메뉴 건너뛰기




Volumn 110, Issue 48, 2013, Pages 19507-19512

Bioavailable copper modulates oxidative phosphorylation and growth of tumors

Author keywords

Cancer metabolism; Mitochondria; Pancreatic neuroendocrine tumor; Tumor energetics; Warburg effect

Indexed keywords

ADENOSINE TRIPHOSPHATE; COPPER; CYTOCHROME C OXIDASE; DRINKING WATER; GLUCOSE; TETRATHIOMOLYBDATE AMMONIUM;

EID: 84888322308     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1318431110     Document Type: Article
Times cited : (311)

References (47)
  • 1
    • 39349112330 scopus 로고    scopus 로고
    • Mechanisms for copper acquisition, distribution and regulation
    • Kim BE, Nevitt T, Thiele DJ (2008) Mechanisms for copper acquisition, distribution and regulation. Nat Chem Biol 4(3): 176-185.
    • (2008) Nat Chem Biol , vol.4 , Issue.3 , pp. 176-185
    • Kim, B.E.1    Nevitt, T.2    Thiele, D.J.3
  • 3
    • 0019416222 scopus 로고
    • Ceruloplasmin assays in diagnosis and treatment of human lung, breast, and gastrointestinal cancers
    • Linder MC, Moor JR,Wright K (1981) Ceruloplasmin assays in diagnosis and treatment of human lung, breast, and gastrointestinal cancers. J Natl Cancer Inst 67(2): 263-275.
    • (1981) J Natl Cancer Inst , vol.67 , Issue.2 , pp. 263-275
    • Linder, M.C.1    Moor, J.R.2    Wright, K.3
  • 4
    • 0345402588 scopus 로고
    • Clinical significance of the blood copper in Hodgkin's disease
    • Pagliardi E, Giangrandi E (1960) Clinical significance of the blood copper in Hodgkin's disease. Acta Haematol 24: 201-212.
    • (1960) Acta Haematol , vol.24 , pp. 201-212
    • Pagliardi, E.1    Giangrandi, E.2
  • 5
    • 0025202925 scopus 로고
    • Inhibition of angiogenesis and tumor growth in the brain. Suppression of endothelial cell turnover by penicillamine and the depletion of copper, an angiogenic cofactor
    • Brem SS, et al. (1990) Inhibition of angiogenesis and tumor growth in the brain. Suppression of endothelial cell turnover by penicillamine and the depletion of copper, an angiogenic cofactor. Am J Pathol 137(5): 1121-1142.
    • (1990) Am J Pathol , vol.137 , Issue.5 , pp. 1121-1142
    • Brem, S.S.1
  • 6
    • 0035073521 scopus 로고    scopus 로고
    • The role of copper suppression as an antiangiogenic strategy in head and neck squamous cell carcinoma
    • Cox C, et al. (2001) The role of copper suppression as an antiangiogenic strategy in head and neck squamous cell carcinoma. Laryngoscope 111(4 Pt 1): 696-701.
    • (2001) Laryngoscope , vol.111 , Issue.4 PART 1 , pp. 696-701
    • Cox, C.1
  • 7
    • 0035892359 scopus 로고    scopus 로고
    • The copper-chelating agent, trientine, suppresses tumor development and angiogenesis in the murine hepatocellular carcinoma cells
    • Yoshii J, et al. (2001) The copper-chelating agent, trientine, suppresses tumor development and angiogenesis in the murine hepatocellular carcinoma cells. Int J Cancer 94(6): 768-773.
    • (2001) Int J Cancer , vol.94 , Issue.6 , pp. 768-773
    • Yoshii, J.1
  • 8
    • 0036733754 scopus 로고    scopus 로고
    • Copper deficiency induced by tetrathiomolybdate suppresses tumor growth and angiogenesis
    • Pan Q, et al. (2002) Copper deficiency induced by tetrathiomolybdate suppresses tumor growth and angiogenesis. Cancer Res 62(17): 4854-4859.
