메뉴 건너뛰기




Volumn 38, Issue 12, 2013, Pages 966-971

Targeted α-particle therapy of bone metastases in prostate cancer

Author keywords

>; ALSYMPCA; cancer; prostate; radium; therapy

Indexed keywords

ABIRATERONE ACETATE; ACTINIUM 225; BISMUTH 212; BISMUTH 213; CABAZITAXEL; DOCETAXEL; ENZALUTAMIDE; LEAD 212; PHOSPHORUS 32; PLACEBO; PREDNISONE; RADIOISOTOPE; RADIUM CHLORIDE RA 223; RHENIUM 186; RHENIUM 188; SAMARIUM 153; SIPULEUCEL T; STRONTIUM 89; TERBIUM 149; TIN 117M; UNCLASSIFIED DRUG;

EID: 84888303650     PISSN: 03639762     EISSN: 15360229     Source Type: Journal    
DOI: 10.1097/RLU.0000000000000290     Document Type: Article
Times cited : (47)

References (68)
  • 1
    • 84872930341 scopus 로고    scopus 로고
    • Why are investors not interested in my radiotracer? The industrial and regulatory constraints in the development of radiopharmaceuticals
    • Zimmermann RG. Why are investors not interested in my radiotracer? The industrial and regulatory constraints in the development of radiopharmaceuticals. Nucl Med Biol. 2013;40:155-166.
    • (2013) Nucl Med Biol , vol.40 , pp. 155-166
    • Zimmermann, R.G.1
  • 2
    • 54049137660 scopus 로고    scopus 로고
    • Clinical trials of targeted alpha therapy for cancer
    • Allen BJ. Clinical trials of targeted alpha therapy for cancer. Rev Recent Clin Trials. 2008;3:185-191.
    • (2008) Rev Recent Clin Trials , vol.3 , pp. 185-191
    • Allen, B.J.1
  • 3
    • 80052203481 scopus 로고    scopus 로고
    • Future prospects for targeted alpha therapy
    • Allen BJ. Future prospects for targeted alpha therapy. Curr Radiopharm. 2011;4:336-342.
    • (2011) Curr Radiopharm , vol.4 , pp. 336-342
    • Allen, B.J.1
  • 4
    • 0032726066 scopus 로고    scopus 로고
    • Targeted alpha therapy: Evidence for potential efficacy of alphaimmunoconjugates in the management of micrometastatic cancer
    • Allen BJ. Targeted alpha therapy: evidence for potential efficacy of alphaimmunoconjugates in the management of micrometastatic cancer. Australas Radiol. 1999;43:480-486.
    • (1999) Australas Radiol , vol.43 , pp. 480-486
    • Allen, B.J.1
  • 6
    • 35549000927 scopus 로고    scopus 로고
    • Targeted alpha-therapy: Past, present, future?
    • Brechbiel MW. Targeted alpha-therapy: past, present, future? Dalton Trans. 2007;43:4918-4928.
    • (2007) Dalton Trans , vol.43 , pp. 4918-4928
    • Brechbiel, M.W.1
  • 7
    • 0029784810 scopus 로고    scopus 로고
    • Targeted therapy using alpha emitters
    • Vaidyanathan G, Zalutsky MR. Targeted therapy using alpha emitters. Phys Med Biol. 1996;41:1915-1931.
    • (1996) Phys Med Biol , vol.41 , pp. 1915-1931
    • Vaidyanathan, G.1    Zalutsky, M.R.2
  • 8
    • 80052242015 scopus 로고    scopus 로고
    • Applications of 211At and 223Ra in targeted alpha-particle radiotherapy
    • Vaidyanathan G, Zalutsky MR. Applications of 211At and 223Ra in targeted alpha-particle radiotherapy. Curr Radiopharm. 2011;4:283-294.
    • (2011) Curr Radiopharm , vol.4 , pp. 283-294
    • Vaidyanathan, G.1    Zalutsky, M.R.2
  • 9
    • 46949111791 scopus 로고    scopus 로고
    • Alpha particles for targeted therapy
    • Sgourous G. Alpha particles for targeted therapy. Adv Drug Deliv Rev. 2008;60:1402-1406.
