Rac and Cdc42 team up for platelets

Blood

Volumn 122, Issue 18, 2013, Pages 3096-3097

  Aslan, Joseph E ^a   McCarty, Owen J T ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; P21 ACTIVATED KINASE; PROTEIN CDC42; RAC PROTEIN; RAC1 PROTEIN; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; TUBULIN;

ACTIN FILAMENT; ARTICLE; BLOOD CLOTTING; CELL DIFFERENTIATION; CELL FUNCTION; CELL MIGRATION; DYNAMICS; HEMOSTASIS; IMMUNORECEPTOR TYROSINE BASED ACTIVATION MOTIF; MEGAKARYOCYTE; NONHUMAN; PRIORITY JOURNAL; THROMBOCYTE; THROMBOCYTE ACTIVATION; THROMBOCYTE COUNT; THROMBOCYTE MEMBRANE; THROMBOCYTE RELEASE REACTION; THROMBOCYTE SHAPE; THROMBOCYTOPENIA; THROMBOCYTOPOIESIS; UPREGULATION; WILD TYPE;

EID: 84888269144     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2013-08-516906     Document Type: Article

References (9)

1. Pleines I, Dütting S, Cherpokova D, et al. Defective tubulin organization and proplatelet formation in murine megakaryocytes lacking Rac1 and Cdc42. Blood. 2013;122(18):3178-3187.
2. Ruggeri ZM. Platelet adhesion under flow. Microcirculation. 2009;16(1):58-83.
3. Italiano JE Jr. Unraveling mechanisms that control platelet production. Semin Thromb Hemost. 2013;39(1):15-24.
4. Aslan JE, McCarty OJ. Rho GTPases in platelet function. J Thromb Haemost. 2013;11(1):35-46.
5. Heasman SJ, Ridley AJ. Mammalian Rho GTPases: new insights into their functions from in vivo studies. Nat Rev Mol Cell Biol. 2008;9(9):690-701.
6. Pleines I, Hagedorn I, Gupta S, et al. Megakaryocytespecific RhoA deficiency causes macrothrombocytopenia and defective platelet activation in hemostasis and thrombosis. Blood. 2012;119(4):1054-1063.
7. McCarty OJ, Larson MK, Auger JM, et al. Rac1 is essential for platelet lamellipodia formation and aggregate stability under flow. J Biol Chem. 2005;280(47):39474-39484.
8. Pleines I, Eckly A, Elvers M, et al. Multiple alterations of platelet functions dominated by increased secretion in mice lacking Cdc42 in platelets. Blood. 2010;115(16):3364-3373.
9. Aslan JE, Itakura A, Haley KM, et al. p21 activated kinase signaling coordinates glycoprotein receptor VI-mediated platelet aggregation, lamellipodia formation, and aggregate stability under shear. Arterioscler Thromb Vasc Biol. 2013;33(7):1544-1551.