    • (2002) Cancer Res , vol.62 , Issue.17 , pp. 4854-4859
    • Pan, Q.1
  • 9
    • 77953270903 scopus 로고    scopus 로고
    • Enhancing tumor-specific uptake of the anticancer drug cisplatin with a copper chelator
    • Ishida S, McCormick F, Smith-McCune K, Hanahan D (2010) Enhancing tumor-specific uptake of the anticancer drug cisplatin with a copper chelator. Cancer Cell 17(6): 574-583.
    • (2010) Cancer Cell , vol.17 , Issue.6 , pp. 574-583
    • Ishida, S.1    McCormick, F.2    Smith-Mccune, K.3    Hanahan, D.4
  • 10
    • 0021888904 scopus 로고
    • Heritable formation of pancreatic β-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes
    • Hanahan D (1985) Heritable formation of pancreatic β-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes. Nature 315(6015): 115-122.
    • (1985) Nature , vol.315 , Issue.6015 , pp. 115-122
    • Hanahan, D.1
  • 11
    • 0024549349 scopus 로고
    • Induction of angiogenesis during the transition from hyperplasia to neoplasia
    • Folkman J, Watson K, Ingber D, Hanahan D (1989) Induction of angiogenesis during the transition from hyperplasia to neoplasia. Nature 339(6219): 58-61.
    • (1989) Nature , vol.339 , Issue.6219 , pp. 58-61
    • Folkman, J.1    Watson, K.2    Ingber, D.3    Hanahan, D.4
  • 12
    • 0026035891 scopus 로고
    • Initial therapy of patients with Wilson's disease with tetrathiomolybdate
    • Brewer GJ, et al. (1991) Initial therapy of patients with Wilson's disease with tetrathiomolybdate. Arch Neurol 48(1): 42-47.
    • (1991) Arch Neurol , vol.48 , Issue.1 , pp. 42-47
    • Brewer, G.J.1
  • 13
    • 0031960875 scopus 로고    scopus 로고
    • Human whole-body copper metabolism
    • Turnlund JR (1998) Human whole-body copper metabolism. Am J Clin Nutr 67(5, Suppl):960S-964S.
    • (1998) Am J Clin Nutr , vol.67 , Issue.5 SUPPL.
    • Turnlund, J.R.1
  • 14
    • 0000181874 scopus 로고
    • β-cell lines derived from transgenic mice expressing a hybrid insulin gene-oncogene
    • Efrat S, et al. (1988) β-cell lines derived from transgenic mice expressing a hybrid insulin gene-oncogene. Proc Natl Acad Sci USA 85(23): 9037-9041.
    • (1988) Proc Natl Acad Sci USA , vol.85 , Issue.23 , pp. 9037-9041
    • Efrat, S.1
  • 15
    • 77950400107 scopus 로고    scopus 로고
    • ATP is required for the release of the anaphase-promoting complex/cyclosome from inhibition by the mitotic checkpoint
    • Miniowitz-Shemtov S, Teichner A, Sitry-Shevah D, Hershko A (2010) ATP is required for the release of the anaphase-promoting complex/cyclosome from inhibition by the mitotic checkpoint. Proc Natl Acad Sci USA 107(12): 5351-5356.
    • (2010) Proc Natl Acad Sci USA , vol.107 , Issue.12 , pp. 5351-5356
    • Miniowitz-Shemtov, S.1    Teichner, A.2    Sitry-Shevah, D.3    Hershko, A.4
  • 16
  • 17
    • 73349127026 scopus 로고    scopus 로고
    • Cohesin: Its roles and mechanisms
    • Nasmyth K, Haering CH (2009) Cohesin: Its roles and mechanisms. Annu Rev Genet 43: 525-558.
    • (2009) Annu Rev Genet , vol.43 , pp. 525-558
    • Nasmyth, K.1    Haering, C.H.2
  • 18
    • 0028886527 scopus 로고
    • Accumulation of human promyelocytic leukemic (HL-60) cells at two energetic cell cycle checkpoints
    • Sweet S, Singh G (1995) Accumulation of human promyelocytic leukemic (HL-60) cells at two energetic cell cycle checkpoints. Cancer Res 55(22): 5164-5167.
