EM, Murray-Kolb LE, Berg A, Vernon-Feagans L, Irlam J, Isaacs W, Sive A, Tomlinson M. Maternal iron deficiency anemia affects postpartum emotions and cognition. J Nutr. 2005; 135:267-72.
9. Murray-Kolb LE, Beard JL. Iron treatment normalizes cognitive functioning in young women. Am J Clin Nutr. 2007; 85:778-87.
10. Umur EE, Oktenli C, Celik S, Tangi F, Sayan O, Sanisoglu YS, Ipcioglu O, Terekeci HM, Top C, Nalbant S, et al. Increased iron and oxidative stress are separately related to cognitive decline in elderly. Geriatr Gerontol Int. 2011; 11:504-9.
11. Loef M, Walach H. Copper and iron in Alzheimer's disease: a systematic review and its dietary implications. Br J Nutr. 2012; 107:7-19.
12. Penke L, Valdes Hernandez MC, Maniega SM, Gow AJ, Murray C, Starr JM, Bastin ME, Deary IJ, Wardlaw JM. Brain iron deposits are associated with general cognitive ability and cognitive aging. Neurobiol Aging. 2012; 33:510-7.
13. de la Torre JC. Alzheimer's disease is incurable but preventable. J Alzheimers Dis. 2010; 20:861-70.
14. Mortimer JA, Borenstein AR, Gosche KM, Snowdon DA. Very early detection of Alzheimer neuropathology and the role of brain reserve in modifying its clinical expression. J Geriatr Psychiatry Neurol. 2005; 18:218-23.
15. Hughes TF, Ganguli M. Modifiable midlife risk factors for late-life cognitive impairment and dementia. Curr Psychiatry Rev. 2009; 5:73-92.
16. Hercberg S, Galan P, Preziosi P, Bertrais S, Mennen L, Malvy D, Roussel AM, Favier A, Briançon S. The SU.VI.MAX Study: a randomized, placebo-controlled trial of the health effects of antioxidant vitamins and minerals. Arch Intern Med. 2004; 164:2335-42.
17. Kesse-Guyot E, Fezeu L, Jeandel C, Ferry M, Andreeva V, Amieva H, Hercberg S, Galan P. French adults' cognitive performance after daily supplementation with antioxidant vitamins and minerals at nutritional doses: a post hoc analysis of the Supplementation in Vitamins and Mineral Antioxidants (SU.VI.MAX) trial. Am J Clin Nutr. 2011; 94:892-9.
18. Adam S, Van der Linden M, Poitrenaud J, Kalafat M. L'épreuve de rappel indicé à48 items (RI-48). In: Van der Linden M, editor. L'évaluation des troubles de la mémoire: présentation de quatre tests de mémoire épisodique avec leur étalonnage. Marseille: Solal;2004. p. 49-67.
19. Cardebat D, Doyon B, Puel M, Goulet P, Joanette Y. Evocation lexicale formelle et sémantique chez des sujets normaux. Performances et dynamiques de production en fonction du sexe, de l'âge et du niveau d'étude. Acta Neurol Belg. 1990; 90:207-17.
20. Wechsler D. Wechsler Adult Intelligence Scale-Revised. New York: Psychological Corporation; 1981.
21. Delis DC, Kaplan E, Kramer JH. Delis-Kaplan Executive Function System: examiner's manual. San Antonio: The Psychological Corp.; 2001.
22. RadloffLS. The CES-D scale. A self-report depression scale for research in the general population. Appl Psychol Meas. 1977; 1:385-401.
23. Hercberg S, Chat-Yung S, Chaulia M. The French National Nutrition and Health Program:2001-2006-2010. Int J Public Health. 2008; 53:68-77.
24. Fuhrer R, Rouillon F. La version française de l'échelle CES-D. Description et traduction de l'échelle d'autoévaluation. Psychiatr Psychobiol. 1989; 4:163-6.
25. Thurnham DI, McCabe LD, Haldar S, Wieringa FT, Northrop-Clewes CA, McCabe GP. Adjusting plasma ferritin concentrations to remove the effects of subclinical inflammation in the assessment of iron deficiency: a meta-analysis. Am J Clin Nutr. 2010; 92:546-55.
26. Brayne C, Calloway P. Normal ageing, impaired cognitive function, and senile dementia of the Alzheimer's type: a continuum? Lancet. 1988; 1:1265-7.
27. Walston JD. Inflammation and aging. In: Halter JB, Ouslander JG, Tinetti ME, Studenski S, High KP, Asthana S, editors. Hazzard's geriatric medicine and gerontology. 6th ed. New York: McGraw-Hill; 2009. p. 37-44.
28. Greendale GA, Wight RG, Huang MH, Avis N, Gold EB, Joffe H, Seeman T, Vuge M, Karlamangla AS. Menopause-associated symptoms and cognitive performance: results from the study of women's health across the nation. Am J Epidemiol. 2010; 171:1214-24.
29. Sullivan Mitchell E, Fugate Woods N. Midlife women's attributions about perceived memory changes: observations from the Seattle Midlife Women's Health Study. J Womens Health Gend Based Med. 2001; 10:351-62.
30. Greendale GA, Huang MH, Wight RG, Seeman T, Luetters C, Avis NE, Johnston J, Karlamangla AS. Effects of the menopause transition and hormone use on cognitive performance in midlife women. Neurology. 2009; 72:1850-7.
