Ejaculatory dysfunction

Urologic Clinics of North America

Volumn 41, Issue 1, 2014, Pages 115-128

  Phillips, Elizabeth ^a   Carpenter, Christina ^b   Oates, Robert D ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Ambulatory Care Center   (United States)

Author keywords

Anejaculation; Ejaculation; Electroejaculation; Emission; Infertility

Indexed keywords

ANEJACULATION; EJACULATION; ELECTROEJACULATION; EMISSION; INFERTILITY;

DIABETES COMPLICATIONS; EJACULATION; EJACULATORY DUCTS; EPIDIDYMIS; HUMANS; INFERTILITY, MALE; MALE; NERVOUS SYSTEM DISEASES; NEURONS, AFFERENT; NEURONS, EFFERENT; POSTOPERATIVE COMPLICATIONS; SEMINAL VESICLES; SEXUAL DYSFUNCTION, PHYSIOLOGICAL; SPINAL CORD; SPINAL CORD INJURIES; VAS DEFERENS;

EID: 84888290336     PISSN: 00940143     EISSN: 1558318X     Source Type: Journal    
DOI: 10.1016/j.ucl.2013.08.018     Document Type: Review

References (89)

1. Muller A., Mulhall J.P. The epididymis and accessory sex organs erection, emission and ejaculation: mechanisms of control. Infertility in the male 2009, 132-152. Cambridge University Press, Cambridge (United Kingdom). 4th edition. L.I. Lipshultz, H.S. Nagler, C.S. Niederberger (Eds.).
2. Turner T. The epididymis and accessory sex organs. Infertility in the male 2009, 90-103. Cambridge University Press, Cambridge (United Kingdom). 4th edition. L.I. Lipshultz, H.S. Nagler, C.S. Niederberger (Eds.).
3. Belleannee C., Thimon V., Sullivan R. Region-specific gene expression in the epididymis. Cell Tissue Res 2012, 349(3):717-731. PubMed PMID: 22427067.
4. Vignozzi L., Filippi S., Morelli A., et al. Regulation of epididymal contractility during semen emission, the first part of the ejaculatory process: a role for estrogen. JSex Med 2008, 5(9):2010-2016. [quiz: 7]. PubMed PMID: 18783525.
5. Oates R.D. Using transrectal ultrasonography in the diagnosis of ejaculatory duct obstruction. Contemp Urol 1991, 3(7):47. 50-8; 63. PubMed PMID: 10148059.
6. Paniagua R., Regadera J., Nistal M., et al. Histological, histochemical and ultrastructural variations along the length of the human vas deferens before and after puberty. Acta Anat (Basel) 1982, 111(3):190-203. PubMed PMID: 7064642.
7. Westfall T.D., Westfall D.P. Pharmacological techniques for the invitro study of the vas deferens. JPharmacol Toxicol Methods 2001, 45(2):109-122. PubMed PMID: 11687379.
8. Burnstock G., Verkhratsky A. Vas deferens-a model used to establish sympathetic cotransmission. Trends Pharmacol Sci 2010, 31(3):131-139. PubMed PMID: 20074819.
9. Medina P., Segarra G., Mauricio M.D., et al. Role of Ca(2+)-activated K(+) channels and Na(+), K(+)-ATPase in prostaglandin E(1)- and E(2)-induced inhibition of the adrenergic response in human vas deferens. Biochem Pharmacol 2011, 82(1):65-71. PubMed PMID: 21458424.
10. Zahalsky M., Nagler H.M. Ultrasound and infertility: diagnostic and therapeutic uses. Curr Urol Rep 2001, 2(6):437-442. PubMed PMID: 12084228.
11. Giuliano F., Clement P. Neuroanatomy and physiology of ejaculation. Annu Rev Sex Res 2005, 16:190-216. PubMed PMID: 16913292.
12. Uckert S., Stanarius A., Stief C.G., et al. Immunocytochemical distribution of nitric oxide synthase in the human seminal vesicle: a light and electron microscopical study. Urol Res 2003, 31(4):262-266. PubMed PMID: 12802542.
13. Nguyen H.T., Etzell J., Turek P.J. Normal human ejaculatory duct anatomy: a study of cadaveric and surgical specimens. JUrol 1996, 155(5):1639-1642. PubMed PMID: 8627842.