    • (1995) Cancer Res , vol.55 , Issue.22 , pp. 5164-5167
    • Sweet, S.1    Singh, G.2
  • 19
    • 0014007264 scopus 로고
    • Reconstitution of cytochrome c oxidase from an apoenzyme and Cu (I)
    • Nair PM, Mason HS (1966) Reconstitution of cytochrome c oxidase from an apoenzyme and Cu (I). Biochem Biophys Res Commun 23(1): 12-17.
    • (1966) Biochem Biophys Res Commun , vol.23 , Issue.1 , pp. 12-17
    • Nair, P.M.1    Mason, H.S.2
  • 20
    • 0018734969 scopus 로고
    • Changes in activity of the Cu-Zn superoxide dismutase enzyme in tissues of the rat with changes in dietary copper
    • Paynter DI, Moir RJ, Underwood EJ (1979) Changes in activity of the Cu-Zn superoxide dismutase enzyme in tissues of the rat with changes in dietary copper.JNutr 109(9): 1570-1576.
    • (1979) JNutr , vol.109 , Issue.9 , pp. 1570-1576
    • Paynter, D.I.1    Moir, R.J.2    Underwood, E.J.3
  • 21
    • 84858782079 scopus 로고    scopus 로고
    • AMPK: A nutrient and energy sensor that maintains energy homeostasis
    • Hardie DG, Ross FA, Hawley SA (2012) AMPK: A nutrient and energy sensor that maintains energy homeostasis. Nat Rev Mol Cell Biol 13(4): 251-262.
    • (2012) Nat Rev Mol Cell Biol , vol.13 , Issue.4 , pp. 251-262
    • Hardie, D.G.1    Ross, F.A.2    Hawley, S.A.3
  • 22
    • 66249108601 scopus 로고    scopus 로고
    • Understanding the Warburg effect: The metabolic requirements of cell proliferation
    • Vander Heiden MG, Cantley LC, Thompson CB (2009) Understanding the Warburg effect: The metabolic requirements of cell proliferation. Science 324(5930): 1029-1033.
    • (2009) Science , vol.324 , Issue.5930 , pp. 1029-1033
    • Vander Heiden, M.G.1    Cantley, L.C.2    Thompson, C.B.3
  • 23
    • 78049465544 scopus 로고    scopus 로고
    • Personalized versus evidence-based medicine with PET-based imaging
    • Basu S (2010) Personalized versus evidence-based medicine with PET-based imaging. Nat Rev Clin Oncol 7(11): 665-668.
    • (2010) Nat Rev Clin Oncol , vol.7 , Issue.11 , pp. 665-668
    • Basu, S.1
  • 24
    • 0025326091 scopus 로고
    • Anticopper treatment inhibits pseudopodial protrusion and the invasive spread of 9L gliosarcoma cells in the rat brain
    • Brem S, Tsanaclis AM, Zagzag D (1990) Anticopper treatment inhibits pseudopodial protrusion and the invasive spread of 9L gliosarcoma cells in the rat brain. Neurosurgery 26(3): 391-396.
    • (1990) Neurosurgery , vol.26 , Issue.3 , pp. 391-396
    • Brem, S.1    Tsanaclis, A.M.2    Zagzag, D.3
  • 25
    • 0041928194 scopus 로고    scopus 로고
    • Tetrathiomolybdate inhibits angiogenesis andmetastasis through suppression of the NFkappaB signaling cascade
    • Pan Q, Bao LW, Merajver SD (2003) Tetrathiomolybdate inhibits angiogenesis andmetastasis through suppression of the NFkappaB signaling cascade. Mol Cancer Res 1(10): 701-706.
    • (2003) Mol Cancer Res , vol.1 , Issue.10 , pp. 701-706
    • Pan, Q.1    Bao, L.W.2    Merajver, S.D.3
  • 26
    • 0031571663 scopus 로고    scopus 로고
    • Superoxide-mediated cytotoxicity in superoxide dismutasedeficient fetal fibroblasts
    • Huang TT, et al. (1997) Superoxide-mediated cytotoxicity in superoxide dismutasedeficient fetal fibroblasts. Arch Biochem Biophys 344(2): 424-432.