    • (2008) Adv Drug Deliv Rev , vol.60 , pp. 1402-1406
    • Sgourous, G.1
  • 10
    • 84863576788 scopus 로고    scopus 로고
    • An overview of targeted alpha therapy
    • Kim YS, Brechbiel MW. An overview of targeted alpha therapy. Tumor Biol. 2012;33:573-590.
    • (2012) Tumor Biol , vol.33 , pp. 573-590
    • Kim, Y.S.1    Brechbiel, M.W.2
  • 11
    • 47749154422 scopus 로고    scopus 로고
    • Therapeutic radionuclides: Biophysical and radiobiologic principles
    • Kassis AI. Therapeutic radionuclides: biophysical and radiobiologic principles. Semin Nucl Med. 2008;38:358-366.
    • (2008) Semin Nucl Med , vol.38 , pp. 358-366
    • Kassis, A.I.1
  • 12
    • 0027211856 scopus 로고
    • Microdosimetric concepts in radioimmunotherapy
    • Humm JL, Rueske JC, Fisher DR, et al. Microdosimetric concepts in radioimmunotherapy. Med Phys. 1993;20:535-541.
    • (1993) Med Phys , vol.20 , pp. 535-541
    • Humm, J.L.1    Rueske, J.C.2    Fisher, D.R.3
  • 13
    • 84881505886 scopus 로고    scopus 로고
    • Molecular classification of prostate cancer progression: Foundation for marker-driven treatment of prostate cancer
    • Logothetis CJ, Gallick GE, Maity SN, et al. Molecular classification of prostate cancer progression: foundation for marker-driven treatment of prostate cancer. Cancer Discov. 2013;3:849-861.
    • (2013) Cancer Discov , vol.3 , pp. 849-861
    • Logothetis, C.J.1    Gallick, G.E.2    Maity, S.N.3
  • 14
    • 84888308407 scopus 로고    scopus 로고
    • US Food and Drug Administration. Accessed May 15
    • FDA Approves New Drug for Advanced Prostate Cancer. US Food and Drug Administration. Available at: http://www. fda. gov/NewsEvents/Newsroom/ PressAnnouncements/ucm352363. htm. Accessed May 15, 2013.
    • (2013) FDA Approves New Drug for Advanced Prostate Cancer
  • 15
    • 84856072451 scopus 로고    scopus 로고
    • Louis-Frédéric Wickham (1861-1913): Father of radium therapy
    • Mould RF, Robison RF, Tiggelen RV. Louis-Frédéric Wickham (1861-1913): father of radium therapy. J Oncol. 2010;60:79eY103e.
    • (2010) J Oncol , vol.60
    • Mould, R.F.1    Robison, R.F.2    Tiggelen, R.V.3
  • 16
    • 84888305880 scopus 로고
    • Radium in cancer therapy
    • Quick D. Radium in cancer therapy. Br Med J. 1930;2:765-769.
    • (1930) Br Med J , vol.2 , pp. 765-769
    • Quick, D.1
  • 17
    • 77049164732 scopus 로고
    • The influence of radium in cancer therapy
    • Quick D. The influence of radium in cancer therapy. Can Med Assoc J. 1954;71:103-109.
    • (1954) Can Med Assoc J , vol.71 , pp. 103-109
    • Quick, D.1
  • 18
    • 84880416044 scopus 로고    scopus 로고
    • Fighting prostate cancer with Radium-223Vnot your Madame's isotope
    • Vapiwala N, Glatstein E. Fighting prostate cancer with Radium-223Vnot your Madame's isotope. N Engl J Med. 2013;369:276-278.
    • (2013) N Engl J Med , vol.369 , pp. 276-278
    • Vapiwala, N.1    Glatstein, E.2
  • 19
    • 79952945610 scopus 로고    scopus 로고
    • National Cancer Institute Website. Accessed June 5
    • SEER Stat Fact Sheets: Prostate. National Cancer Institute Website. Available at: http://seercancer. gov/statfacts/html/prost. html. Accessed June 5, 2013.
