Poly(γ-benzyl-l-glutamate)-PEG-alendronate multivalent nanoparticles for bone targeting

International Journal of Pharmaceutics

Volumn 460, Issue 1-2, 2014, Pages 73-82

  De Miguel, Laura ^a   Noiray, Magali ^a   Surpateanu, Georgiana ^b   Iorga, Bogdan I ^b   Ponchel, Gilles ^a  

^a UNIVERSITÉ PARIS SACLAY   (France)

^b INSTITUT DE CHIMIE DES SUBSTANCES NATURELLES   (France)

Author keywords

Adsorption; Bone targeting; Isothermal titration calorimetry; Nanoparticles

Indexed keywords

ALENDRONIC ACID; COPOLYMER; HYDROXYAPATITE; NANOPARTICLE; POLY(GAMMA BENZYL LEVO GLUTAMIC ACID); POLYGLUTAMIC ACID; UNCLASSIFIED DRUG;

ALPHA HELIX; ARTICLE; BINDING AFFINITY; BINDING SITE; BIOCOMPATIBILITY; BIODEGRADABILITY; BONE; CALCIUM BINDING; CHEMICAL INTERACTION; COMPLEX FORMATION; HYDROGEN BOND; ISOTHERM; ISOTHERMAL TITRATION CALORIMETRY; MOLECULAR MODEL; PARTICLE SIZE; POLYMERIZATION; PRIORITY JOURNAL; SIGNAL NOISE RATIO; STOICHIOMETRY; SURFACE PROPERTY; ZETA POTENTIAL;

(1)H NMR; ADSORPTION; ATR; ATTENUATED TOTAL REFLECTION; BENZYL; BLG-NCA; BNZ; BONE TARGETING; CARBOXYLIC ACID; CDCL(3); CF3COOK; COOH; DCC; DCTB; DEE; DEGREE OF POLYMERIZATION; DEUTERATED CHLOROFORM; DIETHYL ETHER; DIMETHYL SULFOXIDE; DIMETHYLFORMAMIDE; DMF; DMSO; DPN; ETHANOL; ETOH; FITC; FLUORESCEIN ISOTHIOCYANATE; HAP; HYDROXYAPATITE; ISOTHERMAL TITRATION CALORIMETRY; ITC; MALDI-TOF; MATRIX-ASSISTED LASER DESORPTION/IONIZATION TIME-OF-FLIGHT MASS SPECTROMETRY; MEO-PEG5K-NH2; MEOH; METHANOL; N,N′-DICYCLOHEXYLCARBODIIMIDE; N-CARBOXYLIC ANHYDRIDE; N-HYDROXYSUCCINIMIDE; NANOPARTICLES; NCA; NHS; NMR; NUCLEAR MAGNETIC RESONANCE; PBLG; PBS; PEG; PHOSPHATE BUFFER SALINE; POLY(Γ-BENZYL-L-GLUTAMATE); POLYETHYLENE GLYCOL; POTASSIUM TRIFLUOROACETATE; PROTON NUCLEAR MAGNETIC RESONANCE; TEA; TEM; TETRAHYDROFURAN; TFA; THF; TRANS-2-[3-(4-TERT-BUTYLPHENYL)-2-METHYL-2-PROPENYLIDENE]MALONITRILE; TRANSMISSION ELECTRON MICROSCOPY; TRIETHYLAMINE; TRIFLUOROACETIC ACID; ULTRAVIOLET; UV; Α-METHOXY-Ω-AMINO POLY(ETHYLENE GLYCOL)5000, NHSPEG6K-NHS, Α,Ω-BIS-N-HYDROXYSUCCINIMIDE-POLY(ETHYLENE GLYCOL)6000; Γ-BENZYL-L-GLUTAMATE-N-CARBOXYLIC ANHYDRIDE;

ALENDRONATE; BONE AND BONES; BONE DENSITY CONSERVATION AGENTS; DRUG DELIVERY SYSTEMS; DURAPATITE; MODELS, MOLECULAR; NANOPARTICLES; POLYETHYLENE GLYCOLS; POLYGLUTAMIC ACID;

EID: 84888376317     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2013.10.048     Document Type: Article

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