Neural regulation of ejaculation

Journal of Sexual Medicine

Volumn 6, Issue SUPPL. 3, 2009, Pages 229-233

  Young, Brandt ^a,b   Coolen, Lique ^c   Mckenna, Kevin ^a,b  

^a NORTHWESTERN UNIVERSITY   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c UNIVERSITY OF WESTERN ONTARIO   (Canada)

Author keywords

Ejaculation; NMDA; Physiology

Indexed keywords

N METHYL DEXTRO ASPARTIC ACID RECEPTOR; SEROTONIN UPTAKE INHIBITOR; SILDENAFIL; TRICYCLIC ANTIDEPRESSANT AGENT;

CELL FUNCTION; CONFERENCE PAPER; DRUG ACTIVITY; DRUG EFFICACY; EJACULATION; ERECTILE DYSFUNCTION; HUMAN; MALE; MALE SEXUAL DYSFUNCTION; NERVE CELL; NEUROPHYSIOLOGY; PENIS ERECTION; PREMATURE EJACULATION; PRIORITY JOURNAL; QUALITY OF LIFE; SEXUAL BEHAVIOR; SPINAL CORD INJURY; SPINOTHALAMIC TRACT;

EID: 61849128761     PISSN: 17436095     EISSN: 17436109     Source Type: Journal    
DOI: 10.1111/j.1743-6109.2008.01181.x     Document Type: Conference Paper

References (36)