    • (2013) SEER Stat Fact Sheets: Prostate
  • 20
    • 41949104346 scopus 로고    scopus 로고
    • Design and end points of clinical trials for patients with progressive prostate cancer and castrate levels of testosterone: Recommendations of the prostate cancer clinical trialsworking group
    • Scher HI, Halabi S, Tannock I, et al. Design and end points of clinical trials for patients with progressive prostate cancer and castrate levels of testosterone: recommendations of the Prostate Cancer Clinical TrialsWorking Group. J Clin Oncol. 2008;26:1148-1159.
    • (2008) J Clin Oncol , vol.26 , pp. 1148-1159
    • Scher, H.I.1    Halabi, S.2    Tannock, I.3
  • 21
    • 0032497522 scopus 로고    scopus 로고
    • Bilateral orchiectomy with or without flutamide for metastatic prostate cancer
    • Eisenberger MA, Blumenstein BA, Crawford ED, et al. Bilateral orchiectomy with or without flutamide for metastatic prostate cancer. N Engl J Med. 1998;339:1036-1042.
    • (1998) N Engl J Med , vol.339 , pp. 1036-1042
    • Eisenberger, M.A.1    Blumenstein, B.A.2    Crawford, E.D.3
  • 22
    • 79957451082 scopus 로고    scopus 로고
    • Developing imaging strategies for castration resistant prostate cancer
    • Fox JJ, Morris MJ, Larson SM, et al. Developing imaging strategies for castration resistant prostate cancer. Acta Oncol. 2011;50:39-48.
    • (2011) Acta Oncol , vol.50 , pp. 39-48
    • Fox, J.J.1    Morris, M.J.2    Larson, S.M.3
  • 23
    • 8944220720 scopus 로고    scopus 로고
    • Chemotherapy with mitoxantrone plus prednisone or prednisone alone for symptomatic hormone-resistant prostate cancer: A Canadian randomized trial with palliative end points
    • Tannock IF, Osoba D, Stockler MR, et al. Chemotherapy with mitoxantrone plus prednisone or prednisone alone for symptomatic hormone-resistant prostate cancer: a Canadian randomized trial with palliative end points. J Clin Oncol. 1996;14:1756-1764.
    • (1996) J Clin Oncol , vol.14 , pp. 1756-1764
    • Tannock, I.F.1    Osoba, D.2    Stockler, M.R.3
  • 24
    • 0032800631 scopus 로고    scopus 로고
    • Mechanisms, hypotheses and questions regarding prostate cancer micrometastases to bone
    • Lange PH, Vessella Rl. Mechanisms, hypotheses and questions regarding prostate cancer micrometastases to bone. Cancer Metastasis Rev. 1998;17: 331-336.
    • (1998) Cancer Metastasis Rev , vol.17 , pp. 331-336
    • Lange, P.H.1    Vessella, R.L.2
  • 25
    • 0034085989 scopus 로고    scopus 로고
    • Metastatic patterns of prostate cancer: An autopsy study of 1,589 patients
    • Bubendorf L, Schopfer A, Wagner U, et al. Metastatic patterns of prostate cancer: an autopsy study of 1,589 patients. Hum Pathol. 2000;31:578-583.
    • (2000) Hum Pathol , vol.31 , pp. 578-583
    • Bubendorf, L.1    Schopfer, A.2    Wagner, U.3
  • 26
    • 79957443342 scopus 로고    scopus 로고
    • Abiraterone and increased survival in metastatic prostate cancer
    • de Bono JS, Logothetis CJ, Molina A, et al. Abiraterone and increased survival in metastatic prostate cancer. N Engl J Med. 2011;364:1995-2005.
    • (2011) N Engl J Med , vol.364 , pp. 1995-2005
    • De Bono, J.S.1    Logothetis, C.J.2    Molina, A.3
  • 27
    • 77955066199 scopus 로고    scopus 로고
    • Sipuleucel-T immunotherapy for castration-resistant prostate cancer
    • Kantoff PW, Higano CS, Shore ND, et al. Sipuleucel-T immunotherapy for castration-resistant prostate cancer. N Engl J Med. 2010;363:411-422.
