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Volumn 27, Issue 6, 2013, Pages 783-793

Determination of human chorionic gonadotropin

Author keywords

epitopes; hCG; hCG ; hCG cf; human chorionic gonadotropin; preeclampsia; pregnancy test; testicular cancer; trophoblastic cancer

Indexed keywords

CHORIONIC GONADOTROPIN; CHORIONIC GONADOTROPIN BETA SUBUNIT; EPITOPE; TUMOR MARKER;

EID: 84888353594     PISSN: 1521690X     EISSN: 15321908     Source Type: Journal    
DOI: 10.1016/j.beem.2013.10.005     Document Type: Review
Times cited : (41)

References (50)
  • 1
    • 33750218125 scopus 로고    scopus 로고
    • The classification, functions and clinical use of different isoforms of HCG
    • DOI 10.1093/humupd/dml029
    • U.H. Stenman, A. Tiitinen, and H. Alfthan The classification, functions and clinical use of different isoforms of hCG Hum Reprod Update 12 2006 769 784 (Pubitemid 44605514)
    • (2006) Human Reproduction Update , vol.12 , Issue.6 , pp. 769-784
    • Stenman, U.-H.1    Tiitinen, A.2    Alfthan, H.3    Valmu, L.4
  • 2
    • 3042600899 scopus 로고    scopus 로고
    • Human chorionic gonadotropin in cancer
    • DOI 10.1016/j.clinbiochem.2004.05.008, PII S0009912004001274
    • U.H. Stenman, H. Alfthan, and K. Hotakainen Human chorionic gonadotropin in cancer Clin Biochem 37 2004 549 561 (Pubitemid 38845018)
    • (2004) Clinical Biochemistry , vol.37 , Issue.7 , pp. 549-561
    • Stenman, U.-H.1    Alfthan, H.2    Hotakainen, K.3
  • 3
    • 0023116880 scopus 로고
    • Serum levels of human chorionic gonadotropin in nonpregnant women and men are modulated by gonadotropin-releasing hormone and sex steroids
    • U.H. Stenman, H. Alfthan, and T. Ranta Serum levels of human chorionic gonadotropin in nonpregnant women and men are modulated by gonadotropin- releasing hormone and sex steroids J Clin Endocrinol Metab 64 1987 730 736 (Pubitemid 17044540)
    • (1987) Journal of Clinical Endocrinology and Metabolism , vol.64 , Issue.4 , pp. 730-736
    • Stenman, U.-H.1    Alfthan, H.2    Ranta, T.3
  • 4
    • 67650077148 scopus 로고    scopus 로고
    • False-negative results in point-of-care qualitative human chorionic gonadotropin (hCG) devices due to excess hcgbeta core fragment
    • A.M. Gronowski, M. Cervinski, and U.H. Stenman False-negative results in point-of-care qualitative human chorionic gonadotropin (hCG) devices due to excess hcgbeta core fragment Clin Chem 55 2009 1389 1394
    • (2009) Clin Chem , vol.55 , pp. 1389-1394
    • Gronowski, A.M.1    Cervinski, M.2    Stenman, U.H.3
  • 5
    • 0031196046 scopus 로고    scopus 로고
    • Carbohydrate and Peptide Structure of the α- and β-Subunits of Human Chorionic Gonadotropin from Normal and Aberrant Pregnancy and Choriocarcinoma
    • M.M. Elliott, A. Kardana, and J.W. Lustbader Carbohydrate and peptide structure of the alpha- and beta-subunits of human chorionic gonadotropin from normal and aberrant pregnancy and choriocarcinoma Endocrine 7 1997 15 32 (Pubitemid 127483081)
    • (1997) Endocrine , vol.7 , Issue.1 , pp. 15-32
    • Elliott, M.M.1    Kardana, A.2    Lustbader, J.W.3    Cole, L.A.4
  • 7
    • 33751383272 scopus 로고    scopus 로고
    • Site-specific glycan analysis of human chorionic gonadotropin β-subunit from malignancies and pregnancy by liquid chromatography - Electrospray mass spectrometry
    • DOI 10.1093/glycob/cwl034
    • L. Valmu, H. Alfthan, and K. Hotakainen Site-specific glycan analysis of human chorionic gonadotropin beta-subunit from malignancies and pregnancy by liquid chromatography-electrospray mass spectrometry Glycobiology 16 2006 1207 1218 (Pubitemid 44811584)
