Plasma total ghrelin and leptin levels in human narcolepsy and matched healthy controls: Basal concentrations and response to sodium oxybate

Journal of Clinical Sleep Medicine

Volumn 9, Issue 8, 2013, Pages 797-803

  Donjacour, Claire E H M ^a   Pardi, Daniel ^a   Aziz, N Ahmad ^a   Frölich, Marijke ^a   Roelfsema, Ferdinand ^a   Overeem, Sebastiaan ^b,c   Pijl, Hanno ^a   Lammers, Gert Jan ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^c Sleep Medicine Center   (Netherlands)

Author keywords

Ghrelin; Hypocretin; Leptin; Narcolepsy; Orexin; Sodium oxybate

Indexed keywords

GHRELIN; LEPTIN; OREXIN; OXYBATE SODIUM;

ADULT; ARTICLE; BLOOD SAMPLING; BODY FAT; BODY MASS; CATAPLEXY; CLINICAL ARTICLE; CLINICAL ASSESSMENT; HORMONE BLOOD LEVEL; HORMONE RELEASE; HUMAN; MALE; NARCOLEPSY; NERVE CELL; OBESITY; SLEEP PATTERN; SLEEP WAKING CYCLE; SYSTEMATIC REVIEW; WAIST HIP RATIO;

GHRELIN; HYPOCRETIN; LEPTIN; NARCOLEPSY; OREXIN; SODIUM OXYBATE;

ADJUVANTS, ANESTHESIA; ADULT; BODY COMPOSITION; BODY MASS INDEX; GHRELIN; HUMANS; LEPTIN; MALE; NARCOLEPSY; OBESITY; SODIUM OXYBATE;

EID: 84888249616     PISSN: 15509389     EISSN: 15509397     Source Type: Journal    
DOI: 10.5664/jcsm.2924     Document Type: Article

References (40)