1. Bennett CJ, Seager SW, Vasher EA, McGuire EJ. Dysfunction sexual and electroejaculation in men with spinal cord injury: Review. J Urol 1988; 139: 453-7.
2. Patrick DL, Rowland D, Rothman M. Interrelationships among measures of premature ejaculation: The central role of perceived control. J Sex Med 2007; 4: 780-8.
3. Soler JM, Previnaire JG, Plante P, Denys P, Chartier-Kastler E. Midodrine improves orgasm in spinal cord-injured men: The effects of autonomic stimulation. J Sex Med 2008; 5: 2935-41.
4. Monga M, Bernie J, Rajasekaran M, Male infertility and erectile dysfunction in spinal cord injury: A review. Arch Phys Med Rehabil 1999; 80: 1331-9.
5. Waldinger MD. Ejaculation premature: Definition and drug treatment. Drugs 2007; 67: 547-68.
6. Waldinger MD. The neurobiological approach to premature ejaculation. J Urol 2002; 168: 2359-67.
7. Allard J, Truitt WA, McKenna KE, Coolen LM. Spinal cord control of ejaculation. World J Urol 2005; 23: 119-26.
8. McKenna KE. Ejaculation. In: Knobil E, Neill J, eds. Encyclopedia of reproduction. New York: Academic Press; 1999: 1002-8.
9. Sonksen J, Biering-Sorensen F, Kristensen JK. Ejaculation induced by penile vibratory stimulation in men with spinal cord injuries. The importance of vibratory amplitude. Paraplegia 1994; 32: 651-60.
10. Brackett NL, Ferrell SM, Aballa TC, Amador MJ, Padron OF, Sonksen J, Lynne CM. An analysis of 653 trials of penile vibratory stimulation in men with spinal cord injury. J Urol 1998; 159: 1931-4.
11. Biering-Sorensen F, Laeessoe L, Sonksen J, Bagi P, Nielsen JB, Kristensen JK. The effect of penile vibratory stimulation on male fertility potential, spasticity and neurogenic detrusor overactivity in spinal cord lesioned individuals. Acta Neurochir Suppl 2005; 93: 159-63.
12. McKenna KE, Chung SK, McVary KT. A model for the study of sexual funciton in anesthetized male and female rats. Am J Physiol 1991; 261: 1276-85.
13. Gravitt K, Marson L. Effect of destruction of cells containing the serotonin reuptake transporter on urethrogenital reflexes. J Sex Med 2007; 4: 322-31.
14. Veening JG, Coolen LM. Neural activation following sexual behavior in the male and female rat brain. Behav Brain Res 1998; 92: 181-93.
15. Coolen LM, Peters HJ, Veening JG. Anatomical interrelationships of the medial preoptic area and other brain regions activated following male sexual behavior: A combined fos and tract-tracing study. J Comp Neurol 1998; 397: 421-35.
16. Coolen LM, Peters JPW, Veening JG. Fos immunoreactivity in the rat brain following consummatory elements of sexual behavior: A sex comparison. Brain Res 1996; 738: 67-82.
17. Coolen LM, Peters JPW, Veening JG. The distribution of Fos-immunoreactivity following mating versus anogenital investigation in the male rat brain. Neuroscience 1997; 77: 1151-61.
18. Coolen LM, Veening JG, Petersen DW, Shipley MT. Parvocellular subparafascicular thalamic nucleus in the rat: Anatomical and functional compartmentalization. J Comp Neurol 2003; 463: 117-31.
19. Coolen LM, Peters HJ, Veening JG. Distribution of Fos immunoreactivity following mating versus anogenital investigation in the male rat brain. Neuroscience 1997; 77: 1151-61.
20. Coolen LM. Control neural of ejaculation. J Comp Neurol 2005; 493: 39-45.
21. Mas M, Fumero B, Fernandez-Vera JR, Gonzalez JL. Neurochemical correlates of sexual exhaustion and recovery as assessed by in vivo microdialysis. Brain Res 1995; 675: 16-9.
22. Rodriquez-Manzo G, Pellicer F, Larsson K, Fernandez-Guasti A. Stimulation of the medial preoptic area facilitates sexual behavior but does not reverse sexual satiation. Behav Neurosci 2000; 114: 553-60.
23. Marson L, McKenna KE. Stimulation of the hypothalamus initiates the urethrogenital reflex in male rats. Brain Res 1994; 638: 103-8.
24. Marson L, Platt KB, McKenna KE. Central nervous system innervation of the penis as revealed by the transneuronal transport of pseudorabies virus. Neuroscience 1993; 55: 263-80.
25. Marson L, McKenna KE. CNS cell groups involved in the control of the ischiocavernosus and bulbospongiosus muscles: A transneuronal tracing study using pseudorabies virus. J Comp Neurol 1996; 374: 161-79.
26. Coolen LM, Peters HJ, Veening JG. Anatomical interrelationships of the medial preoptic area and other brain regions activated following male sexual behavior: A combined fos and tract-tracing study. J Comp Neurol 1998; 397: 421-35.
27. Coolen LM, Wood RI. Bidirectional connections of the medial amygdaloid nucleus in the Syrian hamster brain: Simultaneous anterograde and retrograde tract tracing. J Comp Neurol 1998; 399: 189-209.
28. Coolen LM, Veening JG, Wells AB, Shipley MT. Afferent connections of the subparafascicular thalamic nucleus in the rat: Evidence for functional subdivisions. J Comp Neurol 2003; 463: 132-56.
29. Coolen LM, Veening JG, Petersen DW, Shipley MT. Parvocellular subparafascicular thalamic nucleus in the rat: Anatomical and functional compartmentalization. J Comp Neurol 2003; 463: 117-31.
30. De Groat WC, Steers WD. Autonomic regulation of the urinary bladder and sexual organs. In: Loewy AD, Spyer KM, eds. Central regulation of autonomic function, Oxford, New York: Oxford University Press; 1990: 310-33.
31. Truitt WA, Shipley MT, Veening JG, Coolen LM. Activation of a subset of lumbar spinothalamic neurons after copulatory behavior in male but not female rats. J Neurosci 2003; 23: 325-31.
32. Ahlenius S, Larsson K, Svensson L, Hjorth S, Carlsson A, Lindberg P, Wikstrom H, Sanchez D, Arvidsson LE, Hacksell U, Nilsson JL. Effects of a new type of 5-HT receptor agonist on male rat sexual behavior. Pharmaco Biochem Behav 1981; 15: 785-92.
33. Lee RL, Smith ER, Mas M, Davidson JM. Effects of intrathecal administration of 8-OH-DPAT on genital reflexes and mating behavior in male rats. Physiol Behav 1990; 47: 665-9.
34. Coolen LM, Olivier B, Peters HJ, Veening JG. Demonstration of ejaculation-induced neural activity in the male rat brain using 5-HT1A agonist 8-OH-DPAT. Physiol Behav 1997; 62: 881-91.
35. Truitt WA, Coolen LM. Identification of a potential ejaculation generator in the spinal cord. Science 2002; 297: 1566-9.
36. Feldman RS, Meyer JS, Quenzer LF. Principles of neuropsychopharmacology. Sunderland, MA: Sinauer Associates, Inc.; 1997: 909.