    • (2006) Glycobiology , vol.16 , Issue.12 , pp. 1207-1218
    • Valmu, L.1    Alfthan, H.2    Hotakainen, K.3    Birken, S.4    Stenman, U.-H.5
  • 9
    • 11144348654 scopus 로고    scopus 로고
    • Establishment, value assignment, and characterization of new WHO reference reagents for six molecular forms of human chorionic gonadotropin
    • DOI 10.1373/clinchem.2004.038679
    • A. Bristow, P. Berger, and J.M. Bidart Establishment, value assignment, and characterization of new who reference reagents for six molecular forms of human chorionic gonadotropin Clin Chem 51 2005 177 182 (Pubitemid 40024028)
    • (2005) Clinical Chemistry , vol.51 , Issue.1 , pp. 177-182
    • Bristow, A.1    Berger, P.2    Bidart, J.-M.3    Birken, S.4    Norman, R.5    Stenman, U.-H.6    Sturgeon, C.7
  • 11
    • 68149169590 scopus 로고    scopus 로고
    • Differences in recognition of the 1st who international reference reagents for hCG-related isoforms by diagnostic immunoassays for human chorionic gonadotropin
    • C.M. Sturgeon, P. Berger, and J.M. Bidart Differences in recognition of the 1st who international reference reagents for hCG-related isoforms by diagnostic immunoassays for human chorionic gonadotropin Clin Chem 55 2009 1484 1491
    • (2009) Clin Chem , vol.55 , pp. 1484-1491
    • Sturgeon, C.M.1    Berger, P.2    Bidart, J.M.3
  • 12
    • 77957258102 scopus 로고    scopus 로고
    • Differences in total human chorionic gonadotropin immunoassay analytical specificity and ability to measure human chorionic gonadotropin in gestational trophoblastic disease and germ cell tumors
    • R.A. Harvey, H.D. Mitchell, and U.H. Stenman Differences in total human chorionic gonadotropin immunoassay analytical specificity and ability to measure human chorionic gonadotropin in gestational trophoblastic disease and germ cell tumors J Reprod Medicine 55 2010 285 295
    • (2010) J Reprod Medicine , vol.55 , pp. 285-295
    • Harvey, R.A.1    Mitchell, H.D.2    Stenman, U.H.3
  • 13
    • 0023711893 scopus 로고
    • Structure of the human chorionic gonadotropin beta-subunit fragment from pregnancy urine
    • S. Birken, E.G. Armstrong, and M.A. Kolks Structure of the human chorionic gonadotropin beta-subunit fragment from pregnancy urine Endocrinology 123 1988 572 583
    • (1988) Endocrinology , vol.123 , pp. 572-583
    • Birken, S.1    Armstrong, E.G.2    Kolks, M.A.3
  • 15
    • 0036124932 scopus 로고    scopus 로고
    • The ISOBM TD-7 Workshop on hCG and related molecules: Towards user-oriented standardization of pregnancy and tumor diagnosis: Assignment of epitopes to the three-dimensional structure of diagnostically and commercially relevant monoclonal antibodies directed against human chorionic gonadotropin and derivatives
    • DOI 10.1159/000048686
    • P. Berger, C. Sturgeon, and J.M. Bidart The ISOBM TD-7 workshop on hCG and related molecules. Towards user-oriented standardization of pregnancy and tumor diagnosis: assignment of epitopes to the three-dimensional structure of diagnostically and commercially relevant monoclonal antibodies directed against human chorionic gonadotropin and derivatives Tumour Biol 23 2002 1 38 (Pubitemid 34225019)
    • (2002) Tumor Biology , vol.23 , Issue.1 , pp. 1-38
    • Berger, P.1    Sturgeon, C.2    Bidart, J.M.3    Paus, E.4    Gerth, R.5    Niang, M.6    Bristow, A.7    Birken, S.8    Stenman, U.H.9
  • 16
    • 0020602131 scopus 로고
    • Ultrarapid and highly sensitive time-resolved fluoroimmunometric assay for chorionic gonadotropin