1. Burdakov D, Gonzalez JA. Physiological functions of glucose-inhibited neurones. Acta Physiol (Oxf) 2009;195:71-8.
2. Sakurai T. Roles of orexins and orexin receptors in central regulation of feeding behavior and energy homeostasis. CNS Neurol Disord Drug Targets 2006;5:313-25. (Pubitemid 43884171)
3. Kok SW, Overeem S, Visscher TL, et al. Hypocretin deficiency in narcoleptic humans is associated with abdominal obesity. Obes Res 2003;11:1147-54. (Pubitemid 41151593)
4. Schuld A, Blum WF, Uhr M, et al. Reduced leptin levels in human narcolepsy. Neuroendocrinology 2000;72:195-8.
5. Kok SW, Meinders AE, Overeem S, et al. Reduction of plasma leptin levels and loss of its circadian rhythmicity in hypocretin (orexin)-deficient narcoleptic humans. J Clin Endocrinol Metab 2002;87:805-9. (Pubitemid 34158256)
6. Arnulf I, Lin L, Zhang J, et al. CSF versus serum leptin in narcolepsy: is there an effect of hypocretin deficiency? Sleep 2006;29:1017-24. (Pubitemid 44257378)
7. Chabas D, Foulon C, Gonzalez J, et al. Eating disorder and metabolism in narcoleptic patients. Sleep 2007;30:1267-73. (Pubitemid 47548277)
8. Poli F, Plazzi G, Di Dalmazi G, et al. Body mass index-independent metabolic alterations in narcolepsy with cataplexy. Sleep 2009;32:1491-7.
9. Dahmen N, Tonn P, Messroghli L, Ghezel-Ahmadi D, Engel A. Basal metabolic rate in narcoleptic patients. Sleep 2009;32:962-4.
10. Kotagal S, Krahn LE, Slocumb N. A putative link between childhood narcolepsy and obesity. Sleep Med 2004;5:147-50. (Pubitemid 38351826)
11. Dahmen N, Becht J, Engel A, Thommes M, Tonn P. Prevalence of eating disorders and eating attacks in narcolepsy. Neuropsychiatr Dis Treat 2008;4:257-61. (Pubitemid 351460962)
12. Fortuyn HA, Swinkels S, Buitelaar J, et al. High prevalence of eating disorders in narcolepsy with cataplexy: a case-control study. Sleep 2008;31:335-41. (Pubitemid 351536505)
13. Tschop M, Smiley DL, Heiman ML. Ghrelin induces adiposity in rodents. Nature 2000;407:908-13.
14. Yin X, Li Y, Xu G, An W, Zhang W. Ghrelin fluctuation, what determines its production? Acta Biochim Biophys Sin (Shanghai) 2009;41:188-97.
15. Hosoda H, Kangawa K. The autonomic nervous system regulates gastric ghrelin secretion in rats. Regul Pept 2008;146:12-8.
16. Toshinai K, Mondal MS, Nakazato M, et al. Upregulation of Ghrelin expression in the stomach upon fasting, insulin-induced hypoglycemia, and leptin administration. Biochem Biophys Res Commun 2001;281:1220-5. (Pubitemid 32924549)
17. Dzaja A, Dalal MA, Himmerich H, Uhr M, Pollmacher T, Schuld A. Sleep enhances nocturnal plasma ghrelin levels in healthy subjects. Am J Physiol Endocrinol Metab 2004;286:E963-7. (Pubitemid 38668819)
18. Yamanaka A, Beuckmann CT, Willie JT, et al. Hypothalamic orexin neurons regulate arousal according to energy balance in mice. Neuron 2003;38:701-13. (Pubitemid 36694778)
19. Toshinai K, Date Y, Murakami N, et al. Ghrelin-induced food intake is mediated via the orexin pathway. Endocrinology 2003;144:1506-12. (Pubitemid 36428493)
20. Perello M, Sakata I, Birnbaum S, et al. Ghrelin increases the rewarding value of high-fat diet in an orexin-dependent manner. Biol Psychiatry 2010;67:880-6.
21. Ahima RS, Prabakaran D, Mantzoros C, et al. Role of leptin in the neuroendocrine response to fasting. Nature 1996;382:250-2. (Pubitemid 26251358)
22. Spiegel K, Leproult R, L'Hermite-Baleriaux M, Copinschi G, Penev PD, Van Cauter E. Leptin levels are dependent on sleep duration: relationships with sympathovagal balance, carbohydrate regulation, cortisol, and thyrotropin. J Clin Endocrinol Metab 2004;89:5762-71. (Pubitemid 39518469)
23. Licinio J, Mantzoros C, Negrao AB, et al. Human leptin levels are pulsatile and inversely related to pituitary-adrenal function. Nat Med 1997;3:575-9. (Pubitemid 27198660)
24. Chaput JP, Despres JP, Bouchard C, Tremblay A. Short sleep duration is associated with reduced leptin levels and increased adiposity: Results from the Quebec family study. Obesity (Silver Spring) 2007;15:253-61. (Pubitemid 46219806)
25. Hakansson M, de Lecea L, Sutcliffe JG, Yanagisawa M, Meister B. Leptin receptor- and STAT3-immunoreactivities in hypocretin/orexin neurones of the lateral hypothalamus. J Neuroendocrinol 1999;11:653-63. (Pubitemid 29338682)
26. Flier JS. Clinical review 94: What's in a name? In search of leptin's physiologic role. J Clin Endocrinol Metab 1998;83:1407-13. (Pubitemid 28500994)
27. Ferguson AV, Samson WK. The orexin/hypocretin system: a critical regulator of neuroendocrine and autonomic function. Front Neuroendocrinol 2003;24:141-50. (Pubitemid 37329470)
28. Zhang W, Sakurai T, Fukuda Y, Kuwaki T. Orexin neuron-mediated skeletal muscle vasodilation and shift of baroreflex during defense response in mice. Am J Physiol Regul Integr Comp Physiol 2006;290:R1654-63. (Pubitemid 43830832)
29. Okun ML, Lin L, Pelin Z, Hong S, Mignot E. Clinical aspects of narcolepsy-cataplexy across ethnic groups. Sleep 2002;25:27-35. (Pubitemid 34072656)
30. Nishino S, Ripley B, Overeem S, et al. Low cerebrospinal fluid hypocretin (Orexin) and altered energy homeostasis in human narcolepsy. Ann Neurol 2001;50:381-8. (Pubitemid 32848741)
31. Schuld A, Hebebrand J, Geller F, Pollmacher T. Increased body-mass index in patients with narcolepsy. Lancet 2000;355:1274-5. (Pubitemid 30184546)
32. Pardi D, Black J. gamma-Hydroxybutyrate/sodium oxybate: neurobiology, and impact on sleep and wakefulness. CNS Drugs 2006;20:993-1018. (Pubitemid 44912708)
33. Husain AM, Ristanovic RK, Bogan RK. Weight loss in narcolepsy patients treated with sodium oxybate. Sleep Med 2009;10:661-3.
34. Van Cauter E, Plat L, Scharf M, et al. Simultaneous stimulation of slow-wave sleep and growth hormone secretion by gamma-hydroxybutyrate in normal young men. J Clin Invest 1997;100:745.
35. Nishino S, Ripley B, Overeem S, Lammers GJ, Mignot E. Hypocretin (orexin) deficiency in human narcolepsy. Lancet 2000;355:39-40. (Pubitemid 30072183)
36. Liu PY, Keenan DM, Kok P, Padmanabhan V, O'Byrne KT, Veldhuis JD. Sensitivity and specificity of pulse detection using a new deconvolution method. Am J Physiol Endocrinol Metab 2009;297:E538-44.
37. Donjacour CE, Aziz NA, Roelfsema F, et al. The effect of sodium oxybate on growth hormone secretion in narcolepsy patients and healthy controls. Am J Physiol Endocrinol Metab 2011;300:E1069-75.
38. Marzullo P, Verti B, Savia G, et al. The relationship between active ghrelin levels and human obesity involves alterations in resting energy expenditure. J Clin Endocrinol Metab 2004;89:936-9. (Pubitemid 38269914)
39. Dahmen N, Engel A, Helfrich J, et al. Peripheral leptin levels in narcoleptic patients. Diabetes Technol Ther 2007;9:348-53. (Pubitemid 47340084)
40. Silha JV, Krsek M, Skrha JV, Sucharda P, Nyomba BL, Murphy LJ. Plasma resistin, adiponectin and leptin levels in lean and obese subjects: correlations with insulin resistance. Eur J Endocrinol 2003;149:331-5. (Pubitemid 37304704)