14. Michel M.C., Barendrecht M.M. Physiological and pathological regulation of the autonomic control of urinary bladder contractility. Pharmacol Ther 2008, 117(3):297-312. PubMed PMID: 18221785.
15. Yang C.C., Bradley W.E. Somatic innervation of the human bulbocavernosus muscle. Clin Neurophysiol 1999, 110(3):412-418. PubMed PMID: 10363763.
16. Yang C.C., Bradley W.E. Reflex innervation of the bulbocavernosus muscle. BJU Int 2000, 85(7):857-863. PubMed PMID: 10792166.
17. Seftel A.D., Oates R.D. Disturbed sexual function in patients with spinal cord disease. Neurologic clinics: disorders of the spinal cord 1991, vol. 9:757-778. W.B. Saunders Company, Philadelphia.
18. Coolen L.M., Allard J., Truitt W.A., et al. Central regulation of ejaculation. Physiol Behav 2004, 83(2):203-215. PubMed PMID: 15488540.
19. Staudt M.D., Truitt W.A., McKenna K.E., et al. Apivotal role of lumbar spinothalamic cells in the regulation of ejaculation via intraspinal connections. JSex Med 2012, 9(9):2256-2265. PubMed PMID: 22189051.
20. Young B., Coolen L., McKenna K. Neural regulation of ejaculation. JSex Med 2009, 6(Suppl 3):229-233. PubMed PMID: 19267846.
21. Staudt M.D., de Oliveira C.V., Lehman M.N., et al. Activation of NMDA receptors in lumbar spinothalamic cells is required for ejaculation. JSex Med 2011, 8(4):1015-1026. PubMed PMID: 21235717. Pubmed Central PMCID: 3253366.
22. Gougis S., Prud'homme M.J., Rampin O. Presence of the N-methyl-D-aspartic acid R1 glutamatergic receptor subunit in the lumbosacral spinal cord of male rats. Neurosci Lett 2002, 323(3):224-228. PubMed PMID: 11959425.
23. Truitt W.A., Coolen L.M. Identification of a potential ejaculation generator in the spinal cord. Science 2002, 297(5586):1566-1569. PubMed PMID: 12202834.
24. Dominguez J.M., Hull E.M. Dopamine, the medial preoptic area, and male sexual behavior. Physiol Behav 2005, 86(3):356-368. PubMed PMID: 16135375.
25. Wagner C.K., Clemens L.G. Neurophysin-containing pathway from the paraventricular nucleus of the hypothalamus to a sexually dimorphic motor nucleus in lumbar spinal cord. JComp Neurol 1993, 336(1):106-116. PubMed PMID: 8254108.
26. Marson L., McKenna K.E. Arole for 5-hydroxytryptamine in descending inhibition of spinal sexual reflexes. Exp Brain Res 1992, 88(2):313-320. PubMed PMID: 1577105.
27. Comarr A.E. Sexual concepts in traumatic cord and cauda equina lesions. JUrol 1971, 106(3):375-378. PubMed PMID: 5097190.
28. Alm P. On the autonomic innervation of the human vas deferens. Brain Res Bull 1982, 9(1-6):673-677. PubMed PMID: 6184134.
29. Hubscher C.H. Ascending spinal pathways from sexual organs: effects of chronic spinal lesions. Prog Brain Res 2006, 152:401-414. PubMed PMID: 16198716.
30. Kihara K., Sato K., Oshima H. Sympathetic efferent pathways projecting to the vas deferens. Microsc Res Tech 1998, 42(6):398-408. PubMed PMID: 9817547.
31. Mauroy B., Demondion X., Drizenko A., et al. The inferior hypogastric plexus (pelvic plexus): its importance in neural preservation techniques. Surg Radiol Anat 2003, 25(1):6-15. PubMed PMID: 12690518.
32. Chehensse C., Bahrami S., Denys P., et al. The spinal control of ejaculation revisited: a systematic review and meta-analysis of anejaculation in spinal cord injured patients. Hum Reprod Update 2013, 19(5):507-526. PubMed PMID: 23820516.
33. Johnson R.D. Descending pathways modulating the spinal circuitry for ejaculation: effects of chronic spinal cord injury. Prog Brain Res 2006, 152:415-426. PubMed PMID: 16198717.