    • U.H. Stenman, H. Alfthan, and L. Myllynen Ultrarapid and highly sensitive time-resolved fluoroimmunometric assay for chorionic gonadotropin Lancet 2 1983 647 649 (Pubitemid 13003485)
    • (1983) Lancet , vol.2 , Issue.8351 , pp. 647-649
    • Stenman, U.H.1    Myllynen, L.2    Alfthan, H.3    Seppala, M.4
  • 17
    • 0020680639 scopus 로고
    • Time-resolved fluoroimmunoassay of human choriogonadotropin
    • K. Pettersson, H. Siitari, and I. Hemmila Time-resolved fluoroimmunoassay of human choriogonadotropin Clin Chem 29 1983 60 64 (Pubitemid 13167621)
    • (1983) Clinical Chemistry , vol.29 , Issue.1 , pp. 60-64
    • Pettersson, K.1    Siitari, H.2    Hemmila, I.3
  • 18
    • 0015509601 scopus 로고
    • A radioimmunoassay which specifically measures human chorionic gonadotropin in the presence of human luteinizing hormone
    • J.L. Vaitukaitis, G.D. Braunstein, and G.T. Ross A radioimmunoassay which specifically measures human chorionic gonadotropin in the presence of human luteinizing hormone Am J Obstet Gynecol 113 1972 751 758
    • (1972) Am J Obstet Gynecol , vol.113 , pp. 751-758
    • Vaitukaitis, J.L.1    Braunstein, G.D.2    Ross, G.T.3
  • 19
    • 0026675258 scopus 로고
    • Elevation of free beta subunit of human choriogonadotropin and core beta fragment of human choriogonadotropin in the serum and urine of patients with malignant pancreatic and biliary disease
    • H. Alfthan, C. Haglund, and P. Roberts Elevation of free beta subunit of human choriogonadotropin and core beta fragment of human choriogonadotropin in the serum and urine of patients with malignant pancreatic and biliary disease Cancer Res 52 1992 4628 4633
    • (1992) Cancer Res , vol.52 , pp. 4628-4633
    • Alfthan, H.1    Haglund, C.2    Roberts, P.3
  • 21
    • 0000003614 scopus 로고
    • An immunological pregnancy test
    • L. Wide, and C.A. Gemzell An immunological pregnancy test Acta Endocrinologica 35 1960 261 267
    • (1960) Acta Endocrinologica , vol.35 , pp. 261-267
    • Wide, L.1    Gemzell, C.A.2
  • 22
    • 0022271439 scopus 로고
    • ImmunoConcentration(TM) a new format for solid-phase immunoassays
    • G.E. Valkirs, and R. Barton Immunoconcentration-a new format for solid-phase immunoassays Clin Chem 31 1985 1427 1431 (Pubitemid 16011824)
    • (1985) Clinical Chemistry , vol.31 , Issue.9 , pp. 1427-1431
    • Valkirs, G.E.1    Barton, R.2
  • 23
    • 84888349473 scopus 로고    scopus 로고
    • Candidate epitopes for measurement of hcg and related molecules: The 2nd ISOBM TD-7 workshop
    • [in press]
    • P. Berger, E. Paus, and C. Sturgeon Candidate epitopes for measurement of hcg and related molecules: the 2nd ISOBM TD-7 workshop Tumour Biol 2013 [in press]
    • (2013) Tumour Biol
    • Berger, P.1    Paus, E.2    Sturgeon, C.3
  • 24
    • 0028586148 scopus 로고
    • Immunological recognition and clinical significance of nicked human chorionic gonadotropin in testicular cancer
    • R. Hoermann, P. Berger, and G. Spoettl Immunological recognition and clinical significance of nicked human chorionic gonadotropin in testicular cancer Clin Chem 40 1994 2306 2312
    • (1994) Clin Chem , vol.40 , pp. 2306-2312
    • Hoermann, R.1    Berger, P.2    Spoettl, G.3
  • 25
    • 84899117135 scopus 로고    scopus 로고
    • Epitope analysis and detection of human chorionic gonadotropin (hCG) variants by monoclonal antibodies and mass spectrometry
    • [Epub ahead of print]
    • H. Lund, E. Paus, and P. Berger Epitope analysis and detection of human chorionic gonadotropin (hCG) variants by monoclonal antibodies and mass spectrometry Tumour Biol 2013 Sep 7 [Epub ahead of print]
