NMDA receptor antagonists potently suppress the spontaneous withdrawal signs induced by discontinuation of long-term diazepam treatment in Fischer 344 rats

Brain Research

Volumn 790, Issue 1-2, 1998, Pages 82-90

  Tsuda, Makoto ^a   Suzuki, Tsutomu ^a   Misawa, Miwa ^a  

^a HOSHI UNIVERSITY   (Japan)

Author keywords

Dizocilpine; Drug admixed food (DAF) method; Fischer 344 rat; Ifenprodil; Long term diazepam treatment; Spontaneous diazepam withdrawal

Indexed keywords

CHLORIDE CHANNEL; DIAZEPAM; DIZOCILPINE; IFENPRODIL; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DRUG EFFECT; DRUG POTENCY; DRUG RECEPTOR BINDING; NEUROTRANSMITTER RELEASE; NONHUMAN; POSTSYNAPTIC INHIBITION; PRIORITY JOURNAL; RAT; RECEPTOR AFFINITY; WEIGHT REDUCTION; WITHDRAWAL REFLEX;

ADMINISTRATION, ORAL; ANIMALS; ANOREXIA; ANTI-ANXIETY AGENTS; BEHAVIOR, ANIMAL; DIAZEPAM; DIZOCILPINE MALEATE; EATING; EMOTIONS; EXCITATORY AMINO ACID ANTAGONISTS; MALE; MOTOR ACTIVITY; PIPERIDINES; RATS; RATS, INBRED F344; RECEPTORS, N-METHYL-D-ASPARTATE; SUBSTANCE WITHDRAWAL SYNDROME; TIME FACTORS; WEIGHT LOSS;

EID: 0032550205     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(98)00052-3     Document Type: Article

References (63)

