Implications of intercellular signaling for radiation therapy: A theoretical dose-planning study

International Journal of Radiation Oncology Biology Physics

Volumn 87, Issue 5, 2013, Pages 1148-1154

  McMahon, Stephen J ^a   McGarry, Conor K ^a,b   Butterworth, Karl T ^a   O'Sullivan, Joe M ^a,b   Hounsell, Alan R ^a,b   Prise, Kevin M ^a  

^a QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^b ROYAL GROUP OF HOSPITALS TRUST   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CLINICAL OBSERVATION; DOSE-VOLUME HISTOGRAMS; INTENSITY-MODULATED RADIATION THERAPY; INTERCELLULAR COMMUNICATIONS; INTERCELLULAR SIGNALING; METHODS AND MATERIALS; PLANNING TARGET VOLUMES; VOLUMETRIC MODULATED ARC THERAPY;

DOSIMETRY; MATHEMATICAL MODELS; PHYSICAL THERAPY; RADIOTHERAPY; SIGNALING;

CELL SIGNALING;

ARTICLE; CANCER THERAPY; DOSIMETRY; HUMAN; INTENSITY MODULATED RADIATION THERAPY; PRIORITY JOURNAL; PROSTATE CANCER; RADIATION DOSE; THREE DIMENSIONAL CONFORMAL THERAPY; TREATMENT PLANNING; VOLUMETRIC MODULATED ARC THERAPY; BIOLOGICAL MODEL; BLADDER; BYSTANDER EFFECT; CELL COMMUNICATION; CELL SURVIVAL; COMPUTER ASSISTED RADIOTHERAPY; MALE; ORGANS AT RISK; PHYSIOLOGY; PROCEDURES; PROSTATIC NEOPLASMS; RADIATION RESPONSE;

BYSTANDER EFFECT; CELL COMMUNICATION; CELL SURVIVAL; HUMANS; MALE; MODELS, BIOLOGICAL; ORGANS AT RISK; PROSTATIC NEOPLASMS; RADIOTHERAPY DOSAGE; RADIOTHERAPY PLANNING, COMPUTER-ASSISTED; RADIOTHERAPY, CONFORMAL; RADIOTHERAPY, INTENSITY-MODULATED; URINARY BLADDER;

EID: 84888301693     PISSN: 03603016     EISSN: 1879355X     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2013.08.021     Document Type: Article

References (21)

1. S.M. Bentzen Theragnostic imaging for radiation oncology: dose-painting by numbers Lancet Oncol 6 2005 112 117
2. E.C. Mackonis, N. Suchowerska, and M. Zhang Cellular response to modulated radiation fields Phys Med Biol 52 2007 5469 5482
3. K.T. Butterworth, C.K. McGarry, and C. Trainor Out-of-field cell survival following exposure to intensity-modulated radiation fields Int J Radiat Oncol Biol Phys 79 2011 1516 1522
4. K.M. Prise, and J.M. O'Sullivan Radiation-induced bystander signalling in cancer therapy Nature Rev Cancer 9 2009 351 360
5. M. Ebert, N. Suchowerska, and M. Jackson A mathematical framework for separating the direct and bystander components of cellular radiation response Acta Oncol 49 2010 1334 1343
6. S.J. McMahon, K.T. Butterworth, and C.K. McGarry A computational model of cellular response to modulated radiation fields Int J Radiat Oncol Biol Phys 84 2012 250 256
7. S. McMahon, K. Butterworth, and C. Trainor A kinetic-based model of radiation-induced intercellular signalling PLoS ONE 8 2013 e54526
8. B. Blyth, and P. Sykes Radiation-induced bystander effects: What are they, and how relevant are they to human radiation exposures? Radiat Res 176 2011 139 157
9. M. Mancuso, P. Giardullo, and S. Leonardi Dose and spatial effects in long-distance radiation signaling in vivo: Implications for abscopal tumorigenesis Int J Radiat Oncol Biol Phys 85 2013 813 819
10. M. Partridge A radiation damage repair model for normal tissues Phys Med Biol 53 2008 3595 3608
11. A.M. Mastro, M.A. Babich, and W.D. Taylor Diffusion of a small molecule in the cytoplasm of mammalian cells Proc Natl Acad Sci U S A 81 1984 3414 3418
12. V.S. Khoo, and D.P. Dearnaley Question of dose, fractionation and technique: Ingredients for testing hypofractionation in prostate cancer - the CHHiP trial Clin Oncol 20 2008 12 14
13. C.K. McGarry, S.J. McMahon, and D. Craft Inverse planned constant dose rate volumetric modulated arc therapy (VMAT) as an efficient alternative to five-field intensity modulated radiation therapy (IMRT) for prostate J Radiother Pract 2013 1 11 In press
14. C. Trainor, K.T. Butterworth, and C. McGarry DNA damage responses following exposure to modulated radiation fields PLoS ONE 7 2012 e43326
15. K.T. Butterworth, C.K. McGarry, and C. Trainor Dose, dose-rate and field size effects on cell survival following exposure to non-uniform radiation fields Phys Med Biol 57 2012 3197 3206
16. G. Kutcher, C. Burman, and L. Brewster Histogram reduction method for calculating complication probabilities for three-dimensional treatment planning evaluations Int J Radiat Oncol Biol Phys 21 1991 137 146
17. C. Burman, G.J. Kutcher, and B. Emami Fitting of normal tissue tolerance data to an analytic function Int J Radiat Oncol Biol Phys 21 1991 123 135
18. J.M. Michalski, H. Gay, and A. Jackson Radiation dose-volume effects in radiation-induced rectal injury Int J Radiat Oncol Biol Phys 76 2010 S123 S129
19. D.J. Brenner, R. Doll, and D.T. Goodhead Cancer risks attributable to low doses of ionizing radiation: Assessing what we really know Proc Natl Acad Sci U S A 100 2003 13761 13766
20. F. Verhaegen, P. Granton, and E. Tryggestad Small animal radiotherapy research platforms Phys Med Biol 56 2011 55 83
21. O.V. Belyakov, S.A. Mitchell, and D. Parikh Biological effects in unirradiated human tissue induced by radiation damage up to 1 mm away Proc Natl Acad Sci U S America 102 2005 14203 14208