    • (2013) Tumour Biol
    • Lund, H.1    Paus, E.2    Berger, P.3
  • 26
    • 18344364663 scopus 로고    scopus 로고
    • Differential expression of human chorionic gonadotropin (hCG) glycosylation isoforms in failing and continuing pregnancies: Preliminary characterization of the hyperglycosylated hCG epitope
    • DOI 10.1677/joe.0.1720497
    • G. Kovalevskaya, S. Birken, and T. Kakuma Differential expression of human chorionic gonadotropin (hCG) glycosylation isoforms in failing and continuing pregnancies: preliminary characterization of the hyperglycosylated hCG epitope J Endocrinol 172 2002 497 506 (Pubitemid 34232691)
    • (2002) Journal of Endocrinology , vol.172 , Issue.3 , pp. 497-506
    • Kovalevskaya, G.1    Birken, S.2    Kakuma, T.3    Ozaki, N.4    Sauer, M.5    Lindheim, S.6    Cohen, M.7    Kelly, A.8    Schlatterer, J.9    O'Connor, J.F.10
  • 27
    • 0035136811 scopus 로고    scopus 로고
    • Utility of commonly used commercial human chorionic gonadotropin immunoassays in the diagnosis and management of trophoblastic diseases
    • L.A. Cole, S. Shahabi, and S.A. Butler Utility of commonly used commercial human chorionic gonadotropin immunoassays in the diagnosis and management of trophoblastic diseases Clin Chem 47 2001 308 315 (Pubitemid 32142930)
    • (2001) Clinical Chemistry , vol.47 , Issue.2 , pp. 308-315
    • Cole, L.A.1    Shahabi, S.2    Butler, S.A.3    Mitchell, H.4    Newlands, E.S.5    Behrman, H.R.6    Verrill, H.L.7
  • 28
    • 0036065722 scopus 로고    scopus 로고
    • Serum HCG 12 days after embryo transfer in predicting pregnancy outcome
    • P. Poikkeus, V. Hiilesmaa, and A. Tiitinen Serum hCG 12 days after embryo transfer in predicting pregnancy outcome Hum Reprod 17 2002 1901 1905 (Pubitemid 34790318)
    • (2002) Human Reproduction , vol.17 , Issue.7 , pp. 1901-1905
    • Poikkeus, P.1    Hiilesmaa, V.2    Tiitinen, A.3
  • 29
    • 84858159137 scopus 로고    scopus 로고
    • Hyperglycosylated hcg and pregnancy failures
    • L.A. Cole Hyperglycosylated hcg and pregnancy failures J Reprod Immunol 93 2012 119 122
    • (2012) J Reprod Immunol , vol.93 , pp. 119-122
    • Cole, L.A.1
  • 30
    • 33947266381 scopus 로고    scopus 로고
    • Normal production of human chorionic gonadotropin in menopause [21]
    • DOI 10.1056/NEJMc066500
    • L.A. Cole, Y. Sasaki, and C.Y. Muller Normal production of human chorionic gonadotropin in menopause New Engl J Med 356 2007 1184 1186 (Pubitemid 46425625)
    • (2007) New England Journal of Medicine , vol.356 , Issue.11 , pp. 1184-1186
    • Cole, L.A.1    Sasaki, Y.2    Muller, C.Y.3
  • 31
    • 34547638085 scopus 로고    scopus 로고
    • Increased human chorionic gonadotropin due to hypogonadism after treatment of a testicular seminoma [7]
    • DOI 10.1373/clinchem.2007.088518
    • A. Lempiainen, K. Hotakainen, and C. Blomqvist Increased human chorionic gonadotropin due to hypogonadism after treatment of a testicular seminoma Clin Chem 53 2007 1560 1561 (Pubitemid 47206362)
    • (2007) Clinical Chemistry , vol.53 , Issue.8 , pp. 1560-1561
    • Lempiainen, A.1    Hotakainen, K.2    Blomqvist, C.3    Alfthan, H.4    Stenman, U.-H.5
  • 33
    • 0017152619 scopus 로고
    • Serum human chorionic gonadotropin levels throughout normal pregnancy
    • G.D. Braunstein, J. Rasor, and H. Danzer Serum human chorionic gonadotropin levels throughout normal pregnancy Am J Obstet Gynecol 126 1976 678 681
    • (1976) Am J Obstet Gynecol , vol.126 , pp. 678-681