31. Holyoake TL, Stott DJ, McKay PJ, Hendry A, MacDonald JB, Lucie NP. Use of plasma ferritin concentration to diagnose iron deficiency in elderly patients. J Clin Pathol. 1993; 46:857-60.
32. Custer EM, Finch CA, Sobel RE, Zettner A. Population norms for serum ferritin. J Lab Clin Med. 1995; 126:88-94.
33. Kurella Tamura M, Wadley VG, Newsome BB, Zakai NA, McClure LA, Howard G, Warnock DG, McClellan W. Hemoglobin concentration and cognitive impairment in the renal REasons for Geographic And Racial Differences in Stroke (REGARDS) Study. J Gerontol A Biol Sci Med Sci. 2010; 65:1380-6.
34. Zuccalà G, Marzetti E, Cesari M, Lo Monaco MR, Antonica L, Cocchi A, Carbonin P, Bernabei R. Correlates of cognitive impairment among patients with heart failure: results of a multicenter survey. Am J Med. 2005; 118:496-502.
35. Chaves PH, Carlson MC, Ferrucci L, Guralnik JM, Semba R, Fried LP. Association between mild anemia and executive function impairment in community-dwelling older women: The Women's Health and Aging Study II. J Am Geriatr Soc. 2006; 54:1429-35.
36. Khedr E, Hamed SA, Elbeih E, El-Shereef H, Ahmad Y, Ahmed S. Iron states and cognitive abilities in young adults: neuropsychological and neurophysiological assessment. Eur Arch Psychiatry Clin Neurosci. 2008; 258:489-96.
37. Atti AR, Palmer K, Volpato S, Zuliani G, Winblad B, Fratiglioni L. Anaemia increases the risk of dementia in cognitively intact elderly. Neurobiol Aging. 2006; 27:278-84.
38. Aisen P, Enns C, Wessling-Resnick M. Chemistry and biology of eukaryotic iron metabolism. Int J Biochem Cell Biol. 2001; 33:940-59.
39. Stankiewicz JM, Brass SD. Role of iron in neurotoxicity: a cause for concern in the elderly? Curr Opin Clin Nutr Metab Care. 2009; 12:22-9.
40. Wang W, Knovich MA, Coffman LG, Torti FM, Torti SV. Serum ferritin: past, present and future. Biochim Biophys Acta. 2010; 1800:760-9.
41. Smorgon C, Mari E, Atti AR, Dalla Nora E, Zamboni PF, Calzoni F, Passaro A, Fellin R. Trace elements and cognitive impairment: an elderly cohort study. Arch Gerontol Geriatr Suppl. 2004;(9):393-402.
42. Yavuz BB, Cankurtaran M, Haznedaroglu IC, Halil M, Ulger Z, Altun B, Ariogul S. Iron deficiency can cause cognitive impairment in geriatric patients. J Nutr Health Aging. 2012; 16:220-4.
43. Milward EA, Bruce DG, Knuiman MW, Divitini ML, Cole M, Inderjeeth CA, Clarnette RM, Maier G, Jablensky A, Olynyk JK. A cross-sectional community study of serum iron measures and cognitive status in older adults. J Alzheimers Dis. 2010; 20:617-23.
44. Lam PK, Kritz-Silverstein D, Barrett Connor E, Milne D, Nielsen F, Gamst A, Morton D, Wingard D. Plasma trace elements and cognitive function in older men and women: the Rancho Bernardo study. J Nutr Health Aging. 2008; 12:22-7.
45. Schiepers OJ, van Boxtel MP, de Groot RH, Jolles J, de Kort WL, Swinkels DW, Kok FJ, Verhoef P, Durga J. Serum iron parameters, HFE C282Y genotype, and cognitive performance in older adults: results from the FACIT study. J Gerontol A Biol Sci med Sci. 2010; 65:1312-21.
46. Bartzokis G, Lu PH, Tingus K, Peters DG, Amar CP, Tishler TA, Finn JP, Villablanca P, Altshuler LL, Mintz J, et al. Gender and iron genes may modify associations between brain iron and memory in healthy aging. Neuropsychopharmacology. 2011; 36:1375-84.
47. Bartzokis G, Tishler TA, Lu PH, Villablanca P, Altshuler LL, Carter M, Huang D, Edwards N, Mintz J. Brain ferritin iron may influence age and gender-related risks of neurodegeneration. Neurobiol Aging. 2007; 28:414-23.
48. Rodrigue KM, Haacke EM, Raz N. Differential effects of age and history of hypertension on regional brain volumes and iron. Neuroimage. 2011; 54:750-9.
49. Kretchmer N, Beard JL, Carlson S. The role of nutrition in the development of normal cognition. Am J Clin Nutr. 1996; 63:997S-1001S.
50. Hallberg L, Hulthen L. High serum ferritin is not identical to high iron stores. Am J Clin Nutr. 2003; 78:1225-6.
51. Borel MJ, Smith SM, Derr J, Beard JL. Day-to-day variation in iron status indices in healthy men and women. Am J Clin Nutr. 1991; 54:729-35.
52. Kheir F, Haddad R. Anemia in the elderly. Dis Mon. 2010; 56:456-67.
53. Vogel T, Dali-Youcef N, Kaltenbach G, Andres E. Homocysteine, vitamin B12, folate and cognitive functions: a systematic and critical review of the literature. Int J Clin Pract. 2009; 63:1061-7.