Value of p16INK4a as a marker of progression/regression in cervical intraepithelial neoplasia grade 1

American Journal of Obstetrics and Gynecology

Volumn 201, Issue 5, 2009, Pages 488.e1-488.e7

  del Pino, Marta ^a   Garcia, Sònia ^a   Fusté, Victòria ^a   Alonso, Immaculada ^a   Fusté, Pere ^a   Torné, Aureli ^a   Ordi, Jaume ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

Author keywords

cervical intraepithelial neoplasia; CIN1; follow up; human papillomavirus; immunohistochemistry; progression; regression

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 2A; TUMOR MARKER;

ADULT; AGED; ARTICLE; CANCER DIAGNOSIS; CANCER GRADING; CANCER GROWTH; CANCER REGRESSION; CLINICAL EVALUATION; COLPOSCOPY; CONTROLLED STUDY; CYTOLOGY; FEMALE; FOLLOW UP; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROSPECTIVE STUDY; SQUAMOUS CELL CARCINOMA; TUMOR BIOPSY; UTERINE CERVIX CARCINOMA IN SITU; VIRUS DETECTION; WART VIRUS;

ADULT; AGED; BIOLOGICAL MARKERS; CERVICAL INTRAEPITHELIAL NEOPLASIA; CYCLIN-DEPENDENT KINASE INHIBITOR P16; DISEASE PROGRESSION; FEMALE; HUMANS; MIDDLE AGED; PROSPECTIVE STUDIES; REMISSION INDUCTION; UTERINE CERVICAL NEOPLASMS; YOUNG ADULT;

EID: 70350565964     PISSN: 00029378     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ajog.2009.05.046     Document Type: Article

References (35)

