Modulation of motor cortex excitability in obsessive-compulsive disorder: An exploratory study on the relations of neurophysiology measures with clinical outcome

Psychiatry Research

Volumn 210, Issue 3, 2013, Pages 1026-1032

  Mantovani, Antonio ^a,b   Rossi, Simone ^b   Bassi, Bruce D ^c   Simpson, Helen B ^a   Fallon, Brian A ^a   Lisanby, Sarah H ^d  

^a NEW YORK STATE PSYCHIATRIC INSTITUTE   (United States)

^b UNIVERSITY OF SIENA   (Italy)

^c UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^d DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cortical silent period; Intracortical facilitation; Motor threshold; Obsessive compulsive disorder; Short interval intracortical inhibition; Supplementary motor area; Transcranial magnetic stimulation

Indexed keywords

ADULT; ARTICLE; BRAIN ASYMMETRY; BRAIN REGION; CLINICAL ARTICLE; CLINICAL EFFECTIVENESS; CLINICAL GLOBAL IMPRESSION SCALE; FEMALE; HUMAN; LEFT HEMISPHERE; MALE; MOTOR CORTEX; NERVE EXCITABILITY; NEUROMODULATION; OBSESSIVE COMPULSIVE DISORDER; PRIORITY JOURNAL; RIGHT HEMISPHERE; SELF REPORT; TRANSCRANIAL MAGNETIC STIMULATION; TREATMENT DURATION; TREATMENT RESPONSE; YALE BROWN OBSESSIVE COMPULSIVE SCALE; AGED; BRAIN CORTEX; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; MIDDLE AGED; NEUROPHYSIOLOGY; OBSESSIVE-COMPULSIVE DISORDER; PATHOPHYSIOLOGY; PROCEDURES; PSYCHOLOGY; RANDOMIZED CONTROLLED TRIAL; TREATMENT OUTCOME;

ADULT; AGED; CEREBRAL CORTEX; DOUBLE-BLIND METHOD; FEMALE; HUMANS; MALE; MIDDLE AGED; MOTOR CORTEX; NEUROPHYSIOLOGY; OBSESSIVE-COMPULSIVE DISORDER; TRANSCRANIAL MAGNETIC STIMULATION; TREATMENT OUTCOME;

EID: 84888298729     PISSN: 01651781     EISSN: 18727123     Source Type: Journal    
DOI: 10.1016/j.psychres.2013.08.054     Document Type: Article

References (53)