1. A receptor-operated chloride channel, J. Pharmacol. Exp. Ther. 261 (1992) 395-402.
2. 3 receptor ligands following chronic diazepam treatment?, Psychopharmacology 108 (1992) 333-337.
3. G.A. Burns, R.C. Ritter, The non-competitive NMDA antagonist MK-801 increases food intake in rats, Pharmacol. Biochem. Behav. 56 (1997) 145-149.
4. C. Carter, J. Benavides, C. Dana, H. Schoemaker, G. Perrault, D. Sanger, B. Scatton, Non-competitive NMDA receptor antagonist acting on the polyamine site, in: B.S. Meldrum (Ed.), Excitatory Amino Acid Antagonists, Blackwell, Oxford, 1991, pp. 130-163.
5. 3H]dopamine release from mesencephalic cell cultures, Eur. J. Pharmacol. 264 (1994) 361-369.
6. B.L. Chenard, J. Bordner, T.W. Butler, L.K. Chambers, M.A. Collins, D.L. De Costa, M.F. Ducat, M.L. Dumont, C.B. Fox, E.E. Mena, F.S. Menniti, J. Nielsen, M.J. Pagnozzi, K.E.G. Richter, R.T. Ronau, I.A. Shalaby, J.Z. Stemple, W.F. White, (1S,2S)-1-(4-hydroxyphenyl)-2-hydroxy-4-phenylpiperidino)-1-propanol: a potent new neuroprotectant which blocks N-methyl-D-aspartate responses, J. Med. Chem. 38 (1995) 3138-3145.
7. M.G. Corda, M. Orlandi, D. Lecca, O. Giorgi, Decrease in gabaergic function induced by pentylenetetrazol kindling in rats: antagonism by MK-801, J. Pharmacol. Exp. Ther. 262 (1992) 792-800.
8. B. Costall, B.J. Jones, M.E. Kelly, R.J. Naylor, N.R. Oakley, E. Onaivi, M.B. Tyers, The effects of ondansetron (GR38032F) in rats and mice treated subchronically with diazepam, Pharmacol. Biochem. Behav. 34 (1989) 769-778.
9. S.J. Dolin, T.L. Patch, M. Rabbani, R.J. Siarey, A.R. Bowhay, H.J. Little, Nitrendipine decreases benzodiazepine withdrawal seizure but not the development of benzodiazepine tolerance or withdrawal signs, Br. J. Pharmacol. 101 (1990) 691-697.
10. O. Giorgi, M. Orlandi, D. Lecca, M. Corda, MK-801 prevents chemical kindling induced by pentylenetetrazol in rats, Eur. J. Pharmacol. 193 (1991) 363-365.
11. 3 antagonist GR38032F (ondansetron) on benzodiazepine withdrawal in rats, Eur. J. Pharmacol. 185 (1990) 179-186.
12. 1A agonist ipsapirone in rats and of its effects on benzodiazepine withdrawal, Psychopharmacology 103 (1991) 529-537.
13. B antagonist L-365, 260 on benzodiazepine withdrawal-induced hypophagia in rats, Psychopharmacology 118 (1995) 57-64.
14. A.J. Goudie, A.A. Harrison, M.J. Leathley, Evidence for a dissociation between benzodiazepine withdrawal signs, NeuroReport 4 (1993) 295-298.
15. K.A. Grant, P. Valverius, M. Hudspith, B. Tabakoff, Ethanol withdrawal seizure and the NMDA receptor complex, Eur. J. Pharmacol. 176 (1990) 286-296.
16. S.J. Grant, M.P. Galloway, R. Mayor, J.P. Fenerty, M.F. Finkelstein, R.H. Roth, D.E. Redmond Jr., Precipitated diazepam withdrawal elevates noradrenergic metabolism in primate brain, Eur. J. Pharmacol. 107 (1985) 127-132.
17. 2+ influx into cell stably expressing recombinant human NMDA receptors by ligands acting at distinct recognition sites, J. Neurochem. 66 (1996) 2589-2595.
18. K. Gulya, K.A. Grant, P. Valverius, P.L. Hoffman, B. Tabakoff, Brain regional specificity and time-course of changes in the NMDA receptor-ionophore complex during ethanol withdrawal, Brain Res. 547 (1991) 129-134.
19. D.C. Javitt, S.R. Zukin, Recent advances in the phencyclidine model of schizophrenia, Am. J. Psychiatry 148 (1991) 1301-1308.
20. 3H](+)-3-PPP-labeled σ binding sites in guinea pig brain membranes, Eur. J. Pharmacol. 176 (1990) 247-248.
21. J. Kotlinska, S. Liljequist, Oral administration of glycine and polyamine receptor antagonists blocks ethanol withdrawal seizures, Psychopharmacology 127 (1996) 238-244.
22. J. Kunchandy, S.K. Kulkarni, Reversal by alpha-2 agonists of diazepam withdrawal hyperactivity in rats, Psychopharmacology 90 (1986) 198-202.
23. T. Kutsuwada, N. Kashiwabuti, H. Mori, K. Sakimura, E. Kushiya, K. Araki, H. Meguro, H. Masaki, T. Kumanishi, M. Arakawa, M. Mishina, Molecular diversity of the NMDA receptor channel, Nature 358 (1992) 36-41.
24. D.J. Laurie, P.H. Seeburg, Ligand affinities at recombinant N-methyl-D-aspartate receptors depend on subunit composition, Eur. J. Pharmacol. 268 (1994) 335-345.
25. S. Liljequist, Genetic differences in the effects of competitive and non-competitive NMDA receptor antagonists on locomotor activity in mice, Psychopharmacology 104 (1991) 17-21.
26. R. Lister, D.J. Nutt, Mice and rats are sensitized to the proconvulsant action of a benzodiazepine-receptor inverse agonist (FG 7142) following a single dose of lorazepam, Brain Res. 379 (1986) 364-366.
27. H.J. Little, R. Gale, N. Sellars, D.J. Nutt, S.C. Taylor, Chronic benzodiazepine treatment increases the effects of the inverse agonist FG7142, Neuropharmacology 27 (1988) 383-389.
28. W. Löscher, D. Hönack, The behavioral effects of MK-801 in rats: involvement of dopaminergic, serotonergic and noradrenargic systems, Eur. J. Pharmacol. 215 (1992) 199-208.
29. A /benzodiazepine receptor heterogeneity: neurophysiological implications, Neuropharmacology 34 (1995) 245-254.
30. C.J. McBain, M.L. Mayer, N-Methyl-D-aspartate receptor structure and function, Physiol. Rev. 74 (1994) 723-760.