    • (2010) N Engl J Med , vol.363 , pp. 411-422
    • Kantoff, P.W.1    Higano, C.S.2    Shore, N.D.3
  • 28
    • 77957682309 scopus 로고    scopus 로고
    • Prednisone plus carbazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: A randomized open-label trial
    • de Bono JS, Oudard S, Ozguroglu M, et al. Prednisone plus carbazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomized open-label trial. Lancet. 2010;376: 1147-1154.
    • (2010) Lancet , vol.376 , pp. 1147-1154
    • De Bono, J.S.1    Oudard, S.2    Ozguroglu, M.3
  • 29
    • 84866770294 scopus 로고    scopus 로고
    • Increased survival with enzalutamide in prostate cancer after chemotherapy
    • Scher HI, Fizazi K, Saad F, et al. Increased survival with enzalutamide in prostate cancer after chemotherapy. N Engl J Med. 2012;367:1187-1197.
    • (2012) N Engl J Med , vol.367 , pp. 1187-1197
    • Scher, H.I.1    Fizazi, K.2    Saad, F.3
  • 30
    • 80053567168 scopus 로고    scopus 로고
    • The changing therapeutic landscape of castration-resistant prostate cancer
    • Yap TA, Zivi A, Omlin A, et al. The changing therapeutic landscape of castration-resistant prostate cancer. Nat Rev Clin Oncol. 2011;8:597-610.
    • (2011) Nat Rev Clin Oncol , vol.8 , pp. 597-610
    • Yap, T.A.1    Zivi, A.2    Omlin, A.3
  • 32
    • 84864569535 scopus 로고    scopus 로고
    • Novel options for the treatment of castration-resistant prostate cancer
    • Ohlmann CH, Merseburger AS, Suttmann H, et al. Novel options for the treatment of castration-resistant prostate cancer. World J Urol. 2012;30: 495-503.
    • (2012) World J Urol , vol.30 , pp. 495-503
    • Ohlmann, C.H.1    Merseburger, A.S.2    Suttmann, H.3
  • 33
    • 84870165370 scopus 로고    scopus 로고
    • New perspectives in the therapy of castration resistant prostate cancer
    • Rescigno P, Buonerba C, Bellmunt J, et al. New perspectives in the therapy of castration resistant prostate cancer. Curr Drug Targets. 2012;13:1676-1686.
    • (2012) Curr Drug Targets , vol.13 , pp. 1676-1686
    • Rescigno, P.1    Buonerba, C.2    Bellmunt, J.3
  • 34
    • 84866754578 scopus 로고    scopus 로고
    • Novel and bone-targeted agents for CRPC
    • Fizazi K, Albiges L, Massard C, et al. Novel and bone-targeted agents for CRPC. Ann Oncol. 2012;23(suppl 10):x264Yx267.
    • (2012) Ann Oncol , vol.23 , Issue.SUPPL. 10
    • Fizazi, K.1    Albiges, L.2    Massard, C.3
  • 35
    • 84859425018 scopus 로고    scopus 로고
    • Novel molecular targets for the therapy of castration-resistant prostate cancer
    • Agarwal N, Sonpavde G, Sternberg CN. Novel molecular targets for the therapy of castration-resistant prostate cancer. Eur Urol. 2012;61:950-960.
    • (2012) Eur Urol , vol.61 , pp. 950-960
    • Agarwal, N.1    Sonpavde, G.2    Sternberg, C.N.3
  • 36
    • 84856406031 scopus 로고    scopus 로고
    • Biomarkers in the management and treatment of men with metastatic castration-resistant prostate cancer
    • Armstrong AJ, Eisenberger MA, Halabi S, et al. Biomarkers in the management and treatment of men with metastatic castration-resistant prostate cancer. Eur Urol. 2012;61:549-559.