1. Baer L., Brown-Beasley M.W., Sorce J., Henriques A.I. Computer-assisted telephone administration of a structured interview for obsessive-compulsive disorder. American Journal of Psychiatry 1993, 150:1737-1738.
2. Bäumer T., Schippling S., Kroeger J., Zittel S., Koch G., Thomalla G., Rothwell J.C., Siebner H.R., Orth M., Münchau A. Inhibitory and facilitatory connectivity from ventral premotor to primary motor cortex in healthy humans at rest-a bifocal TMS study. Clinical Neurophysiology 2009, 120:1724-1731.
3. Benedetti F., Mayberg H.S., Wager T.D., Stohler C.S., Zubieta J.K. Neurobiological mechanisms of the placebo effect. Journal of Neuroscience 2005, 25:10390-10402.
4. Bestmann S., Baudewig J., Siebner H.R., Rothwell J.C., Frahm J. BOLD MRI responses to repetitive TMS over human dorsal premotor cortex. Neuroimage 2005, 28:22-29.
5. Brasil-Neto J.P., Cammarota J., Valls-Sole J., Pascual-Leone A., Hallett M., Cohen L.G. Role of intracortical mechanisms in the late part of the silent period to transcranial stimulation of the human motor cortex. Acta Neurologica Scandinavia 1995, 92:383-386.
6. Chamberlain S.R., Blackwell A.D., Fineberg N.A., Robbins T.W., Sahakian B.J. The neuropsychology of obsessive compulsive disorder: the importance of failures in cognitive and behavioural inhibition as candidate endophenotypic markers. Neuroscience and Biobehavioral Review 2005, 29:399-419.
7. Chen R., Classen J., Gerloff C., Celnik P., Wassermann E.M., Hallett M. Depression of motor cortex excitability by low-frequency transcranial magnetic stimulation. Neurology 1997, 48:1398-1403.
8. Cincotta M., Giovannelli F., Borgheresi A., Balestrieri F., Toscani L., Zaccara G., Carducci F., Viggiano M.P., Rossi S. Optically tracked neuronavigation increases the stability of hand-held focal coil positioning: evidence from "transcranial" magnetic stimulation-induced electrical field measurements. Brain Stimulation 2010, 3:119-123.
9. ® Axis I Disorders (SCID-I), Clinician Version 1997, American Psychiatry Publishing Inc., Virginia.
10. Fisher R.J., Nakamura Y., Bestmann S., Rothwell J.C., Bostock H. Two phases of intracortical inhibition revealed by transcranial magnetic threshold tracking. Experimental Brain Research 2002, 143:240-248.
11. Fried I., Katz A., McCarthy G., Sass K.J., Williamson P., Spencer S.S., Spencer D.D. Functional organization of human supplementary motor cortex studied by electrical stimulation. Journal of Neuroscience 1991, 11:3656-3666.
12. Gerdelat-Mas A., Loubinoux I., Tombari D., Rascol O., Chollet F., Simonetta-Moreau M. Chronic administration of selective serotonin reuptake inhibitor (SSRI) paroxetine modulates human motor cortex excitability in healthy subjects. Neuroimage 2005, 27:314-322.
13. Goodman W.K., Price L.H., Rasmussen S.A., Mazure C., Fleischmann R.L., Hill C.L., Heninger G.R., Charney D.S. The Yale-Brown Obsessive Compulsive Scale. I. Development, use, and reliability. Archives of General Psychiatry 1989, 46:1006-1011.
14. Goodman W.K., Price L.H., Rasmussen S.A., Mazure C., Delgado P., Heninger G.R., Charney D.S. The Yale-Brown Obsessive Compulsive Scale. II. Validity. Archives of General Psychiatry 1989, 46:1012-1016.
15. Greenberg B.D., Ziemann U., Harmon A., Murphy D.L., Wassermann E.M. Decreased neuronal inhibition in cerebral cortex in obsessive-compulsive disorder on transcranial magnetic stimulation. Lancet 1998, 352:881-882.
16. Greenberg B.D., Ziemann U., Cora-Locatelli G., Harmon A., Murphy D.L., Keel J.C., Wassermann E.M. Altered cortical excitability in obsessive-compulsive disorder. Neurology 2000, 54:142-147.
17. Guy W. ECDEU Assessment Manual for Psychopharmacology. Revised 1976, National Institute of Mental Health, Rockville, MD, (DHEW publication no. (ADM) 76-338).
18. Harrison B.J., Soriano-Mas C., Pujol J., Ortiz H., López-Solà M., Hernández-Ribas R., Deus J., Alonso P., Yücel M., Pantelis C., Menchon J.M., Cardoner N. Altered corticostriatal functional connectivity in obsessive-compulsive disorder. Archives of General Psychiatry 2009, 66:1189-1200.
19. Hanajima R., Furubayashi T., Iwata N.K., Shiio Y., Okabe S., Kanazawa I., Ugawa Y. Further evidence to support different mechanisms underlying intracortical inhibition of the motor cortex. Experimental Brain Research 2003, 151:427-434.