31. 3 receptor, Neuropharmacology 34 (1995) 621-629.
32. H. Meguro, H. Mori, K. Araki, E. Kushiya, T. Kutsuwada, M. Yamazaki, T. Kumanishi, M. Arakawa, K. Sakimura, M. Mishina, Functional characterization of a heteromeric NMDA receptor channel expressed from cloned cDNA, Nature 357 (1992) 70-74.
33. A receptor complex binding and function, J. Pharmacol. Exp. Ther. 246 (1988) 176-182.
34. H. Mizoguchi, T. Suzuki, M. Misawa, Effects of serotonergic anxiolytics on physical dependence on diazepam in mice, Neurosci. Lett. 160 (1993) 41-44.
35. H. Mizoguchi, N. Shirayama, M. Tsuda, M. Yoshiike, T. Suzuki, M. Misawa, Potentiation of physical dependence on diazepam by ondansetron in rats, Life Sci. 54 (1994) 131-136.
36. P.B. Molinoff, K. Williams, D.B. Pritchett, J. Zhong, Molecular pharmacology of NMDA receptors: modulatory role of NR2 subunits, Prog. Brain Res. 100 (1994) 39-45.
37. D.J. Nutt, M.J. Costello, Rapid induction of lorazepam dependence and reversal with flumazenil, Life Sci. 43 (1988) 1045-1053.
38. S. Ohkuma, S.H. Chen, M. Katsura, D.Z. Chen, K. Kuriyama, Muscimol prevents neuronal injury induced by NMDA, Jpn. J. Pharmacol. 64 (1994) 125-128.
39. O. Piot, J. Betschart, J.M. Stutzmann, J.C. Blanchard, Cyclopyrrolones, unlike some benzodiazepines, do not induce physical dependence in mice, Neurosci. Lett. 117 (1990) 140-143.
40. M. Rabbani, J. Wright, Q. Butterworth, H.J. Little, Possible involvement of NMDA receptor-mediated transmission in barbiturate physical dependence, Br. J. Pharmacol. 111 (1994) 89-96.
41. A receptor research, Synapse 21 (1995) 189-274.
42. Z.L. Rossetti, S. Carboni, Ethanol withdrawal is associated with increased extracellular glutamate in the rat striatum, Eur. J. Pharmacol. 283 (1995) 177-183.
43. C. Rundfeldt, P. Wlaz, D. Hönack, W. Löscher, Anticonvulsant tolerance and withdrawal characteristics of benzodiazepine receptor ligands in different seizure models in mice. Comparison of diazepam, bretazenil and abecarnil, J. Pharmacol. Exp. Ther. 275 (1995) 693-702.
44. K. Rusmussen, D.R. Helton, J.E. Berger, E. Scearce, The CCK-B antagonist LY288513 blocks effects of diazepam withdrawal on auditory startle, NeuroReport 5 (1993) 154-156.
45. G.P. Ryan, N.R. Boisse, Experimental induction of benzodiazepine tolerance and physical dependence, J. Pharmacol. Exp. Ther. 226 (1983) 100-107.
46. A receptor subtypes, Pharmacol. Rev. 47 (1995) 181-234.
47. A receptors, Trends Pharmacol. Sci. 16 (1995) 162-168.
48. A. Stelzer, N.T. Slater, G. ten Bruggencate, Activation of NMDA receptors blocks GABAergic inhibition in an in vitro model of epilepsy, Nature 326 (1987) 698-701.
49. K.G. Steppuhn, H.H. Schneider, L. Turski, D.N. Stephens, Long-term treatment with abecarnil does not induce diazepam-like dependence in mice, J. Pharmacol. Exp. Ther. 264 (1993) 1395-1400.
50. N.J. Sucher, M. Awobuluyi, Y.B. Choi, S.A. Lipton, NMDA receptors: from genes to channel, Trends Pharmacol. Sci. 17 (1996) 348-355.
51. T. Suzuki, M.S. Lu, H. Motegi, T. Yoshii, M. Misawa, Genetic differences in the development of physical dependence upon diazepam in Lewis and Fischer 344 inbred rat strains, Pharmacol. Biochem. Behav. 43 (1992) 387-393.
52. T. Suzuki, H. Mizoguchi, H. Motegi, H. Awano, M. Misawa, Effects of nifedipine on physical dependence on barbital or diazepam in rats, J. Toxicol. Sci. 20 (1995) 415-425.
53. T. Suzuki, H. Katoh, H. Suzuki, M. Misawa, Effect of ifenprodil on psychic and physical dependence on morphine, Folia Pharmacol. Jpn. 110 (1997) 70.
54. A receptor function, Life Sci. 59 (1996) 1631-1641.
55. M.D. Tricklebank, L. Singh, R.J. Oles, C. Preston, S.D. Iversen, The behavioral effects of MK-801: a comparison with antagonists acting non-competitively and competitively at the NMDA receptor, Eur. J. Pharmacol. 167 (1989) 127-135.
56. M. Tsuda, T. Suzuki, M. Misawa, Role of the NMDA receptor complex in DMCM-induced seizure in mice, NeuroReport 8 (1997) 603-606.
57. M. Tsuda, T. Suzuki, M. Misawa, Recovery of decreased seizure threshold for pentylenetetrazole during diazepam withdrawal by NMDA receptor antagonists, Eur. J. Pharmacol. 324 (1997) 63-66.
58. M. Tsuda, N. Shimizu, Y. Yajima, T. Suzuki, M. Misawa, hypersusceptibility to DMCM-induced seizure during diazepam withdrawal in mice: evidence for upregulation of NMDA receptor, Naunyn-Schmiedeberg's Arch. Pharmacol., (1998) in press.
59. K. Williams, Ifenprodil discriminates subtypes of the N-methyl-D-aspartate receptor: selectivity and mechanisms at recombinant heteromeric receptors, Mol. Pharmacol. 44 (1993) 851-859.
60. K. Williams, S.J. Russell, Y.M. Shen, P.B. Molinoff, Developmental switch in the expression of NMDA receptors occurs in vivo and in vitro, Neuron 10 (1993) 267-278.
61. J.H. Woods, J.L. Katz, G. Winger, Abuse liability of benzodiazepines, Pharmacol. Rev. 39 (1987) 267-277.
62. J.H. Woods, J.L. Katz, G. Winger, Benzodiazepines: use, abuse and consequences, Pharmacol. Rev. 44 (1992) 151-347.
63. S. Yanaura, E. Tagashira, T. Nagase, T. Izumi, Physical dependence liability test of ifenprodil in rats, Folia Pharmacol. Jpn. 74 (1978) 303-316.