    • (2012) Eur Urol , vol.61 , pp. 549-559
    • Armstrong, A.J.1    Eisenberger, M.A.2    Halabi, S.3
  • 37
    • 84855669062 scopus 로고    scopus 로고
    • Emerging treatment options for patients with castrationresistant prostate cancer
    • George D, Moul JW. Emerging treatment options for patients with castrationresistant prostate cancer. Prostate. 2012;72:338-349.
    • (2012) Prostate , vol.72 , pp. 338-349
    • George, D.1    Moul, J.W.2
  • 38
    • 80755169423 scopus 로고    scopus 로고
    • New and emerging agents for the treatment of castration-resistant prostate cancer
    • Higano CS, Crawford ED. New and emerging agents for the treatment of castration-resistant prostate cancer. Urol Oncol. 2011; 29:S1YS8.
    • (2011) Urol Oncol , vol.29
    • Higano, C.S.1    Crawford, E.D.2
  • 39
    • 16244420755 scopus 로고    scopus 로고
    • Prostate cancer metastases to bone: Pathophysiology, pain management, and the premise of targeted therapy
    • Pinski J, Dorff TB. Prostate cancer metastases to bone: pathophysiology, pain management, and the premise of targeted therapy. Eur J Cancer. 2005;41:932-940.
    • (2005) Eur J Cancer , vol.41 , pp. 932-940
    • Pinski, J.1    Dorff, T.B.2
  • 41
    • 14844361408 scopus 로고    scopus 로고
    • Bone-seeking radionuclides for therapy
    • Lewington V. Bone-seeking radionuclides for therapy. J Nucl Med. 2005;46: 38SY47S.
    • (2005) J Nucl Med , vol.46
    • Lewington, V.1
  • 42
    • 84863717293 scopus 로고    scopus 로고
    • Therapeutic strategies for bone metastases and their clinical sequelae in prostate cancer
    • Autio KA, Scher HI, Morris MJ. Therapeutic strategies for bone metastases and their clinical sequelae in prostate cancer. Curr Treat Options Oncol. 2012;13: 174-188.
    • (2012) Curr Treat Options Oncol , vol.13 , pp. 174-188
    • Autio, K.A.1    Scher, H.I.2    Morris, M.J.3
  • 43
    • 33746707858 scopus 로고    scopus 로고
    • High-linear energy transfer irradiation targeted to skeletal metastases by the alpha-emitter 223Ra: Adjuvant or alternative to conventional modalities?
    • Bruland O, Nilsson S, Fisher DR, et al. High-linear energy transfer irradiation targeted to skeletal metastases by the alpha-emitter 223Ra: adjuvant or alternative to conventional modalities? Clin Cancer Res. 2006;12:6250sY6257s.
    • (2006) Clin Cancer Res , vol.12
    • Bruland, O.1    Nilsson, S.2    Fisher, D.R.3
  • 44
    • 84860150328 scopus 로고    scopus 로고
    • Alpha particles as radiopharmaceuticals in the treatment of bone metastases: Mechanism of action of radium-223 chloride (Alpharadin) and radiation protection
    • 341
    • Cheetham PJ, Petrylak DP. Alpha particles as radiopharmaceuticals in the treatment of bone metastases: mechanism of action of radium-223 chloride (Alpharadin) and radiation protection. Oncology (Williston Park). 2012;26: 330-337, 341.
    • (2012) Oncology (Williston Park) , vol.26 , pp. 330-337
    • Cheetham, P.J.1    Petrylak, D.P.2
  • 45
    • 0028598194 scopus 로고
    • The use of strontium 89 for palliation of pain from bone metastases associated with hormone-refractory prostate cancer
    • Crawford ED, Kozlowski JM, Debruyne FM, et al. The use of strontium 89 for palliation of pain from bone metastases associated with hormone-refractory prostate cancer. Urology. 1994;44:481-485.