    • (1997) Arch Biochem Biophys , vol.344 , Issue.2 , pp. 424-432
    • Huang, T.T.1
  • 27
    • 0032578458 scopus 로고    scopus 로고
    • Mitochondrial reactive oxygen species trigger hypoxiainduced transcription
    • Chandel NS, et al. (1998) Mitochondrial reactive oxygen species trigger hypoxiainduced transcription. Proc Natl Acad Sci USA 95(20): 11715-11720.
    • (1998) Proc Natl Acad Sci USA , vol.95 , Issue.20 , pp. 11715-11720
    • Chandel, N.S.1
  • 30
    • 0000459772 scopus 로고
    • Über den stoffwechsel der carcinomzelle
    • Warburg O, Posener K, Negelein E (1924) Über den stoffwechsel der carcinomzelle. Biochem Z 152: 309-344.
    • (1924) Biochem Z , vol.152 , pp. 309-344
    • Warburg, O.1    Posener, K.2    Negelein, E.3
  • 31
    • 79251517382 scopus 로고    scopus 로고
    • Regulation of cancer cell metabolism
    • Cairns RA, Harris IS, Mak TW (2011) Regulation of cancer cell metabolism. Nat Rev Cancer 11(2): 85-95.
    • (2011) Nat Rev Cancer , vol.11 , Issue.2 , pp. 85-95
    • Cairns, R.A.1    Harris, I.S.2    Mak, T.W.3
  • 32
    • 11444255268 scopus 로고
    • On respiratory impairment in cancer cells
    • Weinhouse S (1956) On respiratory impairment in cancer cells. Science 124(3215): 267-269.
    • (1956) Science , vol.124 , Issue.3215 , pp. 267-269
    • Weinhouse, S.1
  • 33
    • 0347694776 scopus 로고    scopus 로고
    • Cancer metabolism: Facts, fantasy, and fiction
    • Zu XL, Guppy M (2004) Cancer metabolism: Facts, fantasy, and fiction. Biochem Biophys Res Commun 313(3): 459-465.
    • (2004) Biochem Biophys Res Commun , vol.313 , Issue.3 , pp. 459-465
    • Zu, X.L.1    Guppy, M.2
  • 35
    • 34547509586 scopus 로고    scopus 로고
    • Transformation of human mesenchymal stem cells increases their dependency on oxidative phosphorylation for energy production
    • Funes JM, et al. (2007) Transformation of human mesenchymal stem cells increases their dependency on oxidative phosphorylation for energy production. Proc Natl Acad Sci USA 104(15): 6223-6228.
    • (2007) Proc Natl Acad Sci USA , vol.104 , Issue.15 , pp. 6223-6228
    • Funes, J.M.1
  • 36
    • 77749334738 scopus 로고    scopus 로고
    • Mitochondrial p32 protein is a critical regulator of tumor metabolism via maintenance of oxidative phosphorylation
    • Fogal V, et al. (2010) Mitochondrial p32 protein is a critical regulator of tumor metabolism via maintenance of oxidative phosphorylation. Mol Cell Biol 30(6): 1303-1318.
    • (2010) Mol Cell Biol , vol.30 , Issue.6 , pp. 1303-1318
    • Fogal, V.1
  • 37
    • 0034614420 scopus 로고    scopus 로고
    • Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex i
    • El-Mir MY, et al. (2000) Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I. J Biol Chem 275(1): 223-228.
    • (2000) J Biol Chem , vol.275 , Issue.1 , pp. 223-228
    • El-Mir, M.Y.1
  • 38
    • 0034659785 scopus 로고    scopus 로고
    • Evidence that metformin exerts its antidiabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain
    • Owen MR, Doran E, Halestrap AP (2000) Evidence that metformin exerts its antidiabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain. Biochem J 348(Pt 3): 607-614.
