HCV NS3 protease enhances liver fibrosis via binding to and activating TGF-β type i receptor

Scientific Reports

Volumn 3, Issue , 2013, Pages

  Sakata, Kotaro ^a,b,c   Hara, Mitsuko ^a   Terada, Takaho ^a,d   Watanabe, Noriyuki ^e   Takaya, Daisuke ^a,d   Yaguchi, So Ichi ^d   Matsumoto, Takehisa ^a,d   Matsuura, Tomokazu ^f   Shirouzu, Mikako ^a,d   Yokoyama, Shigeyuki ^a,d   Yamaguchi, Tokio ^d   Miyazawa, Keiji ^f   Aizaki, Hideki ^e   Suzuki, Tetsuro ^f   Wakita, Takaji ^e   Imoto, Masaya ^b   Kojima, Soichi ^a  

^a RIKEN   (Japan)

^b KEIO UNIVERSITY   (Japan)

^c WAKUNAGA PHARMACEUTICAL CO LTD   (Japan)

^d Institute of Physical and Chemical Research   (Japan)

^e NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

^f JIKEI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; COLLAGEN TYPE 1; NS3 PROTEIN, HEPATITIS C VIRUS; PROTEIN SERINE THREONINE KINASE; TGF-BETA TYPE I RECEPTOR; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA2; TUMOR NECROSIS FACTOR ALPHA; VIRUS PROTEIN;

AMINO ACID SEQUENCE; ANIMAL; BINDING SITE; CELL LINE; CHEMISTRY; ENZYMOLOGY; GENETICS; HEK293 CELL LINE; HEPACIVIRUS; HUMAN; IMMUNOLOGY; LIVER CIRRHOSIS; METABOLISM; MOLECULAR DOCKING; MOLECULAR GENETICS; MOUSE; PATHOLOGY; PROTEIN TERTIARY STRUCTURE; SCID MOUSE; TRANSGENIC MOUSE;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES; BINDING SITES; CELL LINE; COLLAGEN TYPE I; HEK293 CELLS; HEPACIVIRUS; HUMANS; LIVER CIRRHOSIS; MICE; MICE, SCID; MICE, TRANSGENIC; MOLECULAR DOCKING SIMULATION; MOLECULAR SEQUENCE DATA; PROTEIN STRUCTURE, TERTIARY; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA2; TUMOR NECROSIS FACTOR-ALPHA; VIRAL NONSTRUCTURAL PROTEINS;

EID: 84888358608     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep03243     Document Type: Article

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