20. Hatanaka N., Tokuno H., Hamada I., Inase M., Ito Y., Imanishi M., Hasegawa N., Akazawa T., Nambu A., Takada M. Thalamocortical and intracortical connections of monkey cingulate motor areas. Journal of Comprehensive Neurology 2003, 462:121-138.
21. Kang D.H., Kwon J.S., Kim J.J., Youn T., Park H.J., Kim M.S., Lee D.S., Lee M.C. Brain glucose metabolic changes associated with neuropsychological improvements after 4 months of treatment in patients with obsessive-compulsive disorder. Acta Psychiatrica Scandinavica 2003, 107:291-297.
22. Kang S.Y., Shin H.W., Sohn Y.H. Different modulation of the cortical silent period by two phases of short interval intracortical inhibition. Yonsei Medical Journal 2007, 48:795-801.
23. Koran L.M., Hanna G.L., Hollander E., Nestadt G., Simpson H.B. American Psychiatric Association: practice guideline for the treatment of patients with obsessive-compulsive disorder. American Journal of Psychiatry 2007, 164:5-53.
24. Kujirai T., Caramia M.D., Rothwell J.C., Day B.L., Thompson P.D., Ferbert A., Wroe S., Asselman P., Marsden C.D. Corticocortical inhibition in human motor cortex. Journal of Physiology 1993, 471:501-519.
25. Leocani L., Locatelli M., Bellodi L., Fornara C., Hénin M., Magnani G., Mennea S., Comi G. Abnormal pattern of cortical activation associated with voluntary movement in obsessive-compulsive disorder: an EEG study. American Journal of Psychiatry 2001, 158:140-142.
26. Loubinoux I., Tombari D., Pariente J., Gerdelat-Mas A., Franceries X., Cassol E., Rascol O., Pastor J., Chollet F. Modulation of behavior and cortical motor activity in healthy subjects by a chronic administration of a serotonin enhancer. Neuroimage 2005, 27:299-313.
27. Mantovani A., Lisanby S.H., Pieraccini F., Ulivelli M., Castrogiovanni P., Rossi S. Repetitive transcranial magnetic stimulation (rTMS) in the treatment of obsessive-compulsive disorder (OCD) and Tourette's syndrome (TS). International Journal of Neuropsychopharmacology 2006, 9:95-100.
28. Mantovani A., Leckman J.F., Grantz H., King R.A., Sporn A.L., Lisanby S.H. Repetitive transcranial magnetic stimulation of the supplementary motor area in the treatment of Tourette syndrome: report of two cases. Clinical Neurophysiology 2007, 118:2314-2315.
29. Mantovani A., Fallon B., Simpson H., Rossi S., Lisanby S.H. Randomized sham-controlled trial of repetitive transcranial magnetic stimulation in treatment-resistant obsessive-compulsive disorder. International Journal of Neuropsychopharmacology 2010, 13:217-227.
30. Mantovani A., Kegeles L.S., Simpson B.H., Aly M., Allart A., Harrison A., Rossi S., Lisanby S.H. Modulation of premotor GABAergic circuits in Obsessive-Compulsive Disorder (OCD) via transcranial magnetic stimulation: evidence from magnetic resonance spectroscopy. Clinical Neurophysiology 2011, 122(1S-214S):181.
31. Mantovani A., Leckman J., Aly M., Harrison A., Murphy D., Lisanby S. Effect of transcranial magnetic stimulation (TMS) on clinical symptoms and motor cortex excitability measures in tourette's syndrome. International. Journal of Neuropsychopharmacology 2012, 15:1S-271S.
32. Menzies L., Chamberlain S.R., Laird A.R., Thelen S.M., Sahakian B.J., Bullmore E.T. Integrating evidence from neuroimaging and neuropsychological studies of obsessive-compulsive disorder: the orbitofronto-striatal model revisited. Neuroscience & Biobehavioral Reviews 2008, 32:525-549.
33. Picard N., Strick P.L. Imaging the premotor areas. Current Opinions in Neurobiology 2001, 11:663-672.
34. Rauch S.L., Dougherty D.D., Malone D., Rezai A., Friehs G., Fischman A.J., Alpert N.M., Haber S.N., Stypulkowski P.H., Rise M.T., Rasmussen S.A., Greenberg B.D. A functional neuroimaging investigation of deep brain stimulation in patients with obsessive-compulsive disorder. Journal of Neurosurgery 2006, 104:558-565.
35. Reis J., John D., Heimeroth A., Mueller H.H., Oertel W.H., Arndt T., Rosenow F. Modulation of human motor cortex excitability by single doses of amantadine. Neuropsychopharmacology 2006, 31:2758-2766.
