Rescuing Z+ agrin splicing in Nova null mice restores synapse formation and unmasks a physiologic defect in motor neuron firing

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 9, 2009, Pages 3513-3518

  Ruggiu, Matteo ^a,d   Herbst, Ruth ^b,e   Kim, Natalie ^b   Jevsek, Marko ^b,f   Fak, John J ^a   Mann, Mary Anne ^c   Fischbach, Gerald ^c   Burden, Steven J ^b   Darnell, Robert B ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

^b NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Och Spine at New York Presbyterian Hospitals   (United States)

^d NewYork Presbyterian Hospital   (United States)

^e Medical University of Vienna   (Austria)

^f UNIVERSITY OF MARIBOR   (Slovenia)

Author keywords

Alternative splicing; Neuromuscular junction; Neuron activity; Physiology

Indexed keywords

ACETYLCHOLINESTERASE; AGRIN; RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; AUTOIMMUNE DISEASE; CONTROLLED STUDY; ELECTROPHYSIOLOGY; MOTONEURON; MOUSE; NEUROMUSCULAR SYNAPSE; NONHUMAN; NOVA1 GENE; NOVA2 GENE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SYNAPSE; SYNAPTIC TRANSMISSION; TRANSGENE;

AGRIN; ALTERNATIVE SPLICING; AMINO ACID SEQUENCE; ANIMALS; ANTIGENS, NEOPLASM; ELECTROPHYSIOLOGY; EMBRYO, MAMMALIAN; GENE EXPRESSION REGULATION; MICE; MICE, KNOCKOUT; MOLECULAR SEQUENCE DATA; MOTOR NEURON DISEASE; NERVE TISSUE PROTEINS; PROTEIN ISOFORMS; RNA-BINDING PROTEINS; SYNAPSES;

MUS; MUS MUSCULUS;

EID: 62549111005     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0813112106     Document Type: Article

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