    • (2000) Biochem J , vol.348 , Issue.PART 3 , pp. 607-614
    • Owen, M.R.1    Doran, E.2    Halestrap, A.P.3
  • 40
    • 84864371674 scopus 로고    scopus 로고
    • Metformin and cancer: New applications for an old drug
    • Kourelis TV, Siegel RD (2012) Metformin and cancer: New applications for an old drug. Med Oncol 29(2): 1314-1327.
    • (2012) Med Oncol , vol.29 , Issue.2 , pp. 1314-1327
    • Kourelis, T.V.1    Siegel, R.D.2
  • 41
    • 53849099653 scopus 로고    scopus 로고
    • The production of reactive oxygen species by complex i
    • Hirst J, King MS, Pryde KR (2008) The production of reactive oxygen species by complex I. Biochem Soc Trans 36(Pt 5): 976-980.
    • (2008) Biochem Soc Trans , vol.36 , Issue.PART 5 , pp. 976-980
    • Hirst, J.1    King, M.S.2    Pryde, K.R.3
  • 42
    • 0036903625 scopus 로고    scopus 로고
    • Complex I-mediated reactive oxygen species generation: Modulation by cytochrome c and NAD(P)+ oxidation-reduction state
    • Kushnareva Y, Murphy AN, Andreyev A (2002) Complex I-mediated reactive oxygen species generation: modulation by cytochrome c and NAD(P)+ oxidation-reduction state. Biochem J 368(Pt 2): 545-553.
    • (2002) Biochem J , vol.368 , Issue.PART 2 , pp. 545-553
    • Kushnareva, Y.1    Murphy, A.N.2    Andreyev, A.3
  • 43
    • 84873584845 scopus 로고    scopus 로고
    • LKB1 inactivation dictates therapeutic response of nonsmall cell lung cancer to the metabolism drug phenformin
    • Shackelford DB, et al. (2013) LKB1 inactivation dictates therapeutic response of nonsmall cell lung cancer to the metabolism drug phenformin. Cancer Cell 23(2): 143-158.
    • (2013) Cancer Cell , vol.23 , Issue.2 , pp. 143-158
    • Shackelford, D.B.1
  • 44
    • 84856553941 scopus 로고    scopus 로고
    • The power of life - Cytochrome c oxidase takes center stage in metabolic control, cell signalling and survival
    • Arnold S (2012) The power of life - cytochrome c oxidase takes center stage in metabolic control, cell signalling and survival. Mitochondrion 12(1): 46-56.
    • (2012) Mitochondrion , vol.12 , Issue.1 , pp. 46-56
    • Arnold, S.1
  • 45
    • 34347193833 scopus 로고
    • Über den kupfergehalt menschlicher tumoren in beziehung zum kupfergehalt der leber
    • Gerlach W (1935) Über den kupfergehalt menschlicher tumoren in beziehung zum kupfergehalt der leber. Z Krebsforsch 42: 290-294.
    • (1935) Z Krebsforsch , vol.42 , pp. 290-294
    • Gerlach, W.1
  • 46
    • 45749117702 scopus 로고    scopus 로고
    • The distribution of trace elements Ca, Fe, Cu and Zn and the determination of copper oxidation state in breast tumour tissue using muSRXRF and muXANES
    • Farquharson MJ, et al. (2008) The distribution of trace elements Ca, Fe, Cu and Zn and the determination of copper oxidation state in breast tumour tissue using muSRXRF and muXANES. Phys Med Biol 53(11): 3023-3037.
    • (2008) Phys Med Biol , vol.53 , Issue.11 , pp. 3023-3037
    • Farquharson, M.J.1
  • 47
    • 0037195066 scopus 로고    scopus 로고
    • Uptake of the anticancer drug cisplatin mediated by the copper transporter Ctr1 in yeast and mammals
    • Ishida S, Lee J, Thiele DJ, Herskowitz I (2002) Uptake of the anticancer drug cisplatin mediated by the copper transporter Ctr1 in yeast and mammals. Proc Natl Acad Sci USA 99(22): 14298-14302.
    • (2002) Proc Natl Acad Sci USA , vol.99 , Issue.22 , pp. 14298-14302
    • Ishida, S.1    Lee, J.2    Thiele, D.J.3    Herskowitz, I.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.