    • (1994) Urology , vol.44 , pp. 481-485
    • Crawford, E.D.1    Kozlowski, J.M.2    Debruyne, F.M.3
  • 46
    • 0035798930 scopus 로고    scopus 로고
    • Bone-targeted therapy for advanced androgen-independent carcinoma of the prostate: A randomized phase II trial
    • Tu SM, Millikan RE, Mengistu B, et al. Bone-targeted therapy for advanced androgen-independent carcinoma of the prostate: a randomized phase II trial. Lancet. 2001;357:336-341.
    • (2001) Lancet , vol.357 , pp. 336-341
    • Tu, S.M.1    Millikan, R.E.2    Mengistu, B.3
  • 47
    • 84873864130 scopus 로고    scopus 로고
    • Bone targeting radiopharmaceuticals including radium-223
    • Brady D, Parker C, O'Sullivan JM. Bone targeting radiopharmaceuticals including radium-223. Cancer J. 2013;19:71-78.
    • (2013) Cancer J , vol.19 , pp. 71-78
    • Brady, D.1    Parker, C.2    O'sullivan, J.M.3
  • 48
    • 84873691909 scopus 로고    scopus 로고
    • Radium-223 for the treatment of prostate cancer
    • Hafeez S, Parker C. Radium-223 for the treatment of prostate cancer. Expert Opin Investig Drugs. 2013;22:379-387
    • (2013) Expert Opin Investig Drugs , vol.22 , pp. 379-387
    • Hafeez, S.1    Parker, C.2
  • 49
    • 80053077567 scopus 로고    scopus 로고
    • Emerging therapies to prevent skeletal morbidity in men with prostate cancer
    • Saylor PJ, Lee RJ, Smith MR. Emerging therapies to prevent skeletal morbidity in men with prostate cancer. J Clin Oncol. 2011;29:3705-3714.
    • (2011) J Clin Oncol , vol.29 , pp. 3705-3714
    • Saylor, P.J.1    Lee, R.J.2    Smith, M.R.3
  • 50
    • 0037315930 scopus 로고    scopus 로고
    • Targeting of osseous sites with alpha-emitting 223Ra: Comparison with the beta-emitter 89Sr in mice
    • Henriksen G, Fisher DR, Roeske JC, et al. targeting of osseous sites with alpha-emitting 223Ra: comparison with the beta-emitter 89Sr in mice. J Nucl Med. 2003;44:252-259.
    • (2003) J Nucl Med , vol.44 , pp. 252-259
    • Henriksen, G.1    Fisher, D.R.2    Roeske, J.C.3
  • 51
    • 84869081194 scopus 로고    scopus 로고
    • Targeted radionuclide therapy of skeletal metastases
    • Sartor O, Hoskin P, Bruland OS. Targeted radionuclide therapy of skeletal metastases. Cancer Treat Rev. 2013;39:18-26.
    • (2013) Cancer Treat Rev , vol.39 , pp. 18-26
    • Sartor, O.1    Hoskin, P.2    Bruland, O.S.3
  • 52
    • 84872507131 scopus 로고    scopus 로고
    • Radium-223 chloride: A potential new treatment for castration-resistant prostate cancer patients with metastatic bone disease
    • Harrison MR,Wong TZ, Armstrong AJ, et al. Radium-223 chloride: a potential new treatment for castration-resistant prostate cancer patients with metastatic bone disease. Cancer Manag Res. 2013;5:1-14.
    • (2013) Cancer Manag Res , vol.5 , pp. 1-14
    • Harrison, M.R.1    Wong, T.Z.2    Armstrong, A.J.3
  • 53
    • 2942580978 scopus 로고    scopus 로고
    • Targeted alpha-therapy for control of micrometastatic prostate cancer
    • Li Y, Russell PJ, Allen BJ. Targeted alpha-therapy for control of micrometastatic prostate cancer. Expert Rev Anticancer Ther. 2004;4:459-468.
    • (2004) Expert Rev Anticancer Ther , vol.4 , pp. 459-468
    • Li, Y.1    Russell, P.J.2    Allen, B.J.3
  • 54
    • 71249088083 scopus 로고    scopus 로고
    • Alpharadin, a 223Ra-based alpha particle-emitting pharmaceutical for the treatment of bone metastases in patients with cancer
    • Liepe K. Alpharadin, a 223Ra-based alpha particle-emitting pharmaceutical for the treatment of bone metastases in patients with cancer. Curr Opin Investig Drugs. 2009;10:1346-1358.
