Deferoxamine: Emerging, new neuro-protective benefits

Neurological Sciences

Volumn 34, Issue 11, 2013, Pages 2069-2070

  Kapoor, Shailendra ^a  

^a NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEFEROXAMINE; FERRITIN; HEME OXYGENASE 1;

AMNESIA; BRAIN EDEMA; BRAIN INFARCTION; BRAIN INJURY; DRUG MECHANISM; ENZYME ACTIVITY; LETTER; NEUROPROTECTION; NONHUMAN; SPATIAL MEMORY;

ANIMALS; BRAIN INJURIES; DEFEROXAMINE; IRON; MALE; NEUROTOXICITY SYNDROMES; SIDEROPHORES;

EID: 84888305620     PISSN: 15901874     EISSN: 15903478     Source Type: Journal    
DOI: 10.1007/s10072-013-1441-6     Document Type: Letter

References (16)

1. Zhang L, Hu R, Li M et al (2012) Deferoxamine attenuates iron-induced long-term neurotoxicity in rats with traumatic brain injury. Neurol Sci (in press)
2. Lee JY, Keep RF, Hua Y, Ernestus RI, Xi G (2011) Deferoxamine reduces early brain injury following subarachnoid hemorrhage. Acta Neurochir Suppl 112:101-106
3. Lee JY, Keep RF, He Y, Sagher O, Hua Y, Xi G (2010) Hemoglobin and iron handling in brain after subarachnoid hemorrhage and the effect of deferoxamine on early brain injury. J Cereb Blood Flow Metab 30:1793-1803
4. Hatakeyama T, Okauchi M, Hua Y, Keep RF, Xi G (2011) Deferoxamine reduces cavity size in the brain after intracerebral hemorrhage in aged rats. Acta Neurochir Suppl 111:185-190
5. Okauchi M, Hua Y, Keep RF, Morgenstern LB, Xi G (2009) Effects of deferoxamine on intracerebral hemorrhage-induced brain injury in aged rats. Stroke 40:1858-1863
6. Song S, Hua Y, Keep RF et al (2008) Deferoxamine reduces brain swelling in a rat model of hippocampal intracerebral hemorrhage. Acta Neurochir Suppl 105:13-18
7. Nakamura T, Keep RF, Hua Y, Schallert T, Hoff JT, Xi G (2004) Deferoxamine-induced attenuation of brain edema and neurological deficits in a rat model of intracerebral hemorrhage. J Neurosurg 100:672-678
8. Hanson LR, Roeytenberg A, Martinez PM et al (2009) Intranasal deferoxamine provides increased brain exposure and significant protection in rat ischemic stroke. J Pharmacol Exp Ther 330:679-686
9. Canuelo A, Martinez-Romero R, Martinez-Lara E, Sanchez-Alcazar JA, Siles E (2012) The hypoxic preconditioning agent deferoxamine induces poly(ADP-ribose) polymerase-1-dependent inhibition of the mitochondrial respiratory chain. Mol Cell Biochem 363:101-108
10. Cassol OJ Jr, Rezin GT, Petronilho FC et al (2010) Effects of N-acetylcysteine/deferoxamine, taurine and RC-3095 on respiratory chain complexes and creatine kinase activities in rat brain after sepsis. Neurochem Res 35:515-521
11. Vlahakos D, Arkadopoulos N, Kostopanagiotou G et al (2012) Deferoxamine attenuates lipid peroxidation, blocks interleukin-6 production, ameliorates sepsis inflammatory response syndrome, and confers renoprotection after acute hepatic ischemia in pigs. Artif Organs 36:400-408
12. Fine JM, Baillargeon AM, Renner DB et al (2012) Intranasal deferoxamine improves performance in radial arm water maze, stabilizes HIF-1α, and phosphorylates GSK3β in P301L tau transgenic mice. Exp Brain Res 219:381-390
13. Intranasal delivery of deferoxamine reduces spatial memory loss in APP/PS1 mice LR Hanson, JM Fine, DB Renner, AL Svitak. - Drug Delivery and., 2012 - Springer (in press)
14. Percy ME, Kruck TP, Pogue AI, Lukiw WJ (2011) Towards the prevention of potential aluminum toxic effects and an effective treatment for Alzheimer's disease. J Inorg Biochem 105:1505-1512
15. Huang XJ, Ma ZQ, Zhang WP, Lu YB, Wei EQ (2007) Dihydroartemisinin exerts cytotoxic effects and inhibits hypoxia inducible factor-1alpha activation in C6 glioma cells. J Pharm Pharmacol 59:849-856
16. Valdes PA, Samkoe K, O'Hara JA, Roberts DW, Paulsen KD, Pogue BW (2010) Deferoxamine iron chelation increases delta-aminolevulinic acid induced protoporphyrin IX in xenograft glioma model. Photochem Photobiol 86:471-475