Pharmacodynamic interaction of Quercetin with Silymarin against paracetamol induced hepatotoxicity in rats

International Journal of Pharmacy and Pharmaceutical Sciences

Volumn 5, Issue SUPPL.4, 2013, Pages 104-106

  Jashitha, M ^a   Chakraborty, M ^a   Kamath, J V ^a  

^a Shree Devi college of Pharmacy   (India)

Author keywords

Hepatoprotective; Histopathology; Paracetamol; Quercetin; Retro orbital puncture; Silymarin

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; PARACETAMOL; QUERCETIN; SILYMARIN; SUCROSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEGRANULATION; DRUG BIOAVAILABILITY; DRUG POTENTIATION; HISTOPATHOLOGY; LIVER INJURY; LIVER PROTECTION; LIVER TOXICITY; LOW DRUG DOSE; NONHUMAN; PHARMACODYNAMICS; RAT;

EID: 84888370931     PISSN: None     EISSN: 09751491     Source Type: Journal    
DOI: None     Document Type: Article

References (11)

1. Sharma J, Gairola S, Gaur RD, Painuli RM. The treatment of jaundice with medicinal plants in indigenous communities of the Sub-Himalayan region of Uttarakhand, India. J Ethnopharmacol. 2012; 143(1): 262-91.
2. Brijesh k Tiwari, R L Khosa. Evaluation of the hepatoprotective and antioxidant effect of Berberis aslatica against experimentally induced liver injury in rats. Int J Pharm Pharm Sci 2010; 2(Suppl 1): 92-7.
3. Flora K, Hahn M, Rosen H, Benner K. Milk thistle (Silybum marianum) for the therapy of liver disease. Am J Gastroenterol 1998; 93: 139-143.
4. Askari G, Ghiasvand R, Feizi A, Ghanadian SM, Karimian J. The effect of quercetin supplementation on selected markers of inflammation and oxidative stress. J Res Med Sci. 2012; 17(7): 637-41.
5. Choi JS, Piao YJ, Kang KW. Effects of quercetin on the bioavailability of doxorubicin in rats: role of CYP3A4 and P-gp inhibition by quercetin. Arch Pharm Res. 2011; 34(4): 607-13.
6. Mazumdar M, Giri S, Giri A. Role of quercetin on mitomycin C induced genotoxicity: analysis of micronucleus and chromosome aberrations in vivo. Mutat Res. 2011; 721(2): 147-52.
7. El-Awady el-SE, Moustafa YM, Abo-Elmatty DM, Radwan A. Cisplatin-induced cardiotoxicity: Mechanisms and cardioprotective strategies. Eur J Pharmacol. 2011; 650(1): 335-41.
8. Anbarasu C, Rajkapoor B, Bhat K, Giridharan J, Amuthan AA, Satish K. Protective effect of Pisonia aculeata on thioacetamide induced hepatotoxicity in rats. Asian Pac J Trop Biomed. 2012; 2(7): 511-5.
9. Ramachandra S, Ahmed A, Swamy V, Patil T, Prakash T, Prabhu k et al. Hepatoprotective activity of Calotropis procera flowers against paracetamol induced hepatic injury in rats. Fitoterapia 2007; 78: 451-4.
10. Price VF, Miller MG, Jollow DJ. Mechanism of fasting induced potentiation of acetaminophen hepatotoxicity in rat. Biochem Pharmacol 1987; 36(4): 427-33.
11. Navdeep Singh Sandhu, Divneet Chopra, Sarabjit Kaur. Amelioration of paracetamol induced hepatotoxicity by a protein isolated from the leaves of the herb Cajanus acutifolius Linn. Int J Pharm Pharm Sci 2010; 2(3): 75-80.