    • (2009) Curr Opin Investig Drugs , vol.10 , pp. 1346-1358
    • Liepe, K.1
  • 55
    • 34347244905 scopus 로고    scopus 로고
    • Bone-targeted radium-223 in symptomatic, hormone-refractory prostate cancer: A randomized, multicenter, placebocontrolled phase II study
    • Nilsson S, Franzén L, Parker C, et al. Bone-targeted radium-223 in symptomatic, hormone-refractory prostate cancer: a randomized, multicenter, placebocontrolled phase II study. Lancet Oncol. 2007;8:587-594.
    • (2007) Lancet Oncol , vol.8 , pp. 587-594
    • Nilsson, S.1    Franzén, L.2    Parker, C.3
  • 56
    • 20644447798 scopus 로고    scopus 로고
    • First clinical experience with alphaemitting radium-223 in the treatment of skeletal metastases
    • Nilsson S, Larsen RH, FossûËSD, et al. First clinical experience with alphaemitting radium-223 in the treatment of skeletal metastases. Clin Cancer Res. 2005;11:4451-4459.
    • (2005) Clin Cancer Res , vol.11 , pp. 4451-4459
    • Nilsson, S.1    Larsen, R.H.2    Fossûë, S.D.3
  • 57
    • 84874543674 scopus 로고    scopus 로고
    • Two-year survival follow-up of the randomized, double-blind, placebo-controlled phase II study of radium-223 chloride in patients with castration-resistant prostate cancer and bone metastases
    • Nilsson S, Franzén L, Parker C, et al. Two-year survival follow-up of the randomized, double-blind, placebo-controlled phase II study of radium-223 chloride in patients with castration-resistant prostate cancer and bone metastases. Clin Genitourin Cancer. 2013;11:20-26.
    • (2013) Clin Genitourin Cancer , vol.11 , pp. 20-26
    • Nilsson, S.1    Franzén, L.2    Parker, C.3
  • 58
    • 84858706749 scopus 로고    scopus 로고
    • A randomized, dose-response, multicenter phase II study of radium-223 chloride for the palliation of painful bone metastases in patients with castration-resistant prostate cancer
    • Nilsson S, Strang P, Aksnes AK, et al. A randomized, dose-response, multicenter phase II study of radium-223 chloride for the palliation of painful bone metastases in patients with castration-resistant prostate cancer. Eur J Cancer. 2012;48:678-686.
    • (2012) Eur J Cancer , vol.48 , pp. 678-686
    • Nilsson, S.1    Strang, P.2    Aksnes, A.K.3
  • 59
    • 84871926771 scopus 로고    scopus 로고
    • A randomized, double-blind, dosefinding, multicenter, phase 2 study of radium chloride (Ra 223) in patients with bone metastases and castration-resistant prostate cancer
    • Parker CC, Pascoe S, Chodacki A, et al. A randomized, double-blind, dosefinding, multicenter, phase 2 study of radium chloride (Ra 223) in patients with bone metastases and castration-resistant prostate cancer. Eur Urol. 2013;63:189-197.
    • (2013) Eur Urol , vol.63 , pp. 189-197
    • Parker, C.C.1    Pascoe, S.2    Chodacki, A.3
  • 60
    • 84880428467 scopus 로고    scopus 로고
    • Alpha emitter Radium-223 and survival in metastatic prostate cancer
    • Parker C, Nilsson S, Heinrich D, et al. Alpha emitter Radium-223 and survival in metastatic prostate cancer. N Engl J Med. 2013;369:213-223.
