Follow-up study of patients with cervical intraepithelial neoplasia grade 1 overexpressing p16Ink4a

International Journal of Gynecological Cancer

Volumn 23, Issue 9, 2013, Pages 1663-1669

  Cortecchia, Stefania ^a   Galanti, Giuseppe ^a   Sgadari, Cecilia ^b   Costa, Silvano ^c   De Lillo, Margherita ^a   Caprara, Licia ^a   Barillari, Giovanni ^d   Monini, Paolo ^b   Nannini, Roberto ^a   Ensoli, Barbara ^b   Bucchi, Lauro ^e  

^a Health Care District Hospital   (Italy)

^b ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^c UNIVERSITY OF BOLOGNA   (Italy)

^d UNIVERSITY OF ROME TOR VERGATA   (Italy)

^e DEPARTMENT OF MEDICAL ONCOLOGY   (Italy)

Author keywords

Cervical intraepithelial neoplasia; P16Ink4a; Progression; Regression

Indexed keywords

TUMOR SUPPRESSOR PROTEIN; TUMOR SUPPRESSOR PROTEIN P16 INK4A; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CANCER GRADING; CANCER GROWTH; FEMALE; FOLLOW UP; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROTEIN EXPRESSION; UTERINE CERVIX CARCINOMA IN SITU;

ADOLESCENT; ADULT; AGED; CASE-CONTROL STUDIES; CERVICAL INTRAEPITHELIAL NEOPLASIA; DISEASE PROGRESSION; FEMALE; FOLLOW-UP STUDIES; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, P16; HUMANS; MIDDLE AGED; NEOPLASM GRADING; PROGNOSIS; UTERINE CERVICAL NEOPLASMS; YOUNG ADULT;

EID: 84888379732     PISSN: 1048891X     EISSN: 15251438     Source Type: Journal    
DOI: 10.1097/IGC.0b013e3182a80b14     Document Type: Article

References (26)

1. Doorbar J. Molecular biology of human papillomavirus infection and cervical cancer. Clin Sci (Lond). 2006; 110: 525-541.
2. Cuschieri K,Wentzensen N. Human papillomavirus mRNA and p16 detection as biomarkers for the improved diagnosis of cervical neoplasia. Cancer Epidemiol Biomarkers Prev. 2008; 17: 2536-2545.
3. Tsoumpou I, Arbyn M, Kyrgiou M, et al. p16(INK4a) immunostaining in cytological and histological specimens from the uterine cervix: a systematic review and meta-analysis. Cancer Treat Rev. 2009; 35: 210-220.
4. Darragh TM, Colgan TJ, Thomas Cox J, et al. The Lower Anogenital Squamous Terminology Standardization project for HPV-associated lesions: background and consensus recommendations from the College of American Pathologists and the American Society for Colposcopy and Cervical Pathology. Int J Gynecol Pathol. 2013; 32: 76-115.
5. Negri G, Vittadello F, Romano F, et al. p16INK4a expression and progression risk of low-grade intraepithelial neoplasia of the cervix uteri. Virchows Arch. 2004; 445: 616-620.
6. Wang SS, Trunk M, Schiffman M, et al. Validation of p16INK4a as a marker of oncogenic human papillomavirus infection in cervical biopsies from a population-based cohort in Costa Rica. Cancer Epidemiol Biomarkers Prev. 2004; 13: 1355-1360.
7. Hariri J, Øster A. The negative predictive value of p16INK4a to assess the outcome of cervical intraepithelial neoplasia 1 in the uterine cervix. Int J Gynecol Pathol. 2007; 26: 223-228.
8. del Pino M, Garcia S, Fusté V, et al. Value of p16(INK4a) as a marker of progression/regression in cervical intraepithelial neoplasia grade 1. Am J Obstet Gynecol. 2009; 201:488.
9. Sherman ME, Lorincz AT, Scott DR, et al. Baseline cytology, human papillomavirus testing, and risk for cervical neoplasia: a 10-year cohort analysis. J Natl Cancer Inst. 2003; 95: 46-52.
10. Ferenczy A, Franco E. Persistent human papillomavirus infection and cervical neoplasia. Lancet Oncol. 2002; 3: 11-16.
11. Bucchi L, Pierri C, Caprara L, et al. Computerized monitoring for integrated cervical screening: rationale, methods and indicators of participation. Pathologica. 2003; 95: 9-21.
12. Coté RA, Rothwell DJ, Palotay JL, et al. The Systematized Nomenclature of Human and Veterinary Medicine: SNOMED International. Northfield, IL: College of American Pathologists; 1993.
13. The revised Bethesda System for reporting cervical/vaginal cytologic diagnoses: report of the 1991 Bethesda workshop. Acta Cytol. 1992; 36: 273-276.
14. Solomon D, Davey D, Kurman R, et al. The 2001 Bethesda System: terminology for reporting results of cervical cytology. JAMA. 2002; 287: 2114-2119.
15. Carozzi F, Confortini M, Dalla Palma P, et al. Use of p16-INK4A overexpression to increase the specificity of human papillomavirus testing: a nested substudy of the NTCC randomised controlled trial. Lancet Oncol. 2008; 9: 937-945.
16. Dalla Palma P, Giorgi Rossi P, Collina G, et al. The reproducibility of CIN diagnoses among different pathologists: data from histology reviews from a multicenter randomized study. Am J Clin Pathol. 2009; 132: 125-132.
17. Confortini M, Bergeron C, Desai M, et al. Accuracy of liquid-based cytology: comparison of the results obtained within a randomized controlled trial (the New Technologies for Cervical Cancer Screening Study) and an external group of experts. Cancer Cytopathol. 2010; 118: 203-208.
18. Ronco G, Giorgi-Rossi P, Carozzi F, et al. Efficacy of human papillomavirus testing for the detection of invasive cervical cancers and cervical intraepithelial neoplasia: a randomised controlled trial. Lancet Oncol. 2010; 11: 249-257.
19. Carozzi F, Gillio-Tos A, Confortini M, et al. Risk of high-grade cervical intraepithelial neoplasia during follow-up in HPV-positive women according to baseline p16-INK4A results: a prospective analysis of a nested substudy of the NTCC randomised controlled trial. Lancet Oncol. 2013; 14: 168-176.
20. Gardner MJ, Altman DG. Confidence intervals rather than P values: estimation rather than hypothesis testing. Br Med J (Clin Res Ed). 1986; 292: 746-750.
21. Jin SL, Zhang ZS, Yang YH. The expression of p16 and Rb protein in the tissue of cervical squamous carcinoma. Hunan Yi Ke Da Xue Xue Bao. 2000; 25: 393-396.
22. Wu H, Shi H, Kong L. Relationship of HPVL1 and p16 expression with different cervical lesions. Sci Res Essays. 2011; 6: 3724-3728.
23. Wang JL, Zheng BY, Li XD, et al. Predictive significance of the alterations of p16INK4A, p14ARF, p53, and proliferating cell nuclear antigen expression in the progression of cervical cancer. Clin Cancer Res. 2004; 10: 2407-2414.
24. Mazarico E, Gonzalez-Bosquet E. Prevalence of infection by different genotypes of human papillomavirus in women with cervical pathology. Gynecol Oncol. 2012; 125: 181-185.
25. Bergeron C, Ordi J, Schmidt D, et al. Conjunctive p16INK4a testing significantly increases accuracy in diagnosing high-grade cervical intraepithelial neoplasia. Am J Clin Pathol. 2010; 133: 395-406.
26. Ostör AG. Natural history of cervical intraepithelial neoplasia: a critical review. Int J Gynecol Pathol. 1993; 12: 186-192.