1. el Hamidi A., Kocjan G., and Du M.Q. Clonality analysis of archival cervical smears: correlation of monoclonality with grade and clinical behavior of cervical intraepithelial neoplasia. Acta Cytol 47 (2003) 117-123
2. Schneider V. CIN prognostication: will molecular techniques do the trick?. Acta Cytol 47 (2003) 115-116
3. Wright Jr. T.C., Cox J.T., Massad L.S., Carlson J., Twiggs L.B., and Wilkinson E.J. 2001 consensus guidelines for the management of women with cervical intraepithelial neoplasia. Am J Obstet Gynecol 189 (2003) 295-304
4. American College of Obstetricians and Gynecologists. ACOG practice bulletin no. 66. Management of abnormal cervical cytology and histology. Obstet Gynecol 106 (2005) 645-664
5. Cox J.T., Schiffman M., and Solomon D. Prospective follow-up suggests similar risk of subsequent cervical intraepithelial neoplasia grade 2 or 3 among women with cervical intraepithelial neoplasia grade 1 or negative colposcopy and directed biopsy. Am J Obstet Gynecol 188 (2003) 1406-1412
6. Ostor A.G. Natural history of cervical intraepithelial neoplasia: a critical review. Int J Gynecol Pathol 12 (1993) 186-192
7. Solomon D., Schiffman M., and Tarone R. Comparison of three management strategies for patients with atypical squamous cells of undetermined significance: baseline results from a randomized trial. J Natl Cancer Inst 93 (2001) 293-299
8. Schiffman M., Khan M.J., Solomon D., et al. A study of the impact of adding HPV types to cervical cancer screening and triage tests. J Natl Cancer Inst 97 (2005) 147-150
9. Ordi J., Garcia S., del Pino M., et al. p16INK4a Immunostaining identifies occult CIN lesions in HPV-positive women. Int J Gynecol Pathol 28 (2009) 90-97
10. Giarre M., Caldeira S., Malanchi I., Ciccolini F., Leao M.J., and Tommasino M. Induction of pRb degradation by the human papillomavirus type 16 E7 protein is essential to efficiently overcome p16INK4a-imposed G1 cell cycle. Arrest J Virol 75 (2001) 4705-4712
11. Sano T., Oyama T., Kashiwabara K., Fukuda T., and Nakajima T. Expression status of p16 protein is associated with human papillomavirus oncogenic potential in cervical and genital lesions. Am J Pathol 153 (1998) 1741-1748
12. von Knebel D.M. New markers for cervical dysplasia to visualise the genomic chaos created by aberrant oncogenic papillomavirus infections. Eur J Cancer 38 (2002) 2229-2242
13. Klaes R., Friedrich T., Spitkovsky D., et al. Overexpression of p16(INK4A) as a specific marker for dysplastic and neoplastic epithelial cells of the cervix uteri. Int J Cancer 92 (2001) 276-284
14. Negri G., Egarter-Vigl E., Kasal A., Romano F., Haitel A., and Mian C. p16INK4a is a useful marker for the diagnosis of adenocarcinoma of the cervix uteri and its precursors: an immunohistochemical study with immunocytochemical correlations. Am J Surg Pathol 27 (2003) 187-193
15. Ozalp S.S., Yalcin O.T., Tanir H.M., Dundar E., and Yildirim S. Bcl-2 expression in preinvasive and invasive cervical lesions. Eur J Gynaecol Oncol 23 (2002) 419-422
16. Kong C.S., Balzer B.L., Troxell M.L., Patterson B.K., and Longacre T.A. p16INK4A immunohistochemistry is superior to HPV in situ hybridization for the detection of high-risk HPV in atypical squamous metaplasia. Am J Surg Pathol 31 (2007) 33-43
17. Ordi J., Alonso I., Torne A., et al. Human papillomavirus load in Hybrid Capture II assay: does increasing the cutoff improve the test?. Gynecol Oncol 99 (2005) 313-319
18. Hariri J., and Oster A. The negative predictive value of p16INK4a to assess the outcome of cervical intraepithelial neoplasia 1 in the uterine cervix. Int J Gynecol Pathol 26 (2007) 223-228
19. Negri G., Vittadello F., Romano F., et al. p16INK4a expression and progression risk of low-grade intraepithelial neoplasia of the cervix uteri. Virchows Arch 445 (2004) 616-620
20. Agoff S.N., Lin P., Morihara J., Mao C., Kiviat N.B., and Koutsky L.A. p16(INK4a) expression correlates with degree of cervical neoplasia: a comparison with Ki-67 expression and detection of high-risk HPV types. Mod Pathol 16 (2003) 665-673
21. Schorge J.O., Lea J.S., Elias K.J., et al. P16 as a molecular biomarker of cervical adenocarcinoma. Am J Obstet Gynecol 190 (2004) 668-673
22. Tringler B., Gup C.J., Singh M., et al. Evaluation of p16INK4a and pRb expression in cervical squamous and glandular neoplasia. Hum Pathol 35 (2004) 689-696
23. Santos M., Montagut C., Mellado B., et al. Immunohistochemical staining for p16 and p53 in premalignant and malignant epithelial lesions of the vulva. Int J Gynecol Pathol 23 (2004) 206-214
24. Santos M., Landolfi S., Olivella A., et al. p16 overexpression identifies HPV-positive vulvar squamous cell carcinomas. Am J Surg Pathol 30 (2006) 1347-1356
25. Rubin M.A., Kleter B., Zhou M., et al. Detection and typing of human papillomavirus DNA in penile carcinoma: evidence for multiple independent pathways of penile carcinogenesis. Am J Pathol 159 (2001) 1211-1218
26. Lu D.W., El-Mofty S.K., and Wang H.L. Expression of p16, Rb, and p53 proteins in squamous cell carcinomas of the anorectal region harboring human papillomavirus DNA. Mod Pathol 16 (2003) 692-699
27. Klussmann J.P., Weissenborn S.J., Wieland U., et al. Human papillomavirus-positive tonsillar carcinomas: a different tumor entity?. Med Microbiol Immunol 192 (2003) 129-132
28. El-Mofty S.K., and Lu D.W. Prevalence of high-risk human papillomavirus DNA in nonkeratinizing (cylindrical cell) carcinoma of the sinonasal tract: a distinct clinicopathologic and molecular disease entity. Am J Surg Pathol 29 (2005) 1367-1372
29. Guimaraes M.C., Goncalves M.A., Soares C.P., Bettini J.S., Duarte R.A., and Soares E.G. Immunohistochemical expression of p16INK4a and bcl-2 according to HPV type and to the progression of cervical squamous intraepithelial lesions. J Histochem Cytochem 53 (2005) 509-516
30. Guo M., Hu L., Baliga M., He Z., and Hughson M.D. The predictive value of p16(INK4a) and hybrid capture 2 human papillomavirus testing for high-grade cervical intraepithelial neoplasia. Am J Clin Pathol 122 (2004) 894-901
31. Hu L., Guo M., He Z., Thornton J., McDaniel L.S., and Hughson M.D. Human papillomavirus genotyping and p16INK4a expression in cervical intraepithelial neoplasia of adolescents. Mod Pathol 18 (2005) 267-273
32. Klaes R., Benner A., Friedrich T., et al. p16INK4a immunohistochemistry improves interobserver agreement in the diagnosis of cervical intraepithelial neoplasia. Am J Surg Pathol 26 (2002) 1389-1399
33. Hilfrich R., and Hariri J. Prognostic relevance of human papillomavirus L1 capsid protein detection within mild and moderate dysplastic lesions of the cervix uteri in combination with p16 biomarker. Anal Quant Cytol Histol 30 (2008) 78-82
34. Negri G., Bellisano G., Zannoni G.F., et al. p16 ink4a and HPV L1 immunohistochemistry is helpful for estimating the behavior of low-grade dysplastic lesions of the cervix uteri. Am J Surg Pathol 32 (2008) 1715-1720
35. Youkeles L., Forsythe A.B., and Stern E. Evaluation of Papanicolaou smear and effect of sample biopsy in follow-up of cervical dysplasia. Cancer Res 36 (1976) 2080-2084