    • (2013) N Engl J Med , vol.369 , pp. 213-223
    • Parker, C.1    Nilsson, S.2    Heinrich, D.3
  • 61
    • 84862239106 scopus 로고    scopus 로고
    • Quantitative imaging of 223Rachloride (Alpharadin) for targeted alpha-emitting radionuclide therapy of bone metastases
    • Hindorf C, Chittenden S, Aksenes AK, et al. Quantitative imaging of 223Rachloride (Alpharadin) for targeted alpha-emitting radionuclide therapy of bone metastases. Nucl Med Commun. 2012;33:726-732.
    • (2012) Nucl Med Commun , vol.33 , pp. 726-732
    • Hindorf, C.1    Chittenden, S.2    Aksenes, A.K.3
  • 62
    • 84875912339 scopus 로고    scopus 로고
    • 18F-fluoride PET: Changes in uptake as a method to assess response to bone metastases from castrate-resistant prostate cancer patients treated with 223Ra-chlroide (Alpharadin)
    • Cook G Jr, Parker C, Chua S, et al. 18F-fluoride PET: changes in uptake as a method to assess response to bone metastases from castrate-resistant prostate cancer patients treated with 223Ra-chlroide (Alpharadin). EJNMMI Res. 2011;1:4.
    • (2011) EJNMMI Res , vol.1 , pp. 4
    • Cook Jr., G.1    Parker, C.2    Chua, S.3
  • 63
    • 84888285894 scopus 로고    scopus 로고
    • United States Nuclear Regulatory Commission. NUREG/BR-0117; No. 13-01. Accessed August 16
    • Licensing Decision for Radium-223 Dichloride. United States Nuclear Regulatory Commission. NUREG/BR-0117; No. 13-01. Available at: http:// www. nrc. gov/reading-rm/doc-collections/nuregs/brochures/br0117/13-01. pdf Accessed August 16, 2013. .
    • (2013) Licensing Decision for Radium-223 Dichloride
  • 64
    • 84874106208 scopus 로고    scopus 로고
    • Dosimetry of (223)Ra-chloride: Dose to normal organs and tissues
    • Lassmann M, Nosske D. Dosimetry of (223)Ra-chloride: dose to normal organs and tissues. Eur J Nucl Med Mol Imaging. 2013;40:207-212.
    • (2013) Eur J Nucl Med Mol Imaging , vol.40 , pp. 207-212
    • Lassmann, M.1    Nosske, D.2
  • 65
    • 84860677986 scopus 로고    scopus 로고
    • A bone marrow toxicity model for 223Ra alpha emitter radiopharmaceutical therapy
    • Hobbs RF, Song H, Watchman CJ, et al. A bone marrow toxicity model for 223Ra alpha emitter radiopharmaceutical therapy. Phys Med Biol. 2012;57: 3207-3222.
    • (2012) Phys Med Biol , vol.57 , pp. 3207-3222
    • Hobbs, R.F.1    Song, H.2    Watchman, C.J.3
  • 66
    • 79959437613 scopus 로고    scopus 로고
    • Alpha particle microdosimetry
    • Chouin N, Bardies M. Alpha particle microdosimetry. Curr Radiopharm. 2011;4:266-280.
    • (2011) Curr Radiopharm , vol.4 , pp. 266-280
    • Chouin, N.1    Bardies, M.2
  • 67
    • 84881630281 scopus 로고    scopus 로고
    • Phase i pahramacoknietic and biodistribution study with escalating doses of 223 Ra-dichloride in men with castration-resistant metastatic prostate cancer
    • Carrasquillo JA, O'Donoghue JA, Pandit-Taskar N, et al. Phase I pahramacoknietic and biodistribution study with escalating doses of 223 Ra-dichloride in men with castration-resistant metastatic prostate cancer. Eur J Nucl Med Mol Imaging. 2013;40:1384-1393.
    • (2013) Eur J Nucl Med Mol Imaging , vol.40 , pp. 1384-1393
    • Carrasquillo, J.A.1    O'donoghue, J.A.2    Pandit-Taskar, N.3
  • 68
    • 84888301741 scopus 로고    scopus 로고
    • Hooper S. http://www. npl. co. uk/upload/pdf/20070131-rcuf-hooper-1. pdf.
    • Hooper, S.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.