34. Sultan R., Vaucher L., Bolyakov A., et al. Anejaculation. Surgical and medical management of male infertility 2013, 105-118. Cambridge University Press, New York. M. Goldstein, P.S. Schlegel (Eds.).
35. Newman H.F., Reiss H., Northup J.D. Physical basis of emission, ejaculation, and orgasm in the male. Urology 1982, 19(4):341-350. PubMed PMID: 6122300.
36. Shafik A. Response of the urethral and intracorporeal pressures to cavernosus muscle stimulation: role of the muscles in erection and ejaculation. Urology 1995, 46(1):85-88. PubMed PMID: 7604482.
37. Mitsuya H., Asai J., Suyama K., et al. Application of x-ray cinematography in urology: I. Mechanism of ejaculation. JUrol 1960, 83:86-92. PubMed PMID: 14423047.
38. Ichijo S., Sigg C., Nagasawa M., et al. Vasoseminal vesiculography before and after ejaculation. Urol Int 1981, 36(1):35-45. PubMed PMID: 7257012.
39. Koraitim M., Schafer W., Melchior H., et al. Dynamic activity of bladder neck and external sphincter in ejaculation. Urology 1977, 10(2):130-132. PubMed PMID: 898451.
40. Gosling J.A., Dixon J.S., Lendon R.G. The autonomic innervation of the human male and female bladder neck and proximal urethra. JUrol 1977, 118(2):302-305. PubMed PMID: 894809.
41. Allard J., Truitt W.A., McKenna K.E., et al. Spinal cord control of ejaculation. World J Urol 2005, 23(2):119-126. PubMed PMID: 15947961.
42. Basiri A., Ghaed M.A., Simforoosh N., et al. Is modified retroperitoneal lymph node dissection alive for clinical stage I non-seminomatous germ cell testicular tumor?. Urol J 2013, 10(2):873-877. PubMed PMID: 23801470.
43. Kimura Y., Nakamura T., Kawauchi A., et al. Post-chemotherapy nerve-sparing laparoscopic retroperitoneal lymph node dissection in stage IIB testicular cancer. Int J Urol 2013, 20(8):837-841. PubMed PMID: 23305547.
44. Beck S.D., Bey A.L., Bihrle R., et al. Ejaculatory status and fertility rates after primary retroperitoneal lymph node dissection. JUrol 2010, 184(5):2078-2080. PubMed PMID: 20850817.
45. May A.G., DeWeese J.A., Rob C.G. Changes in sexual function following operation on the abdominal aorta. Surgery 1969, 65(1):41-47. PubMed PMID: 5762416.
46. van Schaik J., van Baalen J.M., Visser M.J., et al. Nerve-preserving aortoiliac reconstruction surgery: anatomical study and surgical approach. JVasc Surg 2001, 33(5):983-989. PubMed PMID: 11331838.
47. Nishizawa Y., Ito M., Saito N., et al. Male sexual dysfunction after rectal cancer surgery. Int J Colorectal Dis 2011, 26(12):1541-1548. PubMed PMID: 21562743.
48. Liang J.T., Lai H.S., Lee P.H. Laparoscopic pelvic autonomic nerve-preserving surgery for patients with lower rectal cancer after chemoradiation therapy. Ann Surg Oncol 2007, 14(4):1285-1287. PubMed PMID: 17235719.
49. Lu S., Xu Y.Q., Chang S., et al. Clinical anatomy study of autonomic nerve with respective to the anterior approach lumbar surgery. Surg Radiol Anat 2009, 31(6):425-430. PubMed PMID: 19190849.
50. Bischoff J.M., Linderoth G., Aasvang E.K., et al. Dysejaculation after laparoscopic inguinal herniorrhaphy: a nationwide questionnaire study. Surg Endosc 2012, 26(4):979-983. PubMed PMID: 22011952.
51. Aasvang E.K., Kehlet H. Postherniotomy dysejaculation: successful treatment with mesh removal and nerve transection. Hernia 2008, 12(6):645-647. PubMed PMID: 18437287.
52. Orasanu B., Frasure H., Wyman A., et al. Sexual dysfunction in patients with multiple sclerosis. Mult Scler Relat Disord 2013, 2:117-123.
53. Celik D.B., Poyraz E.C., Bingol A., et al. Sexual dysfunction in multiple sclerosis: gender differences. JNeurol Sci 2013, 324(1-2):17-20. PubMed PMID: 23079605.
