Treatment of allergic inflammation and hyperresponsiveness by a simple compound, Bavachinin, isolated from Chinese herbs

Cellular and Molecular Immunology

Volumn 10, Issue 6, 2013, Pages 497-505

  Chen, Xi ^a   Wen, Ti ^b,c   Wei, Jun ^b   Wu, Zhenzhou ^b   Wang, Puyue ^b   Hong, Zhangyong ^b   Zhao, Liqing ^b   Wang, Bin ^d   Flavell, Richard ^e   Gao, Shumei ^f   Wang, Min ^a   Yin, Zhinan ^b  

^a TIANJIN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b NANKAI UNIVERSITY   (China)

^c CHINA MEDICAL UNIVERSITY   (China)

^d FUDAN UNIVERSITY   (China)

^e YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f TIANJIN UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

Author keywords

asthma; bavachinin; IL 4

Indexed keywords

BAVACHININ; GREEN FLUORESCENT PROTEIN; HERBACEOUS AGENT; INTERLEUKIN 13; INTERLEUKIN 4; INTERLEUKIN 5; MESSENGER RNA; OVALBUMIN; TRANSCRIPTION FACTOR GATA 3; UNCLASSIFIED DRUG;

ALLERGIC ASTHMA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHINESE HERB; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG MECHANISM; FEMALE; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTIC INFILTRATION; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; RNA STABILITY; SENSITIZATION; TH2 CELL;

ANIMALS; ASTHMA; BRONCHIAL HYPERREACTIVITY; CELL DIFFERENTIATION; CYTOKINES; DISEASE MODELS, ANIMAL; DRUGS, CHINESE HERBAL; FEMALE; FLAVONOIDS; GATA3 TRANSCRIPTION FACTOR; HYPERSENSITIVITY; INFLAMMATION; LUNG; MALE; MICE; MICE, INBRED BALB C; RNA STABILITY; RNA, MESSENGER; TH2 CELLS;

EID: 84888336462     PISSN: 16727681     EISSN: None     Source Type: Journal    
DOI: 10.1038/cmi.2013.27     Document Type: Article

References (30)