36. Richter M.A., de Jesus D.R., Hoppenbrouwers S., Daigle M., Deluce J., Ravindran L.N., Fitzgerald P.B., Daskalakis Z.J. Evidence for cortical inhibitory and excitatory dysfunction in obsessive compulsive disorder. Neuropsychopharmacology 2012, 37:1144-1151.
37. Roshan L., Paradiso G.O., Chen R. Two phases of short-interval intracortical inhibition. Experimental Brain Research 2003, 151:330-337.
38. Rossi S., Bartalini S., Ulivelli M., Mantovani A., Di Muro A., Goracci A., Castrogiovanni P., Battistini N., Passero S. Hypofunctioning of sensory gating mechanisms in patients with obsessive-compulsive disorder. Biological Psychiatry 2005, 57:16-20.
39. Rossi S., De Capua A., Tavanti M., Calossi S., Polizzotto N.R., Mantovani A., Falzarano V., Bossini L., Passero S., Bartalini S., Ulivelli M. Dysfunctions of cortical excitability in drug-naïve post-traumatic stress disorder patients. Biological Psychiatry 2009, 166:54-61.
40. Rossi S., Hallett M., Rossini P.M., Pascual-Leone A. Safety of TMS Consensus Group: safety, ethical considerations, and application guidelines for the use of transcranial magnetic stimulation in clinical practice and research. Clinical Neurophysiology 2009, 120:2008-2039.
41. Rossini P.M., Barker A.T., Berardelli A., Caramia M.D., Caruso G., Cracco R.Q., Dimitrijević M.R., Hallett M., Katayama Y., Lücking C.H., de Noordhout M., Marsden C.D., Murray N.M.F., Rothwell J.C., Swash M., Tomberg C. Non-invasive electrical and magnetic stimulation of the brain, spinal cord and roots: basic principles and procedures for routine clinical application. Electroencephalography and Clinical Neurophysiology 1994, 91:79-92.
42. Saxena S., Rauch S.L. Functional neuroimaging and the neuroanatomy of OCD. Psychiatric Clinics of North America 2000, 23:563-586.
43. Saxena S., Brody A.L., Ho M.L., Alborzian S., Maidment K.M., Zohrabi N., Ho M.K., Huang S.C., Wu H.M., Baxter L.R. Differential cerebral metabolic changes with paroxetine treatment of obsessive-compulsive disorder vs major depression. Archives of General Psychiatry 2002, 59:250-261.
44. Schwenkreis P., Liepert J., Witscher K., Fischer W., Weiller C., Malin J.P., Tegenthoff M. Riluzole suppresses motor cortex facilitation in correlation to its plasma level. A study using transcranial magnetic stimulation. Experimental Brain Research 2000, 135:293-299.
45. Siebner H.R., Dressnandt J., Auer C., Conrad B. Continuous intrathecal baclofen infusions induced a marked increase of the transcranially evoked silent period in a patient with generalized dystonia. Muscle & Nerve 1998, 21:1209-1212.
46. Simpson H.B., Huppert J.D., Petkova E., Foa E.B., Liebowitz M.R. Response versus remission in obsessive-compulsive disorder. Journal of Clinical Psychiatry 2006, 67:269-276.
47. Simpson H.B., Shungu D.S., Bender J., Mao X., Xu X., Slifstein M., Kegeles L.S. Investigation of cortical glutamate-glutamine and γ-aminobutyric acid in obsessive-compulsive disorder by proton magnetic resonance spectroscopy. Neurpsychopharmacology 2012, 37:2684-2692.
48. Steketee G., Frost R., Bogart K. The Yale-Brown Obsessive Compulsive Scale: interview versus self-report. Behavioral Research and Therapy 1996, 34:675-684.
49. Van den Heuvel O.A., Veltman D.J., Groenewegen H.J., Cath D.C., van Balkom A.J., van Hartskamp J., Barkhof F., van Dyck R. Frontal-striatal dysfunction during planning in OCD. Archives of General Psychiatry 2005, 62:301-309.
50. Yücel M., Harrison B.J., Wood S.J., Fornito A., Wellard R.M., Pujol J., Clarke K., Phillips M.L., Kyrios M., Velakoulis D., Pantelis C. Functional and biochemical alterations of the medial frontal cortex in OCD. Archives of General Psychiatry 2007, 64:946-955.
51. Ziemann U., Lönnecker S., Steinhoff B.J., Paulus W. Effects of antiepileptic drugs on motor cortex excitability in humans: a transcranial magnetic stimulation study. Annals of Neurology 1996, 40:367-378.
52. Ziemann U., Lönnecker S., Steinhoff B.J, Paulus W. The effect of lorazepam on the motor cortical excitability in man. Experimental Brain Research 1996, 109:127-135.
53. Ziemann U., Chen R., Cohen L.G., Hallett M. Dextromethorphan decreases the excitability of the human motor cortex. Neurology 1998, 51:1320-1324.