54. Guo Z.N., He S.Y., Zhang H.L., et al. Multiple sclerosis and sexual dysfunction. Asian J Androl 2012, 14(4):530-535. PubMed PMID: 22447199.
55. McDougall A.J., McLeod J.G. Autonomic nervous system function in multiple sclerosis. JNeurol Sci 2003, 215(1-2):79-85. PubMed PMID: 14568133.
56. Scott T.F., Frohman E.M., De Seze J., et al. Evidence-based guideline: clinical evaluation and treatment of transverse myelitis: report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology. Neurology 2011, 77(24):2128-2134. PubMed PMID: 22156988.
57. Laurence K.M., Beresford A. Continence, friends, marriage and children in 51 adults with spina bifida. Dev Med Child Neurol Suppl 1975, 35:123-128. PubMed PMID: 1107110.
58. Reilly J.M., Oates R.D. Preliminary investigation of the fertility status of post-pubertal males with myelodysplasia 1992, International Pediatric Nephrology Association, Jerusalem (Israel).
59. Hultling C., Levi R., Amark S.P., et al. Semen retrieval and analysis in men with myelomeningocele. Dev Med Child Neurol 2000, 42(10):681-684. PubMed PMID: 11085296.
60. Patel R.P., Kolon T.F., Huff D.S., et al. Cryptorchid testis histopathology in myelomeningocele patients. JPediatr Urol 2008, 4(6):434-437. PubMed PMID: 18644747.
61. Kamenov Z.A., Traykov L.D. Diabetic autonomic neuropathy. Adv Exp Med Biol 2012, 771:176-193. PubMed PMID: 23393679.
62. Oates R.D. Poor quality ejaculate sperm: do the data support the use of testis sperm?. Bienniel review of infertility 2013, 9-15. Springer Press, New York. P.N. Schlegel, B. Fauser, D.T. Carrell (Eds.).
63. Dunsmuir W.D., Holmes S.A. The aetiology and management of erectile, ejaculatory, and fertility problems in men with diabetes mellitus. Diabet Med 1996, 13(8):700-708. PubMed PMID: 8862943.
64. La Vignera S., Condorelli R., Vicari E., et al. Diabetes mellitus and sperm parameters. JAndrol 2012, 33(2):145-153. PubMed PMID: 21474785.
65. Roessner C., Paasch U., Kratzsch J., et al. Sperm apoptosis signalling in diabetic men. Reprod Biomed Online 2012, 25(3):292-299. PubMed PMID: 22796231.
66. National Spinal Cord Injury Statistical Center Spinal cord injury facts and figures at a glance. JSpinal Cord Med 2013, 36(1):1-2. PubMed PMID: 23433327. Pubmed Central PMCID: 3555099.
67. Schoenfeld A.J., Lehman R.A., Hsu J.R. Evaluation and management of combat-related spinal injuries: a review based on recent experiences. Spine J 2012, 12(9):817-823. PubMed PMID: 21640658.
68. Sidhu G.S., Ghag A., Prokuski V., et al. Civilian gunshot injuries of the spinal cord: a systematic review of the current literature. Clin Orthop Relat Res 2013, [Epub ahead of print]. PubMed PMID: 23479233.
69. Brown D.J., Hill S.T., Baker H.W. Male fertility and sexual function after spinal cord injury. Prog Brain Res 2006, 152:427-439. PubMed PMID: 16198718.
70. Brackett N.L., Lynne C.M., Ibrahim E., et al. Treatment of infertility in men with spinal cord injury. Nat Rev Urol 2010, 7(3):162-172. PubMed PMID: 20157304.
71. Virseda-Chamorro M., Salinas-Casado J., Lopez-Garcia-Moreno A.M., et al. Sexual dysfunction in men with spinal cord injury: a case-control study. Int J Impot Res 2013, 25(4):133-137. PubMed PMID: 23425974.
72. Gilja I., Parazajder J., Radej M., et al. Retrograde ejaculation and loss of emission: possibilities of conservative treatment. Eur Urol 1994, 25(3):226-228. PubMed PMID: 8200405.
73. Kamischke A., Nieschlag E. Update on medical treatment of ejaculatory disorders. Int J Androl 2002, 25(6):333-344. PubMed PMID: 12406365.
