Deferoxamine reduces cavity size in the brain after intracerebral hemorrhage in aged rats

Acta Neurochirurgica, Supplementum

Volumn , Issue 111, 2011, Pages 185-190

  Hatakeyama, Tetsuhiro ^a,b   Okauchi, Masanobu ^a,b   Hua, Ya ^a   Keep, Richard F ^a   Xi, Guohua ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b KAGAWA UNIVERSITY   (Japan)

Author keywords

Cavity size; Cerebral hemorrhage; Deferoxamine; Iron; Oxidative stress

Indexed keywords

DEFEROXAMINE; FERRITIN; GLIAL FIBRILLARY ACIDIC PROTEIN; HEME OXYGENASE 1; DIFFERENTIATION ANTIGEN; OX 62 ANTIGEN, RAT; OX-62 ANTIGEN, RAT; SIDEROPHORE;

AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; BASAL GANGLION; BRAIN DISEASE; BRAIN HEMORRHAGE; CAUDATE NUCLEUS; CONFERENCE PAPER; EPIDURAL SPACE; HISTOLOGY; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MALE; NONHUMAN; RAT; AGING; ANIMAL; ANIMAL BEHAVIOR; ARTICLE; BRAIN INFARCTION; CELL COUNT; DISEASE MODEL; DRUG EFFECT; FORELIMB; HEMATOMA; METABOLISM; METHODOLOGY; NONPARAMETRIC TEST; PATHOLOGY; PATHOPHYSIOLOGY;

AGING; ANIMALS; ANTIGENS, DIFFERENTIATION; BEHAVIOR, ANIMAL; BRAIN INFARCTION; CELL COUNT; CEREBRAL HEMORRHAGE; DEFEROXAMINE; DISEASE MODELS, ANIMAL; FERRITINS; FORELIMB; GLIAL FIBRILLARY ACIDIC PROTEIN; HEMATOMA; HEME OXYGENASE-1; MALE; RATS; SIDEROPHORES; STATISTICS, NONPARAMETRIC;

EID: 79960692573     PISSN: 00651419     EISSN: 00016268     Source Type: Book Series    
DOI: 10.1007/978-3-7091-0693-8_31     Document Type: Conference Paper

References (19)

1. Kase CS, Caplan LR (1994) Intracerebral hemorrhage. Kase CS, Caplan LR eds. Butterworth-Heinemann, Boston
2. Wu J, Hua Y, Keep RF, Schallert T, Hoff JT, Xi G (2002) Oxidative brain injury from extravasated erythrocytes after intracerebral hem¬orrhage. Brain Res 953:45-52 (Pubitemid 35217806)
3. Wu J, Hua Y, Keep RF, Nakamura T, Hoff JT, Xi G (2003) Iron and iron-handling proteins in the brain after intracerebral hemorrhage. Stroke 34:2964-2969 (Pubitemid 37517778)
4. Keberle H (1964) The biochemistry of desferrioxamine and its relation to iron metabolism. Ann NY Acad Sci 119:758-768
5. Palmer C, Roberts RL, Bero C (1994) Deferoxamine posttreat-ment reduces ischemic brain injury in neonatal rats. Stroke 25: 1039-1045 (Pubitemid 24130313)
6. Gu Y, Hua Y, Keep RF, Morgenstern LB, Xi G (2009) Deferoxamine reduces intracerebral hematoma-induced iron accumulation and neuronal death in piglets. Stroke 40:2241-2243
7. Hua Y, Nakamura T, Keep RF, Wu J, Schallert T, Hoff JT, Xi G (2006) Long-term effects of experimental intracerebral hemor¬rhage: the role of iron. J Neurosurg 104:305-312
8. Nakamura T, Keep RF, Hua Y, Schallert T, Hoff JT, Xi G (2004) Deferoxamine-induced attenuation of brain edema and neurological defcits in a rat model of intracerebral hemorrhage. J Neurosurg 100:672-678 (Pubitemid 38372849)
9. Song S, Hua Y, Keep RF, Hoff JT, Xi G (2007) A new hippocampal model for examining intracerebral hemorrhage-related neuronal death: effects of deferoxamine on hemoglobin-induced neuronal death. Stroke 38:2861-2863 (Pubitemid 47494032)
10. Nakamura T, Keep RF, Hua Y, Hoff JT, Xi G (2005) Oxidative DNA injury after experimental intracerebral hemorrhage. Brain Res 1039:30-36 (Pubitemid 40386824)
11. Nakamura T, Xi G, Park JW, Hua Y, Hoff JT, Keep RF (2005) Holo-transferrin and thrombin can interact to cause brain damage. Stroke 36:348-352 (Pubitemid 40170821)
12. Xi G, Keep RF, Hoff JT (2006) Mechanisms of brain injury after intracerebral haemorrhage. Lancet Neurol 5:53-63 (Pubitemid 41790696)
13. Huang FP, Xi G, Keep RF, Hua Y, Nemoianu A, Hoff JT (2002) Brain edema after experimental intracerebral hemorrhage: role of hemoglobin degradation products. J Neurosurg 96:287-293 (Pubitemid 34230243)
14. Wagner KR, Hua Y, de Courten-Myers GM, Broderick JP, Nishimura RN, Lu SY, Dwyer BE (2000) Tin-mesoporphyrin, a potent heme oxygenase inhibitor, for treatment of intracerebral hemorrhage: in vivo and in vitro studies. Cell Mol Biol (Noisy-le-grand) 46:597-608
15. Castillo J, Davalos A, Alvarez-Sabin J, Pumar JM, Leira R, Silva Y, Montaner J, Kase CS (2002) Molecular signatures of brain injury after intracerebral hemorrhage. Neurology 58:624-629 (Pubitemid 34164947)
16. Papazisis G, Pourzitaki C, Sardeli C, Lallas A, Amaniti E, Kouvelas D (2008) Deferoxamine decreases the excitatory amino acid levels and improves the histological outcome in the hippocampus of neo¬natal rats after hypoxia-ischemia. Pharmacol Res 57:73-78
17. Alvarez-Sabin J, Delgado P, Abilleira S, Molina CA, Arenillas J, Ribo M, Santamarina E, Quintana M, Monasterio J, Montaner J (2004) Temporal profle of matrix metalloproteinases and their inhibitors after spontaneous intracerebral hemorrhage: relationship to clinical and radiological outcome. Stroke 35:1316-1322 (Pubitemid 38697450)
18. Sobrino T, Arias S, Rodriguez-Gonzalez R, Brea D, Silva Y, de la Ossa NP, Agulla J, Blanco M, Pumar JM, Serena J, Davalos A, Castillo J (2009) High serum levels of growth factors are associated with good outcome in intracerebral hemorrhage. J Cereb Blood Flow Metab 29:1968-1974
19. Schallert T, Fleming SM, Leasure JL, Tillerson JL, Bland ST (2000) CNS plasticity and assessment of forelimb sensorimotor outcome in unilateral rat models of stroke, cortical ablation, parkinsonism and spinal cord injury. Neuropharmacology 39:777-787 (Pubitemid 30103682)