    • Braunstein, G.D.1    Rasor, J.2    Danzer, H.3
  • 34
    • 84864278628 scopus 로고    scopus 로고
    • Early administration of low-dose aspirin for the prevention of severe and mild preeclampsia: A systematic review and meta-analysis
    • S. Roberge, Y. Giguere, and P. Villa Early administration of low-dose aspirin for the prevention of severe and mild preeclampsia: a systematic review and meta-analysis Am J Perinatol 29 2012 551 556
    • (2012) Am J Perinatol , vol.29 , pp. 551-556
    • Roberge, S.1    Giguere, Y.2    Villa, P.3
  • 35
    • 33646485511 scopus 로고    scopus 로고
    • Vascular endothelial growth factor, its receptors, and the tie receptors in the placental bed of women with preeclampsia, diabetes, and intrauterine growth retardation
    • P. Vuorela, and E. Halmesmaki Vascular endothelial growth factor, its receptors, and the tie receptors in the placental bed of women with preeclampsia, diabetes, and intrauterine growth retardation Am J Perinatol 23 2006 255 263
    • (2006) Am J Perinatol , vol.23 , pp. 255-263
    • Vuorela, P.1    Halmesmaki, E.2
  • 36
    • 84886593602 scopus 로고    scopus 로고
    • First trimester hyperglycosylated human chorionic gonadotrophin in serum - A marker of early-onset preeclampsia
    • E. Keikkala, P. Vuorela, and H. Laivuori First trimester hyperglycosylated human chorionic gonadotrophin in serum - a marker of early-onset preeclampsia Placenta 34 2013 1059 1065
    • (2013) Placenta , vol.34 , pp. 1059-1065
    • Keikkala, E.1    Vuorela, P.2    Laivuori, H.3
  • 37
    • 79959768250 scopus 로고    scopus 로고
    • Elimination of complement interference in immunoassay of hyperglycosylated human chorionic gonadotropin
    • U.H. Stenman, S. Birken, and A. Lempiainen Elimination of complement interference in immunoassay of hyperglycosylated human chorionic gonadotropin Clin Chem 57 2011 1075 1077
    • (2011) Clin Chem , vol.57 , pp. 1075-1077
    • Stenman, U.H.1    Birken, S.2    Lempiainen, A.3
  • 38
    • 84864940774 scopus 로고    scopus 로고
    • The sensitivity and specificity of hyperglycosylated hcg (hhCG) levels to reliably diagnose clinical IVF pregnancies at 6 days following embryo transfer
    • C.M. Strom, R. Bonilla-Guererro, and K. Zhang The sensitivity and specificity of hyperglycosylated hcg (hhCG) levels to reliably diagnose clinical IVF pregnancies at 6 days following embryo transfer J Assisted Reprod Genet 29 2012 609 614
    • (2012) J Assisted Reprod Genet , vol.29 , pp. 609-614
    • Strom, C.M.1    Bonilla-Guererro, R.2    Zhang, K.3
  • 39
    • 0022466470 scopus 로고
    • Radioimmunoassay of free β-subunit of human chorionic gonadotropin as a prognostic test for persistent trophoblastic disease in molar pregnancy
    • M.B. Khazaeli, M.M. Hedayat, and K.D. Hatch Radioimmunoassay of free beta-subunit of human chorionic gonadotropin as a prognostic test for persistent trophoblastic disease in molar pregnancy Am J Obstet Gynecol 155 1986 320 324 (Pubitemid 16054866)
    • (1986) American Journal of Obstetrics and Gynecology , vol.155 , Issue.2 , pp. 320-324
    • Khazaeli, M.B.1    Hedayat, M.M.2    Hatch, K.D.3
  • 40
    • 18844429225 scopus 로고    scopus 로고
    • Testicular cancer: The perfect paradigm for marker combinations
    • U.H. Stenman Testicular cancer: the perfect paradigm for marker combinations Scand J Clin Lab Invest 65 2005 181 188
    • (2005) Scand J Clin Lab Invest , vol.65 , pp. 181-188
    • Stenman, U.H.1
  • 41
    • 0014292996 scopus 로고
    • The concentration of hCG in the plasma and spinal fluid of patients with trophoblastic tumours in the central nervous system