74. Oates R.D., Kasabian N. The use of vibratory stimulation for ejaculatory abnormalities. Management of impotence and infertility 1994, 314-320. JB Lippincott Co, Philadelphia. H.M. Nagker, E.D. Whitehead (Eds.).
75. Bird V.G., Brackett N.L., Lynne C.M., et al. Reflexes and somatic responses as predictors of ejaculation by penile vibratory stimulation in men with spinal cord injury. Spinal Cord 2001, 39(10):514-519. PubMed PMID: 11641794.
76. Nehra A., Werner M.A., Bastuba M., et al. Vibratory stimulation and rectal probe electroejaculation as therapy for patients with spinal cord injury: semen parameters and pregnancy rates. JUrol 1996, 155(2):554-559. PubMed PMID: 8558659.
77. Sonksen J., Biering-Sorensen F., Kristensen J.K. Ejaculation induced by penile vibratory stimulation in men with spinal cord injuries. The importance of the vibratory amplitude. Paraplegia 1994, 32(10):651-660. PubMed PMID: 7831070.
78. Van Voorhis B.J., Barnett M., Sparks A.E., et al. Effect of the total motile sperm count on the efficacy and cost-effectiveness of intrauterine insemination and invitro fertilization. Fertil Steril 2001, 75(4):661-668. PubMed PMID: 11287015.
79. Fode M., Krogh-Jespersen S., Brackett N.L., et al. Male sexual dysfunction and infertility associated with neurological disorders. Asian J Androl 2012, 14(1):61-68. PubMed PMID: 22138899.
80. Brackett N.L., Lynne C.M., Sonksen J., et al. Penile vibratory stimulation. Surgical and medical management of male infertility 2013, 119-129. Cambridge University Press, New York. M. Goldstein, P.S. Schlegel (Eds.).
81. Brackett N.L., Kafetsoulis A., Ibrahim E., et al. Application of 2 vibrators salvages ejaculatory failures to 1 vibrator during penile vibratory stimulation in men with spinal cord injuries. JUrol 2007, 177(2):660-663. PubMed PMID: 17222653.
82. Kafetsoulis A., Brackett N.L., Ibrahim E., et al. Current trends in the treatment of infertility in men with spinal cord injury. Fertil Steril 2006, 86(4):781-789. PubMed PMID: 16963042.
83. Sonksen J. Assisted ejaculation and semen characteristics in spinal cord injured males. Scand J Urol Nephrol Suppl 2003, (213):1-31. PubMed PMID: 12881148.
84. Bauman C.A., Milligan J.D., Lee F.J., et al. Autonomic dysreflexia in spinal cord injury patients: an overview. JCan Chiropr Assoc 2012, 56(4):247-250. PubMed PMID: 23204565. Pubmed Central PMCID: 3501908.
85. Ohl D.A., Wolf L.J., Menge A.C., et al. Electroejaculation and assisted reproductive technologies in the treatment of anejaculatory infertility. Fertil Steril 2001, 76(6):1249-1255. PubMed PMID: 11730759.
86. Brackett N.L., Ibrahim E., Iremashvili V., et al. Treatment for ejaculatory dysfunction in men with spinal cord injury: an 18-year single center experience. JUrol 2010, 183(6):2304-2308. PubMed PMID: 20400139.
87. Hsiao W., Deveci S., Mulhall J.P. Outcomes of the management of post-chemotherapy retroperitoneal lymph node dissection-associated anejaculation. BJU Int 2012, 110(8):1196-1200. PubMed PMID: 22233208.
88. Hsiao W., Stahl P.J., Osterberg E.C., et al. Successful treatment of postchemotherapy azoospermia with microsurgical testicular sperm extraction: the Weill Cornell experience. JClin Oncol 2011, 29(12):1607-1611. PubMed PMID: 21402606.
89. Gur S., Kadowitz P.J., Hellstrom W.J. Purinergic (P2) receptor control of lower genitourinary tract function and new avenues for drug addiction: anoverview. Curr Pharm Des 2013, 13(31):3236-3244.