Delivery of analgesic peptides to the brain by nano-sized bolaamphiphilic vesicles made of monolayer membranes

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 85, Issue 3 PART A, 2013, Pages 381-389

  Popov, Mary ^a   Abu Hammad, Ibrahim ^a   Bachar, Tzach ^a   Grinberg, Sarina ^a   Linder, Charles ^a   Stepensky, David ^a   Heldman, Eliahu ^a  

^a BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

Author keywords

Analgesic peptides; Bolavesicles; Brain delivery of drugs; Drug delivery systems; Liposomes

Indexed keywords

1,2 DIOLEOYL 3 TRIMETHYLAMMONIOPROPANE; ACETYLCHOLINE DERIVATIVE; CHITOSAN; CHOLINESTERASE; KYOTORPHIN; LEUCINE ENKEPHALIN; MORPHINE; NANOCARRIER; PYRIDOSTIGMINE;

ANALGESIA; ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BOLAAMPHIPHILIC VESICLE; BRAIN; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG PENETRATION; DRUG RELEASE; ENZYME ACTIVITY; ENZYME INHIBITION; IN VIVO STUDY; LASER DOPPLER FLOWMETRY; MALE; MEMBRANE VESICLE; MOUSE; NANOENCAPSULATION; NONHUMAN; STATIC ELECTRICITY; ZETA POTENTIAL;

ACETYLCHOLINE; ACH; ANALGESIC PEPTIDES; BBB; BLOOD-BRAIN BARRIER; BOLAVESICLES; BRAIN DELIVERY OF DRUGS; CARBOXYFLUORESCEIN; CF; CHE; CHITOSAN; CHOLINE ESTERASE; CS; DDS; DRUG DELIVERY SYSTEM; DRUG DELIVERY SYSTEMS; LIPOSOMES;

ANALGESICS; ANIMALS; BLOOD-BRAIN BARRIER; BRAIN; CATIONS; CHITOSAN; CHOLINESTERASES; DELAYED-ACTION PREPARATIONS; DISEASE MODELS, ANIMAL; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; ENDORPHINS; ENKEPHALIN, LEUCINE; FURANS; MALE; MICE; MICE, INBRED ICR; NANOPARTICLES; PAIN; PEPTIDES; PYRIDONES; TISSUE DISTRIBUTION;

EID: 84888385488     PISSN: 09396411     EISSN: 18733441     Source Type: Journal    
DOI: 10.1016/j.ejpb.2013.06.005     Document Type: Article

References (22)

1. S. Krol Challenges in drug delivery to the brain: nature is against us J. Control. Release 164 2012 145 155
2. W.M. Pardridge Drug targeting to the brain Pharm. Res. 24 2007 1733 1744
3. S. Wohlfart, S. Gelperina, and J. Kreuter Transport of drugs across the blood-brain barrier by nanoparticles J. Control. Release 161 2012 264 273
4. S. Grinberg, V. Kolot, and D. Mills New chemical derivatives based on vernonia galamensis oil Ind. Crops Prod. 3 2004 115 119
5. M. Popov, C. Linder, R.J. Deckelbaum, S. Grinberg, I.H. Hansen, E. Shaubi, T. Waner, and E. Heldman Cationic vesicles from novel bolaamphiphilic compounds J. Liposome Res. 20 2010 147 159
6. M. Popov, S. Grinberg, C. Linder, T. Waner, B. Levi-Hevroni, R.J. Deckelbaum, and E. Heldman Site-directed decapsulation of bolaamphiphilic vesicles with enzymatic cleavable surface groups J. Control. Release 160 2012 306 314
7. G.R. Dakwar, I. Abu Hammad, M. Popov, C. Linder, S. Grinberg, E. Heldman, and D. Stepensky Delivery of proteins to the brain by bolaamphiphilic nano-sized vesicles J. Control. Release 160 2012 315 321
8. D.A. Brown, B. Venegas, P.H. Cooke, V. English, and P.L. Chong Bipolar tetraether archaeosomes exhibit unusual stability against autoclaving as studied by dynamic light scattering and electron microscopy Chem. Phys. Lipids 159 2009 95 103
9. S. Li, F. Zheng, X. Zhang, and W. Wang Stability and rupture of archaebacterial cell membrane: a model study J. Phys. Chem. B 113 2009 1143 1152
10. J. Stern, H.J. Freisleben, S. Janku, and K. Ring Black lipid membranes of tetraether lipids from Thermoplasma acidophilum Biochim. Biophys. Acta 1128 1992 227 236
11. S. Grinberg, V. Kolot, C. Linder, E. Shaubi, V. Kas'yanov, R.J. Deckelbaum, and E. Heldman Synthesis of novel cationic bolaamphiphiles from vernonia oil and their aggregated structures Chem. Phys. Lipids 153 2008 85 97
12. L. Fenart, A. Casanova, B. Dehouck, C. Duhem, S. Slupek, R. Cecchelli, and D. Betbeder Evaluation of effect of charge and lipid coating on ability of 60-nm nanoparticles to cross an in vitro model of the blood-brain barrier J. Pharmacol. Exp. Ther. 291 1999 1017 1022
13. P. Chen, N. Bodor, W.M. Wu, and L. Prokai Strategies to target kyotorphin analogues to the brain J. Med. Chem. 41 1998 3773 3781
14. U. Schroeder, P. Sommerfeld, S. Ulrich, and B.A. Sabel Nanoparticle technology for delivery of drugs across the blood-brain barrier J. Pharm. Sci. 87 1998 1305 1307
15. N. Bodor, and P. Buchwald Recent advances in the brain targeting of neuropharmaceuticals by chemical delivery systems Adv. Drug Deliv. Rev. 36 1999 229 254
16. Y. Shechter, E. Heldman, K. Sasson, T. Bachar, M. Popov, and M. Fridkin Delivery of neuropeptides from the periphery to the brain: studies with enkephalin ACS Chem. Neurosci. 1 2010 399 406
17. S. Grinberg, C. Linder, V. Kolot, T. Waner, Z. Wiesman, E. Shaubi, and E. Heldman Novel cationic amphiphilic derivatives from vernonia oil: synthesis and self-aggregation into bilayer vesicles, nanoparticles, and DNA complexants Langmuir 21 2005 7638 7645
18. S. Grinberg, N. Kipnis, C. Linder, V. Kolot, and E. Heldman Asymmetric bolaamphiphiles from vernonia oil designed for drug delivery Eur. J. Lipid Sci. Technol. 112 2010 137 151
19. N.B. Vutla, G.V. Betageri, and A.K. Banga Transdermal iontophoretic delivery of enkephalin formulated in liposomes J. Pharm. Sci. 85 1996 5 8
20. M. Machuqueiro, S.R. Campos, C.M. Soares, and A.M. Baptista Membrane-induced conformational changes of kyotorphin revealed by molecular dynamics simulations J. Phys. Chem. B 114 2010 11659 11667
21. G.B. Patel, and G.D. Sprott Archaeobacterial ether lipid liposomes (archaeosomes) as novel vaccine and drug delivery systems Crit. Rev. Biotechnol. 19 1999 317 357
22. F.M. Menger, and D.E. Johnston Jr. Specific enzyme-induced decapsulation J. Am. Chem. Soc. 113 1991 5467 5468