    • A.G. Rushworth, A.H. Orr, and K.D. Bagshawe The concentration of hCG in the plasma and spinal fluid of patients with trophoblastic tumours in the central nervous system Br J Cancer 22 1968 253 257
    • (1968) Br J Cancer , vol.22 , pp. 253-257
    • Rushworth, A.G.1    Orr, A.H.2    Bagshawe, K.D.3
  • 42
    • 0011280213 scopus 로고
    • Determination of chorionic gonadotropin in serum of nonpregnant subjects and patients with trophoblastic cancer by time-resolved immunofluorometric assay
    • U.H. Stenman, H. Alfthan, and H. Halila Determination of chorionic gonadotropin in serum of nonpregnant subjects and patients with trophoblastic cancer by time-resolved immunofluorometric assay Tumour Biol 5 1985 97
    • (1985) Tumour Biol , vol.5 , pp. 97
    • Stenman, U.H.1    Alfthan, H.2    Halila, H.3
  • 43
    • 0242349204 scopus 로고    scopus 로고
    • Elevated hCG and a high proportion of hCGβ in serum preceding the diagnosis of trophoblastic disease by seven months
    • DOI 10.1016/S1470-0328(02)00195-7, PII S1470032802001957
    • J. Vartiainen, H. Alfthan, and P. Lehtovirta Elevated hCG and a high proportion of hCG beta in serum preceding the diagnosis of trophoblastic disease by seven months BJOG: An Int J Obstet Gynaecol 109 2002 589 590 (Pubitemid 37338007)
    • (2002) BJOG: An International Journal of Obstetrics and Gynaecology , vol.109 , Issue.5 , pp. 589-590
    • Vartiainen, J.1    Alfthan, H.2    Lehtovirta, P.3    Stenman, U.-H.4
  • 44
    • 0026533499 scopus 로고
    • Free alpha-subunit, free beta-subunit of human chorionic gonadotropin (hcg), and intact hcg in sera of healthy individuals and testicular cancer patients
    • S. Madersbacher, R. Klieber, and K. Mann Free alpha-subunit, free beta-subunit of human chorionic gonadotropin (hcg), and intact hcg in sera of healthy individuals and testicular cancer patients Clin Chem 38 1992 370 376
    • (1992) Clin Chem , vol.38 , pp. 370-376
    • Madersbacher, S.1    Klieber, R.2    Mann, K.3
  • 45
    • 55349090621 scopus 로고    scopus 로고
    • Free beta-subunit of human chorionic gonadotropin in serum is a diagnostically sensitive marker of seminomatous testicular cancer
    • A. Lempiainen, U.H. Stenman, and C. Blomqvist Free beta-subunit of human chorionic gonadotropin in serum is a diagnostically sensitive marker of seminomatous testicular cancer Clin Chem 54 2008 1840 1843
    • (2008) Clin Chem , vol.54 , pp. 1840-1843
    • Lempiainen, A.1    Stenman, U.H.2    Blomqvist, C.3
  • 46
    • 0015540173 scopus 로고
    • Ectopic production of human chorionic gonadotrophin by neoplasms
    • G.D. Braunstein, J.L. Vaitukaitis, and P.P. Carbone Ectopic production of human chorionic gonadotrophin by neoplasms Ann Intern Med 78 1973 39 45
    • (1973) Ann Intern Med , vol.78 , pp. 39-45
    • Braunstein, G.D.1    Vaitukaitis, J.L.2    Carbone, P.P.3
  • 47
    • 0026773430 scopus 로고
    • Free human chorionic gonadotropin beta subunit in gonadal and nongonadal neoplasms
    • I. Marcillac, F. Troalen, and J.M. Bidart Free human chorionic gonadotropin beta subunit in gonadal and nongonadal neoplasms Cancer Res 52 1992 3901 3907
    • (1992) Cancer Res , vol.52 , pp. 3901-3907
    • Marcillac, I.1    Troalen, F.2    Bidart, J.M.3
  • 50
    • 84856371341 scopus 로고    scopus 로고
    • Familial hCG syndrome
    • L.A. Cole Familial hCG syndrome J Reprod Immunol 93 2012 52 57
    • (2012) J Reprod Immunol , vol.93 , pp. 52-57
    • Cole, L.A.1


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