1. Iwata A, Nishio K, Winn RK, Chi EY, Henderson WR, Harlan JM. A broad-spectrum caspase inhibitor attenuates allergic airway inflammation in murine asthma model. J Immunol 2003; 170: 3386-3391. (Pubitemid 36302218)
2. Rodrigo GJ. Inhaled therapy for acute adult asthma. Curr Opin Allergy Clin Immunol 2003; 3: 169-175. (Pubitemid 36676300)
3. Dhand R. Aerosol therapy for asthma. Curr Opin Pulm Med 2000; 6: 59-70.
4. Whittaker LA, Lauren C. Recent concepts in the pathogenesis and treatment of asthma [obstructive airways disease]. Clin Pulm Med 2002; 9: 135-144. (Pubitemid 34552867)
5. Reich DL, Silvay G. Ketamine: an update on the first twenty five years of clinical experience. Can J Anaesth 1989; 36: 186-197. (Pubitemid 19110402)
6. Youssef-Ahmed MZ, Silver P, Nimkoff L, Sagy M. Continuous infusion of ketamine in mechanically ventilated children with refractory bronchospasm. Intensive Care Med 1996; 22: 972-976. (Pubitemid 26340649)
7. Sarma VJ. Use of ketamine in acute severe asthma. Acta Anaesthesiol Scand 1992; 36: 106-107.
8. Kung TT, Luo B, CrawIey Y, Garlisi CG, Devito K, Minnicozzi M et al. Effect of anti-mIL-9 antibody on the development of pulmonary inflammation and airway hyperresponsiveness in allergic mice. Am J Respir Cell Mol Biol 2001; 25: 600-605. (Pubitemid 33087111)
9. Gavett SH, Madison SL, Stevens MA, Costa DL. Residual oil fly ash amplifies allergic cytokines, airway responsiveness, and inflammation in mice. Am J Respir Crit Care Med 1999; 160: 1897-1904. (Pubitemid 30004693)
10. Morris MJ, Lane DJ. Tidal expiratory flow patterns in airflow obstruction. Thorax 1981; 36: 135-142. (Pubitemid 11147663)
11. McBride JT. Architecture of the tracheobronchial tree. In:Parent RA (ed.)Treatise on Pulmonary Toxicology: Comparative Biology of the Normal Lung. Boca Raton, FL: CRC Press, 1992: 49-61.
12. Bates JH, Irvin CG. Time dependence of recruitment and derec-ruitment in the lung: a theoreticaI modeI. J Appl Physiol 2002; 93: 705-713. (Pubitemid 34810236)
13. Ouyang W, Ranganath SH, Weindel K, Bhattacharya D, Murphy TL, Sha WC et al. Inhibition of Th1 development mediated by GATA-3 through an IL-4-independent mechanism. Immunity 1998; 9: 745-755. (Pubitemid 28557602)
14. Nakamura Y, Ghaffar O, Olivenstein R, Taha RA, Soussi-Gounni A, Zhang DH et al. Gene expression of the GATA-3 transcription factor is increased in atopic asthma. J Allergy Clin Immunol 1999; 103: 215-222. (Pubitemid 29095824)
15. Zhang DH, Yang L, Cohn L, Parkyn L, Homer R, Ray P et al. Inhibition of allergic airway inflammation in a murine model of asthma by expression of a dominant negative mutant of GATA-3. Immunity 1999; 11: 473-482. (Pubitemid 29504202)
16. Ray A, Cohn L. Th2 cells and GATA-3 in asthma: new insights into the regulation of airway inflammation. J Clin Invest 1999; 104: 985-993. (Pubitemid 29536304)
17. Szabo SJ, Sullivan BM, Stemmann C, Satoskar AR, Sleckman BP, Glimcher LH et al. Distinct effects of T-bet in Th1 lineage commitment and IFN-production in CD4 and CD8 T cells. Science 2002; 295: 338-342. (Pubitemid 34074366)
18. Mullen AC, High FA, Hutchins AS, Lee HW, Villarino AV, Livingston DW et al. Role of T-bet in commitment of Th1 cells before IL-12-dependent selection. Science 2001; 292: 1907-1910. (Pubitemid 32538365)
19. 1 T cells. Nat Immunol 2002; 3: 549-557. (Pubitemid 34662307)
20. Nepal M, Choi HJ, Choi BY, Anti-angiogenic and anti-tumor activity of Bavachinin by targeting hypoxia-inducible factor-1a. Eur J Pharmacol 2012; 691: 28-37.
21. Sarada DV, Sangeetha S. Psoralea corylifolia linn. (seeds): a phytochemical review. J Pharm Res 2012; 5: 1694.
22. Veldhoen M, Hirota K, Christensen J, O'Garra A, Stockinger B. Natural agonists for aryl hydrocarbon receptor inculture medium are essential for optimal differentiation ofTh17T cells. J Exp Med 2009; 206: 43-49.
23. Pan M, Kang I, Craft J, Yin Z. Resistance to development of collagen-induced arthritis in C57BL/6 mice is due to a defect in secondary, but not in primary, immune response. J Clin Immunol 2004; 24: 481-491. (Pubitemid 39221666)
24. Yin ZN, Chen CH, Szabo SJ, Glimcher LH, Ray A, Craft J. T-bet expression and failure of GATA-3 cross-regulation lead to default production of IFN-g by gd T cells. J Immunol 2002; 168: 1566-1571. (Pubitemid 34135750)
25. Hitti E, Iakovleva T, Brook M, Deppenmeier S, Gruber AD, Radzioch D et al. Mitogen-activated protein kinase-activated protein kinase 2 regulates tumor necrosis factor mRNA stability and translation mainly by altering tristetraprolin expression, stability, and binding to adenine/uridine-rich element. Mol Cell Biol 2006; 26: 2399-2407. (Pubitemid 43346938)
26. Wen T, Li Y, Wu M, Sun X, Bao X, Liu Y et al. Therapeutic effects of a novel tylophorine analog, NK-007, on collagen-induced arthritis through suppressing tumor necrosis factor a production and Th17 cell differentiation. Arthritis Rheum 2012; 64: 2896-2906.
27. Serre K, Mohr E, Gaspal F, Lane PJ, Bird R, Cunningham AF et al. IL-4 directs both CD4 and CD8 T cells to produce Th2 cytokines in vitro, but only CD4 T cells produce these cytokines in response to alum-precipitated protein in vivo. Mol Immunol 2010; 47: 1914-1922.
28. Ramadas RA, Roche MI, Moon JJ, Ludwig T, Xavier RJ, Medoff BD. CARMA1 is necessary for optimal T cell responses in a murine model of allergic asthma. J Immunol 2011; 187: 6197-6207.
29. Hong Liang, Lee Reinhardt, Jennifer Bando, Brandon Sullivan, Richard Divergent. Expression patterns of IL-4 and IL-13 define unique functions in allergic immunity. Nature Publishing Group 2011; 13: 58-66.
30. Kim SH, Kim, Lee. Antiasthmatic Effects of Hesperidin, a Potential Th2 Cytokine Antagonist, in a Mouse Model of Allergic Asthma. MEDIAT INFLAMM 2011; 2011: 1-12.